OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, Agriculture
PoloxamerPoloxaleneChemistry, PharmaceuticalExcipientsSurface-Active AgentsDosage FormsDrug CompoundingTechnology, PharmaceuticalParticle SizeDelayed-Action PreparationsDrug CarriersGelsTabletsNanocapsulesSophoraPowdersSolubilityPolysorbatesBiological AvailabilityDrug StabilityNanoparticlesCorneal EdemaPolyethylene GlycolsPolyglycolic AcidDrug Delivery SystemsAdministration, RectalBenzalkonium CompoundsCalorimetry, Differential Scanningbeta-CyclodextrinsMicrospheres
DissolutionGelsISENTRESSLipidSurfactantAqueousHyaluronateEvaluationPolymericViscosityRheologyTablet formulationsPharmaceutical formulationsCubosomesPoloxamersLiposomalCyclodextrinRaltegravirCharacterizationPolymersTopicalBiopharmaceuticalParenteralPaediatricVivoAntioxidantMentholRheologicalBioavailabilityEnhancementOralBiologicalGenericReleaseDevelopmentConventionalWoundAnalyticalStudyEfficacyChemicalPresentAlternative
Dissolution3
  • HPLC assay of lidocaine in vitro dissolution test of the poloxamer 407 gels. (innovareacademics.in)
  • The formulations were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, in vitro dissolution study by USP type I apparatus, and recrystallization study by optical microscopy. (ijpsr.com)
  • The solid dispersions formulated with drug and poloxamer ratio of 1:1 showed highest dissolution rate. (ijpsr.com)
Gels1
ISENTRESS3
  • ONCEMRK is assessing a once-daily investigational formulation of ISENTRESS ® (raltegravir), known as reformulated raltegravir, as part of combination HIV therapy for treatment-naïve HIV-1-infected adults. (news-medical.net)
  • The once-daily arm of QDMRK studied the ISENTRESS poloxamer formulation given as two 400 mg tablets simultaneously. (news-medical.net)
  • Due to the higher bioavailability of raltegravir contained in Dutrebis, the exposures provided by the 300 mg dose of raltegravir are comparable to 400 mg of ralegravir given as the raltegravir poloxamer formulation (Isentress), which accounts for the difference in raltegravir dose. (drugs.com)
Lipid5
  • Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. (ualberta.ca)
  • Poloxamer as a surfactant, combined with rubbing and rinsing, ensures effective removal of protein deposits and lipid contamination from all lens types. (eoptiek.nl)
  • Various formulations of luliconazole loaded cubosomes were prepared with different ratios of lipid (glyceryl monooleate) and surfactant (poloxamer 407) using emulsification method. (manipal.edu)
  • The objective of this investigation was to increase the CSA residence time on the ocular surface using solid lipid nanoparticles (SLNs) and its in-situ gel formulation (CSA-SLN-IG), for treatment of dry eye disease. (olemiss.edu)
  • CSA loaded SLNs (CSA-SLN) were prepared with the homogenization method, using Precirol ® ATO 5 as a solid lipid and Tween® 80 and Poloxamer 188 as surfactants. (olemiss.edu)
Surfactant1
Aqueous3
  • The presence of 25R4 allowed the development of formulations that were free flowing liquid at working temperature (22 °C), gelled at body temperature (37 °C) and had improved stability in an aqueous environment. (ku.dk)
  • Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. (ualberta.ca)
  • At body temperature, poloxamer 407 aqueous solutions (more than 18% w/v) can produce in situ gel. (asiapharmaceutics.info)
Hyaluronate1
  • Delivering the drug in a gel formulation (Poloxamer 407, hyaluronate, etc) does NOT slow the rate of decline appreciably. (alecsalt.com)
Evaluation1
  • Formulation optimization and evaluation of Cefdinir nanosuspension using 23 Factorial design. (setpublisher.com)
Polymeric1
  • There is a need for further studies on polymeric nanoformulations for management of HAND with the potential for eliminating latent viral reservoirs and formulation of novel antiretroviral that is safe, effective, easily administered in adult and pediatric HIV positive populations. (rroij.com)
Viscosity2
  • A low-viscosity LCPM (F) consisting of 40% wt/wt polyoxpropylene-(5)-polyoxyethylene-(20)-cetyl alcohol, 50% wt/wt oleic acid, and 10% wt/wt chitosan dispersion at 0.5% with the addition of 16% poloxamer 407 was developed to take advantage of the lyotropic phase behavior of this formulation. (who.int)
  • The formulations were optimized by varying the concentration of poloxamer and water: ethanol ratio and evaluated based on the basis of drying time, sol-gel transition temperature, ex vivo drug release, and viscosity. (eurekaselect.com)
Rheology1
  • Our Excipients are used in drug formulations as Emulsifiers, Rheology Modifiers, Binders, Humectants, Plasticizers etc. for all sorts of pharmaceutical dosage applications. (clariant.com)
Tablet formulations2
