• We performed a meta-analysis to assess the association of HLA-DRB1 alleles with risk of SSc. (nih.gov)
  • Odds ratio (ORs) and 95% confidence intervals were used to assess the association of HLA-DRB1 alleles with SSc. (nih.gov)
  • Recent data also suggest that carriers of specific major histocompatibility complex (MHC) alleles, in particular HLA-DRB1*15, HLA-DQA1*0104, DQB1*0501 and DQB1*0503, are at increased risk of developing keloid scarring. (medscape.com)
  • 17. Frequency analysis of HLA class I alleles in Iranian patients with progressive and non-progressive chronic lymphocytic leukemia. (nih.gov)
  • Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. (cdc.gov)
  • Most HLA-B gene alleles are rare, while others do not affect protein function or change the structure of the protein. (medlineplus.gov)
  • Hundreds of versions (alleles) of the HLA-B gene are known, each of which is given a particular number (such as HLA-B27 ). (medlineplus.gov)
  • for example, more than 60 very similar alleles are subtypes of HLA-B27 . (medlineplus.gov)
  • Additional HLA-B alleles play a smaller role in disease risk: the HLA-B47 and HLA-B51 alleles can contribute to increased risk, whereas the HLA-B7 and HLA-B57 alleles might provide some small amount of protection against developing the condition. (medlineplus.gov)
  • Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
  • Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. (vitamindwiki.com)
  • Furthermore, his research spurred the discovery of H-2 haplotypes, HLA alleles and haplotypes, HLA loci genetic order, the role of histocompatibility antigens in skin graft rejection, and the outcome of kidney allografts. (brighthub.com)
  • Dr. Amos organized the first World Health Organization Nomenclature Committee, which has been responsible for the naming of HLA specificities and alleles since 1967. (brighthub.com)
  • The most clearly defined footprints are those associated with HLA alleles that are linked with successful control of HIV, such as HLA-B*57. (ox.ac.uk)
  • Conclusion: Alleles of HLA-DRB1*04 might affect visual prognosis and be related to early response after initiation of treatment in VKH disease. (researchsquare.com)
  • A role of genetic factors such as HLA alleles in the development of VKH was first considered in 1976, and was supported by the simultaneous development of VKH in monozygotic twins [3]. (researchsquare.com)
  • HLA typing tests detect an individual's alleles by analysing HLA gene sequences. (wellnessofhealth.com)
  • SSO and SSP hybridization tests employ probes that bind to known HLA alleles . (wellnessofhealth.com)
  • These molecular assays discover HLA alleles for medicinal uses. (wellnessofhealth.com)
  • HLA typing tests identify a person's HLA genes and alleles. (wellnessofhealth.com)
  • illness Association Studies: HLA typing is utilised in academic and clinical settings to study illness associations with distinct HLA alleles. (wellnessofhealth.com)
  • Primers that bind to conserved areas surrounding HLA genes preferentially amplify the desired alleles. (wellnessofhealth.com)
  • Detection and Analysis: After DNA amplification, multiple approaches may be used to identify the sample's HLA alleles. (wellnessofhealth.com)
  • SSO Hybridization: SSO probes detect particular HLA alleles by complementary binding to amplified DNA fragments. (wellnessofhealth.com)
  • Probe hybridization identifies HLA alleles. (wellnessofhealth.com)
  • SSP PCR uses primers that complement certain HLA alleles. (wellnessofhealth.com)
  • This precisely identifies the sample's HLA alleles. (wellnessofhealth.com)
  • Reporting: The identified alleles determine the individual's HLA type. (wellnessofhealth.com)
  • Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying in the HLA region are known to be associated with several infectious diseases among which acquired immunodeficiency syndrome, hepatitis B, hepatitis C, tuberculosis, leprosy and malaria are highly prevalent in many human populations worldwide. (unige.ch)
  • Although studies have evaluated the association between HLA-DRB1 allele polymorphisms and systemic sclerosis (SSc), their results are still controversial. (nih.gov)
  • Association of the HLA-DQB*0501, allele of the major histocompatibility complex with gastric cancer in Mexico]. (cdc.gov)
  • It is estimated that among those with the HLA-B27 allele, only one to five percent develop ankylosing spondylitis. (medlineplus.gov)
  • and the African-specific risk allele of HLA-DRB1*15:03 (OR = 1.26 [1.05-1.51], p = 0.012). (vitamindwiki.com)
