AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Complement Factor DEcchymosisComplement Hemolytic Activity AssayComplement Pathway, AlternativeComplement Factor HComplement Factor BComplement Factor IComplement C3Complement ActivationComplement System ProteinsComplement C3bComplement Activating EnzymesComplement C2Complement C3b Inactivator ProteinsComplement C4Complement C5Macular DegenerationComplement C3-C5 ConvertasesComplement C5aCoombs TestAnemia, Hemolytic, AutoimmuneBrucellosisEncyclopedias as TopicAnemia, HemolyticAgglutination TestsErythrocytes
AntibodiesAntibody recognizesClassical complemRabbit Polyclonal AntibodyProteinsELISA KitPathwayProteinMammalian complementRecombinantSerumCatalogTumorReagentsAntigenRegulatorsConvertaseAntiSerumMoleculesAssaysComponentPathwaysPlasminogenPivotalBlood cellsActivation occursRabbitsPhagocytesMembraneEffectorImmuneDetectionSystemChronicCascadeDescriptionMiceCytokinePhosphateVitroQuantitation
Antibodies15
  • The direct Coombs test is used to detect antibodies or complement proteins attached to the surface of red blood cells. (wikipedia.org)
  • If the red cells then agglutinate, the test is positive, a visual indication that antibodies or complement proteins are bound to the surface of red blood cells and may be causing destruction of those cells. (wikipedia.org)
  • citation needed] The direct Coombs test, also referred to as the direct antiglobulin test (DAT), is used to detect if antibodies or complement system factors have bound to RBCs surface antigens. (wikipedia.org)
  • The Response To Alcohol Pathway complements our catalog of research reagents including antibodies and ELISA kits against POMC, ALDH2, AKR1A1, AVP, ADH1B. (novusbio.com)
  • The Interaction With Host Pathway complements our catalog of research reagents including antibodies and ELISA kits against TNF, IL6, IL2, TLR2, TLR4. (novusbio.com)
  • E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays, E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays, Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (gentaur.com)
  • Aves Labs is a leading global provider of polyclonal chicken antibodies (IgY) and custom peptide synthesis for life science research. (linscottsdirectory.com)
  • Aves Labs is dedicated to humane practices in producing polyclonal antibodies in chickens. (linscottsdirectory.com)
  • It reduces the likelihood of having false positives in diagnostic applications, since it is the mammalian Fc domain that binds "rheumatoid factors" or other naturally occurring anti-Fc antibodies. (linscottsdirectory.com)
  • Rabbit polyclonal antibodies (pAb) were used for preparing a gold-pAb conjugate, and the rGroEL-specific mouse monoclonal antibody was used as the antigen detection reagent at the ICT test line. (jsce-ip.com)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • High-titer particular antibodies can bind to SARS-CoV-2 and neutralize the viral contaminants, block usage of uninfected cells, and stimulate potent effector systems (e.g., complement phagocytosis and activation. (sdfca.org)
  • This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)
  • Two types of antibodies include monoclonal and polyclonal antibodies. (conductscience.com)
  • But that's not all - Hycult also has new antibodies to target complement C7 and clusterin, two molecules associated with the formation of the TCC/MAC-complex. (biolynx.ca)
Antibody recognizes3
Classical complem1
  • The C4d activation fragment of C4 is an excellent marker for the activation of the classical complement pathway and MBL pathway. (creative-biolabs.com)
Rabbit Polyclonal Antibody8
Proteins7
  • Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (gentaur.com)
  • Purified human complement Factor B. Factor B is one of the proteins unique to the Alternative Complement Pathway. (quidel.com)
  • The 3 human complement regulators, when attached to candida Gpd2, became functionally active, and the attached host proteins assist in inactivation of the complement cascade or cleave fibrinogen in the extracellular matrix component fibrinogen. (leibniz-hki.de)
  • The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. (antibodypedia.com)
  • We thus sought to complement these approaches with a method that could incorporate synthetic peptides carrying multiple post-translational modifications (PTMs) or ncAAs into both cytosolic and membrane proteins in live eukaryotic cells. (biorxiv.org)
  • Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. (lookformedical.com)
  • Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
ELISA Kit1
  • Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit Introduction: The event of SARS-CoV-2 serological assessments is very large. (elisastrip.com)
Pathway7
