• Diarrhea-predominant IBS (IBS-D) demonstrated shifts in the metatranscriptome and metabolome including increased bile acids, polyamines, succinate pathway intermediates (malate, fumarate), and transcripts involved in fructose, mannose, and polyol metabolism compared to constipation-predominant IBS (IBS-C). A classifier incorporating metabolites and gene-normalized transcripts differentiated IBS-D from IBS-C with high accuracy (AUC 0.86). (biomedcentral.com)
  • Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. (novusbio.com)
  • In enzymology, a d-iditol 2-dehydrogenase (EC 1.1.1.15) is an enzyme that catalyzes the chemical reaction d-iditol + NAD+ ⇌ {\displaystyle \rightleftharpoons } d-sorbose + NADH + H+ Thus, the two substrates of this enzyme are d-iditol and NAD+, whereas its 3 products are d-sorbose, NADH, and H+. (wikipedia.org)
  • The systematic name of this enzyme class is d-iditol:NAD+ 2-oxidoreductase. (wikipedia.org)
  • This enzyme is also called d-sorbitol dehydrogenase. (wikipedia.org)
  • The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. (novusbio.com)
  • This enzyme is also called d-sorbitol dehydrogenase. (wikipedia.org)
  • The chemical activities of violanthin against alpha amylase and sorbitol dehydrogenase were investigated utilizing the molecular docking study. (bvsalud.org)
  • For α-amylase and sorbitol dehydrogenase enzymes, IC50 values were 25.03 and 1.47 µM. (bvsalud.org)
  • Several secondary problems of diabetes mellitus have been discovered to be prevented or treated with sorbitol dehydrogenase inhibitors. (bvsalud.org)
  • IC50 of Wogonoside and Isoliquiritigenin compounds were 18.25±4.18 and 112.64±16.02 nM for α-glucosidase and 54.72±8.61 and 47.12±11.56 nM for sorbitol dehydrogenase, respectively. (bvsalud.org)
  • In enzymology, a d-iditol 2-dehydrogenase (EC 1.1.1.15) is an enzyme that catalyzes the chemical reaction d-iditol + NAD+ ⇌ {\displaystyle \rightleftharpoons } d-sorbose + NADH + H+ Thus, the two substrates of this enzyme are d-iditol and NAD+, whereas its 3 products are d-sorbose, NADH, and H+. (wikipedia.org)