  • Both of these haplotypes contained the TNF promoter polymorphism -1031C, an allele that was associated with disease even in individuals who did not carry either HLA-B*51 or HLA- B*5701. (dundee.ac.uk)
  • The screened epitopes were further validated for their binding with their respective HLA allele binders and TAP (Transporter associated with antigen processing) molecule by molecular docking. (biorxiv.org)
  • We investigated HLA-E allele status in 52 Caucasian and Ashkenazi Jewish Pemphigus vulgaris (PV) patients and 51 healthy controls by restriction fragment length polymorphism-polymerase chain reaction and amplification refractory mutation system. (researchgate.net)
  • Finally, we investigated the impact of HLA selection on within-clade phylogeny and demonstrate that even a single HLA allele footprint can result in significant phylogenetic clustering of sequences. (ox.ac.uk)
  • We found a new HLA-A allele A*2420 in Atayal and Saisiat, and the allele frequencies are 15% and 13%, respectively. (tipp.org.tw)
  • Analysis of allele frequencies and genetic distances of HLA-A gene reveals that Amis and Yami are different from other Taiwan aboriginal tribes. (tipp.org.tw)
  • A Korean study found that the HLA DRB1*0405 allele conferred an increased relative risk of developing VKH compared with the general population, and that the HLA DRB1*0405-DQA1*0302-DQB1*0401 haplotype was associated with poorer visual prognosis [6]. (researchsquare.com)
  • We observed similar proportions of HLA DRB1*1302 carriers in E-P positive cases and controls, but interestingly, this allele was not found in AA cases (p = 0.03, Fisher exact test). (biomedcentral.com)
  • PCR amplification indicates the HLA allele in amplified DNA. (wellnessofhealth.com)
  • The International ImMunoGeneTics (IMGT)/HLA database is used to give allele designations to the findings. (wellnessofhealth.com)
  • A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations. (unige.ch)
  • The present review updates the information regarding the main HLA allele and SNP associations observed to date for six of the most widespread and some other infectious diseases, and provides a synthetic illustration of these findings on a schematic HLA genomic map. (unige.ch)
  • Genotypes of HLA class I genes and germline mutations were obtained for estimation of the binding affinity and number of self-antigens. (nature.com)
  • This four megabase region on chromosome 6 contains at least 150 coding genes, and includes the HLA Class I, II, and III gene families. (nih.gov)
  • We have found strong associations between HCV recovery and polymorphisms in some immune response genes. (nih.gov)
  • Polymorphisms in HLA-DQ genes, together with age, sex, and Helicobacter pylori infection, as potential biomarkers for the early diagnosis of gastric cancer. (cdc.gov)
  • HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • In humans, the HLA-B gene and two related genes, HLA-A and HLA-C , are the main genes in MHC class I. (medlineplus.gov)
  • The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
  • The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
  • Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
  • Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)
  • We attempted to dissect the contribution of individual polymorphisms in this gene-dense region by linkage disequilibrium mapping across 6 adjacent genes. (dundee.ac.uk)
  • A number of single nucleotide polymorphisms (SNPs) within MHC Class I and II genes were found to be associated with variations in the vaccine specific antibody responses and serum levels of immunoglobulins (IgG, IgM) and IgG isotypes (IgG1, IgG4) (all at p (cdc.gov)
  • Genetic imbalances, especially in genes related to human histocompatibility leukocyte antigens (HLA), can predispose individuals to autoimmune diseases. (reinventhealthcare.com)
  • The proteins encoded by the classical HLA class I and class II genes in the major histocompatibility complex (MHC) are highly polymorphic and are essential in self versus non-self immune recognition. (ox.ac.uk)
  • Yet identification of causal variants is problematic owing to linkage disequilibrium that extends across multiple HLA and non-HLA genes in the MHC. (ox.ac.uk)
  • The polygenic HLA (human leukocyte antigen) gene complex is the most polymorphic cluster of functional genes known. (tipp.org.tw)
  • The high polymorphism of HLA genes makes these functional genes ideal genetic markers for studying inter-relationships among various human populations. (tipp.org.tw)
