• Recombinant full length protein corresponding to Human Alpha-synuclein. (abcam.com)
  • A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. (thermofisher.com)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • Full length human alpha Synuclein Recombinant protein. (genetex.com)
  • alpha Synuclein antibody [HL1242] detects alpha Synuclein protein by immunohistochemical analysis. (genetex.com)
  • Acetylated α-synuclein (1-13) is derived from the alpha-synuclein intrinsically disordered protein which is found in the neurons and presynaptic terminals. (bestbiochem.com)
  • There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether differences in the strains of α-synuclein aggregates account for the different pathologies remained unclear. (elifesciences.org)
  • One α-synuclein fibril induced marked accumulation of phosphorylated α-synuclein and ubiquitinated protein aggregates, while the other did not, indicating the formation of α-synuclein two strains. (elifesciences.org)
  • These abnormal α-synuclein species exhibit seeding activity for prion-like conversion, being similar in this respect to the infectious forms of prion protein (PrP) causing Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy ( Goedert, 2015 ). (elifesciences.org)
  • α-Synuclein is a natively unfolded protein of 140 amino acid residues, normally found in both soluble and membrane-associated fractions and localized in synaptic termini. (elifesciences.org)
  • Disease-linked missense mutations and multiplication of the SNCA gene encoding α-synuclein have been reported in familial forms of α-synucleinopathies, indicating that structural changes and overexpression of α-synuclein protein are involved in the development of α-synucleinopathies ( Wong and Krainc, 2017 ). (elifesciences.org)
  • imgenex, 770 antibody to dnmt3b ( clone 52a1018 1:200 ) 771 bcl 6 anti body conc 772 cdk 4 anti body conc 773 gata2 antibody conc 774 mdm2 antibody conc 775 pck1 conc 776 sf 1 conc 777 bob 1 conc 778 pit 1 conc 779 antigap43 antibody 780 anti eber associated protein antibody, polyclonal 781 brilliant cresyl blue 782 phospho. (tendersindelhi.com)
  • The etiology of Parkinson's disease (PD) is linked with cellular inclusions in the substantia nigra pars compacta region of the brain that are enriched in the misfolded presynaptic protein α -synuclein ( α S) and death of the dopaminergic neurons. (hindawi.com)
  • The major constituent of LBs is aggregated α -synuclein ( α S), an intrinsically unfolded protein predominantly localized in the presynaptic regions of dopaminergic neurons. (hindawi.com)
  • This hypomethylation was associated with the overexpression of -synuclein and protein aggregation leading Vofopitant (GR 205171) to PD [7]. (memorial2014.com)
  • Mouse Anti-Human a-Synuclein Protein Name & Synonyms: Alpha-Synuclein Target Species: Human Host Species: Mouse Clonality: Monoclonal Formulation: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. (networkin.info)
  • EnCor Biotechnology is a United States company that manufactures monoclonal and polyclonal antibodies with a focus on reagents targeting neural proteins. (wikipedia.org)
  • Rabbit polyclonal antibodies (pAb) were used for preparing a gold-pAb conjugate, and the rGroEL-specific mouse monoclonal antibody was used as the antigen detection reagent at the ICT test line. (jsce-ip.com)
  • ACI-24.060 p reclinical data published in the peer-reviewed journal Brain Communications , showed it was well tolerated and generated a broad polyclonal immune response with high titers of antibodies against neurotoxic pyroglutamate Abeta (pyroGlu-Abeta), a major component of Abeta plaques. (sunnyvale.com)
  • Western Blot: TNF-alpha Antibody [NBP1-19532] - Recombinant human TNF alpha (10 ng) was separated on a 12% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. (novusbio.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Synuclein Alpha (SNCa) in samples from serum, plasma or other biological fluids. (maracpe.org)
  • We also show that the spatial expression of two genes implicated in alpha-synuclein synthesis and clearance, SNCA and GBA, also influences the atrophy pattern. (bvsalud.org)
  • Immunogen Description A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen. (biosensis.com)
