AntigensAllelesHumansGenotypeSusceptibilityAlleleHaplotypeGenesPolymerase Chain ReLOCUSExtended HLA haplotypesAntigenSNPsMaternal HLA classAngiotensin converTumor necrosVariantsPathogenesisAntibodiesCystic fibrosisCytokinesProteinIntronExonLymphoblastoid cell linesMajor histocoClassMethodsCytokineAssociationAnkylosing spondylitisSpecificitiesEndoplasmicSingleProbesSpecificityDiseaseFrequencyAnalysisDetectionImmunePopulations
Antigens4
- Biochemical analysis of the polymorphism of three HLA-D region antigens. (ox.ac.uk)
- Two-dimensional gel electrophoretic analyses of immunoprecipitates of the HLA-D region antigens revealed three beta (Mr 28 X 10(3) to 30 X 10(3) structurally polymorphic polypeptides. (ox.ac.uk)
- The data indicate that lymphoblastoid cells express at least three sets of HLA-D region antigens that are encoded by different loci including HLA-DR and DC. (ox.ac.uk)
- Thirty-four lymphoblastoid cell lines that had been previously typed for HLA-DP antigens by primed lymphocyte typing (PLT) were tested by Southern blotting and by ELISA. (ox.ac.uk)
Alleles9
- The results support an association of certain HLA class Ib alleles with allo-immunization during pregnancy. (frontiersin.org)
- The frequencies of HLA class I and class II alleles and haplotypes of 104 healthy unrelated Tunisians were analyzed by high-resolution PCR-reverse dot blot hybridization, and was compared with other Mediterranean and Sub-Saharan Africans using genetic distances measurements, Neighbor-joining dendrograms, correspondence, and extended haplotypes analysis. (nih.gov)
- The most frequent HLA class I A alleles were A*02, A*24, and A*30, while the most frequent B alleles were B*44, followed by B*50, B*51, and B*07. (nih.gov)
- One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5′ flanking region of HLA-B and HLA-C. (umn.edu)
- TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. (ox.ac.uk)
- The association of T1D with alleles at HLA loci, especially the HLA class II genes DR and DQ, is well-established. (medcraveonline.com)
- Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
- Hundreds of HLA-A alleles have been described. (sigmaaldrich.com)
- Genetic markers included: HLA alleles, BTNL2 haplotype, Annexin A11 single nucleotide polymorphisms and beryllium-responsive CD4 T cells were also be examined. (cdc.gov)
Humans2
- HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. (wikipedia.org)
- The human leukocyte antigen (HLA) system is a major histocompatibility complex (MHC) protein in humans. (biomedcentral.com)
Genotype7
- The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
- Genetic testing of this variant is indicated: in both individuals of a couple in the case of repeated IVF treatment failures or idiopathic recurrent spontaneous abortions and in the patient in case of heterologous insemination, to identify a donor with the HLA- genotype G compatible. (personalgenomics.it)
- The similarities and differences between Tunisians and neighboring and related communities in HLA genotype distribution provide basic information for further studies of the MHC heterogeneity among Mediterranean and North African countries, and as reference for further anthropological studies. (nih.gov)
- Fetal +14/+14 bp HLA-G genotype may predispose to pre-eclampsia in the mother. (ruc.dk)
- As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)
- Immunochip and targeted single nucleotide polymorphism (SNP) genotype data were produced, respectively, for discovery and replication purposes. (edu.au)
- CONCLUSIONS: HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis. (edu.au)
Susceptibility11
- HLA-DQB1*02 allele was related to cancer susceptibility. (geneticsmr.org)
- The TNF gene is encoded in the class III region of the HLA complex adjacent to HLA-B. This genetic proximity to a gene that is already widely implicated in disease susceptibility led us to investigate the association between TNF promoter polymorphisms and susceptibility to BD. (ox.ac.uk)
- One of them contained the previously recognized susceptibility gene HLA-B*51, while the other was defined by HLA-B*5701. (ox.ac.uk)
- More than 60 genes have been identified to affect the risk of T1D, with the HLA loci having the greatest impact on susceptibility. (medcraveonline.com)
- Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
- Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity. (cdc.gov)
- Publications regarding the associations of toll-like receptor 2 (TLR2) G2258A and T597C polymorphisms with pulmonary tuberculosis (PTB) susceptibility are inconsistent. (cdc.gov)
- A meta-analysis was conducted to investigate the relationship between TLR2 G2258A and T597C polymorphisms with PTB susceptibility. (cdc.gov)