  • The human leukocyte antigen (HLA) system is the locus of genes that encode for major histocompatibility complex (MHC), representing a set of cell surface molecules mediating the interaction of leukocytes [4]. (researchsquare.com)
  • For predicting prognosis and refractoriness to treatment, the focus in recent years has transitioned from the identification of HLA genes associated with increased risk of VKH to the identification of alternate genes [9,10]. (researchsquare.com)
  • We characterized HPV-16 variants by PCR in 107 ICC cases, which were typed for HLA-DQA1 , DRB1 and DQB1 genes and compared to 257 controls. (biomedcentral.com)
  • The human tumor necrosis factor locus (TNF locus) is located within the major histocompatibility complex between the class III genes and HLA-B. We recently characterized and studied two closely linked highly informative dinucleotide repeats (AC/GT)n (designated TNFa) and (TC/GA)k (designated TNFb) in the upstream region of the human TNF-beta (lymphotoxin) gene. (ox.ac.uk)
  • We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. (liverpool.ac.uk)
  • Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. (liverpool.ac.uk)
  • HLA typing is essential for identifying an individual's HLA genes. (wellnessofhealth.com)
  • HLA genes are extremely polymorphic. (wellnessofhealth.com)
  • Although human leukocyte antigens (HLAs) account for approximately 30% of the heritable risk, the identities of non-HLA genes explaining the remainder of the genetic component are largely unknown. (nih.gov)
  • While HLAs are among the most polymorphic genes in humans, several HLA:peptide complexes have been identified as potential neoantigens in human diseases and represent promising therapeutic targets. (sgourakislab.org)
  • However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions. (biomedcentral.com)
  • Genes coding immune system proteins such as the Human leucocyte antigen (HLA)-G are important candidates. (scirp.org)
  • Highly polymorphic regions (such as HLA genes) are not represented either due to difficulty with designing primers because of the lack of constant regions flanking the variants. (dorak.info)
  • 2. HLA Gm systems and susceptibility to alcoholic cirrhosis: a study of mixed-race subjects. (nih.gov)
  • 15. Interaction of IgG heavy-chain allotypes (Gm) and HLA in conferring susceptibility to thyroid carcinoma. (nih.gov)
  • Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease. (cdc.gov)
  • The TNF gene is encoded in the class III region of the HLA complex adjacent to HLA-B. This genetic proximity to a gene that is already widely implicated in disease susceptibility led us to investigate the association between TNF promoter polymorphisms and susceptibility to BD. (dundee.ac.uk)
  • One of them contained the previously recognized susceptibility gene HLA-B*51, while the other was defined by HLA-B*5701. (dundee.ac.uk)
  • A locus telomeric to HLA-DPB encodes susceptibility to coeliac disease. (ox.ac.uk)
  • HLA variation is a crucial determinant of transplant rejection and susceptibility to a large number of infectious and autoimmune diseases. (ox.ac.uk)
  • HLA class II polymorphisms are also associated with genetic susceptibility to ICC. (biomedcentral.com)
  • Modern studies reveal the hereditary nature of the disease and state that susceptibility to it "involves human leucocyte antigen (HLA) class II gene polymorphisms" (Lau & Mok, 2003, p. 481). (123essaywriting.com)
  • These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility. (liverpool.ac.uk)
  • Our findings indicate that a polymorphism in the TRAF1/C5 region increases the susceptibility to and severity of RA, possibly by influencing the structure, function, and/or expression levels of TRAF1 and/or C5. (nih.gov)
  • This study showed that protein dynamics are molecular determinants to the significant differences in how different HLA proteins are recognized by chaperones, and provides insights into how antigen presentation and chaperone recognition influence disease susceptibility between patients with different HLA proteins. (sgourakislab.org)
  • The goal of our study was to investigate the association of 14 bp Indel HLA-G polymorphism with the susceptibility/resistance to HAT. (scirp.org)
  • In 2014, Genome-Wide Association Study (GWAS) was performed with 2,398 individuals with laryngeal squamous cell carcinoma cases and 2,804 cancer-free controls from Chinese populations, and identified a novel susceptibility loci in complex human leukocyte antigen (HLA), which plays crucial role in immune response. (who.int)
