• Liver involvement in pulmonary and extrapulmonary TB is usually clinically silent [ 2 ]. (hindawi.com)
  • Diagnosis of extrapulmonary tuberculosis by smear, culture, and PCR using universal sample processing technology. (microbiologyresearch.org)
  • Extrapulmonary tuberculosis (EPTB) is a significant health problem in both developing & developed countries. (envirobiotechjournals.com)
  • from Madagascar, 14% of 64 patients with Abdominal sonography showed mul- extrapulmonary tuberculosis had tubercular tiple lymphadenopathies in the para-aor- anal fistula [ 3 ]. (who.int)
  • Although extrapulmonary tuberculosis splenomegaly was seen as well. (who.int)
  • The study focused mainly on extrapulmonary tuberculosis where a definitive diagnosis was difficult. (who.int)
  • Tuberculosis should be considered as an important differential diagnosis of liver abscess irrespective of evidence of active tuberculosis elsewhere in the body. (hindawi.com)
  • The radiograph shows a classic posterior segment right upper lobe density consistent with active tuberculosis. (medscape.com)
  • 214 cases of active tuberculosis were identified (132 definite, 82 probable). (unicatt.it)
  • History of contact with a patient with active tuberculosis was associated with pulmonary TB (P=0.0014), while negative history of contact was associated with lymph node (P=0.0064) and central nervous system TB (P=0.05). (unicatt.it)
  • First, the similarities in clinical and histological features of tuberculosis and sarcoidosis that have raised suspicion that mycobacterial infection could be involved in the pathogenesis of sarcoidosis are discussed. (nih.gov)
  • In this context, a cohort study was conducted to assess the prevalence of BL strains among pulmonary tuberculosis (PTB) patients in the Kandy district of Sri Lanka (a popular tourist destination) and its association with patients' sociodemographic and clinical characteristics. (hindawi.com)
  • A lower body mass index, interstitial lung disease, prior pulmonary tuberculosis, larger clinical target volume, history of lung cancer surgery or radiation pneumonitis, and use of inhaled corticosteroids were independent risk factors for CPI development. (e-crt.org)
  • The clinical utility of a commercially developed PCR test(Amplicor) in bronchial washings for detecting pulmonary tuberculosis in smear negative patients was evaluated. (koreamed.org)
  • A candidate tuberculosis vaccine significantly reduced the incidence of pulmonary tuberculosis in HIV-negative adults who were already infected with latent TB at the time of vaccination, according to results from an ongoing clinical trial in in Kenya, South Africa and Zambia . (aleroux.co)
  • The primary results of an ongoing phase IIb clinical trial testing the candidate tuberculosis vaccine M72/AS01E1 have been published. (aleroux.co)
  • Children with clinical and radiological diagnoses of active pulmonary TB who underwent three GAs between March 2007 and June 2019 were retrospectively evaluated. (authorea.com)
  • 2000) Genitourinary tuberculosis in patients with HIV infection: clinical features in an innercity hospital population. (medscape.org)
  • Tuberculosis: a comprehensive clinical reference. (saripediatri.org)
  • Human immunodeficiency virus (HIV)-negative adults 18 to 50 years of age with latent M. tuberculosis infection (by interferon-γ release assay) were randomly assigned (in a 1:1 ratio) to receive two doses of either M72/AS01E or placebo intramuscularly 1 month apart. (isv-online.org)
  • This study aimed to investigate cumulative incidence and risk factors associated with chronic pulmonary infection (CPI) development after radiotherapy for lung cancer. (e-crt.org)
  • Soil saprophytic fungi such as Coccidioides immitis can be aerosolized during occupational disturbance activities and, if inhaled, can result in an acute pulmonary infection [Das et al. (cdc.gov)
  • The study assesses the safety and efficacy of M72/AS01E, in adults with latent tuberculosis infection, against development of pulmonary tuberculosis disease. (aleroux.co)
  • Havlir DV and Barnes PF (1999) Tuberculosis in patients with human immunodeficiency virus infection. (medscape.org)
  • 2007) A systematic review of rapid diagnostic tests for detection of tuberculosis infection. (medscape.org)
  • Bactiar A, Miko TY, Machmud R. Annual risk of tuberculosis infection in West Sumatra Province, Indonesia. (saripediatri.org)
  • Bactiar A, Miko TY, Machmud R. Annual risk of tuberculosis infection in East Nusa Tenggara and Central Java Provinces, Indonesia. (saripediatri.org)
  • Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. (encyclopedia.com)
  • Scientists know it as an infection caused by M. tuberculosis . (encyclopedia.com)
  • When streptomycin, the first antibiotic effective against M. tuberculosis , was discovered in the early 1940s, the infection began to come under control. (encyclopedia.com)
  • Coronavirus disease (COVID-19) infection is associated with increased prevalence of venous thromboembolism and pulmonary embolism (PE). (sajhivmed.org.za)
  • However, chronic pulmonary infection tends to progress and disseminated infections can be fatal. (medscape.com)
  • CPI was defined as pulmonary tuberculosis, non-tuberculous mycobacterial pulmonary disease, chronic pulmonary aspergillosis, or pulmonary actinomycosis. (e-crt.org)
  • Chronic pulmonary infections (CPIs), such as pulmonary tuberculosis (PTB), non-tuberculous mycobacterial pulmonary disease (NTM-PD), and chronic pulmonary aspergillosis (CPA), usually occur in patients with underlying lung diseases. (e-crt.org)
  • The mycobacterial genera comprise more than 140 species, which, for the purpose of diagnosis and treatment, have been grouped into three categories: M. tuberculosis complex (MTC), M. leprae, and non-tuberculous mycobacteria (NTM). (zytovision.com)
  • The aim of this study is to evaluate PCR as a rapid and sensitive tool for diagnosis of clinically suspected cases of Extra pulmonary tuberculosis. (envirobiotechjournals.com)
  • Based on this study PCR was found to be more sensitive than culture or microscopy in those with a final diagnosis of extra pulmonary tuberculosis. (who.int)
  • The specificity does not indicate the growth of M. tuberculosis from all MTD-positive specimens: trials included MTD-positive, culture-negative specimens from patients with other positive cultures, and there are other reports of test readings 'in the low range of positivity' with nontuberculous mycobacteria (2). (cdc.gov)
  • False-negative results may be obtained for specimens containing low numbers of M. tuberculosis or substances inhibiting the assay. (cdc.gov)
  • We have confirmed that pooling of two sputum specimens for testing in a single cartridge is a valid method of reducing the number of cartridges required when using Xpert MTB to detect pulmonary tuberculosis. (biomedcentral.com)
  • In some screening settings, such as general community-wide screening, the prior probability of TB will be lower and likely concentration of M. tuberculosis in sputum specimens submitted for testing will be lower. (biomedcentral.com)
  • Hence, it is encouraging that we have shown, using sputum specimens spiked with a low concentration of M. tuberculosis and diluted from 2- to 12-fold that, despite an expected linear increase in cycle threshold with increasing dilution, the majority of diluted specimens were still Xpert MTB positive [ 9 ]. (biomedcentral.com)
  • This affords the opportunity to obtain critical diagnostic information for tuberculosis patients who struggle to provide respiratory specimens. (biomedcentral.com)
  • thus, procedures such as sputum induction or gastric aspiration are required to collect diagnostic specimens for pulmonary tuberculosis [ 8 ]. (biomedcentral.com)
  • In contrast, stool culture of M. tuberculosis complex strains has a sensitivity of under 30% against respiratory culture, limiting the utility of phenotypic drug susceptibility testing (pDST) from stool specimens [ 14 ]. (biomedcentral.com)
  • The MTD test uses transcription-mediated amplification to detect M. tuberculosis-complex ribosomal RNA (2). (cdc.gov)
  • For this analysis, participants who received two doses of either M72/AS01E or placebo 30 days apart have been followed for at least 2 years to detect evidence of pulmonary tuberculosis disease. (aleroux.co)
  • In this context, we undertook a study in Kandy (a popular tourist destination) with the aim of understanding the prevalence, patient characteristics, and treatment outcomes associated with BL strains among tuberculosis patients in Kandy, Sri Lanka. (hindawi.com)
  • The aim of the present study was to determine the etiological role of tuberculosis in adult patients presenting with features of liver abscess. (hindawi.com)
  • 25% of the patients presenting with liver abscess had tubercular etiology without features of active pulmonary or miliary tuberculosis. (hindawi.com)