- A systematic search was performed for published studies on the relationship between TLR2 polymorphisms and PTB susceptibility. (cdc.gov)
- The associations of T597C polymorphism with PTB susceptibility, in the ethnic-specific analyses, were still not significant. (cdc.gov)
- TLR2 2258G allele may provide protective effects against PTB susceptibility, particularly among Asians, whereas TLR2 T597C polymorphism might not be associated with PTB susceptibility. (cdc.gov)
Allele6
- The maternal HLA-E*01:06 allele was significantly associated with a higher fraction of anti-HLA I immunization (20.0% vs. 4.8%, p = 0.048). (frontiersin.org)
- After stratification for HLA-DRB1*1501 risk allele (T) carrier we showed a significant OR of 0.70 (p = 0.003) for HLA-A. CONCLUSIONS: HLA class I single nucleotide polymorphism rs6457110 is associated with infectious mononucleosis and multiple sclerosis, independent of the major class II allele, supporting the hypothesis that shared genetics may contribute to the association between infectious mononucleosis and multiple sclerosis. (ox.ac.uk)
- Both of these haplotypes contained the TNF promoter polymorphism -1031C, an allele that was associated with disease even in individuals who did not carry either HLA-B*51 or HLA-B*5701. (ox.ac.uk)
- HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint. (nih.gov)
- Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. (upenn.edu)
- In conclusion, this study indicates that the +14 bp HLA-G allele defines a nearly unique exon 8 haplotype, and fetuses homozygous for this haplotype [SNP 2995(C)/SNP 3127(G)/SNP 3172(A)/SNP 3181(G)/+14 bp] are associated with severe pre-eclampsia in primiparas. (ruc.dk)
Haplotype3
- We report, in a study of 27 families, that a specific haplotype (H), containing a 3-kilobase (kb) HRAS1- Tag I DNA polymorphism, segregated differentially in diabetic and nondiabetic siblings ( P = 0.005). (diabetesjournals.org)
- Three-locus haplotype analysis revealed that A*03-B*07-DRB1*1503 and A*02-B*44-DRB1*0402 were the most common HLA class I and II haplotypes in this population. (nih.gov)
- The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
Genes11
- A new study design based on cross-validation of the age at the onset of rectal cancer and the differences between the frequency distributions of relevant genes in 2 groups was developed for identification of disease-related HLA. (geneticsmr.org)
- We attempted to dissect the contribution of individual polymorphisms in this gene-dense region by linkage disequilibrium mapping across 6 adjacent genes. (ox.ac.uk)
- To investigate the possible role of IFNA gene polymorphisms in the pathogenesis of narcolepsy, we have genotyped two single nucleotide polymorphisms in IFNA genes as well as a neighbouring microsatellite. (uni-luebeck.de)
- The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
- The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
- Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
- Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
- Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO , RH , and HLA . (upenn.edu)
- Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
- Association between osteoporosis and polymorphisms of the IL-10 and TGF-beta genes in Turkish postmenopausal women. (cdc.gov)
- Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
Polymerase Chain Re4
- The aim of this study was to detect carriers of CVM in Holstein population using Polymerase Chain Reaction- Primer-introduced restriction analysis and Restriction Fragment Length Polymorphism (PCR-PIRA and RFLP) methods. (researchgate.net)
- Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3′UTR region of HLA-G was amplified via polymerase chain reaction. (biomedcentral.com)
- ACE I/D polymorphism genotypes were determined by using polymerase chain reaction with specific primers. (molvis.org)
- A total of 41 -thalassaemia carriers and 40 control subjects without haemoglobinopathies were screened for the C282Y, H63D and S65C mutations by polymerase chain reaction-restriction fragment-length polymorphism. (who.int)
LOCUS3
- The positional variation of a second beta polypeptide (namely beta-2) was consistent with strong linkage dis-equilibrium between the corresponding genetic locus and the HLA-DR locus. (ox.ac.uk)
- Variation in the HLA-F gene locus with functional impact is associated with pregnancy success and time-to-pregnancy after fertility treatment. (nih.gov)
- are in linkage disequilibria with the HLA-drb1 locus in a japanese population. (lu.se)
Extended HLA haplotypes2
- Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. (ox.ac.uk)
- Subsequent analysis identified 2 extended HLA haplotypes associated with BD. (ox.ac.uk)
Antigen6
