• Then he joined the Max Planck Institute for Polymer Research for PhD thesis, where he obtained his PhD degree in April 2008. (mpg.de)
  • In December 2007, he was appointed as a group leader at the Max-Planck Institute for Polymer Research, and in 2012, he became a distinguished group leader. (mpg.de)
  • In a new study published in Science Advances , Chien-Hua Tu and a research team at the Max Planck Institute for Polymer Research in Germany and the University of Ioannina Greece confined crystals within nanoscopic cylindrical pores to show the flowing nature of semicrystalline polymers below their melting point, alongside an intermediate state of viscosity to the melt and crystal states. (plasticstar.io)
  • Layer-by-Layer Assembly of Polyelectrolytes into Ionic Current Rectifying Solid-State Nanopores: Insights from Theory and Experiment. (mpg.de)
  • These solid state polymeric nanopores are employed as model systems to study the controlled passage of ions through nanochannels. (gsi.de)
  • Another strategy to develop responsive systems and single nanopore sensors rely in incorporating sensing elements into polymer nanochannels and monitoring the intronic output. (gsi.de)
  • Nanoparticle translocation through polymer brush decorated nanochannels: General principles' with funding period 10/2020 - 9/2023. (ipfdd.de)
  • The latter part of this dissertation is about fabrication of nanofluidics components including nanopores and nanochannels. (illinois.edu)
  • Daniel Branton , Harvard's Higgins Professor of Biology, Emeritus, and his collaborators David Deamer and Mark Akeson at the University of California, Santa Cruz, are among the 2023 Golden Goose Award winners for their invention and research developing Nanopore Sequencing . (harvard.edu)
  • Polymer Science - Series C. 2023. (hse.ru)
  • When the Ebola virus spread through West Africa a few years ago, a new, portable DNA sequencer developed by Oxford Nanopore Technologies (ONT) was brought to New Guinea. (genengnews.com)
  • After years of work and publications, Harvard and UC Santa Cruz licensed patents to Oxford Nanopore Technologies (ONT). (harvard.edu)
  • Polymer brush functionalized SiO2 nanoparticle based Nafion nanocomposites: a novel avenue to low-humidity proton conducting membranes. (mpg.de)
  • New theoretical models are also being developed to understand the dynamic and stochastic processes during nanopore electrochemical confinement. (rsc.org)
  • After irradiation, the polymer foil is introduced in a two-compartment electrochemical cell. (gsi.de)
  • Using the same electrochemical cell, the ionic transport through the single nanopore is investigated. (gsi.de)
  • The field of expertise of my group are conducting polymers which are used in a number of polymer electronics devices, but also in electrochemical applications where electronic and ionic charge transport are intimately linked with each other. (uni-stuttgart.de)
  • Mapping of EDOT Polymer Films upon Electrochemical Doping, in „Focus on New Materials and Applications for Organic Electrolyte Gated Transistors", Flex. (uni-stuttgart.de)
  • Confined Nanopore electrochemistry exhibits sensitivity for detecting single entities such as small molecules, nucleic acid polymers, proteins, viruses and nanoparticles using an electrical signal. (rsc.org)
  • In spite of the strong evidence we published in our 1996 PNAS paper, many readers initially doubted that we had in fact electrophoretically drawn a single polymer of nucleic acid through a nanopore. (harvard.edu)
  • Template-free tuning of nanopores in carbonaceous polymers through ionothermal synthesis. (mpg.de)
  • PEG-labeled nucleotides and nanopore detection for single molecule DNA sequencing by synthesis. (phys.org)
  • His current scientific interests include synthetic methodology for new-type of polymers, organic and polymer synthesis, interfacial chemistry, supramolecular chemistry of π-conjugated system, bottom-up synthesis of carbon nanostructures and graphene nanoribbons, 2D polymers and supramolecular polymers, 2D carbon-rich conjugated polymers for electronics, optoelectronics and spintronics, graphene and 2D materials for energy storage and conversion, new energy devices and technologies. (mpg.de)
  • Correction for 'Electrochemistry meets polymer physics: polymerized ionic liquids on an electrified electrode' by Yury A. Budkov et al. (hse.ru)
