• Total cell number, mononuclear phagocytes, polymorphonuclear leukocytes, lymphocytes, and LDH levels were significantly increased in ASB and CNT-exposed mice. (cdc.gov)
  • Lung examination findings reveal an interstitial pneumonitis made up of edema fluid, mononuclear cells, and lymphocytes with polymorphonuclear leukocytes. (medscape.com)
  • The initial tissue reaction to infection is a focal, intensely suppurative necrosis consisting largely of accumulations of polymorphonuclear leukocytes, followed by invasion of macrophages, epithelioid cells, and lymphocytes. (cdc.gov)
  • The inflammatory process that permeates heart lesions is responsible for the recruitment of leukocytes (neutrophils, monocytes and lymphocytes) into the heart tissue, through specific mediators such as chemokines, integrins and selectins that play an important role in the inflammatory process [2, 3]. (fortunejournals.com)
  • Mononuclear cells (monocytes and lymphocytes) have a lower buoyant density than the erythrocytes and the polymorphonuclear (PMN) leukocytes (granulocytes). (aralbio.com)
  • Previous studies have suggested that specific IGF-I receptors are present on peripheral blood leukocytes, including polymorphonuclear leukocytes, lymphocytes, and monocytes. (utmb.edu)
  • Two color flow cytometric analysis of mononuclear cells stained with mouse monoclonal antibodies specific for the human IGF-I receptor, the human insulin receptor, and monoclonal antibodies directed against specific monocyte and lymphocyte subset cell surface antigens revealed that both IGF-I receptors and insulin receptors were present on nearly all monocytes and B-lymphocytes, but were present on only 2% of T-lymphocytes. (utmb.edu)
  • We conclude from these data that among human peripheral blood nonactivated mononuclear cells, IGF-I binds to specific type I IGF receptors found predominately on monocytes and B-lymphocytes. (utmb.edu)
  • Macrophages, lymphocytes, and plasma cells are all considered mononuclear cells. (kembara.co)
  • Aseptic meningitis is a term used to describe a syndrome of meningeal inflammationassociated mostly with an increase of cells (pleocytosis), primarily lymphocytes and other mononuclear cells in the CSF, and absence of readily cultivable bacteria or fungi. (brainkart.com)
  • Effect of purified staphylococcal leukocidal toxins on isolated blood polymorphonuclear leukocytes and peritoneal macrophages in vitro. (nih.gov)
  • There was no PVR cell surface expression on platelets and extremely low levels on polymorphonuclear leukocytes. (nih.gov)
  • Zn concentrations in erythrocytes, platelets, mononuclear cells, and polymorphonuclear leukocytes were not significantly increased by any treatment. (syr.edu)
  • Effect of pneumococci on blood clotting, platelets, and polymorphonuclear leukocytes. (docksci.com)
  • Platelet aggregation, thrombocytopenia, and induction of adherence of platelets to leukocytes by several species of bacteria have also been demonstrated both in vivo (14, 21, 32) and in vitro (10). (docksci.com)
  • expands our previous studies to the effects of virulent pneumococci on clotting factors, platelets and polymorphonulear leukocytes (PMNs and suggests some pathogenetic explanations for the events in lethal pneumococcemia. (docksci.com)
  • Phagocytosis and killing by polymorphonuclear and mononuclear leukocytes are important host resistance factors against invading microorganisms. (jci.org)
  • Therefore, we studied the fate of Escherichia coli DNA following phagocytosis of E. coli by polymorphonuclear and mononuclear leukocytes. (jci.org)
  • Although phagocytosis and killing by mononuclear leukocytes was less efficient than that by polymorphonuclear leukocytes, only mononuclear leukocytes were able to degrade E. coli PC2166 DNA. (jci.org)
  • Although we observed no DNA degradation during phagocytosis by polymorphonuclear leukocytes, lysates of both polymorphonuclear and mononuclear leukocytes contained acid-DNase activity with a pH optimum of 4.9. (jci.org)
  • of 1.0 = 8 x 108 CFU/ml) opsonized in 10% human serum was added to Phagocytosis of bacteria by polymorphonuclear leukocytes (PMNLs) is accompanied by enhancement of PMNL oxidative metabolism. (docksci.com)
  • PVR cell surface expression was detected on most mononuclear cells expressing CD14, a marker for mononuclear phagocytes. (nih.gov)
  • The finding of PVR on mononuclear phagocytes and the ability of primary human blood cells to support PV replication in the absence of cultivation has implications for both the normal and pathogenic role of PVR. (nih.gov)