- During pregnancy the formation of alloreactive anti-human leukocyte antigen (HLA) antibodies are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion. (frontiersin.org)
- Alloreactive anti-human leukocyte antigen (HLA) antibodies formed during pregnancy are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion, such as febrile non-hemolytic transfusion reactions, immunological platelet refractoriness or transfusion-related acute lung injury (TRALI) ( 1 , 2 ). (frontiersin.org)
- To compare single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. (biomedcentral.com)
- Abnormal human leukocyte antigen G (HLA-G) expression may be involved in pre-eclampsia. (ruc.dk)
- Recently, the first set of naturally presented human leukocyte antigen Class I (HLA-I) epitopes of MuV was identified by us. (mdpi.com)
- Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. (edu.au)
SNPs3
- Recently, associations between preeclampsia and SNPs in the 3′ untranslated region (3′UTR) of HLA-G have been observed [ 13 ]. (biomedcentral.com)
- Therefore, the aim of the present study was to compare SNPs in the 3′UTR of the HLA-G between pregnancies complicated with spontaneous preterm births and those with preeclampsia in gestational age matched placentas. (biomedcentral.com)
- SNPs and HLA variants passing quality control filters were tested for association with CC with logistic regression adjusting for age, sex and country of origin. (edu.au)
Maternal HLA class2
- The purpose of the study was to identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization in pregnancy and the degree of tolerance estimated by IgG4 expression. (frontiersin.org)
- The current study is in line with this important scientific theme by investigating a role of maternal HLA class Ib polymorphisms in pregnancy allo-immunization. (frontiersin.org)
Angiotensin conver2
- To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)
- Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism. (cdc.gov)
Tumor necros1
- Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms? (ox.ac.uk)
Variants4
- The genetic variants of HLA-DQB1 were genotyped using an HLA-DQB1 PCR-SSP typing kit. (geneticsmr.org)
- These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. (nih.gov)
- At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
- One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
Pathogenesis3
- Further studies will be required to determine the functional effects of this polymorphism, its influence in disease pathogenesis, and its role in other ethnic groups. (ox.ac.uk)
- To determine the effects of cytokine gene polymorphisms in the pathogenesis of T1D, high risk interferon-gamma (IFN-γ), interleukin-6 (IL-6) as well as transforming growth factor β (TGF-β) gene polymorphisms were considered in HLA DRDQ fixed patients with T1D. (medcraveonline.com)
- In this pilot study, we determined that there may be critical networking among different cytokines and HLA which may play a role in the pathogenesis of T1D. (medcraveonline.com)
Antibodies5
- Maternal blood serum was screened for HLA class I and II antibodies, identification of Donor Specific Antibody (DSA), activation of complement measured by C1q and IgG4 concentrations. (frontiersin.org)
- Mothers were genotyped for HLA class Ib ( HLA-E, -F and -G ). Anti-HLA class I and II antibodies were identified in 24% of the women. (frontiersin.org)
- The discrepancy between studies may be due to screening differences, both in method sensitivity and the sampling time after delivery, as HLA antibodies may persist or become gradually undetectable over time ( 1 - 5 ). (frontiersin.org)
- The level of anti-HLA antibodies increases with the number of pregnancies and the number of children delivered ( 1 - 5 ). (frontiersin.org)
- Identification of HLA-DP polymorphism with DP alpha and DP beta probes and monoclonal antibodies: correlation with primed lymphocyte typing. (ox.ac.uk)
Cystic fibrosis1
- HLA class II polymorphism in cystic fibrosis. (nih.gov)
Cytokines1
- However, a larger scale case control study is required to confirm these findings and to determine the functionality of cytokines and the high-risk HLA patients. (medcraveonline.com)
Protein4
- The protein encoded by this gene belongs to the HLA class II beta chain paralogues. (wikipedia.org)
- The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
- The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
- HLA-A (NP_002107.3, 1 a.a. ~ 365 a.a) full-length human protein. (sigmaaldrich.com)
Intron1
- Association analysis of the functional MAOA gene promoter and MAOB gene intron 13 polymorphisms in tension type headache patients. (cdc.gov)
Exon4
- Our results show that one out of 60 bulls tested exhibited polymorphism (G→T) at position 559 in exon 4 of SLC35A3 gene. (researchgate.net)
