MycobacteriumReactionExtrapulmonaryActive tuberculosisClinicalInfectionMycobacterialExtra pulmonary tuberculosisSpecimensDetectPatientsIS6110Anti-tuberculosis therapyStrainsPrevalenceComplicationsCutaneous tuberculosisMycobacteriaDrug-resistant tuDivision of PulmonaryLatentParticipants in the placebo groupInfectious DiseasesAcuteMorbidity and mortaMethodsEmbolismMeaslesChronicAdultsCultureInfectionsSouth AfricaRapidIncidenceLungOrgansPopulationsOrganismsIsolationDiagnosticVaccineIndiaComplexInvolvement
Mycobacterium32
- An NAA test for Mycobacterium tuberculosis complex (Amplified Mycobacterium Tuberculosis Direct Test or MTD {Gen-Probe{Registered}, San Diego, California}) * was recently approved by the Food and Drug Administration (FDA) for use on processed clinical specimens (1), and others are under development. (cdc.gov)
- Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? (hindawi.com)
- Mycobacterium tuberculosis belonging to Beijing sublineage (BL) is associated with high tuberculosis (TB) transmission, multidrug resistance, and adverse treatment outcomes. (hindawi.com)
- Seven lineages of Mycobacterium tuberculosis (MTB), the bacteria that causes "Tuberculosis" (TB), have been identified till date [ 1 ]. (hindawi.com)
- The present study was designed to define the role of Mycobacterium tuberculosis (M. tb) as the etiological agent for liver abscess in adult patients with no evidence of active TB elsewhere in the body. (hindawi.com)
- Zishiri and colleagues have shown, in 20 acid-fast bacilli smear positive and 17 smear negative sputum specimens that were Mycobacterium tuberculosis (MTB) culture positive and Xpert MTB positive, that pooling up to five-fold (that is, each with four negative sputum samples collected from other individuals) was associated with acceptable sensitivity when implemented in a reference laboratory [ 7 ]. (biomedcentral.com)
- In the present work, the detection of Mycobacterium tuberculosis by the Polymerase Chain Reaction (PCR) was standardized, and the laboratory diagnosis of pulmonary tuberculosis was evaluated comparing baciloscopy, culture and PCR tests. (scielo.br)
- No presente trabalho, o método de detecção de Mycobacterium tuberculosis pela Reação em Cadeia da Polimerase (PCR) em amostras de escarro foi padronizado e o diagnóstico laboratorial da tuberculose pulmonar foi avaliado, comparando-se as metodologias de baciloscopia, cultura e PCR. (scielo.br)
- Das 117 amostras analisadas, três (2,56%) apresentaram baciloscopia positiva e PCR positiva para M. tuberculosis (concordância de 100%), e nove (7,69%) tiveram crescimento de Mycobacterium sp. (scielo.br)
- Polymerase chain reaction testing using Mycobacterium genus- and Mycobacterium tuberculosis species-specific primers confirmed the clinical diagnosis of cutaneous tuberculosis. (qxmd.com)
- mpt64 RT-PCR showed high sensitivity and specificity for the detection of Mycobacterium tuberculosis complex in sputum samples. (microbiologyresearch.org)
- Comparison of the Xpert MTB/RIF test with an IS 6110 -TaqMan real-time PCR assay for direct detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens. (microbiologyresearch.org)
- Rapid diagnosis of mycobacterial infections and quantitation of Mycobacterium tuberculosis load by two real-time calibrated PCR assays. (microbiologyresearch.org)
- Rapid and specific detection of Mycobacterium tuberculosis by using the Smart Cycler instrument and a specific fluorogenic probe. (microbiologyresearch.org)
- However, the culture of Mycobacterium tuberculosis ( M. tuberculosis ) complex strains from stool perform poorly. (biomedcentral.com)
- There is an urgent need for rapid, comprehensive detection of drug resistance of Mycobacterium tuberculosis ( M. tuberculosis) complex strains to guide appropriate treatment regimens [ 5 ]. (biomedcentral.com)
- The sensitivity and specificity of Amplicor was compared with that of an in-house PCR test used for detecting the IS6110 sequence of Mycobacterium tuberculosis(M.tbc) in the bronchial washing fluid. (koreamed.org)
- Immune recognition surface construction of Mycobacterium tuberculosis epitope-specific antibody responses in tuberculosis patients identified by peptide microarrays. (cdc.gov)
- Standardization and evaluation of a tetraplex polymerase chain reaction to detect and differentiate Mycobacterium tuberculosis complex and nontuberculous Mycobacteria-a retrospective study on pulmonary TB patients. (gcwtvm.ac.in)
- dc.title: PCR based detection techniques and DNA finger printing by restriction fragment analysis of mycobacterium tuberculosis dc.contributor.author: MAGANAARACHCHI, DN dc.description.abstract: In Sri Lanka definitive diagnosis of tuberculosis depends on the culture of mycobacteria, but the slow growth of the organism delays the diagnosis. (who.int)
- The objective of the study was to develop a rapid method to detect Mycobacterium tuberculosis from clinical samples and the applicability of DNA amplification techniques to a developing country like Sri Lanka. (who.int)
