• Although there are several faults with universal disadvantages, a horse's conformation is usually judged by what its intended use may be. (wikipedia.org)
  • Understanding and appraising a horse's conformation can be a way to look into a crystal ball for that horse's future suitability for eventing. (useventing.com)
  • Here's a collection of different criteria that a variety of young event horse specialists have shared that they use when evaluating a horse's conformation for potential success in eventing. (useventing.com)
  • How much the weight must shift to the hindquarters depends on the horse's conformation, the position of the rider, the gait, the degree of collection, and the style of the performance. (horsekeeping.com)
  • The AKC Conformation point schedule for 2023 has been posted on the website. (essfta.org)
  • Structural analyses and computational modeling indicate that EGFR G724S mutations may induce a conformation of the glycine-rich loop, which is incompatible with the binding of third-generation TKIs. (nature.com)
  • Although essentially all cases of sporadic and early-onset Parkinson's disease are of unknown etiology, two point mutations (A53T and A30P) in the alpha-synuclein gene have been identified in familial early-onset Parkinson's disease. (nih.gov)
  • Neither the natively unfolded nor the partially folded intermediate conformations are affected by the familial Parkinson's disease point mutations. (nih.gov)
  • Detection of point mutations associated with genetic diseases by an exon scanning technique. (nih.gov)
  • As a result of such mutations, p21-RAS becomes locked in its active conformation, leading to the constitutive activation of the protein and tumor development. (medscape.com)
  • Undesirable conformation can limit the ability to perform a specific task. (wikipedia.org)
  • While it would be easier to fill the entire magazine with descriptions of desirable conformation for each breed or type of horse, instead we will concentrate on undesirable conformation, which practicaly is the same for all breeds. (thehorse.com)
  • Under these circumstances, the virus can replicate robustly in proximal tubule epithelial cells (PT). (simonsfoundation.org)
  • Every horse has good and bad points of its conformation and many horses (including Olympic caliber horses) excel even with conformation faults. (wikipedia.org)
  • Conformation is discussed so frequently because it often is what makes horses better able to perform their job, or at least can help them have longevity in regard to performance. (thehorse.com)
  • Horses with good conformation are prized and usually more valuable than a counterpart with poor conformation. (thehorse.com)
  • In this article, we will discuss the good, the bad, and the just plain ugly aspects of conformation in horses. (thehorse.com)
  • Trainers that specialize in working with young horses can develop their own personal preferences for conformation. (useventing.com)
  • Their ground is much softer, and so the defects of a conformation in a horse's leg or foot or something like that would not impact those horses as heavily as they would in the United States. (useventing.com)
  • Wink is our main herd sire here at Two C Ranch Horses,posessing the right mind, conformation& athletisim we are striving to produce in our program. (northernhorse.com)
  • The family manifested no linkage to the p53 gene (a two-point LOD-score of -0.41), and has previously also been excluded for linkage to the BRCA1 and BRCA2 loci, as well as being carrier of a BRCA1 germline mutation. (lu.se)
  • point mutation in the intron 19 Date 29-Dec-2000 (Rel. (lu.se)
  • Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
  • Acta Crystallogr D Struct Biol;78(Pt 1): 91-103, 2022 Jan 01. (bvsalud.org)
  • I like a horse with an uphill conformation, higher in the withers with the head and neck coming out more or less at the top in front of the withers, not set too low. (useventing.com)
  • At a standstill, the center of gravity is the point of intersection of a vertical line dropped from the highest point of the withers and a line from the point of the shoulder to the point of the buttock. (horsekeeping.com)
  • The horse's height or overall limb length (point of withers to ground) should approximate the length of the horse's body (the point of the shoulder to the point of buttock). (horsekeeping.com)
  • The neck is measured from the poll to the highest point of the withers. (horsekeeping.com)
  • Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. (bvsalud.org)
  • These findings challenge previous assumptions gleaned from BtADA regarding the conformation of HsADA1 that may be relevant to its immunological interactions, particularly its ability to bind adenosine receptors . (bvsalud.org)
  • Inheritance of some variant alleles causes a change in conformation of the alpha-1 antitrypsin molecule, leading to polymerization and retention within hepatocytes. (msdmanuals.com)
  • Fifty-one vaccine candidates were designed mainly to mimic fusion intermediate conformations of gp41 and in some instance to increase exposure of the 2F5/4E10 epitopes. (europa.eu)
  • Click the points total to be shown a list of results / achievements included in the tally. (dogzonline.com.au)