  • Hybrid Polymer-Silicon Proton Conducting Membranes via a Pore-Filling Surface-Initiated Polymerization Approach. (mpg.de)
  • Single nanopore membranes are fabricated at GSI by irradiation with a single heavy ion and subsequent chemical etching. (gsi.de)
  • Single nanopore membranes are also used as sensors to detect and control the pass of molecules, viruses, or particles. (gsi.de)
  • The study of polymer transport through nanopores of biological membranes has been a central research subject in the last years. (roconsulboston.com)
  • A nanopore with an embedded electrode is fabricated on a 20 µm thick SU-8 layer by using a focused ion beam. (illinois.edu)
  • We show that the shorter chains penetrate first the nanopores, whereas the longer chains enter only at the late stages of the filling process. (acs.org)
  • Capillary Filling of Polymer Chains in Nanopores. (mpg.de)
  • Though these early simulations were limited to chains of a few $N_e$, they demonstrated the potential of computer simulations to contribute to our understanding of polymer dynamics. (aps.org)
  • Further evidence for the tube models of polymer dynamics has been obtained by identifying the primitive path mesh that characterizes the microscopic topological state of the computer- generated conformations of the chains. (aps.org)
  • End-Adsorbing Chains in Polymer Brushes: Pathway to Highly Metastable Switchable Surfaces' by Markus Koch , Dirk Romeis , and Jens-Uwe Sommer was highlighted as Front Cover in Macromolecules 2020, 53 (17) . (ipfdd.de)
  • Relying on the developed theoretical framework, based on the Noether's theorem, we calculate the stress tensor, containing the term, arising from the conformational entropy of the polymer chains. (hse.ru)
  • We derive an analytical expression for a stress tensor which consists of three terms: isotropic hydrostatic stress, electrostatic (Maxwell) stress, and stress rising from conformational entropy of polymer chains-conformational stress. (hse.ru)
  • The capillary process was strong during the phenomenon and dragged the polymer chains into the pores without melting the crystal. (plasticstar.io)
  • To understand how a polymer worms through a narrow channel, we investigated the translocation dynamics of a Gaussian chain between two compartments connected with a cylindrical channel. (umass.edu)
  • We studied the influence of molar mass, nanopore diameter, and surface functionalization. (acs.org)
  • Design of enzyme-immobilized polymer brush-grafted magnetic nanoparticles for efficient nematicidal activity. (mpg.de)
  • A variety of nanoparticles like metal based, lipid based, polymer based etc. are extensively studied for their role in drug delivery. (omicsonline.org)
  • The 50 nm diameter nanopores increase the sensing area compared to traditional devices and allow the source to penetrate to a depth of 3 μm within the structure. (laserfocusworld.com)
  • Nanopore sequencing involves drawing many single strands of DNA through a two-nanometer diameter pore in an otherwise tightly sealed lipid membrane separating two small liquid filled containers. (harvard.edu)
  • Because the solution Debye length, K -1 , is of the order of the channel diameter, a, in the nanopores, fluidic transfer is controlled through applied bias, polarity and density of the immobile nanopore surface charge, solution ionic strength and the impedance of the nanopore relative to the microfluidic channels. (illinois.edu)
  • The diameter of the nanopore is about 500 nm. (illinois.edu)
  • A) Left: SEM image from a fractured surface of anodic aluminum oxide (AAO) having nanopores with a diameter of 400 nm infiltrated with PEO8k at 330 K for 28 days. (plasticstar.io)
  • Proton and Calcium-Gated Ionic Mesochannels: Phosphate-Bearing Polymer Brushes Hosted in Mesoporous Thin Films As Biomimetic Interfacial Architectures. (mpg.de)
  • Mesoporous Films and Polymer Brushes Helping Each Other To Modulate Ionic Transport in Nanoconfined Environments. (mpg.de)
  • Nucleotides on a strand of DNA are first tagged with different-sized polymers, and then the strand is passed near the nanopore opening, where a polymerase cleaves the polymers and passes them one by one through the nanopore. (phys.org)
