• The proposed project helps to fill this scientific gap by investigating the supergene that controls shell colour polymorphism in a classical model for ecological genetics and climate-induced evolutionary change, the land snail Cepaea nemoralis. (europa.eu)
  • Therefore, since the genetics polymorphisms of eNOS can affect the NO tissue levels, it seems reasonable to suppose that the acute effects of sildenafil may be modulated by them. (clinicaltrials.gov)
  • Molecular genetics allows for the study the genetic make-up of individuals at the DNA level and may provide the tools to make those opportunities a reality, either by direct selection on genes that affect traits of interest major genes or quantitative trait loci (QTL) - or through selection on genetic markers linked to QTL. (intechopen.com)
  • A combination of the Greek words poly (meaning multiple) and morph (meaning form), polymorphism is a term used in genetics to describe multiple forms of a single gene that exists in an individual or among a group of individuals. (thebalance.com)
  • Where monomorphism means having only one form and dimorphism means there are only two forms, the term polymorphism is a very specific term in genetics and biology , relating to the multiple forms of a gene that can exist. (thebalance.com)
  • The use of genetic polymorphisms was one of the strengths of deCODE Genetics , a company that focused on determining genetic risk factors for various diseases. (thebalance.com)
  • Overall the data reported here show that in C. africana genetic diversity occurs and the existence of this intriguing group of C. albicans strains with specific phenotypes associated could be useful for future comparative studies in order to better understand the genetics and evolution of this important human pathogen. (frontiersin.org)
  • Alignment of TRAP-C2 nucleotide positions that show polymorphism among Cryptosporidium parvum isolates from human and nonhuman sources. (cdc.gov)
  • These SNP-based markers were used to construct a genetic map that can be used to address diverse biological questions. (genetics.org)
  • We used sequence-related amplified polymorphism (SRAP) markers and obtained 257 clearly defined bands amplified by 20 primers from 461 individuals. (mdpi.com)
  • Chen, X. Population Structure and Genetic Relationships of Melia Taxa in China Assayed with Sequence-Related Amplified Polymorphism (SRAP) Markers. (mdpi.com)
  • Based on the segregation of 294 amplified fragment length polymorphism markers, two mating type factors, and the sporeless trait, the linkage map consisted of 11 linkage groups with a total length of 837.2 centimorgans (cM). (asm.org)
  • The gene region responsible for the sporeless trait was located in linkage group IX with 32 amplified fragment length polymorphism markers and the B mating type factor. (asm.org)
  • We also identified eight markers closely linked (within 1.2 cM) to the sporeless locus using bulked-segregant analysis-based amplified fragment length polymorphism. (asm.org)
  • One such amplified fragment length polymorphism marker was converted into two sequence-tagged site markers, SD488-I and SD488-II. (asm.org)
  • The structural basis of the barrier to genetic recombination on the molecular level is the difference in their DNA sequences ( 1 , 2 ). (pnas.org)
  • Despite the panoply of complex polymorphisms presumably controlled by supergenes, molecular evidence for their existence is scarce, and the emergence of such genetic architecture is surprisingly poorly understood. (europa.eu)
  • b)-Molecular genetic information can be available at an early age, in principle at the embryo stage, thereby allowing early selection and reduction of generation intervals. (intechopen.com)
  • C) Molecular genetic information can be obtained on all selection candidates, which is especially beneficial for sex-limited traits, traits that are expensive or difficult to record, or traits that require slaughter of the animal (carcass traits) ( Dekkers, 2004 ). (intechopen.com)
  • Restriction fragment length polymorphism (RFLP) analysis using a multilocus heat-inducible cytoplasmic heat-shock protein 70 (Hsp70) hybridization probe with Eco RI-digested genomic DNA was used in molecular typing of 129 Trichomonas vaginalis isolates. (ajtmh.org)
  • Amplified fragment length polymorphism (AFLP) analysis is a rapid and efficient method for producing DNA fingerprints and molecular characterization. (csic.es)
  • In this study, using a sporeless P. eryngii strain, we constructed a genetic linkage map to introduce a molecular breeding program like marker-assisted selection. (asm.org)
  • This paper provides a critical overview and synthesis of the emerging findings on the GHR polymorphisms in relation to GH responsiveness or disease susceptibilities, and the attendant molecular aspects of the characteristic polymorphisms. (eurekaselect.com)
  • Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease process. (bmj.com)
  • Naumov, G. 2017-06-04 00:00:00 Comparative molecular genetic study of Williopsis yeasts isolated in different world regions reveals some peculiarities of species content in Taiwan. (deepdyve.com)
  • Casuistics and Methods: Around 120 patients with HAR will be genotyped for the T-786C eNOS polymorphism, from which the investigators will enroll in this study 15 patients with TT genotype and 15 patients with CC genotype. (clinicaltrials.gov)
  • Prompted by the discovery of this easily identifiable polymorphism and findings from recent laboratory studies showing an important role of CYP1B1 in the metabolic activation of estrogens and environmental mammary carcinogens, we evaluated the relation between CYP1B1 genotype and breast cancer risk in a subset of women who participated in the Shanghai Breast Cancer Study. (aacrjournals.org)
