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  • enzyme
  • The team are the first to crystalize the enzyme bound to its substrate, the small molecule whose addition to polyketides it catalyses. (natureasia.com)
  • By generating mutated versions of the enzyme, the researchers also show that these two residues are critical for binding carbon dioxide, which is required for the extension of polyketides. (natureasia.com)
  • Our findings may lead to ways to deliberately alter and improve polyketides for clinical application," says Müller, "and we are now performing mechanistic and mutational studies of the enzyme. (natureasia.com)
  • type
  • Aurovertins belong to a family of highly reducing polyketides sharing a polyene α-pyrone-type structure. (springer.com)
  • Bu YY, Yamazaki H, Takahashi O, Kirikoshi R, Ukai K, Namikoshi M (2016) Penicyrones A and B, an epimeric pair of alpha-pyrone-type polyketides produced by the marine-derived Penicillium sp. (springer.com)
  • There are three main types of polyketides: Type I, type II and type III. (wikipedia.org)
  • Lovastatin
  • Other industrially important polyketides are sirolimus (immunosuppressant), erythromycin (antibiotic), lovastatin (anticholesterol drug), and epothilone B (anticancer drug). (wikipedia.org)
  • chain
  • The polyketide chain produced is electronically capable to go through a lactonization and a diels alder cyclization, as shown below. (wikipedia.org)
  • Seven standalone PKS modules follow to extend the growing polyketide chain with S-adenosyl methionine (SAM) dependent methylations occurring at positions 10 and 13. (wikipedia.org)