  • This sequencing approach is based upon passing ionic current through protein nanopores that are embedded into a polymer membrane. (genengnews.com)
  • Using this YaxAB nanopore, we demonstrate label-free, single-molecule detection of interactions between the anticancer Bcl-xL protein and small-molecule drugs as well as the Bak-BH3 peptide. (nature.com)
  • To further explore the dynamics of polymer translocation through nanopores, we performed experimental studies of sodium polystyrene sulfonate translocation through α-hemolysin protein nanopores. (umass.edu)
  • Using coarse-grained models of the enzyme and the protein nanopore, and Langevin dynamics simulations, we have characterized the conformational fluctuations of the DNA inside the nanopore. (epj.org)
  • Proton-regulated rectified ionic transport through solid-state conical nanopores modified with phosphate-bearing polymer brushes. (mpg.de)
  • Single polymer passage through geometrically confined regions is ubiquitous in biology. (umass.edu)
  • Nanopores and their interaction with polymer molecules have been a longtime research focus of NIST scientist John Kasianowicz. (phys.org)
  • We studied the capture of DNA molecules by the electroosmotic flow of a nanopore induced by its surface charge under an applied electric field. (umass.edu)
  • We showed theoretically that the DNA molecules underwent coil-stretch transitions at a critical radius around the nanopore and the transition assisted the polymer passage through the pore. (umass.edu)
  • The notion of sequencing nucleic acids by drawing single molecules of DNA or RNA through a nanopore was initially considered quite impossible by most people, including most of the expert scientists who reviewed our grant proposals at NIH. (harvard.edu)
  • Twenty years ago at the APS March Meeting, Kurt Kremer and I presented the first numerical evidence from computer simulations that the reptation model of Edwards and de Gennes correctly describes the dynamics of entangled linear polymer melts. (aps.org)
  • Here I will review the progress over the past twenty years and present an outlook for the future in modeling entangled polymer melts and networks. (aps.org)
  • In particular, the plateau moduli derived on the basis of this analysis quantitatively reproduce experimental data for a wide spectrum of entangled polymer liquids including semi-dilute theta solutions of synthetic polymers, the corresponding dense melts, and solutions of semi-flexible (bio)polymers such as f-actin or suspensions of rodlike viruses. (aps.org)
  • Many biological processes and applications involve the motion of small (nanoscale) spherical particles through a dense (typically) semiflexible polymer matrix. (aps.org)
  • Nanopores are nanoscale-sized channels that address this challenge by providing a confined space that is compatible with single-molecule scale. (rsc.org)
  • Schematic of an artificial membrane, across which a voltage forces an ionized fluid through the nanopore. (phys.org)
  • The new method determines DNA sequences by attaching distinct molecular "tags" to each of the four chemical building blocks, or "bases," that comprise the genetic information in a strand of DNA-abbreviated as A, G, C and T. Each of these polymer tags can then be cut from the strand and passed, one by one, through a nanometer-size hole in a membrane. (phys.org)
  • As the DNA strand is drawn through the nanopore from the container on the first side of membrane to the container on the second side, the different nucleotide bases (known as A, C, G, T or U) trigger different electrical responses allowing researchers to identify the order or sequence of the bases. (harvard.edu)
  • Ultimately, we need to observe the connection between the number of monomers in the given polymer, the intensity of an external guiding electrical field and the required time for the monomer transportation through membrane pores. (roconsulboston.com)
  • 7.02.2017 Kai: We discussed the relaxation time behaviour of the first Rouse mode for uncharged polymers tethered to a wall in the presence of hydrodynamic interactions. (uni-stuttgart.de)
  • Kasianowicz adds that a private company might create a large array of nanopores that can analyze a single individual's genome cut up into many short strands of DNA, each of which could be sequenced quickly. (phys.org)