  • Scientific Background Detects human alpha-, beta-, and gamma synuclein proteins. (biosensis.com)
  • A family of homologous proteins known as alpha-, beta-, and gamma-synuclein are abundantly expressed in brain, especially in the presynaptic terminal of neurons. (biosensis.com)
  • Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. (affbiotech.cn)
  • Although the precise function of these proteins remains unknown, alpha-synuclein has been implicated in synaptic plasticity associated with avian song learning as well as in the pathogenesis of Parkinson's disease (PD), dementia with LBs (DLB), some forms of Alzheimer's disease (AD), and multiple system atrophy (MSA). (biosensis.com)
  • Dot blot of human synuclein proteins (20 ng/dot) with S-044-100, diluted to 1 µg/mL. (biosensis.com)
  • Two further studies describe novel EnCor assays for UCHL1 and alpha-synuclein, two major brain proteins implicated in the development of Parkinson's and other neurological diseases. (wikipedia.org)
  • To test the potential role of parkin in modulating α-Synuclein post-translational modifications (i.e. ubiquitination and phosphorylation) and toxicity, we used lentiviral gene transfer animal models, which allow us to examine the in vivo effects of these proteins. (biomedcentral.com)
  • Specificity Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins This antiserum recognises human and rat alpha-, beta- and gamma synucleins. (biosensis.com)
  • Here, we generated two types of α-synuclein fibrils from identical monomer and investigated their seeding and propagation ability in mice and primary-cultured neurons. (elifesciences.org)
  • These synthetic α-synuclein fibrils can act as seeds and induce seeded aggregation of α-synuclein in cultured cells or primary cultured neurons, as well as in animal brains. (elifesciences.org)
  • The directed expression of alpha-synuclein , a gene contributing to inherited forms of Parkinson disease (PD), in the dopaminergic neurons (DA) of flies provides a robust model of PD complete with the loss of neurons and accompanying motor defects. (sdbonline.org)
  • This study altered the expression of Buffy in the dopamine producing neurons and in the developing neuron-rich eye, with and without the expression of alpha-synuclein. (sdbonline.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • The directed expression of Buffy in DA neurons provides protection and counteracts the alpha-synuclein-induced Parkinson disease-like phenotypes. (sdbonline.org)
  • The expression of human α-synuclein transgene in neuronal populations that include dopamine producing neurons under the control of Ddc -Gal4 produces a robust Parkinson disease model, and results in severely reduced lifespan and locomotor dysfunction. (sdbonline.org)
  • Parkinson's disease (PD) is a neurodegenerative disorder characterized by death of dopaminergic neurons in the substantia nigra (SN) and accumulation of α-Synuclein in intracellular inclusions known as Lewy bodies (LBs) [ 1 - 10 ]. (biomedcentral.com)
  • For example, Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are characterized by accumulation of misfolded α-synuclein in neuronal and/or glial cells, and therefore these diseases are termed α-synucleinopathies. (elifesciences.org)
  • Alpha-synuclein is proposed to act as a prion in Parkinson's disease: In its misfolded pathologic state, it favors the misfolding of normal alpha-synuclein molecules, spreads trans-neuronally, and causes neuronal damage as it accumulates. (bvsalud.org)
  • synuclein, a significant element of Lewy physiques can activate glial cells to induce neuroinflammation [33C35]. (cancer-ecosystem.com)
  • α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. (biomedcentral.com)
  • Phospho-Synuclein alpha (Tyr133) Antibody detects endogenous levels of Synuclein alpha only when phosphorylated at Tyrosine 133. (affbiotech.cn)
  • Significantly, the current presence of gene, encoding for the alpha-2-macroglobulin (a protease inhibitor), is certainly localized in amyloid plaques and interacts using a and APOE also. (memorial2014.com)