  • Moreover, results from bulk transcriptome sequencing (RNA-seq) and SCT experiments revealed distinct transcriptomic signatures representing cell injury and stress in primary RPTE in contrast to the uncultured, freshly dissociated PT from human kidney. (simonsfoundation.org)
  • A horse with poor form for a Grand Prix show jumper could have excellent conformation for a World Champion cutting horse, or to be a champion draft horse. (wikipedia.org)
  • Tri trindle (where the points show a brindle pattern). (papercritters.com)
  • As a three and four year old Saint Cloud was often successful in conformation show classes. (eurodressage.com)
  • In addition, we examined the patterns of global gene expression of primary and immortalized RPTE and compared them with uncultured PT freshly dissociated from human kidney. (simonsfoundation.org)
  • Presenting a horse for their conformation to be evaluated in person also reflects the same attention people might have when adjusting their posture or making sure they look their best right before a potential date walks in the door. (useventing.com)
  • This inhibition reflects the binding of Munc18-1 to a closed conformation of the target-SNARE syntaxin1. (jneurosci.org)
  • Equine conformation evaluates a horse's bone structure, musculature, and its body proportions in relation to each other. (wikipedia.org)
  • Structure of fully liganded Hb zeta(2)beta(s)(2) trapped in a tense conformation. (janelia.org)
  • When fully liganded with carbon monoxide, Hb zeta(2)beta(s)(2) displays a central water cavity, a zeta 1-beta(s)2 (or zeta 2-beta(s)1) interface, intersubunit salt-bridge/hydrogen-bond interactions, C-terminal beta His146 salt-bridge interactions, and a beta-cleft, that are highly unusual for a relaxed hemoglobin structure and are more typical of a tense conformation. (janelia.org)
  • The most promising Ags were submitted to a more in-depth biophysical investigation of their structure and conformation stability, and for their capacity to interact with neutralising antibodies (Abs) and peptides. (europa.eu)
  • The overall objective of EuroNeut-41 was to design a vaccine that raises antibodies able to prevent HIV cell fusion by blocking the virus fusion protein gp41 in its pre-fusogenic conformation. (europa.eu)
  • Denmark, which uses the monocomponent pertussis toxin (PT) vaccine, had no reports of PRN-deficient isolates before 2012, and the 4 PRN-deficient strains detected since have been associated with human migration from countries with PRN in their vaccines ( 6 ). (cdc.gov)
  • These quaternary tense-like features contrast with the tertiary relaxed-like conformations of the zeta 1-beta(s1) dimer and the CD and FG corners, as well as the overall structures of the heme cavities. (janelia.org)
  • The ShowTime Stats Conformation rankings are based on Breed, Group, Specialty Best of Breed & Specialty Group wins at Canadian Kennel Club shows and are not an official CKC record of points or wins. (canuckdogs.com)
  • The relationship between head conformation and performance are not well understood, and an appealing head may be more a matter of marketability than performance. (wikipedia.org)
  • Does conformation really have anything to do with performance? (thehorse.com)
  • He went on to become vice champion at the Munchen - Riem stallion performance test in 1991 with an overall rideability score of 153 points and an index of 137,08 points. (eurodressage.com)
  • mean age 58 years) using single stranded conformation polymorphism and sequence analysis. (lu.se)
  • Just like a lot of emphasis is placed on how to take a good profile picture for a dating website, the same goes into taking a conformation photo-from having the horse being properly balanced to the right angle and lighting to snap the picture. (useventing.com)
  • The initial points are based on the published judging schedule and absentees are not deducted, nor are all-breed Best of Breed wins included in the point total. (canuckdogs.com)
  • These factors suggest that the conformation of a horse's head influences its ability to regulate temperature. (wikipedia.org)
  • Contact us for any info on these boys conformation, minds & riding ability. (northernhorse.com)
  • multiply your bias to this - if its zero don't change that, i.e., multiply only this is used during fold-tree generation to set the cut-points. (rosettacommons.org)
  • The Dogs Defeated points are calculated in two phases. (canuckdogs.com)
  • The American Kennel Club encourages pet owners to spay or neuter their dogs if they do not want to participate in AKC conformation events or engage in responsible breeding programs. (akc.org)
  • I suppose when we're trained up to do it, our eye will go to the weakest points straight away. (useventing.com)
  • British White cattle are white with black points (noses, eyes, ears, teats, and lower front legs) and some cattle have scattered spots of black along their sides. (hobbyfarms.com)
  • Comparison of holo HsADA1 and MmADA reveals that MmADA also adopts a closed conformation. (bvsalud.org)
  • scroll down to the point Institutional credentials , and select the Link your institutional credentials option. (lu.se)