- In this study, the potential use of PCR was investigated using the primers Pt8-Pt9 based on the insertion sequence IS 6110 of the Mycobacterium tuberculosis complex (Kolk etal, 1992). (who.int)
- In this study 465 clinical samples were tested using PCR and the results obtained indicates that this approach offers may advantages over conventional methods and could be used to detect Mycobacterium tuberculosis in clinical samples. (who.int)
- In conclution, DNA amplification is a rapid, reliable and accurate method with a high degree of sensitivity and specificity for the detection of Mycobacterium tuberculosis DNA sequences and it can replace the conventional culture method in the diagnosis of extra pulmonary tuberculosis and tuberculosis meningitis except in the situation when antibiotic sensitivity results are required. (who.int)
- Typing of Mycobacterium tuberculosis isolates is of great potential value for basic and epidemiological studies on tuberculosis. (who.int)
- Results obtained from Restriction fragment length polymorphism typing show that the mahority of circulating Mycobacterium tuberculosis strains in Sri Lanka belong to a limited number of families, but the degree of IS6160 DNA polymorphism among strains were high. (who.int)
- Polymerase chain reaction for Mycobacterium tuberculosis complex DNA by hsp65 amplified probe, and nontuberculous mycobacteria (including Mycobacterium avium complex) by 16s rDNA, hsp65, and rpoB pruner sets were both negative. (bmj.com)
- Diagnosis of lung cancer was made pathologically, while tuberculosis was made by positive acid-fast bacilli on sputum examination, sputum culture positive for Mycobacterium tuberculosis , or polymerase chain reaction positive for M. tuberculosis with a chest x-ray compatible with tuberculosis. (aboutscience.eu)
- Dilakukan pemeriksaan uji tuberkulin dan pengambilan spesimen dari dahak, bilasan lambung, cairan pleura, aspirasi kelenjar getah bening (dengan jarum halus), atau cairan serebrospinal untuk diperiksa PCR, sediaan langsung basil tahan asam dan biakan Mycobacterium tuberculosis. (saripediatri.org)
- It is caused by a bacterial microorganism, the tubercle bacillus or Mycobacterium tuberculosis . (encyclopedia.com)
- Sputa returned positive for mycobacterium TB a day later, and anti-tuberculosis therapy was added. (sajhivmed.org.za)
- Tuberculosis, caused by Mycobacterium tuberculosis can affect almost any part of the human body. (ijorl.com)
Reaction43
- In addition, experimental evidence for and against a role of mycobacterial infection is summarized, including recent attempts to detect mycobacterial DNA in clinical samples from patients with sarcoidosis by polymerase chain reaction. (nih.gov)
- Nucleic acid amplification (NAA) tests, such as polymerase chain reaction (PCR) and other methods for amplifying DNA and RNA, may facilitate rapid detection of microorganisms. (cdc.gov)
- Fresh sputum samples were collected for culturing and conducted polymerase chain reaction using BL-specific primers. (hindawi.com)
- The cause was determined by stool culture and confirmed by polymerase chain reaction (PCR) and direct genotyping. (medscape.com)
- To evaluate the effectiveness of nested polymerase chain reaction (PCR) for diagnosis of extrapulmonary tuberculosis (ETB), as well as the impact of PCR results on clinical management. (scielo.org.mx)
- The development of DNA amplification techniques such as polymerase chain reaction (PCR) has focused the attention of investigators toward this direction. (scielo.org.mx)
- The liver abscess aspirate was subjected to microscopy, culture, and polymerase chain reaction to determine the role of tuberculosis as an etiological factor in liver abscess. (hindawi.com)
- In a total of 40 specimens, 2.5% (1/40) were positive for acid fast bacilli by Ziehl-Neelsen method, while 10% (4/40) were positive for M. tuberculosis by culture using BACTEC 460 and the yield increased to 25% (10/40) by polymerase chain reaction for M. tuberculosis . (hindawi.com)
- The tubercular etiology of the liver abscess was diagnosed by Ziehl-Neelsen (ZN) staining for acid fast bacilli, culture by liquid culture (BACTEC 460), and detection of M. tb DNA using Mpt64 gene polymerase chain reaction performed on the liver aspirate. (hindawi.com)
- Pooling sputum specimens is one potential strategy for reducing the cost of using Xpert MTB/RIF, a rapid polymerase chain reaction (PCR)-based test, for the diagnosis of pulmonary tuberculosis. (biomedcentral.com)
- Improved laboratory techniques, newer diagnostic tests for pleural fluid (eg, adenosine deaminase levels, interferon-gamma, polymerase chain reaction studies for suspected tuberculosis), and more widespread availability of thoracoscopy have made pleural biopsy less necessary and therefore uncommonly done. (msdmanuals.com)
- Identification of M. tuberculosis complex in stool specimens by polymerase chain reaction (PCR), typically with the GeneXpert® MTB/RIF (Xpert), has demonstrated sensitivity between 60 and 70% against culture on respiratory specimens in children and adults [ 9 , 10 ]. (biomedcentral.com)
