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  • Genes
  • Objective] The aim of this study was to investigate the relation between the polymorphism of large molecular weight proteasome (LMP) (LMP2-LMP7) and transporter associated with antigen processing (TAP) (TAP1-TAP2) genes and rheumatoid arthritis (RA). (csic.es)
  • Results] The polymorphism of LMP (LMP2-LMP7) and TAP (TAP1-TAP2) genes was examined in shared epitope positive and negative RA patients and controls. (csic.es)
  • Conclusion] The data suggest that the polymorphisms of LMP and TAP genes do not have an important influence in the pathogenesis of RA, although larger studies will be needed to provide more conclusive evidence on the role of these genes in RA. (csic.es)
  • Single-nucleotide polymorphisms may fall within coding sequences of genes, non-coding regions of genes, or in the intergenic regions (regions between genes). (wikipedia.org)
  • In 1980, Botstein and his colleagues Ray White, Mark Skolnick, and Ronald W. Davis proposed a method for constructing a genetic linkage map using restriction fragment length polymorphisms that was used in subsequent years to identify several human disease genes including Huntington's and BRCA1. (wikipedia.org)
  • relation
  • Differential fragment patterns in relation to different genospecies of Lyme disease spirochetes were observed among tested Borrelia isolates, and all of these Taiwan isolates were closely related to the genospecies of B. burgdorferi sensu stricto. (ajtmh.org)
  • high
  • In regions of high recombination, neutral polymorphism remains in a population because of recombination between the selected and neutral alleles. (genetics.org)
  • A tag SNP is a representative single-nucleotide polymorphism (SNP's) in a region of the genome with high linkage disequilibrium (the non-random association of alleles at two or more loci). (wikipedia.org)
  • However
  • However, restriction and specificity and sensitivity should be lowered and increased, respectively, to be useful for a wide variety of clinical applications. (mysciencework.com)
  • region
  • THE probability of meiotic crossing over is not a uniform function of the physical length of a chromosome region in many plants and animals. (genetics.org)
  • sizes
  • The result is a graph image where the x-axis represents the sizes of the fragment and the y-axis represents their fluorescence intensity. (wikipedia.org)
  • In an electropherogram the X-axis marks the sizes of the fragments while the Y-axis marks the fluorescence intensity of each fragment. (wikipedia.org)
  • method
  • This method fragments DNA either by the simultaneous cleavage of both strands, or by generation of nicks on each strand of dsDNA to produce dsDNA breaks. (wikipedia.org)
  • full-length
  • For a full-length treatment of the language, see Programming Algol 68 Made Easy by Dr. Sian Mountbatten, or Learning Algol 68 Genie by Dr. Marcel van der Veer which includes the Revised Report. (wikipedia.org)