  • Second, we have examined how amino acid polymorphisms in the MHC, called HLA in humans, dictate chaperone recognition and antigen selection. (sgourakislab.org)
  • The process of identifying DNA variation that may be associated with disease is under way through the cataloguing and mapping of single nucleotide polymorphisms (SNPs) throughout the genome. (cdc.gov)
  • Single nucleotide polymorphism (SNP) genotyping was conducted for 76 MS-associated SNPs and 52 ancestry informative marker SNPs selected throughout the genome. (vitamindwiki.com)
  • We as functional practitioners should understand the role of single nucleotide polymorphisms (SNPs) in influencing inflammation and autoimmune conditions. (reinventhealthcare.com)
  • 7,500 common SNPs and deletion-insertion polymorphisms across four population samples. (ox.ac.uk)
  • The analysis provides informative tag SNPs that capture much of the common variation in the MHC region and that could be used in disease association studies, and it provides new insight into the evolutionary dynamics and ancestral origins of the HLA loci and their haplotypes. (ox.ac.uk)
  • We performed a multitiered case-control study using 40 single-nucleotide polymorphisms (SNPs) from the TRAF1 and C5 (TRAF1/C5) region in a set of 290 RA patients and 254 unaffected participants (controls) of Dutch origin. (nih.gov)
  • SNPs in or near DNER (smallest P(JMA = )5.00×10(-11)), HLA-DQB1 and HLA-DQA2 (smallest P(JMA = )4.35×10(-9)), and KCNJ2 and SOX9 (smallest P(JMA = )1.28×10(-8)) were associated with FEV(1)/FVC or FEV(1) in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. (ox.ac.uk)
  • Association between HLA-DQ genotypes and haplotypes vs Helicobacter pylori infection in an Indonesian population. (cdc.gov)
  • Subsequent analysis identified 2 extended HLA haplotypes associated with BD. (dundee.ac.uk)
  • Although the pathogenesis of PSC remains incompletely understood, strong associations with HLA-class II haplotypes have been described. (bmj.com)
  • 11. Selective and non-selective loss of immunoregulatory molecules (HLA-A,B,C antigens and LFA-3) in transitional cell carcinoma. (nih.gov)
  • As immune responses are based on the capability of HLA molecules to differentially bind specific peptides, the strength of immune responses differs according to the presentation of variable HLA antigens. (nature.com)
  • For example, we were the first to show genetic evidence that inhibitory signaling from human leukocyte antigen C (HLA-C) molecules affected the outcome of infection by interaction with the NK cell killer immunoglobulin-like receptor (KIR). (nih.gov)
  • Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
  • As specific HLA-DP molecules can bind the activating NK-cell receptor NKp44, we investigated the role of HLA-DP/NKp44-interactions in PSC. (bmj.com)
  • NK cell activation on NKp44/HLA-DP interactions was assessed in vitro using plate-bound HLA-DP molecules and HLA-DPB wildtype versus knock-out human cholangiocyte organoids. (bmj.com)
  • Primary NKp44+NK cells exhibited significantly higher degranulation in response to plate-bound HLA-DPA1*02:01-DPB1*01:01 compared with control HLA-DP molecules, which were inhibited by anti-NKp44-blocking. (bmj.com)
  • HLA molecules convey antigens to T cells, triggering immunological responses and controlling organ and tissue transplant compatibility. (wellnessofhealth.com)
  • The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. (biomedcentral.com)
  • The high polymorphism of HLA gene is responsible for the complicated ability of the immune system to react to a tremendous variety of different peptides 4 , 5 . (nature.com)
  • 9. [Studies of histocompatibility antigens in otospongiosis]. (nih.gov)
  • 12. [HLA histocompatibility antigens in patients with aortic valve defects]. (nih.gov)
  • This cooperative research group supports projects defining the association between variations in the human leukocyte antigen (HLA), also known as the Major Histocompatibility Complex (MHC), and natural killer cell immunoglobulin-like receptor (KIR) genetic regions and immune-mediated diseases, including outcomes following cell, tissue, and organ transplantation. (nih.gov)
  • This cooperative research group supports studies to discover and characterize associations between polymorphisms in the human leukocyte antigen (HLA, also known as the Major Histocompatibility Complex or MHC), and natural killer cell immunoglobulin-like receptor (KIR) genomic regions and (1) immune-mediated diseases, including risk and phenotype, and (2) cell, tissue, and organ transplantation outcomes, including rejection, tolerance, or graft versus host disease (GVHD). (nih.gov)
  • HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
  • He organized the First International Histocompatibility Workshop in Durham, North Carolina, which fostered previously unheard-of international collaboration, leading to competitive studies that define the MHC (HLA) complex. (brighthub.com)
  • C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients. (fhcrc.org)
  • EXPERIMENTAL DESIGN: CD8+ CTL clones that recognized a novel RCC-associated minor histocompatibility (H) antigen presented by HLA-A*0201 were isolated from two patients with metastatic RCC who experienced tumor regression or stable disease following nonmyeloablative allogeneic HCT. (fhcrc.org)
  • Here, we combine these four markers together with a biallelic TC/GA repeat in the first intron of the TNF-beta gene (TNFc) and a biallelic NcoI RFLP (TNFn) to type 105 cell lines from the American Society of Histocompatibility and Immunogenetics Workshop and the Center for Human Polymorphism Studies reference panels of HLA typing cell lines. (ox.ac.uk)
  • Principal focuses in the lab include antigen processing and presentation by the Major Histocompatibility Complex (MHC), the role of immune chaperones in the assembly of the MHC and effects on antigen repertoires, recognition of antigen/MHC complexes by T cell receptors (TCRs), pleiotropic cytokines function and dynamics, development of new tools to characterize T cell repertoires in diseased patients, and engineering of novel immunotherapies based on T cell-mediated immunity. (sgourakislab.org)
  • HLA-G is a non-classical major histocompatibility complex (MHC) class I gene. (scirp.org)
  • In human genome, the human leukocyte antigen (HLA) gene contains the most polymorphic region, as it codes for antigens directly involved in immunological recognition. (nature.com)
  • The HLA genomic region is the most polymorphic and gene-dense region in the human genome. (nih.gov)
  • Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
  • The strongest determinant is HLA-DR, followed by HLA-B and -A. These 3 loci are therefore the most important for matching donor and recipient. (msdmanuals.com)
  • The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. (ox.ac.uk)
  • Therefore, in this study, we are investigating the relationship between HNC and HLA loci using an advanced fine-mapping approach and a significantly larger dataset. (who.int)
  • Novel HLA loci associated with HNC are expected to be discovered in this study. (who.int)
  • The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (nih.gov)
  • We aim to investigate whether strong-binding affinity self-antigen load is associated with early/late-onset Alzheimer's disease (AD). (nature.com)
  • In addition to supporting HLA and KIR region association studies, a major goal of this program is the assemblage of high-quality, high-resolution genetic data with accompanying disease state and phenotype information. (nih.gov)
  • Several versions of the HLA-B gene, particularly HLA-B51 , are associated with an increased risk of developing Behçet disease, a chronic inflammatory condition that affects many parts of the body. (medlineplus.gov)
  • Mapping the HLA association in Behçet's disease: A role for tumor necrosis factor polymorphisms? (dundee.ac.uk)
  • Further studies will be required to determine the functional effects of this polymorphism, its influence in disease pathogenesis, and its role in other ethnic groups. (dundee.ac.uk)
  • Dive into the research topics of 'Mapping the HLA association in Behçet's disease: A role for tumor necrosis factor polymorphisms? (dundee.ac.uk)
  • We performed a SNP array on chromosome 6 in CD34 + purified blasts from 19 patients diagnosed with advanced MDS and 8 patients with other myeloid malignancies to evaluate the presence of loss of heterozygosity (LOH) in HLA and its impact on disease progression. (oncotarget.com)
  • HLA-E*0103X/*0103X has been associated with Behcet's disease and HLA-E *0101/*0103X with childhood onset diabetes. (researchgate.net)
  • Considering the clinical and genetic heterogeneity of psoriasis which may translate into distinct disease pathology and treatment response, correct typing of the main candidate gene HLA-C is critical but not trivial. (researchgate.net)
  • A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. (ox.ac.uk)
  • Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). (geneticsmr.com)