- Clinical suspicion of tuberculosis was confirmed with sputum by means of a polymerase-chain-reaction test, mycobacterial culture, or both. (isv-online.org)
- CSF may Extremely rare, with more cases in Objective abnormalities on neurologic Presents clinically with a pro- Objective and characteristic abnormali- May be associated with a pe- * PCR denotes polymerase chain reaction, CSF cerebrospinal fluid, CNS central nervous system, and MRI magnetic resonance imaging. (med-abstracts.com)
- There is a well recognized interlaboratory variation in the results using the polymerase chain reaction(PCR) to detect the IS6110 sequence. (koreamed.org)
- It comprises less than 10% berculosis was confirmed at the time by of all perianal diseases and 0.7% of all polymerase chain reaction to amplify poly- tuberculosis cases [ 1 ]. (who.int)
- Bioaerosol monitoring is a rapidly emerging area of industrial hygiene due to the improved analysis methods such as polymerase chain reaction (PCR) and the impact that occupational exposures may have on worker respiratory health, particularly in microbial contaminated environments [Eduard et al. (cdc.gov)
- Since PCR is too expensive to use in routine laboratories in Sri Lanka, one center could function as a reference laboratory where clinical samples can be tested using Polymerase Chain Reaction. (who.int)
- 2017) of mycobacterial genomes by polymerase chain reaction (PCR) using DNA samples extracted from e.g. clinical specimens, pulmonary smears or cultivated samples. (zytovision.com)
- This study aims to investigate the sensitivity of microscopy, culture and polymerase chain reaction on three gastric aspirates (GAs) in the microbiological confirmation of active pulmonary tuberculosis (TB) and to identify possible changes in sensitivity derived from the collection of a different number of aspirates. (authorea.com)
- 1000 copies/mL of P. jirovecii DNA on real-time sputum polymerase chain reaction (PCR). (scielo.org.za)
- Sensitivities for culture, Ziehl-Neelsen staining and polymerase chain reaction were 58%, 25% and 66.3% respectively. (unicatt.it)
- 2000) Rapid diagnosis of genitourinary tuberculosis by polymerase chain reaction and non-radioactive DNA hybridization. (medscape.org)
- 2000) Polymerase chain reaction in clinically suspected genitourinary tuberculosis: comparision with intravenous urography, bladder biopsy, and urine acid fast bacilli culture. (medscape.org)
- Beberapa tahun terakhir telah dikembangkan pemeriksaan polymerase chain reaction (PCR) untuk mendeteksi TB. (saripediatri.org)
- Chaudary M, Baveja CP, Sharma VK, Sethi GR. Clinical utility of Polymerase Chain Reaction for improved diagnosis of pulmonary tuberculosis in children. (saripediatri.org)
- Negi SS, Khan SFB, Gupta S, Pasha ST, Khare S, Lal S. Comparison of the conventional diagnostic modalities, Bactec culture and polymerase chain reaction test for diagnosis of tuberculosis. (saripediatri.org)
- The global demand for Polymerase chain reaction PCRs was valued at USD 7.5 Billion in 2022 and is expected to reach USD 13.5 Billion in 2030, growing at a CAGR of 8.80% between 2023 and 2030. (credenceresearch.com)
- The global Polymerase chain reaction PCR market is classified into Type, Product, Indication, End-User, and Region. (credenceresearch.com)
- The global Polymerase Chain Reaction PCR market is driven by numerous factors, including market growth acceleration due to technological advancements and increased prevalence of tuberculosis and other infectious diseases. (credenceresearch.com)
- Nonetheless, the global Polymerase chain reaction PCR market provides tremendous potential and opportunity, as PCR is becoming more used in research and diagnostics, and demand for personalized medicine is rising. (credenceresearch.com)
- The global Polymerase chain reaction PCR market has witnessed steady growth in recent years and is expected to continue growing at a CAGR of 8.80% between 2023 and 2030. (credenceresearch.com)
- What Are the Primary Forces Driving the Global Polymerase Chain Reaction PCR Market? (credenceresearch.com)
- Several reasons are driving the worldwide Polymerase Chain Reaction PCR market, including market growth acceleration due to technological advances and increased prevalence of tuberculosis and other infectious diseases. (credenceresearch.com)
- What Are the Global Polymerase Chain Reaction PCR Market's Major Challenges? (credenceresearch.com)
- The global Polymerase chain reaction PCR market also confronts many hurdles, including high equipment and reagent prices, as well as the technology's complexity and the need for highly qualified individuals. (credenceresearch.com)
- What Are the Opportunities for Growth in the Global Polymerase Chain Reaction PCR Market? (credenceresearch.com)
- The global Polymerase chain reaction PCR market has great development potential, as PCR is becoming more used in research and diagnostics, and demand for personalized treatment is increasing. (credenceresearch.com)