  • The study was carried out with 117 sputum samples from different patients suspected of having pulmonary tuberculosis, for whom physicians had ordered a baciloscopy test. (scielo.br)
  • tNGS can identify drug resistance from stool provided by tuberculosis patients. (biomedcentral.com)
  • A large case detection gap exists for people living with HIV (PLHIV), children, and patients with drug-resistant tuberculosis [ 1 ]. (biomedcentral.com)
  • Early identification of patients with multidrug-resistant tuberculosis, rapid molecular drug resistance testing (mDST), and linkage to care is paramount to decreasing transmission of MDR M. tuberculosis complex strains. (biomedcentral.com)
  • A growing body of evidence demonstrates that M. tuberculosis can be found in the stool of patients with tuberculosis. (biomedcentral.com)
  • They all had a bronchoscopy performed to determine if there were signs of hemoptysis, patients who could not cough up sputum, lung lesion that exclude pulmonary tuberculosis. (koreamed.org)
  • 19 patients with tuberculosis were identified and samples from 16 patients were later confirmed by culture. (koreamed.org)
  • Bronchial washing for Amplicor PCR proved to be more useful than IS6110 based PCR in rapidly diagnosing smear negative pulmonary pulmoary tuberculosis in patients where tuberculosis was likely to be differential and rapid diagnosis was essential for optimal treatment. (koreamed.org)
  • The inclusion criteria were adult patients 18 years or over, diagnosed with hypertension, lung cancer or pulmonary tuberculosis, and presenting with one of the suggestive symptoms of lung cancer. (aboutscience.eu)
  • The World Health Organization (WHO) algorithm for the diagnosis of tuberculosis in seriously ill HIV-infected patients recommends that treatment for Pneumocystis jirovecii pneumonia (PJP) should be considered without giving clear guidance on selecting patients for empiric PJP therapy. (scielo.org.za)
  • Pulmonary rehabilitation is a multi-disciplinary programme of care for patients with chronic respiratory impairment that is individually designed to optimise physical and social performance. (annals.edu.sg)
  • 1999) Comparison between human immunodeficiency virus positive and negative patients with tuberculosis in Southern Brazil. (medscape.org)
  • Ferrie BG and Rundle JSH (1985) Genito-urinary tuberculosis in Glasgow 1970 to 1979: a review of 230 patients. (medscape.org)
  • 2006) Antiretroviral therapy in AIDS patients with tuberculosis. (medscape.org)
  • Centers for Disease Control and Prevention (CDC) (2007) Reported HIV status of tuberculosis patients- United States, 1993-2005. (medscape.org)
  • AIDS patients are much more likely to develop tuberculosis because of their weakened immune systems. (encyclopedia.com)
  • 1 , 2 , 3 , 4 , 5 Pulmonary embolism carries a high morbidity and mortality burden, and a high index of suspicion for underlying PE must be maintained in all COVID-19 infected patients. (sajhivmed.org.za)
  • Les étudiants en année de doctorat affectés dans le service de médecine interne étaient responsables de la gestion quotidienne du CTE sous la supervision des spécialistes en médecine interne Ce service était subdivisé en deux parties: le CTE qui prenait en charge les cas de Covid -19 et le reste du service qui devait continuer à accueillir les patients atteints d'autres affections ou qui y étaient régulièrement suivies. (bvsalud.org)
  • For PCR, DNA was amplified with a specific pair of primers to the M. tuberculosis complex, with a resulting product of 123 bp from the insertion element IS6110. (scielo.br)
  • Para realização da PCR, o DNA foi amplificado com um par de oligonucleotídeos específicos para o complexo M. tuberculosis, resultando em um produto de 123 pb do elemento de inserção IS6110. (scielo.br)
  • Two hundred samples of clinically suspected cases of EPTB were collected and processed for Mycobacteria by Ziehl-Neelsen staining and also for PCR amplification with primers targeting 123 bp fragment of insertion element IS6110 of M. tuberculosis complex. (envirobiotechjournals.com)
  • Pulmonary tuberculosis was diagnosed on the basis of a positive culture or a response to anti-tuberculosis therapy. (koreamed.org)
  • More than 68 percent had less than 5 copies of the IS sequence suggesting that our local M.tuberculosis strains have a fewer number of copies compared to data shown in most countries. (who.int)
  • Drug resistant M. tuberculosis strains were examined by RFLP typing to determine whether a significant association between specific RFLP types and drug resistance is present. (who.int)