  • Flexible tablet formulations can be conveniently used by the patients as orally swallowable, orally disintegrating, chewable and as dispersible tablets. (ijpsonline.com)
  • Morina D, Sessevmez M, Sinani G, Mülazımoğlu L, Cevher E. Oral tablet formulations containing cyclodextrin complexes of poorly water soluble cefdinir to enhance its bioavailability. (setpublisher.com)
Pharmaceutical formulations2
  • VitiPure L 20 can be used in various pharmaceutical formulations. (clariant.com)
  • Poloxamers are generally considered as non-toxic and non- irritant substances that are used in oral, parenteral and topical pharmaceutical formulations. (actopharma.com)
Cubosomes1
  • The purpose of this study is to develop a thermoresponsive sustained release delivery system combining phytantriol cubosomes and poloxamer 407 (P407). (ku.dk)
Poloxamers1
  • Compared to 1% MgSt, the performance of 2% of both poloxamers in an experimental tablet formulation of ritonavir led to better lubrication, higher tabletability, and enhanced in vitro drug release. (umn.edu)
Liposomal1
  • Our results evidenced equivalent e_cacy between orally administered AMB-MET and the intravenous liposomal AMB marketed formulation. (ucm.es)
Cyclodextrin1
Raltegravir2
  • We look forward to advancing our understanding of this new formulation of once-daily raltegravir with this new trial. (news-medical.net)
  • Reformulated raltegravir is a novel non-poloxamer based formulation. (news-medical.net)
Characterization1
  • Sawant KK, Patel MH, Patel K. Cefdinir nanosuspension for improved oral bioavailability by media milling technique: formulation, characterization and in vitro-in vivo evaluations. (setpublisher.com)
Polymers2
  • The formulations were prepared with HPMC, PVP K30, and poloxamer 407 as polymers and methanol as solvent. (ijpsr.com)
  • A longer persistence of drug concentration may be provided by delivering drug as an undissolved suspension (which dissolves slowly over time) or as a timed release formulation from a substrate (polymers, particles, etc). (alecsalt.com)
Topical2
  • The proposed method can be useful in the quality control of LDC and PLC in their topical formulation. (innovareacademics.in)
  • For this reason, the development of a safe and efficient topical formulation is essential. (embrapa.br)
Biopharmaceutical2
  • VitiPure O 80 is a non-ionic, hydrophilic emulsifier, co-emulsifier, solubilizer and suspension stabilizer used widely in various biopharmaceutical formulations. (clariant.com)
  • These formulations were characterized using rheological, biopharmaceutical (drug release) and morphological (SEM) technique. (eurekaselect.com)
Parenteral1
  • Pharmacokinetic analysis showed that the hCG PLGA MS maintained serum hCG concentration up to 13 days compared to multiple injections of a marketed conventional parenteral injectable formulation of hCG. (pimac.org)
Paediatric5
  • Lack of age-appropriate formulations, inadequate labelling instructions, non-compatible and non-palatable medicines are the main reasons for medication errors in paediatric patients. (ijpsonline.com)
  • This review mainly highlights major issues of paediatric and geriatric drug therapy and provides the design of oral flexible formulations as an alternative formulation design for age appropriate formulation development. (ijpsonline.com)
  • Development of solid oral flexible formulations as an alternative to existing marketed formulations such as conventional tablets, orally disintegrating tablets, chewable and dispersible tablets for paediatric and geriatrics patients is described. (ijpsonline.com)
  • Sprinkle formulations such as pellets, granules packed in capsules or sachets can be conveniently used by paediatric and geriatric patients. (ijpsonline.com)
  • Main reasons for non-availability of paediatric-specific formulations are non-availability of clinical data on paediatric patients, clinical studies conducted mostly with adult patients, the small number of patients in the paediatric age group, varying age groups of paediatric patients, and business focus on the larger population of adult patients [ 5 ]. (ijpsonline.com)
Vivo1
  • The in vivo studies showed that SUM-poloxamer gel was able to increase the corneal antiangiogenic effect compared to the SUM solution and BVM alone at 15 days of follow-up. (eurekaselect.com)
Antioxidant1
  • Its daily use products include formulations that are based on thermal spring water rich in selenium, a powerful antioxidant. (hairboutique.com)
Menthol1
  • Cetylpyridinium chloride is an antiseptic substance present in most mouthwashes available on the market, while products containing essential oils as active principles in their formulations, usually associate thymol, menthol, eucalyptol and methyl salicylate. (bvsalud.org)
Rheological1
