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PolyenesNystatinNatamycinCandicidinFilipinAmphotericin BLucensomycinAntifungal AgentsErgosterolStreptomycesMacrolidesRetinaldehydeMolecular StructurePolyketide SynthasesStreptomycetaceaeCandida albicansSterolsAnti-Bacterial AgentsMepartricinSchiff BasesSpectrophotometry, UltravioletRhodopsins, MicrobialNorisoprenoidsMagnetic Resonance SpectroscopyChromosome WalkingCarotenoidsBiosynthetic PathwaysBacteriorhodopsinsFusidic AcidLactonesHemolysisEchinocandinsKetoconazoleFungiCell Membrane PermeabilityMolecular ConformationPharmacologyGlycosidesAzolesLiposomesCholesterolRhodopsin1,2-DipalmitoylphosphatidylcholineSaccharomycesAlkenesSpectrophotometryIsomerismChemistryFermentationDrug CarriersChemical PhenomenaStereoisomerismSpectrum AnalysisAspergillus fumigatusMicrobial Sensitivity TestsMultigene FamilyCulture MediaCandidaErythrocytesCandidiasisMycoplasmaYeastsLipid BilayersPotassiumFatty Acids, UnsaturatedTemperatureCryptococcus neoformansSpectrometry, FluorescenceMass SpectrometryModels, MolecularDrug SynergismSaccharomyces cerevisiaeStructure-Activity RelationshipCell MembraneChromatography, High Pressure LiquidPhospholipidsKineticsLightPhosphatidylcholinesDrug Resistance, MicrobialCricetinaeBinding SitesOxidation-ReductionMolecular Sequence DataTime FactorsFatty AcidsProtein ConformationMutationDose-Response Relationship, DrugAmino Acid Sequence

AmphotericinAntifungalNystatinAzolesAntibioticsChemistryFluorescenceCandidaCationicIsomerizationOrganicChromophoreBondsStructuresLinearExcited StateStructureEnergySystemLengthAreaHighNaturalMacrolideStreptomycesBiosynthesisPhosphatidylcholineAlkenesMechanismBiosyntheticKineticsProcessesHumanYearDoubleActivity

Amphotericin4

• Another class of important polyenes are polyene antimycotics, Representative Polyenes Amphotericin B is an example of a polyene antifungal (antimycotic) agent. (wikipedia.org)
• The 2 main classes of antifungal medications used to treat mucormycosis are the polyenes (amphotericin formulations) and triazoles (isavuconazole and posaconazole). (medscape.com)
• Complexes of practically important polyene antibiotics (amphotericin B and nystatin A 1 ) with a modern biocompatible electroactive polymer polypyrrol (PP) were obtained for the first time, and their antifungal activities and some physicochemical properties were studied. (genetika.ru)
• It was shown by infra-red spectroscopy that the basis for the adsorption of amphotericin B on PP is the formation of an ionic bond between the COOH-group of the polyene antibiotic and the NH-group of the pyrrol residue, and also the interaction of the polyene system of the antibiotic with the PP polymer chain. (genetika.ru)

Antifungal2

• Nystatin is a polyene antifungal antibiotic obtained from Streptomyces nursei. (nih.gov)
• There are only three main classes of antifungal medications used to treat Candida infections: azoles, polyenes and echinocandins," Lyman said. (livescience.com)

Nystatin1

• The inactivation of the PP-nystatin A 1 complex is supposed to be connected with the complete shielding during the complex formation of the polyene fragment of the antibiotic, and also of amine and carboxylic groups in nystatin A 1 that are responsible for the primary binding of the antibiotic to the micromycete membrane. (genetika.ru)

Azoles2

• Even when there is a broad range of antifungals drugs for Candida infections, azoles, polyenes, and echinocandins are considered among the most effective treatment. (intechopen.com)
• A majority of C. auris cases are resistant to azoles and a high percentage are also resistant to polyenes. (livescience.com)

