• We employ a concept generalization lattice to determine the distance between two residues in a single nucleotide region, which provides the most similar generalized concept for two residues (i.e. adenine and guanine are both purines). (scribd.com)
  • This polymorphism codes for an asparagine to aspartic acid substitution at amino acid 40 in the amino-terminus, thereby removing a potential extracellular glycosylation site. (nih.gov)
  • Mutation detection and single-molecule counting using isothermal rolling-circle amplification. (springer.com)
  • Wee EJ, Shiddiky MJ, Brown MA, Trau M. eLCR: electrochemical detection of single DNA base changes via ligase chain reaction. (springer.com)
  • Most polymorphisms have far less obvious effects though, and many of these may have medical consequences. (snpedia.com)
  • Many polymorphisms are likely to have either no effect at all, or to have such subtle effects that it will be many years before their consequences are understood. (snpedia.com)
  • For example, two sequenced DNA fragments from different individuals, AAGC C TA to AAGC T TA, contain a difference in a single nucleotide. (isogg.org)
  • Polymorphisms are what make individuals different from one another. (snpedia.com)
  • For BSA, tissues from all mutant (or non-mutant) individuals from within the same F 2 family were pooled, and a single DNA isolation was performed or DNA was isolated from each individual and then equal amounts from each individual were bulked. (genetics.org)