  • The classical pathway of complement and the mannose-binding lectin (MBL) activation pathway converge at C4. (creative-biolabs.com)
  • Locally deposited immune complexes in tissue usually contain complement, pointing to activation of the classical pathway. (nordicmubio.com)
  • When the alternative pathway is activated either directly or by the classical pathway via the amplification loop, C3b can bind whole Factor B. Factor D can then cleave Factor B in a single site to yield Ba and Bb. (quidel.com)
  • Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays. (absoluteantibody.com)
  • We are very proud of our newly developed human classical and alternative complement pathway assays. (hycultbiotech.com)
  • A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. (lookformedical.com)
  • Complement C5 plays a crucial role in many disease processes, and this new antibody offers the option to mimic blocking of terminal complement pathway. (biolynx.ca)
Protein12
  • In healthy individuals, cryopyrin and apoptosis-associated speck-like protein (ASC) interact via the oligomerization of ASC to induce both apoptosis and activate nuclear factor (NF)-kappa B. (medscape.com)
  • Complement factor C4 (MW 41 kDa), formerly known as Gg protein, is composed of α, β and γ chains. (creative-biolabs.com)
  • The 93 kD Factor B protein is made up of a single peptide chain. (quidel.com)
  • Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans. (leibniz-hki.de)
  • Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. (leibniz-hki.de)
  • Thus, candida Gpd2 is a novel fungal immune evasion protein that binds several human complement regulators and, in addition, binds human cells. (leibniz-hki.de)
  • The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. (embl.de)
  • C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. (hycultbiotech.com)
  • Vaccinia virus complement control protein (VCP) and curcumin (Cur) are natural compounds with different biological origins reported to regulate complement activation. (openbiochemistryjournal.com)
  • VCP is known to be structurally similar to C4B binding protein (C4Bbp), but functionally to CR1, a human complement regulatory molecule known to bind C3b. (openbiochemistryjournal.com)
  • It is used to measure the human complement factor of H-related protein (hcfhrp) in urine. (icliniq.com)
  • ApoH inhibits thrombosis by blocking the activation of Coagulation Factor XI but also shows procoagulant activity by inhibiting the activation of Protein C (10, 11). (rndsystems.com)
Mammalian complement1
  • Does not activate mammalian complement systems, allowing the use of chicken IgYs in in vivo applications. (linscottsdirectory.com)
Recombinant1
Serum6
  • The Rabbit Human Factor V Antibody reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (sigmabioblogs.com)
  • Description: A sandwich ELISA for quantitative measurement of Rabbit Intrinsic factor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (sigmabioblogs.com)
  • In many diseases, such as rheumatoid arthritis (RA), hereditary angioedema (HAE), systemic lupus erythematosus (SLE) and chronic urticaria, the high complement level of C4d in serum or plasma is significantly increased. (creative-biolabs.com)
  • Normal human serum depleted of factor P by immunoaffinity chromatography. (tecomedical.com)
  • I8/1 antibody can be used for the identification of the complement factor D from human serum and plasma. (absoluteantibody.com)
  • A variety of sero- complexes, serum amyloid, rheumatoid logical tests for the detection of anti-leish- factors and autoantibodies. (who.int)
Catalog1
  • PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
Tumor2
  • Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor. (southernbiotech.com)
  • Bladder tumor cells protect themselves from being destroyed by the complement system. (icliniq.com)
Reagents1
  • Human Antibody Laboratories manufactures the rabbit human factor v antibody reagents distributed by Genprice. (sigmabioblogs.com)
Antigen1
  • Suitability of an antigen for therapy is dependent on various factors including but not limited to the nature of the antigen (e.g. accessibility, abundance, location of expression on cancerous cells etc.), therapeutic approach, antibody affinity and other pharmacokinetic properties. (justia.com)
Regulators1
  • They are produced in response to a growing demand for quantitative investigation of complement inhibitors or regulators at lower sample dilutions. (hycultbiotech.com)
Convertase2
  • C3c is the major fragment resulting from C3 cleavage by C3 convertase and factor I. It is composed of an intact beta chain bound to two fragments of the alpha chain. (nordicmubio.com)
  • C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. (lookformedical.com)