Antibiotics3

• Scholars@Duke publication: Polyene antibiotics. (duke.edu)
• Polyene antibiotics. (duke.edu)
• ransport through liquid membrane bilayers generated by lecithin, cholesterol, and lecithin-cholesterol mixtures-studies in the presence of polyene antibiotics. (csircentral.net)

Chemistry2

• In organic chemistry, polyenes are poly-unsaturated, organic compounds that contain at least three alternating double (C=C) and single (C−C) carbon-carbon bonds. (wikipedia.org)
• While nucleophilic attack on coordinated polyenes is a paradigm of organotransition metal chemistry, not all polyene ligands have been examined. (marquette.edu)

Fluorescence1

• The finding that fluorescence from linear polyenes is so strongly dependent on molecular symmetry requires a reevaluation of the literature on the radiative properties of all-trans polyenes and carotenoids. (psu.edu)

Candida1

• Cette etude menee en 1997 en milieu hospitalier senegalais se propose d'identifier les differentes especes de Candida isoles chez 60 sujets vivant avec le VIH et porteurs de Candidose oropharyngee. (bvsalud.org)

Cationic1

• Many methods for cyclization of polyenes have been developed that involve cationic, anionic, and radical intermediates. (thieme.de)

Isomerization2

• Isomerization of Diphenyl Polyenes. (unthsc.edu)
• Dive into the research topics of 'Isomerization of Diphenyl Polyenes. (unthsc.edu)

Organic1

• Retinal is a polyene organic compound, meaning that this molecule contains multiple alkene functional groups. (dummies.com)

Chromophore1

• Normally alkenes absorb in the ultraviolet region of a spectrum, but the absorption energy state of polyenes with numerous conjugated double bonds can be lowered such that they enter the visible region of the spectrum, resulting in compounds which are coloured (because they contain a chromophore). (wikipedia.org)

Bonds1

• Related to polyenes are dienes, where there are only two alternating double and single bonds. (wikipedia.org)

Structures1

• Most conductive polymers are polyenes, and many have conjugated structures. (wikipedia.org)

Linear1

• Thus many natural dyes contain linear polyenes. (wikipedia.org)

Excited State3

• Excited state non-adiabatic dynamics of the smallest polyene, trans 1,3-butadiene. (elsevierpure.com)
• The ultrafast excited state dynamics of the smallest polyene, trans-1,3-butadiene, were studied by femtosecond time-resolved photoelectron-photoion coincidence (TRPEPICO) spectroscopy. (elsevierpure.com)
• Photoexcited breathers in conjugated polyenes: An excited-state molecular dynamics study. (reprap.org)

Structure2

• Genome-directed lead discovery: biosynthesis, structure elucidation, and biological evaluation of two families of polyene macrolactams against Trypanosoma brucei. (pacb.com)
• In addition, our bioinformatic analysis not only was critical for the structure elucidation of the polyene macrolactam salinilactam A, but its structural analysis aided the genome assembly of the highly repetitive slm loci. (nih.gov)

Energy1

• These experiments imply that the S 1 states of longer polyenes have local energy minima, corresponding to a range of conformations and isomers, separated by relatively low (2-4 kcal) barriers. (psu.edu)

System2

• The printing plate manufacturing process used a photographic system and the photoprepolymer, Y-Polymer, which contains a urethane based polyene, a methacrylate monomer, a photoinitiator, and a polythiol as its major components. (cdc.gov)
• Theamountofgrowthineachtube recently,treatmentoffungalinfections agar(OXOIDLtd,UnitedKingdom) wascomparedtothatofthegrowthina wasstartedwithdrugs,includingazoles twice,for24hand48h,at35°Cto positivecontrol.Antifungalactivitywas and polyenes, which induce severe ensureviabilityandpurity.Thecarbo- expressedastheMICofeachisolateto side-effectsinthehosts.Onlyrecently hydrateassimilationpatternsofal the thedrug.Theresistancecut-offpoints hasantifungaldrugsusceptibilitytest- isolateswerestudiedusingtheAPI32C usedwereaccordingtoCLSIguidelines ingbecomeanimportantissue.There system,accordingtothemanufacturer's [5]orbasedonpreviousinvestigations are2reasonsfortestingsusceptibil- procedure (BioMérieux, France). (who.int)