- A 14 bp insertion/deletion polymorphism exists in exon 8 of the HLA-G gene. (ruc.dk)
- Other polymorphisms, besides the 14 bp polymorphism (rs66554220), in the 3′-untranslated region (3′-UTR) (exon 8) of the HLA-G gene might be associated with severe pre-eclampsia, especially in primiparas. (ruc.dk)
- Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. (sigmaaldrich.com)
Lymphoblastoid cell lines1
- The polymorphism has been examined using lymphoblastoid cell lines that were derived from different geographical populations (North European and Italian) and that expressed various HLA-DR alloantigenic specificities. (ox.ac.uk)
Major histoco1
- The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Class5
- Infectious mononucleosis-linked HLA class I single nucleotide polymorphism is associated with multiple sclerosis. (ox.ac.uk)
- Recent research has shown infectious mononucleosis to be associated with a specific HLA class I polymorphism. (ox.ac.uk)
- OBJECTIVES: Our aim was to test if the infectious mononucleosis-linked HLA class I single nucleotide polymorphism (rs6457110) is also associated with multiple sclerosis. (ox.ac.uk)
- This gene belongs to the HLA class I heavy chain paralogues. (nih.gov)
- HLA Class I Polymorphisms Influencing Both Peptide Binding and KIR Interactions Are Associated with Remission among Children with Atopic Dermatitis: A Longitudinal Study. (upenn.edu)
Methods2
- Length Polymorphism (PCR-PIRA and RF LP) methods. (researchgate.net)
- METHODS: Genotyping of the HLA-A single nucleotide polymorphism rs6457110 using TaqMan was performed in 591 multiple sclerosis cases and 600 controls. (ox.ac.uk)
Cytokine1
- A number of cytokine gene polymorphisms have been shown to be important for the development of T1D both at the level of the immune system and at the level of the target β-cells. (medcraveonline.com)
Association2
- The association of multiple sclerosis with the HLA-A single nucleotide polymorphism was tested using logistic regression adjusted for age, sex and HLA-DRB1*1501. (ox.ac.uk)
- RESULTS: Forty-two markers gave rise to genome-wide significant association signals, all contained within the HLA region on chromosome 6 (best p=4.2×10(-10) for SNP rs4143332). (edu.au)
Ankylosing spondylitis1
- HLA-B27 polymorphism in Turkish patients with ankylosing spondylitis. (cdc.gov)
Specificities2
- that is, apparently the same beta-3 polypeptide was associated with different HLA-DR specificities provided the cells were of the same ethnic origin. (ox.ac.uk)
- Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. (wikipedia.org)
Endoplasmic1
- Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. (nih.gov)
Single1
- Yet, the IFNA10 single nucleotide polymorphisms and the IFNA microsatellite are associated with the DR2 - patient group. (uni-luebeck.de)
Probes3
- Two DNA probes isolated from the region 5′ to the HLA-B gene are described. (umn.edu)
- Using two DP beta probes and a DP alpha probe with a series of enzymes, it is possible to identify restriction fragment length polymorphism (RFLP) patterns characteristic of DPw1, -2, -3, -4, and possibly -5. (ox.ac.uk)
- Thus, using a range of probes and enzymes it is possible to identify DP polymorphism. (ox.ac.uk)
Specificity1
- that is, different beta-2 polypeptides were associated with the same HLA-DR specificity in different geographical populations. (ox.ac.uk)
Disease3
- The new analysis method may be an efficient and reliable approach for the identification of disease-related HLA. (geneticsmr.org)
- In untreated HIV infection, associations between HLA genetic polymorphism and disease progression were identified in several studies, using both candidate gene (reviewed in Carrington and O'Brien, 2003 ), and genome-wide strategies ( The International HIV Controllers Study, 2010 ). (frontiersin.org)
- RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population. (cdc.gov)
Frequency1
- The frequency values of HLA-DQB1*02 were 12.3% higher in the cancer group than in the control population (P HLA-DQB1*02 were 54.0 and 61.0 years, respectively, with significant difference observed between the ages for these groups (P HLA-DQB1*03 were 62.0 and 58.0 years, respectively, and a significant difference was observed. (geneticsmr.org)
Analysis1
- These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies. (ox.ac.uk)
Detection1
- Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5. (medscape.com)
Immune1
- The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
Populations2
- HLA gene frequencies in 11 Israeli populations and nine other relevant populations were used to calculate genetic distances in a quantitative assessment of their similarities and differences. (tau.ac.il)
- There are indications in the HLA data of a common origin for the diverse Jewish populations. (tau.ac.il)