  • Finding a suitable donor with a comparable HLA type to the recipient improves transplant success and minimises the danger of life-threatening graft-versus-host disease. (wellnessofhealth.com)
  • It then discusses these results by stressing the importance of integrating information on HLA population diversity in disease-association studies. (unige.ch)
  • Researchers speculate that HLA-B27 may abnormally display peptides that trigger an immune reaction, resulting in the inflammatory process that causes arthritis. (medlineplus.gov)
  • HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection. (cdc.gov)
  • Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients. (cdc.gov)
  • Subsequently, two separate GWASs has been conducted and consistently identified locus in HLA region in association with HNC. (who.int)
  • Despite these significant findings, it is important to note that imputed data for the HLA locus may pose challenges due to high level of linkage disequilibrium and polymorphism. (who.int)
  • The immune system can recognise and react to many foreign chemicals due to HLA molecule variety. (wellnessofhealth.com)
  • HLA typing assays are essential to studying HLA molecule genetic variability. (wellnessofhealth.com)
  • Molecular dynamics simulations uncovered Uridine triphosphate that peptide comes with an optimum binding sign up for diabetogenic HLA-DQ8. (eprf.ca)
  • Cellular and molecular characterization of antigens recognized by tumor-reactive T cells isolated from responding patients could potentially provide insight into the mechanisms of tumor regression. (fhcrc.org)
  • Molecular biology labs do HLA typing assays. (wellnessofhealth.com)
  • These molecular methods have since replaced the serological methods for HLA typing in most clinical laboratories. (immunopaedia.org.za)
  • HLA-E outcomes included presumed homozygous *0101/*0101 or *0103X/*0103X genotype status or *0101/*0103X heterozygous status. (researchgate.net)
  • Self-antigen presentation outside the central nervous system has crucial role regarding self-proteins tolerance and autoimmunity, leading to neuroinflammation. (nature.com)
  • On the other hand, self-antigen presentation outside the CNS may have crucial role regarding self-proteins tolerance and autoimmunity leading to neuroinflammation 11 . (nature.com)
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
  • The HLA-B gene has many possible variations, that result in the production of proteins that differ by changes in at least one protein building block (amino acid). (medlineplus.gov)
  • Sometimes additional numbers are added after a colon to identify allelic variants that encode identical proteins, and after another colon, other numbers are added to denote polymorphisms in introns or in 5' or 3' untranslated regions (eg, A*02:101:01:02, DRB1*03:01:01:02). (msdmanuals.com)
  • In collaboration with the Procko lab (University of Illinois), We performed deep mutagenesis studies in human cell lines, and experimentally determined protein dynamics in chaperone-dependent and chaperone-independent HLA proteins and correlated observed conformational changes with chaperone recognition ( McShan, Devlin et al, PNAS, 2019 ). (sgourakislab.org)
  • HLA-G can generate four forms of membrane-bound proteins (HLA-G1, G2, G3, and G4) and three forms of soluble proteins (HLA-G5, G6, and G7) due to HLA-G alternative splicing. (scirp.org)
  • Variants in the HLA-B gene, particularly a version called HLA-B27 , significantly increase the risk of developing ankylosing spondylitis. (medlineplus.gov)
  • Our results suggest that the association between HLA polymorphism and risk of ICC might be influenced by the distribution of HPV-16 variants. (biomedcentral.com)
  • Recently, this signal of HLA region was confirmed to be specific to HPV(+) in oropharyngeal cancer suggesting the role of HLA variants in the immune pathogenesis. (who.int)
  • HLA-DP haplotype analysis revealed a highly elevated PSC risk for HLA-DPA1*02:01~B1*01:01 (OR 1.99, p=6.7×10 −50 ). (bmj.com)
  • She displayed HLA DQ 2.5, the haplotype associated to the highest risk of CD. (unicatt.it)
  • This is the first report showing the presence of a HLA haplotype compatible for CD in archaeological specimens. (unicatt.it)
  • This is the first study using NGS to investigate germline mutations generated self-antigen load in AD. (nature.com)
  • Viral evasion of CD8(+) T-cell responses leaves predictable combinations of escape mutations, termed HLA "footprints. (ox.ac.uk)