  • A real-time PCR assay was introduced for genotyping CAT -262 C>T promoter polymorphism. (srce.hr)
  • An Analysis of the Impact of Functional Programming Techniques on Genetic Programming , Phd Thesis, University College London, 1999. (springer.com)
  • Although various allelic forms of different CYPs have been reported, functional polymorphism has only been established for CYP2A6, CYP2C9, CYP2C19 and CYP2D61. (redorbit.com)
  • To explore the prevalence and functional importance of LBX1 polymorphisms in patients with AIS within the northern Chinese Han population. (ovid.com)
  • In this study we explored the prevalence and functional importance of the polymorphisms around LBX1 in patients with AIS within the northern Chinese Han population. (ovid.com)
  • We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts. (harvard.edu)
  • The observed geographic pattern of genetic differentiation and the points of evidence for natural selection and recombination suggest that the functional consequences of the polymorphism should be considered for developing a vaccine based on PfCSP. (springer.com)
  • For polymorphisms in BRCA1 , COMT , CYP17 , CYP1A1 , NAT1 , and NAT2 , the best estimate of risk either from the individual studies or the meta-analyses was sufficiently precise to exclude a relative risk of 1.5 or greater. (aacrjournals.org)
  • The inability to undergo genetic recombination with each other isolates related species independently of geographic isolation. (pnas.org)
  • Furthermore, AFLP typing was able to allocate serologically nontypeable isolates to appropriate genetic groups within the species. (asm.org)
  • Additionally, the polymorphisms existed in the ancestor genomes before the occurrence of adaptive radiations (6) was shown to be contributed to diversification and parallel evolution (7) . (titech.ac.jp)
  • Given the complexity of the genetic polymorphism associated with disease phenotype, as a limitation from the studies, authors agree that the sample size is not large enough, yet the papers found obtained a GRADE B level of evidence after adjustment for confounding factors. (isciii.es)
  • Thus the Gly16 polymorphism of the beta 2AR, which imparts an enhanced downregulation of receptor number, is overrepresented in nocturnal asthma and appears to be an important genetic factor in the expression of this asthmatic phenotype. (jci.org)
  • CYP2C19 polymorphism affected eradication of Helicobacter pylori using diferent PPI based eradication therapies as PM patients demonstrated significantly higher eradication rates compared to EMs. (redorbit.com)
  • Genetic polymorphism affects plasma concentration of antiretroviral therapy in HIV patients. (clinicaltrials.gov)
  • The potential involvement of N-acetyltransferase 1 (NAT1) genetic polymorphisms in prostate cancer (PCa) patients was analyzed in 101 patients with PCa and 97 controls with no incidental malignancy. (nih.gov)
  • Objective: To examine the influence of the T-786C polymorphism of eNOS gene in sildenafil acute effects on hemodynamic and cardiovascular function in resistant hypertensives patients. (clinicaltrials.gov)
  • Hypothesis: The investigators hypothesize that the sildenafil, besides the anti-ischemic effect, will improve the patients hemodynamic status and, moreover, that it will occur a modulation of this effect by the T-786C polymorphism. (clinicaltrials.gov)
  • The effect of CYP polymorphisms on the clinical outcomes in patients treated with prasugrel remains unknown. (ahajournals.org)
  • We have accumulated evidence that autoimmune antibodies observed in sera of patients with tienilic acid induced hepatitis (anti-liver kidney microsome 2 or anti-LKM2 antibodies) specifically recognize the cytochrome P-450 involved in the mephenytoin hydroxylation polymorphism. (uniprot.org)
  • The distribution of TNF-α (-308G/A) and TNF-β (+252A/G) polymorphisms was almost similar in schizophrenia patients with negative or positive symptoms. (dovepress.com)
  • Overall, data presented in this thesis add to increasing evidence that germline polymorphisms can affect drug disposition in EOC patients. (edu.au)
  • These results suggest the importance of delivering pharmacotherapeutic regimes for patients on the basis of their genetic profile. (lboro.ac.uk)
  • The extent of genetic recombination is a key determinant and a measure of genetic isolation. (pnas.org)
  • The results reported here reveal that genetic barriers can be established, eliminated, or modified by manipulating two systems which control genetic recombination, SOS and mismatch repair. (pnas.org)
  • A species may be defined as a population of organisms capable of sharing their gene pool through mating and genetic recombination. (pnas.org)
  • In yeast, DNA sequence divergence inhibits both intra- and interchromosomal recombination in mitosis and meiosis through the activities of MutS and MutL homologs ( 3 - 6 ), implying mechanisms of genetic barriers similar to those studied in bacteria (see also ref. 7 for effects of mouse MutS homolog on mitotic recombination in mice). (pnas.org)
  • Combining my extensive knowledge of animal coloration with my host laboratory's track record in biodiversity research and genomics, this project offers a unique window into the evolution of supergenes and polymorphisms and provides the European research community with a valuable genomic resource. (europa.eu)
  • However, despite this crop's importance, only moderate effort has been invested in studying its biochemical or physiological properties or in establishing genomic and genetic infrastructures. (plos.org)