  • Distinctive nanopore event distributions observed in the two-dimensional (ΔI/I o -versus-I N ) plot illustrate the ability of the YaxAB nanopore to discriminate individual small-molecule drugs bound to Bcl-xL from non-binders. (nature.com)
  • The ability to discriminate between the polymer tags was demonstrated by Kasianowicz, his NIST colleague Joseph Robertson, and others. (phys.org)
  • Surface Initiated Polymerization on Pulsed Plasma Deposited Polyallylamine: A Polymer Substrate-Independent Strategy to Soft Surfaces with Polymer Brushes. (mpg.de)
  • Here, we develop a biological nanopore sensor for single-molecule detection of proteins and PDIs using the pore-forming toxin YaxAB. (nature.com)
  • Taken together, our results present the YaxAB nanopore as a robust platform for label-free, ultrasensitive, single-molecule detection of PDIs, opening up a possibility for low-cost, highly efficient drug discovery against diverse drug targets. (nature.com)
  • His group collaborated with a team led by Jingyue Ju, director of Columbia's Center for Genome Technology and Biomolecular Engineering, which came up with the idea for tagging DNA building blocks for single molecule sequencing by nanopore detection. (phys.org)
  • Dezember 2021, 14:00 Uhr, "Water confined in nanopores: What do we know about it and what is it good for? (uni-stuttgart.de)
  • I remember learning about the nanopore sequencing project as a postdoc in the Department in the late 1990s, and being fascinated by the concept and blown away by the early experiments that hinted that it may actually work someday. (harvard.edu)
  • Charge-compensated n-doped π-conjugated polymers: Toward both thermodynamic stability of n-doped states in water and high electron conductivity' by F. Borrmann, T. Tsuda, O. Guskova , N. Kiriy, et al. (ipfdd.de)
  • In particular, the scientists studied how a DNA double helix unzips when translocated at high velocity through a nanopore, reconstructing fundamental DNA thermodynamic properties from the sole speed of the process. (nanowerk.com)
  • Multi-scale Structure and Dynamics of Dendronized Polymers with Varying Generations. (mpg.de)
  • Motivated by understanding the dynamics of a polymer in a crowded environment, we investigated the dynamics of a chain inside a one dimensional array of periodic cavities. (umass.edu)
  • Ion track technology has been developed to fill certain niche areas where conventional nanolithography fails, including: Direct shaping of radiation-resistant minerals, glasses and polymers Generation of elongated structures with a resolution limit down to 8 nanometers Direct generation of holes in thin films without any development process Defining structural depth by ion range rather than by target thickness Generating structures with aspect ratio (depth divided by width) up to 104. (wikipedia.org)
  • The nanopore structures could be modified to possibly enable single-molecule sensing. (laserfocusworld.com)
  • These NCAM-mediated integrated microfluidic architectures have been used to achieve highly reproducible and tunable injections down to attoliter volumes, sample stacking for preconcentration, preparative analyte band collection from an electrophoretic separation, and an actively-tunable size-dependent transport in hybrid structures with grafted polymers displaying thermally-regulated swelling behavior. (illinois.edu)
  • However, these nanopore sensors are mainly based on specific ligand-induced large conformational changes. (nature.com)
  • The long funnel-shaped structure and nanofluidic characteristics of the YaxAB nanopore enable the electro-osmotic trapping of diverse folded proteins and high-resolution monitoring of PDIs. (nature.com)
  • By changing the polymer-pore interaction using different pH conditions, we identified the physical origins of the three most common event types. (umass.edu)
  • The Louisiana Tech biosensor instead uses a polydimethylsilicone (PDMS) microfluidic chip bonded to a gold-coated nanopore layer inside a μFPI cavity and a lower-cost broadband white-light source. (laserfocusworld.com)
  • The synthetic elaboration of the nanopore interior has also been used to great effect to realize molecular separations of high efficiency. (illinois.edu)
