• Outer Membrane Protein analysis was performed on E.coli, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis and Acinetobacter juni when grown on Mueller Hinton agar ('quasi-biofilm state') and 30% Poloxamer hydrogel ('true- biofilm state). (nih.gov)
  • Similar outer membrane proteins [OMPs] were identified in bacteria grown in a biofilm state and on a 30% poloxamer hydrogel, which were very different to the OMPs identified in bacteria grown on Mueller-Hinton agar and broth. (nih.gov)
  • The present research work was planned to formulate poloxamer 407 based hydrogel formulations of metronidazole and the evaluation of various parameters like swelling behavior, drug PH stability, in-vitro and in-vivo drug release, and in-vitro cytotoxic activity. (ijpsr.com)
  • Two different concentrations of metronidazole hydrogel formulations were prepared using poloxamer 407 and were assessed by a validated HPLC method for drug content, pH stability, and in-vivo drug release. (ijpsr.com)
  • The pharmacokinetics (PK) of moxifloxacin in healthy white New Zealand rabbits was studied following intravenous (IV) and subcutaneous (SC) administration routes as well as a SC long-acting poloxamer 407 gel formulation (SC-P407). (nih.gov)
  • Recently, the non-ionic surfactant poloxamer 188 (P188) has been shown to reduce by approximately 50% the percentage of non-viable chondrocytes 24 hours post injury in chondral explants exposed to 25 MPa of unconfined compression. (msu.edu)
  • They gave a high dose (1 gram per kilogram of body weight) of Poloxamer 407 to mice which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels. (wikipedia.org)
  • The aims of this study were to evaluate the effect of poloxamer 407 administration on atherogenic serum lipoprotein fractions and sub fractions associated with cholesterol, triglycerides and phospholipids, as well as the onset of early atherosclerosis, in mice. (biomedcentral.com)
  • Mice were administered either sterile saline or poloxamer 407 (to induce a dose-controlled hyperlipidemia) for 1 month and then sacrificed at 1, 4 and 10 days after the last dose of poloxamer 407. (biomedcentral.com)
  • Poloxamer 407-treated mice revealed significant hyperlipidemia, moderately elevated blood pressure, general lipidosis in liver cells, increased cysteine protease activity in heart tissue, and contractile-type changes in cardiomyocytes. (biomedcentral.com)
  • Similar to humans, the onset of atherosclerosis in poloxamer 407-treated mice was characterized by a steady increase in serum low-density, intermediate-density and very-low-density lipoprotein fractions, as well as very-low-density lipoprotein sub fractions. (biomedcentral.com)
  • We would propose that the sustained elevation of serum atherogenic lipoprotein fractions and sub fractions induced by the administration of poloxamer 407 to mice resulted in the morphological changes we observed in both heart and liver cells, which are suggested to precede atherosclerosis, since this is a well-established mouse model of atherosclerosis. (biomedcentral.com)
  • Since most of the cellular, biochemical and physiological changes documented in the present study using poloxamer 407-treated mice are related to the symptoms of early atherosclerosis in humans, it is suggested that the poloxamer 407-induced mouse model of hyperlipidemia and atherosclerosis might prove beneficial as an experimental animal model with which to evaluate the pathological features observed in early-stage atherosclerosis. (biomedcentral.com)
  • 4 ]. A particular chemically-induced mouse model of hyperlipidemia and atherosclerosis involves the chronic administration of a block copolymer called poloxamer 407 (P-407) to mice of either sex. (biomedcentral.com)
  • Chronic administration of the poloxamer 407 (P-407), a block copolymer, to elevate serum lipids in mice is a well-established mouse model of hyperlipidemia and atherosclerosis. (sciendo.com)
  • The photosensitizer remained as a CD-inclusion complex in ternary systems containing MβCD while it seemed to be located in the poloxamer phase in the presence of HkβCD or HPβCD. (ndsl.kr)
  • Besides the obvious advantage of delivering SRB in poloxamer micelles, our results provide a obvious example that each photochemotherapeutic combination needs detailed research on their particular connection, and no generalization on enhanced cytotoxic effects should become produced a priori. (researchensemble.com)
  • In this study, we investigated the effects of Poloxamer 407 as a carrier vehicle on rotator cuff healing at the repair site and compared it with those of a collagen sponge, which is a commonly used carrier vehicle. (biomedcentral.com)
  • The use of Poloxamer 407 as a carrier vehicle may be useful for promoting the early stages of healing and for maintaining the initial biomechanical properties of the repaired rotator cuff tendon. (biomedcentral.com)
  • MST-188 (purified poloxamer 188) is a rheologic and membrane stabilizing agent shown to improve LV function in animals with experimental myocardial infarction or with dystrophin deficiency. (ahajournals.org)
  • Evaluating antibiotics for use in medicine using a poloxamer biofilm model. (nih.gov)
  • Susceptibility to antibiotics on 28 clinical isolates was determined using the modified Kirby Bauer disc diffusion method, on agar and 30% Poloxamer. (nih.gov)
  • There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically. (wikipedia.org)
  • However, the use of Poloxamer 407 versus the collagen sponge did not significantly affect the biomechanical properties of the repaired tendons at 8 weeks. (biomedcentral.com)
  • At 4 weeks, more cellular organization, a greater number of collagen fibers, and increased maturity of collagen fibers were observed in the repair with Poloxamer 407 group than in the other groups. (biomedcentral.com)
  • The critical micelle concentration (cmc) of the poloxamer 407 was apparently reduced in the presence of THPP. (ndsl.kr)