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  • cytotoxic
  • This study showed that A398, a novel podophyllotoxin analogue, was cytotoxic to the HT-29, MCF-7, MOLT-4 and HL-60 tumor cell lines, being less active in human peripheral blood mononuclear cells and normal cell lines FGH and IEC-6. (duhnnae.com)
  • Novel
  • With the purpose of creating a multifunctional drug for gastric cancer treatment, a novel all-trans -retinoic acid ( ATRA ) conjugate with podophyllotoxin ( PPT ) was designed and synthesized, and its in vitro antiproliferative activity was evaluated against human gastric cancer cell lines using CCK-8 assay. (mdpi.com)
  • Zhang L, Wang J, Liu L, Zheng C, Wang Y. Synthesis and Antiproliferative Activity of Novel All-Trans -Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells. (mdpi.com)
  • acid
  • Next, the compounds from higher plants like Berbamine, Butulinic acid, Cucurbitacin, taxol and Podophyllotoxin exhibited better interactions in the wild type in the taxol binding site similar to the marine compounds. (thefreedictionary.com)
  • For example, ginsenoside from Panax gingseng, rosmarinic acid from Coleus blumei, shikonin from Lithospermum erythrohizon, diosgenin from Dioscorea, ubiquinone-10 from Nicotiana tabacum, berberin from Coptis japonica, and podophyllotoxin from Juniperus chinensis all accumulated at much higher levels in cultured cells than in intact plants (Misawa et al. (thefreedictionary.com)
  • drug
  • The nickname VP-16 likely comes from a compounding of the last name of one of the chemists who performed early work on the drug (von Wartburg) and podophyllotoxin. (wikipedia.org)
  • cells
  • Mutant Chinese hamster cells resistant to podophyllotoxin are affected in a protein P1 that was later identified as the mammalian HSP60 or chaperonin protein. (wikipedia.org)
  • cancer
  • Podophyllotoxin Takimoto CH, Calvo E. "Principles of Oncologic Pharmacotherapy" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. (wikipedia.org)