  • To understand the ionic flow through natural ion channels and artificial nanopores is of fundamental interest in biology, physics, medicine, and chemistry. (gsi.de)
  • The physics behind this phenomenon has not been fully comprehended and applications like polymer (DNA, RNA etc.) translocation through narrow pores are challenging, even for renowned scientists. (roconsulboston.com)
  • The research team carried out a 28-day imbibition (uptake of water that leads to swelling of materials) of the two polymer materials within anodic aluminum oxide templates and observed the samples with scanning electron microscopy and atomic force microscopy to characterize them. (plasticstar.io)
  • The translocation of polymers through nanopores has long studied as a fundamental theoretical problem as well as for its several practical ramifications, e.g. for genome sequencing. (nanowerk.com)
  • Both computation and experimental studies have utilized single nanopores as test beds to understand the fundamental chemical and physical properties of chemistry and fluid flow at nanometer length scales. (illinois.edu)
  • Stabile, thermoresponsive colloidal clusters: an unusual morphology of polymer dispersions. (mpg.de)
  • Prof. Dr. Arash Nikoubashman is appointed as Heisenberg-Professor for 'Theory of Bioinspired Polymers' at the TU Dresden. (ipfdd.de)
  • Nanowire-nanopore devices combined with AI (machine learning technique) enable us to develop mobile sensors for SARS-CoV-2, PM2.5, bacteria, and virus in the environment. (selectbiosciences.com)
  • Prof. Dr. Jens-Uwe Sommer has been re-elected as a member of the DFG Review Bord 'Polymer Research' for a period of 4 years. (ipfdd.de)
  • This was the challenge taken on by a research team led by SISSA's Cristian Micheletti and recently published on Physical Review Letters ( 'Nonequilibrium Thermodynamics of DNA Nanopore Unzipping' ). (nanowerk.com)
  • The research team used a cluster of computers to simulate the translocation of DNA through nanopores with different driving forces keeping track of the DNA's unzipping speed, a type of data that has rarely been studied despite being directly accessible in experiments Researchers were able to work "backwards", using the information on the speed to accurately reconstruct the thermodynamics of the formation and rupture of the double-helix structure. (nanowerk.com)
  • Branton is quick to note that while the researchers named as Golden Goose awardees developed the germ of the idea, its success depended on decades of hard work by students, postdocs, and research technician in his and his collaborators' laboratories at UC Santa Cruz, as well as scientists and technicians in many different labs that pursued research related to the concept of nanopore sequencing. (harvard.edu)
  • The unexpected improvement in flow facilitated polymer processing conditions applicable to low temperatures, suited for use in organic electronics. (plasticstar.io)
  • To perform a systematic review (SR) of existing literature and a patent landscape report (PLR) regarding the potential applications of shape-memory polymers (SMPs) in dentistry. (encyclopedia.pub)
  • Advanced Polymer Materials Group, Department of Bioresources and Polymer Science, University Politehnica of Bucharest, 1-7 Gh. (mdpi.com)
  • Both, color and motion in plants are examples which can be - to some extent - replicated by stimuli-responsive polymers and materials thereof. (uni-stuttgart.de)
  • As the polymer tags are different sizes, the change in electrical current caused by altered fluid flow shows which of the four bases sits at each point on the DNA strand . (phys.org)
  • Indeed, it took us and our many bright, hardworking postdocs, students, and laboratory technicians some 25 years before the first crude sequence of a strand of DNA was obtained by nanopore sequencing. (harvard.edu)
  • The ITP was strongly represented at the 15th International Saint Petersburg Conference of Young Scientists "Modern Problems of Polymer Science", which took place from 28th to 31st October 2019. (ipfdd.de)
  • As the bases pass through the nanopore, the base sequence is decoded in real time. (genengnews.com)
  • And in the field or in the lab, nanopore sequencing produces direct, real-time sequence reads as soon as the sequencing process begins yielding up to 100 kb long reads or longer. (harvard.edu)