- The Polymerase chain reaction (PCR) market is the market for products and services linked to PCR technology, which is a popular technique for amplifying DNA and RNA sequences. (credenceresearch.com)
- Investigations include smears, biopsy, staining with periodic acid-Schiff (PAS) or Gomori methenamine silver, culture of the affected tissues, polymerase chain reaction (PCR), serodiagnosis (sometimes), physical examination, and chest radiography. (medscape.com)
- Basing on the both domestic and international guidelines and literature, the expert consensus conducted an analysis of the clinical application scenarios, technical characteristics, and performance validation requirements pertaining to real-time fluorescence polymerase chain reaction (PCR), isothermal amplification technology, digital PCR, nucleic acid point-of-care testing, and metagenomics Next Generation Sequencing. (pumch.cn)
- Primary oral tuberculosis: A report of a case diagnosed by polymerase chain reaction. (ijorl.com)
- HIV nucleic acid sequences have been detected in urine by polymerase chain reaction (13). (cdc.gov)
Extrapulmonary6
- Liver involvement in pulmonary and extrapulmonary TB is usually clinically silent [ 2 ]. (hindawi.com)
- Diagnosis of extrapulmonary tuberculosis by smear, culture, and PCR using universal sample processing technology. (microbiologyresearch.org)
- Extrapulmonary tuberculosis (EPTB) is a significant health problem in both developing & developed countries. (envirobiotechjournals.com)
- from Madagascar, 14% of 64 patients with Abdominal sonography showed mul- extrapulmonary tuberculosis had tubercular tiple lymphadenopathies in the para-aor- anal fistula [ 3 ]. (who.int)
- Although extrapulmonary tuberculosis splenomegaly was seen as well. (who.int)
- The study focused mainly on extrapulmonary tuberculosis where a definitive diagnosis was difficult. (who.int)
Active tuberculosis4
- Tuberculosis should be considered as an important differential diagnosis of liver abscess irrespective of evidence of active tuberculosis elsewhere in the body. (hindawi.com)
- The radiograph shows a classic posterior segment right upper lobe density consistent with active tuberculosis. (medscape.com)
- 214 cases of active tuberculosis were identified (132 definite, 82 probable). (unicatt.it)
- History of contact with a patient with active tuberculosis was associated with pulmonary TB (P=0.0014), while negative history of contact was associated with lymph node (P=0.0064) and central nervous system TB (P=0.05). (unicatt.it)
Clinical9
- First, the similarities in clinical and histological features of tuberculosis and sarcoidosis that have raised suspicion that mycobacterial infection could be involved in the pathogenesis of sarcoidosis are discussed. (nih.gov)
- In this context, a cohort study was conducted to assess the prevalence of BL strains among pulmonary tuberculosis (PTB) patients in the Kandy district of Sri Lanka (a popular tourist destination) and its association with patients' sociodemographic and clinical characteristics. (hindawi.com)
- A lower body mass index, interstitial lung disease, prior pulmonary tuberculosis, larger clinical target volume, history of lung cancer surgery or radiation pneumonitis, and use of inhaled corticosteroids were independent risk factors for CPI development. (e-crt.org)
- The clinical utility of a commercially developed PCR test(Amplicor) in bronchial washings for detecting pulmonary tuberculosis in smear negative patients was evaluated. (koreamed.org)
- A candidate tuberculosis vaccine significantly reduced the incidence of pulmonary tuberculosis in HIV-negative adults who were already infected with latent TB at the time of vaccination, according to results from an ongoing clinical trial in in Kenya, South Africa and Zambia . (aleroux.co)
- The primary results of an ongoing phase IIb clinical trial testing the candidate tuberculosis vaccine M72/AS01E1 have been published. (aleroux.co)
- Children with clinical and radiological diagnoses of active pulmonary TB who underwent three GAs between March 2007 and June 2019 were retrospectively evaluated. (authorea.com)
- 2000) Genitourinary tuberculosis in patients with HIV infection: clinical features in an innercity hospital population. (medscape.org)
- Tuberculosis: a comprehensive clinical reference. (saripediatri.org)
Infection13
- Human immunodeficiency virus (HIV)-negative adults 18 to 50 years of age with latent M. tuberculosis infection (by interferon-γ release assay) were randomly assigned (in a 1:1 ratio) to receive two doses of either M72/AS01E or placebo intramuscularly 1 month apart. (isv-online.org)
- This study aimed to investigate cumulative incidence and risk factors associated with chronic pulmonary infection (CPI) development after radiotherapy for lung cancer. (e-crt.org)
- Soil saprophytic fungi such as Coccidioides immitis can be aerosolized during occupational disturbance activities and, if inhaled, can result in an acute pulmonary infection [Das et al. (cdc.gov)