  • Blood is a specialized body fluid composed of four main components: plasma, white blood cells (leukocytes), red blood cells (erythrocytes), and platelets (thrombocytes). (cellculturedish.com)
  • White blood cells ( WBCs, also called leukocytes) are a critical part of our body's immune system. (rsscience.com)
  • In this video] Large cells moving along the blood vessels are leukocytes. (rsscience.com)
  • A simple and effective method for the isolation of mononuclear cells from human blood was reported by Dr. Arne Bøyum in 1968. (aralbio.com)
  • The vast majority of mononuclear cells have densities below 1.077 g/ml. (aralbio.com)
  • These cells can therefore be isolated by centrifugation on an isoosmotic medium with a density of 1.077 g/ml, which allows the erythrocytes and the PMNs to sediment through the medium while retaining the mononuclear cells at the sample/medium interface. (aralbio.com)
  • We sought to determine what type of IGF receptor was present on peripheral blood mononuclear cells and which types of cells possessed these receptors. (utmb.edu)
  • Binding of [ 125 I]IGF-I to mononuclear cells was inhibited by both unlabeled IGF-I and insulin, insulin being 200-fold less potent than IGF-I. Covalent affinity labeling with [ 125 I]IGF-I, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography, revealed a specific binding species with an apparent mol wt of 130 kDa. (utmb.edu)
  • In chronic inflammatory reactions, what are mononuclear cells? (kembara.co)
  • Chronic inflammation is mediated by cells with a nonsegmented single nucleus, as opposed to acute inflammation, which is mediated by polymorphonuclear leukocytes with a segmented nucleus. (kembara.co)
  • Polymorphonuclear leukocytes (PMNs) has a lower buoyant density than erythrocytes (1.09-1.11 g/ml) but a higher buoyant density than the mononuclear cells (higher than 1.085 g/ml). (nabfa-blackfly.org)
  • The PMNs band within this density gradient while the mononuclear cells remain at the sample/medium interface. (nabfa-blackfly.org)
  • The samples were analyzed in duplicate by the Yumizen H2500 to determine the number of leukocytes and erythrocytes, the partial formula (% of mononuclear cells (%MN) and % of polymorphonuclear cells (%PN)) and to detect abnormal cells. (horiba.com)
  • Polymorphonuclear leukocytes (PMN) are main effector cells in the acute immune response. (biomedcentral.com)
  • Numerous white blood cells (WBCs) of the polymorphonuclear (PMN) type represent the prevalent cell type. (cdc.gov)
  • DS patients also present a T cell immunodeficiency causing functional defects of polymorphonuclear leukocytes, reduced chemotaxis, diminished phagocytic ability, defective oxidative response and abnormal bactericidal activity 3 . (bvsalud.org)
  • Therefore, it is difficult to isolate polymorphonuclear granulocytes using a density barrier similar to that used for mononuclear cell. (nabfa-blackfly.org)
  • To further analyze the capacity of mononuclear leukocytes to degrade E. coli DNA, chromosomal and plasmid DNA was isolated from ingested bacteria and subjected to agarose gel-electrophoresis. (jci.org)
  • Leukocytes play a central role in protecting our body from various microorganisms (i.e., bacteria, yeasts, and protozoa), viruses, and parasites (i.e., helminths and ectoparasites). (rsscience.com)
  • No difference was observed between DNase activity from polymorphonuclear and mononuclear leukocytes from a chronic granulomatous disease patient with DNase activity from control polymorphonuclear and mononuclear leukocytes. (jci.org)
  • In addition, data from this study allowed the leukocyte count and the scattergram thresholds used for the differential to be optimized. (horiba.com)
  • 3H]thymidine-labeled, unencapsulated E. coli PC2166 and E. coli 048K1 were incubated in serum, washed, and added to leukocytes. (jci.org)
  • When infection occurs, leukocytes transmigrate through the blood vessel walls and move to the infected site. (rsscience.com)
  • 74 out of 98 samples were used to compare leukocyte and erythrocyte count. (horiba.com)
  • Cannabidiol modulates human polymorphonuclear leukocyte functions: experimental evidence and clinical implications. (curaleafinternational.com)
  • The polymorphonuclear leukocyte-neutrophil is a key cell type and an essential part of the host's inflammatory response. (bvsalud.org)
  • Clinically, the diagnosis of en-cephalitis is applied to patients who may or may not show signs and CSF findings com-patible with aseptic meningitis but also show objective evidence of CNS dysfunction (eg, seizures, paralysis, and disordered mentation). (brainkart.com)
  • Mononuclear leukocytes from Ficoll density centrifugation were found to support PV replication. (nih.gov)