  • The World Health Organisation estimates that one-quarter of the global population has latent tuberculosis, with increasing prevalence of multi-drug resistant strains. (aleroux.co)
  • Nijmegen breakage syndrome complicated with primary cutaneous tuberculosis. (qxmd.com)
  • We report a 7-year-old white girl with NBS associated with cutaneous tuberculosis. (qxmd.com)
  • This is the first report describing the simultaneous presentation of NBS and cutaneous tuberculosis. (qxmd.com)
  • Laboratory confirmation of cutaneous tuberculosis has remained difficult using conventional techniques which include the demonstration of acid-fast bacilli (AFB) on histopathologic examination and culture. (annals.edu.sg)
  • Among six samples with positive results in culture, one was identified by PCR-RFLP as belonging to the M. tuberculosis complex and one was identified as a non-tuberculosis mycobacteria. (scielo.br)
  • Some months ago, a team from Mumbai reported a few cases of "totally drug-resistant tuberculosis" - suggesting that this form of TB was incurable because of resistance to all the TB drugs tested. (citizen-news.org)
  • William N. Rom is the Sol and Judith Bergstein Professor of Medicine and Environmental Medicine, Emeritus at New York University School of Medicine and former Director of the Division of Pulmonary, Critical Care and Sleep Medicine at New York University and Chief of the Chest Service at Bellevue Hospital Center, 1989-2014. (wikipedia.org)
  • This analysis shows that M72/AS01E significantly reduced the incidence of pulmonary tuberculosis disease in HIV-negative adults who were already infected with latent TB at the time of vaccination. (aleroux.co)
  • A total of 10 participants in the M72/AS01E group met the primary case definition (bacteriologically confirmed active pulmonary tuberculosis, with confirmation before treatment), as compared with 22 participants in the placebo group (incidence, 0.3 cases vs. 0.6 cases per 100 person-years). (isv-online.org)
  • Ten participants who received the vaccine developed active pulmonary tuberculosis compared to 22 participants in the placebo group. (aleroux.co)
  • The South African Tuberculosis Vaccine Initiative (SATVI) and the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) , tuberculosis research groups based in the Institute of Infectious Disease & Molecular Medicine at the University of Cape Town , are two of 11 sites in Kenya, South Africa and Zambia where the study is conducted. (aleroux.co)
  • In otherwise healthy persons, acute pulmonary and primary mucocutaneous symptomatic lesions may resolve without treatment. (medscape.com)
  • Furthermore, the consensus of experts also examined the wide-ranging applications of these techniques in diagnosing and managing respiratory tract infections, including acute upper respiratory tract infections, tracheobronchitis, community-acquired pneumonia, hospital-acquired pneumonia/ventilator-associated pneumonia, acute exacerbation of chronic obstructive pulmonary disease, tuberculosis, and respiratory infections in immunocompromised adults. (pumch.cn)
  • Underlying addressing and managing underlying medical conditions, could medical conditions were self-reported and included cardiac help reduce COVID-19-associated morbidity and mortality in disease, hypertension, diabetes, other pulmonary disease, sub-Saharan Africa. (cdc.gov)
  • Traditional methods for laboratory diagnosis of tuberculosis (TB) may require weeks, and delay can impede treatment and control efforts. (cdc.gov)
  • Human immunodeficiency virus (HIV), Tuberculosis (TB) and coronavirus disease (COVID-19) infections independently possess the ability to trigger formation of venous thromboembolism (VTE) and pulmonary embolism (PE). (sajhivmed.org.za)
  • Tuberculosis, measles and shigellosis are not normally infectious agents of nonhuman primates. (scienceopen.com)
  • Some human diseases encountered in healthcare settings such as measles and tuberculosis can be spread by bioaerosols containing infectious microorganisms [Ijaz et al. (cdc.gov)
  • He led an expedition to India to study the chronic effects of Tropical Pulmonary Eosinophilia. (wikipedia.org)
  • When we encounter a case of hypersensitive pneumonitis showing atypical pulmonary mass-like opacities in a patient with chronic granulomatous disease, we should consider hyperinflammatory status and excessive granuloma formation of chronic granulomatous disease and start with high-dose steroid therapy as treatment. (biomedcentral.com)