- The study assesses the safety and efficacy of M72/AS01E, in adults with latent tuberculosis infection, against development of pulmonary tuberculosis disease. (aleroux.co)
- Havlir DV and Barnes PF (1999) Tuberculosis in patients with human immunodeficiency virus infection. (medscape.org)
- 2007) A systematic review of rapid diagnostic tests for detection of tuberculosis infection. (medscape.org)
- Bactiar A, Miko TY, Machmud R. Annual risk of tuberculosis infection in West Sumatra Province, Indonesia. (saripediatri.org)
- Bactiar A, Miko TY, Machmud R. Annual risk of tuberculosis infection in East Nusa Tenggara and Central Java Provinces, Indonesia. (saripediatri.org)
- Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. (encyclopedia.com)
- Scientists know it as an infection caused by M. tuberculosis . (encyclopedia.com)
- When streptomycin, the first antibiotic effective against M. tuberculosis , was discovered in the early 1940s, the infection began to come under control. (encyclopedia.com)
- Coronavirus disease (COVID-19) infection is associated with increased prevalence of venous thromboembolism and pulmonary embolism (PE). (sajhivmed.org.za)
- However, chronic pulmonary infection tends to progress and disseminated infections can be fatal. (medscape.com)
Mycobacterial3
- CPI was defined as pulmonary tuberculosis, non-tuberculous mycobacterial pulmonary disease, chronic pulmonary aspergillosis, or pulmonary actinomycosis. (e-crt.org)
- Chronic pulmonary infections (CPIs), such as pulmonary tuberculosis (PTB), non-tuberculous mycobacterial pulmonary disease (NTM-PD), and chronic pulmonary aspergillosis (CPA), usually occur in patients with underlying lung diseases. (e-crt.org)
- The mycobacterial genera comprise more than 140 species, which, for the purpose of diagnosis and treatment, have been grouped into three categories: M. tuberculosis complex (MTC), M. leprae, and non-tuberculous mycobacteria (NTM). (zytovision.com)
Extra pulmonary tuberculosis2
- The aim of this study is to evaluate PCR as a rapid and sensitive tool for diagnosis of clinically suspected cases of Extra pulmonary tuberculosis. (envirobiotechjournals.com)
- Based on this study PCR was found to be more sensitive than culture or microscopy in those with a final diagnosis of extra pulmonary tuberculosis. (who.int)
Specimens8
- The specificity does not indicate the growth of M. tuberculosis from all MTD-positive specimens: trials included MTD-positive, culture-negative specimens from patients with other positive cultures, and there are other reports of test readings 'in the low range of positivity' with nontuberculous mycobacteria (2). (cdc.gov)
- False-negative results may be obtained for specimens containing low numbers of M. tuberculosis or substances inhibiting the assay. (cdc.gov)
- We have confirmed that pooling of two sputum specimens for testing in a single cartridge is a valid method of reducing the number of cartridges required when using Xpert MTB to detect pulmonary tuberculosis. (biomedcentral.com)
- In some screening settings, such as general community-wide screening, the prior probability of TB will be lower and likely concentration of M. tuberculosis in sputum specimens submitted for testing will be lower. (biomedcentral.com)
- Hence, it is encouraging that we have shown, using sputum specimens spiked with a low concentration of M. tuberculosis and diluted from 2- to 12-fold that, despite an expected linear increase in cycle threshold with increasing dilution, the majority of diluted specimens were still Xpert MTB positive [ 9 ]. (biomedcentral.com)
- This affords the opportunity to obtain critical diagnostic information for tuberculosis patients who struggle to provide respiratory specimens. (biomedcentral.com)
- thus, procedures such as sputum induction or gastric aspiration are required to collect diagnostic specimens for pulmonary tuberculosis [ 8 ]. (biomedcentral.com)
- In contrast, stool culture of M. tuberculosis complex strains has a sensitivity of under 30% against respiratory culture, limiting the utility of phenotypic drug susceptibility testing (pDST) from stool specimens [ 14 ]. (biomedcentral.com)
Detect2
- The MTD test uses transcription-mediated amplification to detect M. tuberculosis-complex ribosomal RNA (2). (cdc.gov)
- For this analysis, participants who received two doses of either M72/AS01E or placebo 30 days apart have been followed for at least 2 years to detect evidence of pulmonary tuberculosis disease. (aleroux.co)
Patients21
- In this context, we undertook a study in Kandy (a popular tourist destination) with the aim of understanding the prevalence, patient characteristics, and treatment outcomes associated with BL strains among tuberculosis patients in Kandy, Sri Lanka. (hindawi.com)
- The aim of the present study was to determine the etiological role of tuberculosis in adult patients presenting with features of liver abscess. (hindawi.com)
- 25% of the patients presenting with liver abscess had tubercular etiology without features of active pulmonary or miliary tuberculosis. (hindawi.com)