AntiSerum2
  • Horseradish peroxidase-conjugated IgG fraction of polyclonal Goat antiSerum to C3c fragment of Monkey complement factor C3. (nordicmubio.com)
  • Polyclonal Gpd2 antiserum was generated and localized Gpd2 at the surface of C. albicans. (leibniz-hki.de)
Molecules2
  • To define the whole panel of fungal complement-evasion molecules, C. albicans cell extract was absorbed to a factor H-coupled matrix. (leibniz-hki.de)
  • Complement regulatory molecules might prove beneficial in the prevention of damage to the central nervous system (CNS) from up-regulated complement components in chronic as well as acute neurodegenerative disorders. (openbiochemistryjournal.com)
Assays1
  • That is why we have committed to the following initiative: Testing our existing complement ELISA assays for NHP research. (hycultbiotech.com)
Component4
Pathways2
Plasminogen1
  • ApoH cleavage reduces its ability to bind phospholipids and inhibit Factor XI activation but confers the ability to bind Plasminogen (10, 12, 14). (rndsystems.com)
Pivotal1
  • It is hypothesised that mononuclear phagocyte TNF-α production early in the pathophysiology of granuloma formation is a pivotal factor in the initiation of disease. (ersjournals.com)
Blood cells1
  • Blocks complement-mediated destruction of PNH red blood cells. (medscape.com)
Activation occurs2
  • C4d levels in the plasma of patients with various humoral autoimmune diseases may also increase, and it is known that complement activation occurs. (creative-biolabs.com)
  • Marks, R., Hindmarsh, E. Complement activation occurs on subendothelial extracelluslar matrix in vitro and is initiated by retraction or removal of overlying endothelial cells, J Immunol 160:6128-6136, 1998. (quidel.com)
Rabbits1
  • Purified preparation of pasteurized polyclonal IgG obtained from rabbits immunized against human thymocytes (T cells) for IV use. (medscape.com)
Phagocytes2
  • This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)
  • Killing of Streptococuss pneumoniae by capsular polysaccharide-specific polymeric IgA complement and phagocytes, J. Clin Invest 104:1139-1147, 1999. (quidel.com)
Membrane1
  • Immunofluorescence staining of K562 cells with anti-Complement Factor D (Ab01588) I8/1 Immunofluorescence analysis of paraformaldehyde fixed K562 cells on Shi-fix™ coverslips stained with the chimeric rabbit IgG version of I8/1 (Ab01588-23.0) at 10 µg/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 µg/ml), showing membrane staining. (absoluteantibody.com)
Effector1
  • The effector functions like antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), structural factors, experience, and availability of IgG determine the preference of one type of immunoglobulin over another (Ryman and Meibohm, 2017). (conductscience.com)
Immune1
  • [ 35 ] The mechanism of action of polyclonal antilymphocyte preparations to suppress immune responses is not fully understood. (medscape.com)
Detection2
  • Description: A polyclonal antibody for detection of CD10 from Human, Mouse, Rat. (bioworldantibodies.com)
  • Detection by RT-PCR for the detection of Factor II, V, MTHFR and A1298C. (lablab.dk)
System1
  • In the past two decades, VCP has been thoroughly investigated for its effect on components of the complement system. (openbiochemistryjournal.com)
Chronic3
  • Tumour necrosis factor (TNF)-α is a key early cytokine in a variety of chronic inflammatory responses, including fibrosing alveolitis and granulomatous disease 6 - 8 . (ersjournals.com)
  • Chronic antigenic stimulation, increased cytokine and growth factor (BLyS) levels and complement activation may are implicated in the pathogenesis of CV, etiology of which remains largely unknown. (gov.rs)
  • 1991). It is particularly useful as factor D plasma levels positively correlate with plasma creatinine and the creatinine clearance in patients with chronic renal failure (Volanakis et al. (absoluteantibody.com)
Cascade1
  • Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. (hycultbiotech.com)
Description1
Mice1
Cytokine1
  • Tumour necrosis factor (TNF)-α is thought to be a key early cytokine in the pathogenesis of sarcoidosis, despite conflicting data. (ersjournals.com)
Phosphate1
  • FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. (tecomedical.com)
Vitro1
  • If immunoglobulin or complement factors have been fixed on to the RBC surface in-vitro, the antihuman globulin will agglutinate the RBCs and the direct Coombs test will be positive. (wikipedia.org)
Quantitation1
  • For instance, this antibody was utilized in the quantitation of the factor D levels in blood of patients with renal failure via a senstive ELISA procedure (Oppermann et al. (absoluteantibody.com)