Loading...
  • fungi
  • Many mycotoxins produced by fungi are polyketides, and many pharmaceuticals are derived from polyketides. (spectrumchemical.com)
  • Sixteen polyketides belonging to diverse structural classes, including monomeric/dimeric tetrahydroxanthones and resorcylic acid lactones, were isolated from an organic extract of a fungal culture Setophoma terrestris (MSX45109) using bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. (rti.org)
  • enzyme
  • The team are the first to crystalize the enzyme bound to its substrate, the small molecule whose addition to polyketides it catalyses. (natureasia.com)
  • By generating mutated versions of the enzyme, the researchers also show that these two residues are critical for binding carbon dioxide, which is required for the extension of polyketides. (natureasia.com)
  • Our findings may lead to ways to deliberately alter and improve polyketides for clinical application," says Müller, "and we are now performing mechanistic and mutational studies of the enzyme. (natureasia.com)
  • Organism
  • This review covers the attempts being made to trigger the activation of polyketide metabolism in the fungal model organism Aspergillus nidulans . (mdpi.com)
  • Lovastatin
  • Other industrially important polyketides are sirolimus (immunosuppressant), erythromycin (antibiotic), lovastatin (anticholesterol drug), and epothilone B (anticancer drug). (wikipedia.org)
  • chain
  • The polyketide chain produced is electronically capable to go through a lactonization and a diels alder cyclization, as shown below. (wikipedia.org)