• JAK2V617F mutational status and allele burden have little influence on clinical phenotype and prognosis in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis. (medscape.com)
  • JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV). (medscape.com)
  • Squizzato A, Romualdi E, Passamonti F, Middeldorp S. Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia. (medscape.com)
  • In oncology, polycythemia vera is an uncommon myeloproliferative neoplasm (chronic leukemia) in which the bone marrow makes too many red blood cells. (wikipedia.org)
  • A classic symptom of polycythemia vera (and the related myeloproliferative disease essential thrombocythemia) is erythromelalgia. (wikipedia.org)
  • Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)
  • Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by the overproduction of RBCs. (lecturio.com)
  • Polycythemia vera is a myeloproliferative neoplasm characterized by clonal hematopoiesis and an absolute increase in the red blood cell mass, with an associated leukocytosis and thrombocytosis. (targetedonc.com)
  • Clinical symptoms of polycythemia vera are mostly due to hyperviscosity of blood. (wikipedia.org)
  • Some patients with polycythemia vera are asymptomatic, whereas others have various nonspecific symptoms. (medscape.com)
  • The patient will be referred to a specialist (hematologist) for further examination if Polycythaemia vera is suspected (due to unspecified symptoms and a change in the blood count such as an increase in hemoglobin or hematocrit). (aop-health.com)
  • The study is designed to evaluate the safety and efficacy of rusfertide in subjects with polycythemia vera (PV) in maintaining hematocrit control and in improving symptoms of PV. (inclinicaltrials.com)
  • On the other hand, around one in 10 people with polycythaemia vera develop acute myeloid leukaemia, which is the most common type of leukaemia affecting adults (particularly older people). (vic.gov.au)
  • Bone marrow and aspirate in polycythemia vera tend to be hypercellular. (medscape.com)
  • Secondary polycythaemia refers to elevated numbers of red blood cells not caused by bone marrow abnormalities. (vic.gov.au)
  • Polycythaemia vera (PV) is a Rare Disease of the blood-building cells in the bone marrow primarily resulting in a chronic increase of red blood cells (erythrocytes), thereby decreasing the flowability of blood. (aop-health.com)
  • A mutation in the JAK2 kinase (V617F) is strongly associated with polycythemia vera. (wikipedia.org)
  • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. (medscape.com)
  • The aim of this study is to analyze the phenotypic divergence between polycytemia vera (PV) and essential thrombocytemia (ET) to find novel therapeutics targets by a proteomic and functional approach to identify alternative routes to JAK2 activation. (biomedcentral.com)
  • Patients with polycythemia vera are more likely to have gouty arthritis. (wikipedia.org)
  • Such itching is present in approximately 40% of patients with polycythemia vera. (wikipedia.org)
  • Untreated, polycythemia vera can be fatal, with the median survival in patients being 1.5-3 years. (wikipedia.org)
  • The long-term risks of polycythemia vera (PV) include leukemic and fibrotic transformation, which occur in fewer than 5% and 10% of patients, respectively, at 10 years. (medscape.com)
  • Rusak T, Ciborowski M, Uchimiak-Owieczko A, Piszcz J, Radziwon P, Tomasiak M. Evaluation of hemostatic balance in blood from patients with polycythemia vera by means of thromboelastography: The effect of isovolemic erythrocytapheresis. (medscape.com)
  • With proper treatment, the majority of patients with Polycythaemia vera have a near-normal life expectancy. (aop-health.com)
  • These organs are sometimes swollen in patients with Polycythaemia vera. (aop-health.com)
  • Polycythemia vera involves increased production of red blood cells (RBCs), white blood cells (WBCs), and platelets. (msdmanuals.com)
  • Treatment of polycythemia vera depends on whether the disease is in the plethoric phase or the spent phase. (medscape.com)
  • Without treatment, around half of all people with symptomatic polycythaemia vera will die in less than two years. (vic.gov.au)
  • Computed tomography (CT) scanning or ultrasonography of the abdomen can be used to assess the size of the spleen, which is frequently enlarged in polycythemia vera. (medscape.com)
  • Polycythemia vera (PV) is a disorder of the multipotent hematopoietic stem cell that manifests as excess production of normal erythrocytes and variable overproduction of leukocytes and platelets. (medscape.com)
  • Polycythaemia vera is a type of blood disorder characterised by the production of too many blood cells, typically red blood cells. (vic.gov.au)
  • Polycythemia vera (PV), being a primary polycythemia (increase in the fraction of volume occupied by red cells in the blood), is caused by neoplastic proliferation and maturation of erythroid, megakaryocytic and granulocytic elements to produce what is referred to as panmyelosis. (wikipedia.org)
  • Typically in primary polycythemia, the ferritin level is low due to constant overproduction of erythrocytes. (medscape.com)
  • Other names for this condition include primary polycythaemia and Vaquez' disease. (vic.gov.au)
  • Most of the health concerns associated with polycythemia vera are caused by the blood being thicker as a result of the increased red blood cells. (wikipedia.org)
  • However, the stem cells of a person with polycythaemia vera are abnormal and produce more blood cells than is necessary. (vic.gov.au)
  • The WHO criteria for polycythemia vera are specifically outlined in Table 4, and emphasis is given to accurate histological observations as proven predictors in the prognosis of the disease. (wikipedia.org)
  • Data on the effect of life-span of an individual with treated polycythemia vera is inconclusive due to the rarity of the disease. (wikipedia.org)
  • Vannucchi AM. From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. (medscape.com)
  • Management of polycythaemia vera: a critical review of current data. (medscape.com)
  • Polycythaemia vera is a rare condition that tends to be slightly more common amongst men and people of Jewish ancestry. (vic.gov.au)
  • Since polycythaemia vera is more common among people with Jewish ancestry, a genetic link could be involved. (vic.gov.au)
  • A classic symptom of polycythemia vera is pruritus or itching, particularly after exposure to warm water (such as when taking a bath), which may be due to abnormal histamine release or prostaglandin production. (wikipedia.org)
  • In polycythemia vera, iron absorption is increased due to suppression of hepcidin production. (msdmanuals.com)