- The study was carried out with 117 sputum samples from different patients suspected of having pulmonary tuberculosis, for whom physicians had ordered a baciloscopy test. (scielo.br)
- tNGS can identify drug resistance from stool provided by tuberculosis patients. (biomedcentral.com)
- A large case detection gap exists for people living with HIV (PLHIV), children, and patients with drug-resistant tuberculosis [ 1 ]. (biomedcentral.com)
- Early identification of patients with multidrug-resistant tuberculosis, rapid molecular drug resistance testing (mDST), and linkage to care is paramount to decreasing transmission of MDR M. tuberculosis complex strains. (biomedcentral.com)
- A growing body of evidence demonstrates that M. tuberculosis can be found in the stool of patients with tuberculosis. (biomedcentral.com)
- They all had a bronchoscopy performed to determine if there were signs of hemoptysis, patients who could not cough up sputum, lung lesion that exclude pulmonary tuberculosis. (koreamed.org)
- 19 patients with tuberculosis were identified and samples from 16 patients were later confirmed by culture. (koreamed.org)
- Bronchial washing for Amplicor PCR proved to be more useful than IS6110 based PCR in rapidly diagnosing smear negative pulmonary pulmoary tuberculosis in patients where tuberculosis was likely to be differential and rapid diagnosis was essential for optimal treatment. (koreamed.org)
- The inclusion criteria were adult patients 18 years or over, diagnosed with hypertension, lung cancer or pulmonary tuberculosis, and presenting with one of the suggestive symptoms of lung cancer. (aboutscience.eu)
- The World Health Organization (WHO) algorithm for the diagnosis of tuberculosis in seriously ill HIV-infected patients recommends that treatment for Pneumocystis jirovecii pneumonia (PJP) should be considered without giving clear guidance on selecting patients for empiric PJP therapy. (scielo.org.za)
- Pulmonary rehabilitation is a multi-disciplinary programme of care for patients with chronic respiratory impairment that is individually designed to optimise physical and social performance. (annals.edu.sg)
- 1999) Comparison between human immunodeficiency virus positive and negative patients with tuberculosis in Southern Brazil. (medscape.org)
- Ferrie BG and Rundle JSH (1985) Genito-urinary tuberculosis in Glasgow 1970 to 1979: a review of 230 patients. (medscape.org)
- 2006) Antiretroviral therapy in AIDS patients with tuberculosis. (medscape.org)
- Centers for Disease Control and Prevention (CDC) (2007) Reported HIV status of tuberculosis patients- United States, 1993-2005. (medscape.org)
- AIDS patients are much more likely to develop tuberculosis because of their weakened immune systems. (encyclopedia.com)
- 1 , 2 , 3 , 4 , 5 Pulmonary embolism carries a high morbidity and mortality burden, and a high index of suspicion for underlying PE must be maintained in all COVID-19 infected patients. (sajhivmed.org.za)
- Les étudiants en année de doctorat affectés dans le service de médecine interne étaient responsables de la gestion quotidienne du CTE sous la supervision des spécialistes en médecine interne Ce service était subdivisé en deux parties: le CTE qui prenait en charge les cas de Covid -19 et le reste du service qui devait continuer à accueillir les patients atteints d'autres affections ou qui y étaient régulièrement suivies. (bvsalud.org)
IS61103
- For PCR, DNA was amplified with a specific pair of primers to the M. tuberculosis complex, with a resulting product of 123 bp from the insertion element IS6110. (scielo.br)
- Para realização da PCR, o DNA foi amplificado com um par de oligonucleotídeos específicos para o complexo M. tuberculosis, resultando em um produto de 123 pb do elemento de inserção IS6110. (scielo.br)
- Two hundred samples of clinically suspected cases of EPTB were collected and processed for Mycobacteria by Ziehl-Neelsen staining and also for PCR amplification with primers targeting 123 bp fragment of insertion element IS6110 of M. tuberculosis complex. (envirobiotechjournals.com)
Anti-tuberculosis therapy1
- Pulmonary tuberculosis was diagnosed on the basis of a positive culture or a response to anti-tuberculosis therapy. (koreamed.org)
Strains3
- More than 68 percent had less than 5 copies of the IS sequence suggesting that our local M.tuberculosis strains have a fewer number of copies compared to data shown in most countries. (who.int)
- Drug resistant M. tuberculosis strains were examined by RFLP typing to determine whether a significant association between specific RFLP types and drug resistance is present. (who.int)
- The World Health Organisation estimates that one-quarter of the global population has latent tuberculosis, with increasing prevalence of multi-drug resistant strains. (aleroux.co)
Prevalence1
- Market growth is accelerating as a result of technological advancements and an increase in the prevalence of tuberculosis and other infectious diseases. (credenceresearch.com)