  • We tested how these two genes interact by examining the effects of parkin on post-translational modification of α-Synuclein in gene transfer animal models, using a lentiviral gene delivery system into the striatum of 2-month old male Sprague Dawley rats. (biomedcentral.com)
  • In complementary experiments the overexpression of Buffy in the developing eye suppressed the mild rough eye phenotype that results from Gal4 expression and from alpha-synuclein expression. (sdbonline.org)
  • These results indicate novel mechanisms for parkin protection against α-Synuclein-induced toxicity in PD. (biomedcentral.com)
  • We have previously developed a Susceptible-Infected-Removed (SIR) computational model that simulates the templating, propagation, and toxicity of alpha-synuclein molecules in the brain. (bvsalud.org)
  • Goat Anti-Mouse PSD95 Goat anti-Mouse DLG4 (aa 1-100) polyclonal antibody for ICC/IF, WB, IHC-P Host Species: Goat Species Reactivity: Mouse, Rat, Human Immunogen: Synthetic peptide derived from residues 1 - 100 of Mouse PSD95. (networkin.info)
  • Parkinson's disease is a progressive neurodegenerative disorder characterized by accumulation of abnormal isoforms of alpha-synuclein. (bvsalud.org)
  • anti nf kb p65 antibody 783 anti stat6 antibody 784 anti cd 19 antibody 785 anti cd 38 antibody 786 anti pten ab 787 anti ck9 antibody 788 anti gh antibody 789 anti lh beta antibody 790 anti tsh alpha antibody 791 anti fsh alpha antibody 792 anti hpv antibody 793 anti ebv nuclear antigen ab 794 anti ebv latent memb. (tendersindelhi.com)
  • Alpha-synuclein (α-Syn), the primary pathological marker of PD, can gather in the SN and trigger a neuroinflammatory response by activating microglia which can further activate the dopaminergic neuron's neuroimmune response mediated by reactive T cells through antigen presentation. (biomedcentral.com)
  • Binolfi et al (2016) Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites. (bestbiochem.com)
  • The following product was used in this experiment: TDP-43 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-29949, RRID AB_2547423. (thermofisher.com)
  • The following product was used in this experiment: Synapsin 1 Polyclonal Antibody from Thermo Fisher Scientific, catalog # A-6442, RRID AB_2536207. (thermofisher.com)
  • Viral expression of wild type α-Synuclein caused accumulation of α-Synuclein and was associated with increased cell death and inflammation. (biomedcentral.com)
  • Human wild type α-synuclein cDNA, a kind gift from Dr. Benoit Giasson, was subcloned into a tetracycline responsive auto-regulated bi-directional expression vector, pBig2i, a kind gift of Dr. Strathdee. (biomedcentral.com)
  • Product Description google Sheep anti-Pan-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen. (biosensis.com)
  • Product Description Sheep anti-Pan-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen. (biosensis.com)
  • Western Blot: TNF-alpha Antibody [NBP1-19532] - Scutellarin attenuates hypertension-induced brain expression of NF-kappaB, TNF-alpha, IL-1beta, and IL-18. (novusbio.com)
  • A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. (lookformedical.com)
  • Genome wide association studies found a direct implication of methylation status of -synuclein and development of PD. (memorial2014.com)
  • Various whole cell extracts (30 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with alpha Synuclein antibody [HL1242] (GTX636641) diluted at 1:1000. (genetex.com)
  • Immunohistochemistry-Paraffin: TNF-alpha Antibody [NBP1-19532] - Analysis of a FFPE tissue section of mouse intestine using TNF-alpha antibody (NBP1-19532) at 1:300 dilution. (novusbio.com)
  • Alpha-synuclein levels in blood plasma decline with healthy aging. (southernbiotech.com)
  • α-Synuclein increased PLK2 levels and GSK-3β activity and increased the levels of phosphorylated α-Synuclein and Tau. (biomedcentral.com)
  • Parkin co-expression reduced the levels of phosphorylated α-Synuclein and attenuated cell death and inflammation. (biomedcentral.com)
  • These data suggest that parkin reduces α-Synuclein levels and alters the balance between phosphatase and kinase activities that affect the levels of phosphorylated α-Synuclein. (biomedcentral.com)
  • Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin. (hersenbank.nl)