  • HLA, and HLA-DRB1*04 in particular, therefore plays a key role in immune systemic function, as well as in the pathogenesis of autoimmune diseases, including VKH [5]. (researchsquare.com)
  • Certain HLA types raise risk or protect against autoimmune illnesses, infectious diseases, and medication hypersensitivity responses. (wellnessofhealth.com)
  • Unravelling how antigens are loaded onto the MHC and subsequently recognized by immune chaperones and TCR receptors will help us understand autoimmune diseases, such as diabetes, multiple sclerosis and arthritis, and immune responses to invading pathogens and developing tumors. (sgourakislab.org)
  • The differential T-cell recognition of donor- and recipient-derived target cells is attributable to a nonsynonymous single-nucleotide polymorphism within the nucleotide interval that encodes the antigenic peptide. (fhcrc.org)
  • HLA-DRB1*03 and DRB1*04 are associated with atrophic gastritis in an Italian population. (cdc.gov)
  • This Funding Opportunity Announcement (FOA) invites applications from investigators to participate in the HLA and KIR Region Genomics in Immune Mediated Diseases Consortium (HLAGC), formerly the HLA Region Genomics in Immune-Mediated Diseases Consortium. (nih.gov)
  • This Funding Opportunity Announcement (FOA) solicits applications from institutions to participate in the HLA and KIR Region Genomics in Immune-Mediated Diseases Consortium (HLAGC), formerly the HLA Region Genomics in Immune-Mediated Diseases Consortium. (nih.gov)
  • Both antigen receptors possess similar buildings and highly different repertoires (Wardemann et al. (eprf.ca)
  • The simplest change is the substitution of one nucleotide for another, which is known as a single nucleotide polymorphism (SNP). (biomedcentral.com)
  • Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV(1) and FEV(1)/FVC across 19 studies (total N = 50,047). (ox.ac.uk)
  • To investigate her human leukocyte antigen (HLA) class II polymorphism, we extracted DNA from a bone sample and a tooth and genotyped HLA using three HLA-tagging single nucleotide polymorphisms for DQ8, DQ2.2 and DQ2.5, specifically associated to CD. (unicatt.it)
  • As strong-binding affinity self-antigen is considered to be pathogenic in neuroinflammation, our finding indicated that self-antigen load did have a role in the pathogenesis of AD owing to its association with neuroinflammation. (nature.com)
  • Similarly, the sites of amino acid variability within a clade were found to overlap with sites of HLA-selected mutation. (ox.ac.uk)
  • However, HLA footprints may underpin founder strains, and we show that amino acid substitutions between clades alter phylogeny, underlining a potentially substantial role for HLA in driving ongoing viral evolution. (ox.ac.uk)
  • 19. Study on the association of HLA with malignant lymphoma. (nih.gov)
  • The protective association of HLA-A*02:01 was confirmed (OR = 0.72 [0.55-0.93], p = 0.013). (vitamindwiki.com)
  • HLA-DPA1 and HLA-DPB1 imputation and association analyses were performed in 3408 individuals with PSC and 34 213 controls. (bmj.com)
  • Association between human leukocyte antigen and COVID-19 severity by: Reza Hajebi, et al. (uitm.edu.my)
  • Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination. (cdc.gov)
  • A systemic literature search of the PubMed and EMBASE databases was conducted to identify eligible studies investigating the association of the HLA-G 14-bp INS/DEL polymorphism with AID. (geneticsmr.com)
  • Organ and bone marrow transplantation, illness association research, and pharmacogenomics need HLA type knowledge. (wellnessofhealth.com)
  • Human leukocyte antigens (HLAs) are essential peptide-presenting complexes relevant to immune response and dysregulated in several human diseases, including cancer. (sgourakislab.org)
  • In our HLA research, we investigate the potential of peptide-centric biologics to selectively recognize and target HLA:peptide complexes present in human diseases. (sgourakislab.org)
  • Accurate imputation of human leukocyte antigens with CookHLA by: Seungho Cook, et al. (uitm.edu.my)
  • HLA imputation was performed with Michigan HLA imputation server with recent multi-ethnic HLA imputation panel. (who.int)
  • Although many people with ankylosing spondylitis have the HLA-B27 variation, most people with this version of the HLA-B gene never develop the disorder. (medlineplus.gov)
  • The other one is that mutation is any variation in the gene that causes an obvious change in phenotype whereas polymorphisms do not cause any obvious phenotypic variation. (dorak.info)