Complications1
- 6.Tuberculosis - complications. (bvsalud.org)
Cutaneous tuberculosis4
- Nijmegen breakage syndrome complicated with primary cutaneous tuberculosis. (qxmd.com)
- We report a 7-year-old white girl with NBS associated with cutaneous tuberculosis. (qxmd.com)
- This is the first report describing the simultaneous presentation of NBS and cutaneous tuberculosis. (qxmd.com)
- Laboratory confirmation of cutaneous tuberculosis has remained difficult using conventional techniques which include the demonstration of acid-fast bacilli (AFB) on histopathologic examination and culture. (annals.edu.sg)
Mycobacteria1
- Among six samples with positive results in culture, one was identified by PCR-RFLP as belonging to the M. tuberculosis complex and one was identified as a non-tuberculosis mycobacteria. (scielo.br)
Drug-resistant tu1
- Some months ago, a team from Mumbai reported a few cases of "totally drug-resistant tuberculosis" - suggesting that this form of TB was incurable because of resistance to all the TB drugs tested. (citizen-news.org)
Division of Pulmonary1
- William N. Rom is the Sol and Judith Bergstein Professor of Medicine and Environmental Medicine, Emeritus at New York University School of Medicine and former Director of the Division of Pulmonary, Critical Care and Sleep Medicine at New York University and Chief of the Chest Service at Bellevue Hospital Center, 1989-2014. (wikipedia.org)
Latent1
- This analysis shows that M72/AS01E significantly reduced the incidence of pulmonary tuberculosis disease in HIV-negative adults who were already infected with latent TB at the time of vaccination. (aleroux.co)
Participants in the placebo group2
- A total of 10 participants in the M72/AS01E group met the primary case definition (bacteriologically confirmed active pulmonary tuberculosis, with confirmation before treatment), as compared with 22 participants in the placebo group (incidence, 0.3 cases vs. 0.6 cases per 100 person-years). (isv-online.org)
- Ten participants who received the vaccine developed active pulmonary tuberculosis compared to 22 participants in the placebo group. (aleroux.co)
Infectious Diseases1
- The South African Tuberculosis Vaccine Initiative (SATVI) and the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) , tuberculosis research groups based in the Institute of Infectious Disease & Molecular Medicine at the University of Cape Town , are two of 11 sites in Kenya, South Africa and Zambia where the study is conducted. (aleroux.co)
Acute2
- In otherwise healthy persons, acute pulmonary and primary mucocutaneous symptomatic lesions may resolve without treatment. (medscape.com)
- Furthermore, the consensus of experts also examined the wide-ranging applications of these techniques in diagnosing and managing respiratory tract infections, including acute upper respiratory tract infections, tracheobronchitis, community-acquired pneumonia, hospital-acquired pneumonia/ventilator-associated pneumonia, acute exacerbation of chronic obstructive pulmonary disease, tuberculosis, and respiratory infections in immunocompromised adults. (pumch.cn)
Morbidity and morta1
- Underlying addressing and managing underlying medical conditions, could medical conditions were self-reported and included cardiac help reduce COVID-19-associated morbidity and mortality in disease, hypertension, diabetes, other pulmonary disease, sub-Saharan Africa. (cdc.gov)
Methods1
- Traditional methods for laboratory diagnosis of tuberculosis (TB) may require weeks, and delay can impede treatment and control efforts. (cdc.gov)
Embolism1
- Human immunodeficiency virus (HIV), Tuberculosis (TB) and coronavirus disease (COVID-19) infections independently possess the ability to trigger formation of venous thromboembolism (VTE) and pulmonary embolism (PE). (sajhivmed.org.za)
Measles2
- Tuberculosis, measles and shigellosis are not normally infectious agents of nonhuman primates. (scienceopen.com)
- Some human diseases encountered in healthcare settings such as measles and tuberculosis can be spread by bioaerosols containing infectious microorganisms [Ijaz et al. (cdc.gov)
Chronic7
- He led an expedition to India to study the chronic effects of Tropical Pulmonary Eosinophilia. (wikipedia.org)
- When we encounter a case of hypersensitive pneumonitis showing atypical pulmonary mass-like opacities in a patient with chronic granulomatous disease, we should consider hyperinflammatory status and excessive granuloma formation of chronic granulomatous disease and start with high-dose steroid therapy as treatment. (biomedcentral.com)
- The risk factors for CPI include fibronodular lesions on chest images, the presence of bronchiectasis or chronic obstructive pulmonary disease (COPD), and sequelae of PTB [ 6 - 8 ]. (e-crt.org)
- The condition may be indistinguishable from other causes of chronic oral ulcers (eg, tuberculosis, malignancy). (medscape.com)
- Pneumoconioses are restrictive pulmonary diseases caused by chronic inhalation of mineral dust. (biomedcentral.com)