  • The risk factors for CPI include fibronodular lesions on chest images, the presence of bronchiectasis or chronic obstructive pulmonary disease (COPD), and sequelae of PTB [ 6 - 8 ]. (e-crt.org)
  • The condition may be indistinguishable from other causes of chronic oral ulcers (eg, tuberculosis, malignancy). (medscape.com)
  • Pneumoconioses are restrictive pulmonary diseases caused by chronic inhalation of mineral dust. (biomedcentral.com)
  • Here we present the case of a 29-year-old patient who developed chronic interstitial pulmonary disease most likely due to long-term smoking of marijuana adulterated with mineral substances. (biomedcentral.com)
  • Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
  • M72/AS01E provided 54.0% protection for M. tuberculosis -infected adults against active pulmonary tuberculosis disease, without evident safety concerns. (isv-online.org)
  • The ongoing trial is conducted in tuberculosis-endemic regions in Kenya, South Africa and Zambia and involves 3,573 HIV-negative adults. (aleroux.co)
  • Since cannabis consumption is widely spread among young adults, it seems to be justified to raise attention to this form of interstitial pulmonary disease. (biomedcentral.com)
  • 56 with and 10 participants without M. tuberculosis complex DNA detected in stool by real-time quantitative PCR), and an independent German validation cohort of participants with culture-confirmed tuberculosis ( n = 21). (biomedcentral.com)
  • The diagnosis of PJP is difficult in low-middle-income countries (LMICs) because facilities for bronchoscopy, sophisticated imaging and microbiologic identification of P. jirovecii are limited and because co-infections are common, especially with tuberculosis. (scielo.org.za)
  • The diagnostic approach to tuberculosis (TB) has changed little since the era of Robert Koch, whose rapid diagnostic test for TB was bacilloscopy, which is insensitive and unspecific. (scielo.org.mx)
  • He was a Senior Investigator at Pulmonary Branch, National Heart Lung and Blood Institute (NHLBI), NIH (1983-1989). (wikipedia.org)
  • Pulmonary function studies showed that first-second vital capacity was 2.68L (86.2% predicted), a vital capacity of 3.25L (72.5% predicted), a ratio of residual volume to total lung capacity of 25.8%, and a single-breath carbon monoxide diffusing capacity of 64.5% predicted. (biomedcentral.com)
  • 1Department of Tuberculosis and HIV/AIDS, National Research Institute of Tuberculosis and Lung Diseases, Tehran, Islamic Republic of Iran (Correspondence to S.M. Mirsaedi: [email protected]). (who.int)
  • Those who were pregnant or had a diagnosis of lung cancer or pulmonary tuberculosis prior to the diagnosis of hypertension were excluded. (aboutscience.eu)
  • Cases were those diagnosed with lung cancer, while controls were those diagnosed with tuberculosis. (aboutscience.eu)
  • Lung-pulmonary tuberculosis. (ijorl.com)
  • Tuberculosis can involve possibly all organs in the human body [ 1 ]. (hindawi.com)
  • Stool is an important diagnostic specimen for tuberculosis in populations who struggle to provide sputum, such as children or people living with HIV. (biomedcentral.com)
  • Currently, there is no available tuberculosis vaccine with proven, consistent efficacy in adult populations. (aleroux.co)
  • However, in order to maintain optimal sensitivity, it seems plausible that a pooling strategy that retains the original concentration of M. tuberculosis organisms would be preferred. (biomedcentral.com)
  • This woman was admitted to isolation and started empirically on a 4-drug regimen in the ED. Tuberculosis was confirmed on sputum testing. (medscape.com)
  • India's Revised National Tuberculosis Control Programme (RNTCP) is widely appreciated for having made a big contribution by expanding basic diagnostic and treatment services to cover 100% of the Indian population. (citizen-news.org)
  • Improved diagnostic value of PCR in the diagnosis of female genital tuberculosis leading to infertility. (microbiologyresearch.org)
  • A 2011 Global TB Report by the World Health Organization estimated that approximately 64,000 cases of multidrug-resistant TB emerge annually from the notified cases of pulmonary TB in India. (citizen-news.org)
  • Despite reports of involvement of liver in miliary TB, demonstrated in the form of tubercular granulomas in liver tissues [ 3 , 4 ], local or primary hepatic TB without active pulmonary or miliary TB is considered an uncommon diagnosis [ 5 ]. (hindawi.com)