  • He is one of the central figures in the development of allotransplantation, his role in developing methods to match MHC antigens in particular. (brighthub.com)
  • HLA types were previously determined by serological methods like the CDC test. (wellnessofhealth.com)
  • First, we have described the role of switch in the MHC (called the alpha2-1 helix), which undergoes significant conformational changes during a "tug-of-war" between the incoming peptide antigen and the TAPBPR chaperone. (sgourakislab.org)
  • Interestingly, for the peptide antigen to win the "tug-of-war", allosteric communication between MHC sites spanning the antigen binding groove are required ( McShan et al, Nature Chemical Biology, 2018 ). (sgourakislab.org)
  • While these peptide-centric biologics are difficult to design without cross-reactivity to other endogenous HLA complexes, the Maris lab at CHOP has spearheaded the development of a chimeric antigen receptor (CAR) which binds an HLA:peptide target expressed exclusively in neuroblastoma. (sgourakislab.org)
  • Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. (cdc.gov)
  • In this study we have used sequence-based typing (SBT) to analyze the degree of polymorphism of classΙ HLA-A gene in the nine Taiwan aboriginal tribes (Amis, Atayal, Bunun, Paiwan, Puyuma, Rukai, Saisiat, Tsou, and Yami) and Taiwan Han Chinese. (tipp.org.tw)
  • Human leukocyteantigen (HLA) is the most important gene for immune system regulation. (nih.gov)
  • The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • Three patients had acquired copy-neutral LOH (CN-LOH) on 6p arms, which may disrupt antigen presentation and act as a mechanism for immune system evasion. (oncotarget.com)
  • HLA compatibility helps the recipient's immune system recognise the transplanted organ or tissue as "self" rather than alien. (wellnessofhealth.com)
  • CN-LOH HLA may therefore be a factor favoring MDS progression to AML independently of the somatic tumor mutation load. (oncotarget.com)
  • This is one definition of mutation and polymorphism. (dorak.info)
  • 18. Gm allotypes and HLA in rheumatoid arthritis patients with circulating antibodies to native type II collagen. (nih.gov)
  • Matching donor and recipient HLA types increases success and lowers rejection. (wellnessofhealth.com)
  • This study provided a new mechanism into how chaperones can help shape antigen repertoires. (sgourakislab.org)
  • Non-classical human leucocyte antigen-E (HLA-E) mediates natural killer and CD8+ T-cell activity, suggesting a role in the regulation of autoimmunity. (researchgate.net)
  • A total of 104 consecutive patients with Hashimoto's thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. (wjgnet.com)
  • Each receptor includes a hypervariable area formulated with V (adjustable), D (variety in case there is IGH and TCR), and J (signing up for) gene sections randomly chosen from large private pools of unarranged sections and recombined to create a complementarity-determining area (CDR3) that denotes the specificity of every clonotype and comprises its antigen binding site. (eprf.ca)
  • The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-α, and IL-1 receptor antagonist polymorphisms. (biomedcentral.com)
  • In conclusion, these data highlight the fact that HLA can be a strong selection force for both intra- and interclade HIV evolution at a population level. (ox.ac.uk)
  • It is uncertain how the HLA-B27 gene variant causes the increased risk. (medlineplus.gov)
  • It is possible that HLA-B27 may increase the risk of ankylosing spondylitis through more than one mechanism, or by different mechanisms in different individuals based on their genetic and environmental background. (medlineplus.gov)
  • Researchers do not know how HLA-B51 increases the risk of this disorder. (medlineplus.gov)
  • LOH HLA was not detected in the remaining 24 patients, who all had adverse risk factors. (oncotarget.com)
  • Our data provide the first evidence that HLA-E*0103X is a marker for genetic risk in PV. (researchgate.net)
  • Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. (geneticsmr.com)
  • HLA typing may identify those at increased risk of these responses, enabling personalised treatment options and doses. (wellnessofhealth.com)
  • Genetic polymorphisms in HLA-G may be associated with a variable risk to develop HAT. (scirp.org)
  • Genetic polymorphisms within HLA-G could influence the level of HLA-G expression and therefore play a critical role in infection outcomes. (scirp.org)