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  • genes
  • Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation. (wikipedia.org)
  • cellular
  • The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. (cellsignal.com)
  • Here, we report on recent neutron measurements performed directly in living cells by using isotope labelling to explore the dynamics of specific cellular components. (royalsocietypublishing.org)
  • The ocular lens has a unique cellular architecture consisting of a single layer of epithelial cells at the anterior surface and concentric layers of highly specialized, terminally differentiated fiber cells. (arvojournals.org)
  • Many of these processes are mediated by extensive and intimate interactions of actin with cellular membranes. (wikipedia.org)
  • Actin therefore contributes to processes such as the intracellular transport of vesicles and organelles as well as muscular contraction and cellular migration. (wikipedia.org)
  • Cellular microbiology is a discipline that bridges microbiology and cell biology. (wikipedia.org)
  • Cellular microbiology attempts to use pathogenic microbes as tools for cell-biology research, and to employ cell-biology methods to understand the pathogenicity of microbes. (wikipedia.org)
  • Recently, the field of Cellular Microbiology has been expanded to incorporate investigation of the cell biology of microbes themselves. (wikipedia.org)
  • The field of cellular microbiology is a coalescence of two fields: molecular microbiology and cell biology," said Professor Jacek Hawiger, Chair of Microbiology and Immunology at Vanderbilt University. (wikipedia.org)
  • An asymmetric cell division produces two daughter cells with different cellular fates. (wikipedia.org)
  • A neuron receives signals from neighboring cells through branched, cellular extensions called dendrites. (wikipedia.org)
  • All CAPs appear to contain a C-terminal actin-binding domain that regulates actin remodelling in response to cellular signals and is required for normal cellular morphology, cell division, growth and locomotion in eukaryotes. (wikipedia.org)
  • binds
  • When a B cell is activated by its first encounter with an antigen that binds to its receptor (its "cognate antigen"), the cell proliferates and differentiates to generate a population of antibody-secreting plasma B cells and memory B cells. (wikipedia.org)
  • filamentous
  • The assembly of filamentous actin arises as a result of weak, noncovalent interactions between G-actin and appears in the arrangement of a two-stranded asymmetrical helical polymer. (wikipedia.org)
  • adhesion
  • Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). (cellsignal.com)
  • We show that Src is overexpressed in Waldenstrom macroglobulinemia cells compared with control B cells, and that the use of the Src inhibitor AZD0530 led to significant inhibition of adhesion, migration, and cytoskeletal signaling induced by SDF1. (aacrjournals.org)
  • The use of the Src inhibitor AZD0530 led to significant inhibition of adhesion, migration, and cytoskeletal signaling induced by SDF1, as well as cell cycle. (aacrjournals.org)
  • In addition, RhoA is believed to act primarily at the rear (uropod) of migrating cells to promote detachment, similar to the attachment and detachment process found in the focal adhesion mechanism. (wikipedia.org)
  • It has also been proposed that microdomain interaction marks the formation of new focal adhesion sites at the cell periphery. (wikipedia.org)
  • Finally, continuous application of stress on the old focal adhesion sites could result in the calcium-induced activation of calpain, and consequently the detachment of focal adhesions which completes the cycle. (wikipedia.org)
  • gene
  • We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 (zeige CDC23 Antikörper ) which are known to be key function elements. (antikoerper-online.de)
  • Lastly, actin plays an important role in the control of gene expression. (wikipedia.org)
  • P27 transcription has also been linked to another tumor suppressor gene, MEN1, in pancreatic islet cells where it promotes CDKN1B expression. (wikipedia.org)
  • Thus
  • Thus, there is a positive-feedback loop between the Lm cell division cycle and a physical interaction with the host cytoskeleton. (umass.edu)
  • Hair shaft keratinocytes containing melanosomes are transported towards the skin surface while they differentiate into pigmented cortex and medulla cells, thus giving the hair shaft its characteristic pigmentation pattern. (biologists.org)
  • Recent studies found that immunogenic cell death (ICD) improves T cell responses against different tumors, thus indicating that ICD may further augment antitumor immunity elicited by anti-PD1. (jci.org)
