Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis. (bvsalud.org)
To investigate the efficacy and safety of poly ( adenosine diphosphate [ ADP ]- ribose ) polymerase (PARP) inhibitors (including their different types) as maintenance therapy in women with newly diagnosed ovarian cancer , and to explore whether this therapy produces a survival benefit in a subgroup population with specific clinical characteristics. (bvsalud.org)
citation needed] Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is found universally in all eukaryotes and is encoded by the PARP-1 gene. (wikipedia.org)
It belongs to the PARP family, which is a group of catalysts that transfer ADP-ribose units from NAD (nicotinamide dinucleotide) to protein targets, thus creating branched or linear polymers. (wikipedia.org)
PARP-1 accomplishes many of its roles through regulating poly(ADP-ribose) (PAR). (wikipedia.org)
This was associated with time-dependent increases in expression of proliferating cell nuclear antigen, a marker of cell proliferation, and poly(ADP-ribose) polymerase (PARP) and phosphorylated histone H2AX, markers of DNA damage. (nih.gov)
11. EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. (nih.gov)
3. May have received poly adenosine diphosphate-ribose polymerase (PARP) inhibitors, bevacizumab (or any other antiangiogenic agent), immunotherapy, or cell therapies. (nih.gov)
We observed an inactivation of the bacterial formamidopyrimidine-DNA glycosylase (Fpg), the mammalian xeroderma pigmentosum group A protein (XPA), and the poly(adenosine diphosphate-ribose)polymerase (PARP). (nih.gov)
The U.S. Food and Drug Administration (FDA) has approved BRCA genetic tests as companion diagnostics to guide cancer treatment with poly adenosine diphosphate-ribose polymerase (PARP) inhibitors . (cdc.gov)
In addition to poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors, immunotherapy has shown the potential in targeted therapy of OC [ 5 , 6 ]. (biomedcentral.com)
Activation of the enzyme poly(ADP-ribose) polymerase (PARP) has been shown to contribute to cell necrosis and organ failure in various disease conditions associated with oxidative stress. (utmb.edu)
There was a massive activation of PARP, detected by poly(ADP-ribose) immunohistochemistry, which localized to the areas of the most severe intestinal injury, i.e., the necrotic epithelial cells at the tip of the intestinal villi, and colocalized with tyrosine nitration, an index of peroxynitrite generation. (utmb.edu)
But today we see poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors being examined. (medscape.com)
Poly(adenosine di-phosphate-ribose) polymerase (PARP) inhibitors are effective in controlling the disease and increasing progression-free survival (PFS) [3]. (amjcaserep.com)
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors may offer a therapeutic benefit in patients with metastatic urothelial cancer (mUC). (guoncologynow.com)
Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR. (nih.gov)
Rucaparib is an anticancer drug that belongs to the class of medications called PARP (poly ADP-ribose polymerase) inhibitors. (mrmed.in)
Rucaparib is an inhibitor of poly Adenosine diphosphate-ribose polymerase enzymes, including PARP-1, PARP-2, and PARP-3, which play a role in DNA repair. (mrmed.in)
Poly(adeno sine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) have emerged as a promising class of chemotherapeutic agents in cancers associated with defects in DNA repair. (ncl.ac.uk)
This nuclear enzyme is poly(adenosine diphosphate-ribose [ADP]) polymerase [PARP], which is involved in the DNA repair process, maintaining genomic stability, and regulating the cellular response to any injuries that skin undergoes. (dliquet.ca)
EMBRACE is a phase 2 clinical trial of the poly adenosine diphosphate-ribose polymerase (PARP) inhibitor, olaparib, in homologous recombinant- (HR-) deficient metastatic breast and relapsed ovarian cancer in patients without germline mutations in BRCA1 and BRCA2. (gccti.org.au)
Inhibitors3
Undoubtedly, the introduction of poly(adenosine diphosphate-ribose) polymerase inhibitors such as olaparib will alter this clinical picture. (amjcaserep.com)
such strategies include administering concurrent TRT and chemotherapy, and the use of TRT with known or putative radiosensitizers such as poly(adenosine diphosphate ribose) polymerase and mammalian-target-of-rapamycin inhibitors. (ox.ac.uk)
High risk of recurrent disease after treatment of advanced-stage EOC has prompted an intensive search for maintenance strategies, and poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors have been found to be particularly efficacious in this setting. (mhmedical.com)
Polymerases6
Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. (nih.gov)
Although they have been considered as resident nuclear elements of the DNA repair machinery, recent works revealed a more intricate physiologic role of poly(ADP-ribose) polymerases with numerous extranuclear activities. (nih.gov)
Indeed, poly(ADP-ribose) polymerases participate in fundamental cellular processes like chromatin remodelling, transcription or regulation of the cell-cycle. (nih.gov)
These new insight into the physiologic roles of poly(ADP-ribose) polymerases widens the range of human pathologies in which pharmacologic inhibition of these enzymes might have a therapeutic potential. (nih.gov)
Here, we overview our current knowledge on extranuclear functions of poly(ADP-ribose) polymerases with a particular focus on the mitochondrial ones and discuss potential fields of future clinical applications. (nih.gov)
A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide ( NAD ) by POLY(ADP-RIBOSE ) POLYMERASES. (nih.gov)
PARPi1
Strategies to enhance response to poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi) in primary and acquired homologous recombination (HR)-proficient tumors would be a major advance in cancer care. (nih.gov)
Glycohydrolase2
PAR degradation is mainly controlled by poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribose-acceptor hydrolase 3 (ARH3). (nih.gov)
Originally called C6orf130 , the scientists renamed this gene TARG1 and its protein terminal ADP-ribose protein glycohydrolase (TARG1) because it cuts off ADP-ribose and poly(ADP-ribose) units that are directly attached to proteins. (nih.gov)
Molecule3
Poly(ADP-ribose) (PAR) is a cell-signaling molecule that mediates changes in protein function through binding at PAR binding sites. (johnshopkins.edu)
Poly(adenosine diphosphate-ribose) polymerase activation plays a part in Tenovin-6 IC50 the manifestation of P-selectin and intracellular adhesion molecule (ICAM)-1 (22). (immune-source.com)
3. Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts. (nih.gov)
14. Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities. (nih.gov)
Protein2
Thus, poly(ADP-ribose) polymerase-1, DNA polymerase beta, and ligase III interact with x-ray repair cross-complementing protein-1 within the BER complex, which ensures that ATP is generated and specifically used for DNA ligation. (nih.gov)
Poly(ADP-ribosyl)ation refers to the covalent attachment of ADP-ribose to protein, generating branched, long chains of ADP-ribose moieties, known as poly(ADP-ribose) (PAR). (nih.gov)
Proteins3
An international research team that included several NIEHS scientists has identified a novel factor that removes poly[adenosine diphosphate (ADP)-ribose] chains from proteins. (nih.gov)
The tagging of ADP-ribose chains to proteins controls gene expression, cell death, and cellular responses to DNA damage. (nih.gov)
Using X-ray crystallography and cell biological and biochemical approaches, the research team demonstrated that TARG1, a member of a large class of macrodomain proteins, homes in on and erases ADP-ribose tags. (nih.gov)
Parthanatos1
While necrosis is caused by acute cell injury resulting in traumatic cell death and apoptosis is a highly controlled process signalled by apoptotic intracellular signals, parthanatos is caused by the accumulation of Poly(ADP ribose) (PAR) and the nuclear translocation of apoptosis-inducing factor (AIF) from mitochondria. (wikipedia.org)
Nuclear1
This conclusion was drawn from experiments in which the fate of [(32)P]poly(ADP-ribose) or [(32)P]NAD added to HeLa nuclear extracts was systematically followed. (nih.gov)
Ation1
When using NAD, but not poly(ADP-ribose), in the presence of 3-aminobenzamide, the entire process was blocked, confirming poly(ADP-ribosyl)ation to be the essential initial step. (nih.gov)
Activation1
the same was confirmed by activation of caspases through cleavage of endogenous substrate poly (adenosine diphosphate-ribose) polymerase. (phcog.com)
Response2
Poly(ADP-ribose) polymerase 1 (PARP1) is the main polymerase and acceptor of PAR in response to DNA damage. (nih.gov)
Although the well-known poly(ADP-ribosylating) (PARylating) PARPs primarily function in the DNA damage response, many noncanonical mono(ADP-ribosylating) (MARylating) PARPs are associated with cellular antiviral responses. (nih.gov)
Cell death1
FWGE treatment also induced programmed cell death by activating the caspase-7 cleavage in both SKOV-3 and ES-2 cells, but only caspase-3 and poly(adenosine diphosphate-ribose) polymerase cleavages were activated in SKOV-3 cells. (tmu.edu.tw)
Shown1
It is shown here that poly(ADP-ribose) serves as an energy source for the final and rate-limiting step of BER, DNA ligation. (nih.gov)