Length1

• Experimental estimates of the vertical transition energies of unsubstituted, all-trans polyenes in vacuum as a function of conjugation length are compared with long-standing multireference configuration interaction (MRCI) treatments and with more recent ab initio calculations of the energies of the 2 1 A g - (S 1 ) and 1 1 B u + (S 2 ) states. (psu.edu)

Area1

• Despite the many advances that have been made in this area, catalytic, enantioselective polyene cyclizations are significantly less well developed. (thieme.de)

High1

• Recently, the group of Professor Scott Denmark at the University of Illinois (USA) described a chiral thiiranium ion induced, polyene cyclization that proceeds in good yields with high enantioselectivities under mild conditions. (thieme.de)

Natural1

• Polyene cyclization is one of the most general methods for constructing diverse polycyclic skeletons, such as those found in steroid and terpenoid natural products. (thieme.de)

Macrolide4

• The present invention is directed to a process for purifying natamycin, to an epoxide polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide. (justia.com)
• trioxatricyclo[22.3.1.0 5,7 ]octacosa-8, 14, 16, 18, 20-pentaene-25-carboxyl ic acid) is an all-trans epoxide polyene amphoteric macrolide antifungal used to treat fungal infections around the eye. (justia.com)
• Control of polyene macrolide production in Streptomyces natalensis is mediated by the transcriptional activator PimM. (insa-toulouse.fr)
• PimD is a cytochrome P450 monooxygenase with native epoxidase activity that is critical in the biosynthesis of the polyene macrolide antibiotic pimaricin. (nih.gov)

Streptomyces5

• Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei. (sintef.no)
• Seven polyene macrolides with alterations in the polyol region and exocyclic carboxy group were obtained via genetic engineering of the nystatin biosynthesis genes in Streptomyces noursei. (sintef.no)
• Nystatin is a polyene antimycotic obtained from Streptomyces noursei. (nih.gov)
• Amphotericin B is a polyene antifungal agent produced by a strain of Streptomyces nodosus. (medscape.com)
• Production of a Novel Amide ]Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. (google.de)

Biosynthesis1

• Discovery and biosynthesis of the cytotoxic polyene terpenomycin in human pathogenic Nocardia. (leibniz-hki.de)

Phosphatidylcholine1

• 7. Polyene phosphatidylcholine overcomes oxaliplatin resistance in human gastric cancer BGC823 cells. (nih.gov)

Alkenes2

• Normally alkenes absorb in the ultraviolet region of a spectrum, but the absorption energy state of polyenes with numerous conjugated double bonds can be lowered such that they enter the visible region of the spectrum, resulting in compounds which are coloured (because they contain a chromophore). (wikipedia.org)
• Polyenes tend to be more reactive than simpler alkenes. (wikipedia.org)

Mechanism1

• Mechanism of polyene susceptibility in environmental isolates of Cryptococcus neoformans. (nih.gov)

Biosynthetic1

• This regulator, which combines an N-terminal PAS domain with a C-terminal helix-turn-helix motif, is highly conserved among polyene biosynthetic gene clusters. (insa-toulouse.fr)

Kinetics1

• Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. (nih.gov)

Processes1

• BinaryoptionrobotinfoAuthentic Russian thinking processes, specified selections and easy permanent polyene. (ne.jp)

Human1

• Here, we combine chemistry, genomics, and molecular microbiology to reveal the production of terpenomycin, a new cytotoxic and antifungal polyene from a human pathogenic Nocardia terpenica isolate. (leibniz-hki.de)

Year1

• This graph shows the total number of publications written about "Polyenes" by people in this website by year, and whether "Polyenes" was a major or minor topic of these publications. (ucdenver.edu)

Double1

• Related to polyenes are dienes, where there are only two alternating double and single bonds. (wikipedia.org)

Activity1

• Developed activity assays for enzymes from polyene oxygenase family (BCMO1, BCMO2 and RPE65), studied its catalytic mechanisms and try to find crucial amino acid residues, which are necessary for their activity. (nih.gov)