  • found that inhibiting changes in the cytoskeleton of the tumor cells and thus preventing activation of YAP/TAZ may overcome drug resistance in BRAF-mutant melanoma. (sciencemag.org)
  • Thus, inhibiting actin remodeling might improve therapeutic outcome for BRAF inhibitor-resistant melanoma patients. (sciencemag.org)
  • This, together with actin-polymerisation there, helps extend the lamella forward and thus advance the cell's front. (wikipedia.org)
  • It thus acts as a steering device for cells in the process of chemotaxis. (wikipedia.org)
  • Sarcomas, or cancers arising from connective tissue cells, are particularly adept at amoeboid movement, thus leading to their high rate of metastasis. (wikipedia.org)
  • This step occurs very early when the cell is exiting the quiescent phase and thus is independent of Skp2 degradation of p27. (wikipedia.org)
  • cortical
  • Disorganization of medulla cells correlates with the absence of cortical, keratin-filled spikes that normally protrude from the cortex into the medulla. (biologists.org)
  • Formation of these cortical protrusions during hair differentiation is probably initiated by medullar keratinocytes as it is preceded by the occurrence of pseudopodia in restricted areas of medulla cells. (biologists.org)
  • Loss of PAK function in G1 depolarized the cortical actin cytoskeleton and blocked bud emergence, but allowed isotropic growth and led to defects in septin assembly, indicating that PAKs are effectors of the Rho-guanosine triphosphatase Cdc42. (rupress.org)
  • Loss of PAK function in mitosis caused a defect in cytokinesis and a failure to polarize the cortical actin cytoskeleton to the mother-bud neck. (rupress.org)
  • Before anaphase, the actin cytoskeleton of the bud depolarizes, resulting in a random distribution of cortical patches and subsequent isotropic growth of the bud. (rupress.org)
  • Cell surface (cortical) actin remodeling is a cyclic (9-step) process where each step is directly responsive to a cell signaling mechanism. (wikipedia.org)
  • inhibitor
  • Cytochalasin D is a cell-permeable and potent inhibitor of actin polymerization. (wikipedia.org)
  • Prolonged exposure of cultured melanoma cells to the BRAF inhibitor vemurafenib induced drug resistance that was associated with a change in shape, increased actin polymerization, and nuclear localization and induction of the transcriptional activity of YAP/TAZ. (sciencemag.org)
  • M. H. Kim, J. Kim, H. Hong, S.‐H. Lee, J.‐K. Lee, E. Jung, J. Kim, Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. (sciencemag.org)
  • epithelial cells
  • Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7,8). (cellsignal.com)
  • Larson and Bement, 2017 ), suggesting that epithelial cells can delay anaphase until the spindle has achieved the correct position and orientation. (rupress.org)
  • Epithelial cells in the germinative zone proliferate continuously to replicate throughout the life of an organism. (arvojournals.org)
  • The newly formed epithelial cells migrate to the lens equator in the transitional zone, where they elongate and differentiate into secondary fiber cells. (arvojournals.org)
  • Epithelial cells adhere to one another through tight junctions, desmosomes and adherens junctions, forming sheets of cells that line the surface of the animal body and internal cavities (e.g., digestive tract and circulatory system). (wikipedia.org)
  • mammalian
  • The tip of the lamellipodium is the site where exocytosis occurs in migrating mammalian cells as part of their clathrin-mediated endocytic cycle. (wikipedia.org)
  • bacterial cell
  • Growth and division are two of the most fundamental capabilities of a bacterial cell. (umass.edu)
  • Instead, polymerization of host-derived actin at the bacterial cell surface extends the non-dividing elongation period and compresses the division period. (umass.edu)
  • 2015. Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface. . (umass.edu)
  • tumor
  • Indeed, tumor cells treated with dinaciclib showed the hallmarks of ICD including surface calreticulin expression and release of high mobility group box 1 (HMGB1) and ATP. (jci.org)
  • Mice treated with both anti-PD1 and dinaciclib showed increased T cell infiltration and DC activation within the tumor, indicating that this combination improves the overall quality of the immune response generated. (jci.org)
  • Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5,6). (cellsignal.com)
  • For one particular PTEN-mutant cell line, co-silencing resulted in tumor eradication. (wikipedia.org)
  • elongation
  • Play media Initiation Consists of a number of different possible mechanisms that ultimately determine where and when actin filament elongation is to occur. (wikipedia.org)
  • The elongation phase begins when the concentration of short, F-actin polymers is significantly larger than at equilibrium. (wikipedia.org)