  • Polarized light microscopy and rheological studies revealed that F behaved like an isotropic formulation, whereas F30 and F100 behaved like an anisotropic liquid crystalline system (LCS). (who.int)
Bioavailability3
  • The area under the curve of optimized formulation (F2) was 3.98 and 1.53 times more than oral drug solution and intranasal gel respectively, confirming improvement in bioavailability. (ijpsonline.com)
  • The need for bioavailability and bioequivalence studies for flexible formulations also described. (ijpsonline.com)
  • Medicinal modification and new drug delivery methods have led to the development of new derivatives and formulations of scutellarin with improved bioavailability, efficacy, and safety. (cdc.gov)
Enhancement1
  • Prepared formulations were also evaluated for % drug permeation using non-everted rat intestinal sac method which showed that Pluronic was not involved in permeability enhancement of Cefixime. (omicsonline.org)
Oral1
  • However, the problem associated with nasal drug delivery is lower penetrability of drug through nasal mucosa and drainage of formulation into oral cavity. (ijpsonline.com)
Biological2
  • The presence of Poloxamer, known to modulate control release of biological agents, seems to have a favorable effect on SUM subconjunctival administered. (eurekaselect.com)
  • Research design and methods In this study, a poloxamer 407 thermosensitive hydrogel loaded with KGF-2 and/or FGF-21 was prepared and its physical and biological properties were characterized. (bmj.com)
Generic1
Release5
  • In vitro release data demonstrates ondansetron release from suppositories up to 12hrs and follows the zero order kinetics from poloxamer mixture based suppositories. (japsonline.com)
  • Results A 17.0% (w/w) poloxamer 407 combined with 1.0% (w/w) glycerol exhibited controlled release characteristics and a three-dimensional structure. (bmj.com)
  • The situation may be simplified when drug suspensions or timed-release formulations are applied, providing more sustained drug levels over time. (alecsalt.com)
  • The in vitro diffusion study showed that the developed formulation had a higher release rate than the marketed formulation. (manipal.edu)
  • 4]Orasugh JT,Dutta S,Das D, et al .Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations[J].Int J Biol Macromol,2019,140:441-453. (magtechjournal.com)
Development4
  • Development of flexible formulations as an alternative to marketed different formulations of the same drug would reduce the cost of the formulation for patients particularly developing countries where accessibility to various types of formulations is less. (ijpsonline.com)
  • The Ishikawa diagram was used to analyze potential risk factors in formulation development. (pimac.org)
  • Objective The present study focused on the development of a poloxamer 407 thermosensitive hydrogel loaded with keratinocyte growth factor-2 (KGF-2) and fibroblast growth factor-21 (FGF-21) as a therapeutic biomaterial in a scald-wound model of type-2 diabetes in Goto-Kakizaki (GK) rats. (bmj.com)
  • Analytical method development and validation of lidocaine in ointment Formulation by UV spectrophotometric method. (innovareacademics.in)
Conventional1
  • Conventional hCG solution formulations require multiple administration of Gentaur Homogenizers hCG per week and cause patient noncompliance. (pimac.org)
Wound1
  • Conclusions A KGF-2/FGF-21 poloxamer hydrogel accelerated wound healing of scalded skin in GK rats, which was attributed to a synergistic effect of KGF-2-mediated cellular proliferation and FGF-21-mediated inhibition of inflammatory responses. (bmj.com)
Analytical1
  • The aim of this work was to validate an analytical methodology to quantify EB in a new poloxamer-based formulation by high-performance liquid chromatography (HPLC). (embrapa.br)
Study3
  • In the present study we aimed at evaluating the effect of Poloxamer to prolong the effect of SUM. (eurekaselect.com)
  • The in vitro antifungal activity study confirmed that the prepared emulsion formulation was also effective against Candida albicans. (manipal.edu)
  • The present study demonstrated the EB vehiculated in poloxamer gel is promising as a new insect repellent formulation, since it could be quantified and quality control evaluated. (embrapa.br)
Efficacy1
  • Formulations are clinically proven for safety and efficacy that enhance overall treatment results and reduce related side effects that can improve consumer quality of life. (hairboutique.com)
Chemical1
  • Properly designed and developed flexible formulations for new chemical entities and off-patent drugs are need of the hour to provide better treatment to varying age groups of paediatrics and geriatrics. (ijpsonline.com)
Present1
  • The present invention provides an enteral nutritional formulation that meets the nutrient requirements of patients with wounds. (everypatent.com)
Alternative1