- Here we present the case of a 29-year-old patient who developed chronic interstitial pulmonary disease most likely due to long-term smoking of marijuana adulterated with mineral substances. (biomedcentral.com)
- Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
Adults3
- M72/AS01E provided 54.0% protection for M. tuberculosis -infected adults against active pulmonary tuberculosis disease, without evident safety concerns. (isv-online.org)
- The ongoing trial is conducted in tuberculosis-endemic regions in Kenya, South Africa and Zambia and involves 3,573 HIV-negative adults. (aleroux.co)
- Since cannabis consumption is widely spread among young adults, it seems to be justified to raise attention to this form of interstitial pulmonary disease. (biomedcentral.com)
Culture1
- 56 with and 10 participants without M. tuberculosis complex DNA detected in stool by real-time quantitative PCR), and an independent German validation cohort of participants with culture-confirmed tuberculosis ( n = 21). (biomedcentral.com)
Infections1
- The diagnosis of PJP is difficult in low-middle-income countries (LMICs) because facilities for bronchoscopy, sophisticated imaging and microbiologic identification of P. jirovecii are limited and because co-infections are common, especially with tuberculosis. (scielo.org.za)
South Africa2
- We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South Africa, and Zambia. (isv-online.org)
- In South Africa, the estimated incidence of tuberculosis is 781 per 100,000 of the population. (aleroux.co)
Rapid1
- The diagnostic approach to tuberculosis (TB) has changed little since the era of Robert Koch, whose rapid diagnostic test for TB was bacilloscopy, which is insensitive and unspecific. (scielo.org.mx)
Incidence2
- However, their unit cost remains a barrier to implementation at scale, especially in countries with a high incidence of tuberculosis. (biomedcentral.com)
- India is the highest tuberculosis burden country accounting for one fifth of the global incidence ranges between 8.3% and 13.1% in different districts. (envirobiotechjournals.com)
Lung6
- He was a Senior Investigator at Pulmonary Branch, National Heart Lung and Blood Institute (NHLBI), NIH (1983-1989). (wikipedia.org)
- Pulmonary function studies showed that first-second vital capacity was 2.68L (86.2% predicted), a vital capacity of 3.25L (72.5% predicted), a ratio of residual volume to total lung capacity of 25.8%, and a single-breath carbon monoxide diffusing capacity of 64.5% predicted. (biomedcentral.com)
- 1Department of Tuberculosis and HIV/AIDS, National Research Institute of Tuberculosis and Lung Diseases, Tehran, Islamic Republic of Iran (Correspondence to S.M. Mirsaedi: [email protected]). (who.int)
- Those who were pregnant or had a diagnosis of lung cancer or pulmonary tuberculosis prior to the diagnosis of hypertension were excluded. (aboutscience.eu)
- Cases were those diagnosed with lung cancer, while controls were those diagnosed with tuberculosis. (aboutscience.eu)
- Lung-pulmonary tuberculosis. (ijorl.com)
Organs1
- Tuberculosis can involve possibly all organs in the human body [ 1 ]. (hindawi.com)
Populations2
- Stool is an important diagnostic specimen for tuberculosis in populations who struggle to provide sputum, such as children or people living with HIV. (biomedcentral.com)
- Currently, there is no available tuberculosis vaccine with proven, consistent efficacy in adult populations. (aleroux.co)
Organisms1
- However, in order to maintain optimal sensitivity, it seems plausible that a pooling strategy that retains the original concentration of M. tuberculosis organisms would be preferred. (biomedcentral.com)
Isolation1
- This woman was admitted to isolation and started empirically on a 4-drug regimen in the ED. Tuberculosis was confirmed on sputum testing. (medscape.com)
Diagnostic2
- India's Revised National Tuberculosis Control Programme (RNTCP) is widely appreciated for having made a big contribution by expanding basic diagnostic and treatment services to cover 100% of the Indian population. (citizen-news.org)
- Improved diagnostic value of PCR in the diagnosis of female genital tuberculosis leading to infertility. (microbiologyresearch.org)
Vaccine1
- A vaccine to interrupt the transmission of tuberculosis is needed. (isv-online.org)
India1
- A 2011 Global TB Report by the World Health Organization estimated that approximately 64,000 cases of multidrug-resistant TB emerge annually from the notified cases of pulmonary TB in India. (citizen-news.org)
Complex2
- for 28 of 38 (74%) samples, a full M. tuberculosis complex drug resistance prediction report was obtained. (biomedcentral.com)
- 65 samples were positive for M.tuberculosis complex by nPCR. (envirobiotechjournals.com)
Involvement1
- Despite reports of involvement of liver in miliary TB, demonstrated in the form of tubercular granulomas in liver tissues [ 3 , 4 ], local or primary hepatic TB without active pulmonary or miliary TB is considered an uncommon diagnosis [ 5 ]. (hindawi.com)