• Mutants resistant to either podophyllotoxin, or to its topoisomerase II inhibitory derivatives such as etoposide (VP-16), have been described in Chinese hamster cells. (wikipedia.org)
  • The mutually exclusive cross-resistance patterns of these mutants provide a highly specific means to distinguish the two kinds of podophyllotoxin derivatives. (wikipedia.org)
  • Derivatives of podophyllotoxin are synthesized as properties of the rings and carbon 1 through 4 are diversified. (wikipedia.org)
  • Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. (drugsandpoisons.com)
  • Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins. (ac.ir)
  • Etoposide is in a class of medications known as podophyllotoxin derivatives. (medlineplus.gov)
  • Etoposide, a derivative of podophyllotoxin, inhibits topoisomerase activity. (enzolifesciences.com)
  • Apoptosis was induced by dealing with 4 × 107 Jurkat T cells with etoposide (10 μM) camptothecin Podophyllotoxin (10 μg/ml) 7 Podophyllotoxin (UCN-01) (5 μM) or staurosporine (STS) (1 μM) (all from Sigma-Aldrich Co. St. Louis MO). (bioinf.org)
  • During October 2005-December 2009, the patient received topical and ablative treatments for the warts (salicylic acid, podophyllotoxin, 5-fluoruracil cream, imiquimod 5% cream, cryosurgery, surgical curettage, electrocautery, and CO 2 laser therapy), but clinical improvement was not sustained. (cdc.gov)
  • Podophyllotoxin (PPT) is the active ingredient in Podofilox, which is a medical cream that is used to treat genital warts and molluscum contagiosum. (wikipedia.org)
  • Podophyllotoxin cream is commonly prescribed as a potent topical antiviral. (wikipedia.org)
  • Additionally, it has not been determined if podophyllotoxin can pass into breast milk from topical applications and therefore it is not recommended for breastfeeding women. (wikipedia.org)
  • Antivirals for topical use, including gynecological use, such as podophyllotoxin, are classified in D06 - Antibiotics and chemotherapeutics for dermatological use. (whocc.no)
  • A series of 4b-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4b-azido podophyllotoxin and C4b-azido-49-O-demethyl podophyllotoxin.All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. (csircentral.net)
  • Among these, 49-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells. (csircentral.net)
  • Condyline is an alcoholic solution that contains the active ingredient podophyllotoxin. (dokteronline.com)
  • Podophyllotoxin : Also known trade name ( Condylox) , quite effective against common ones such as Plantar Warts. (dane101.com)
  • Small sores, itching and peeling skin can also follow, for these reasons it is recommended that application be done in a way that limits contact with surrounding, uninfected tissue Neither podophyllin resin nor podophyllotoxin lotions or gels are used during pregnancy because these medications have been shown to be embryotoxic in both mice and rats. (wikipedia.org)
  • Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. (ac.ir)
  • Furthermore, podophyllotoxin is classified as an arytetralin lignan for[dubious - discuss] its ability to bind and deactivate DNA. (wikipedia.org)
  • 2014. Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis). (ac.ir)
  • Do not use Condyline if you are allergic to one of the ingredients in this medicine (see section 'What Condyline contains') or if you are currently using other preparations containing podophyllotoxin. (dokteronline.com)
  • Mutant Chinese hamster cells resistant to podophyllotoxin are affected in a protein P1 that was later identified as the mammalian HSP60 or chaperonin protein. (wikipedia.org)
  • Inhibition of transport by podophyllotoxin: an interaction with microtubule protein. (rupress.org)
  • A number of by-products have been explored, including podophyllotoxin for health treatments ( Stenmark 2021 ) and furniture ( Hiziroglu 2018 ). (ashs.org)
  • The most common side effects of podophyllotoxin cream are typically limited to irritation of tissue surrounding the application site, including burning, redness, pain, itching, swelling. (wikipedia.org)
  • Podophyllotoxin cream (0.5%) is reliable as a home therapy for men but is not recommended for pregnant women because of presumed toxicity to the fetus. (cdc.gov)
  • Co-culture of arbuscular mycorrhiza-like fungi (Piriformospora indica and Sebacina vermifera) with plant cells of Linum album for enhanced production of podophyllotoxins: a first report. (ac.ir)
  • 100 μM) or 1 μM STS to check Podophyllotoxin effects of following incubation and caspase activity on phenotype. (bioinf.org)
  • The in vivo effects of β-peltatin and podophyllotoxin were evaluated on a subcutaneously-xenografted BxPC-3 cell nude mice model. (biomedcentral.com)
  • Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss. (ac.ir)
  • However the diffuse reflectance IR measurements is an important role in contaminant podophyllotoxin analysis and polymorphism. (tercovci.cz)
  • Podophyllotoxin possesses a large number of medical applications, as it is able to stop replication of both cellular and viral DNA by binding necessary enzymes. (wikipedia.org)
  • According to the SMC there is currently an unmet need for an effective, licensed, well-tolerated treatment for this condition, but the regulator has restricted its use to patients not suitable or unresponsive to podophyllotoxin. (pharmatimes.com)
  • Teniposide differs from etoposide, another podophyllotoxin derivative, by the substitution of a thenylidene group on the glucopyranoside ring. (nih.gov)
  • Many antitumor drugs currently in clinical use, such as paclitaxel, vinca alkaloids (vinblastine and vincristine), podophyllotoxin analogues (etoposide and teniposide), and topotecan (camptothecin analog) are based on natural plants. (technologynetworks.com)
  • The most common side effects of podophyllotoxin cream are typically limited to irritation of tissue surrounding the application site, including burning, redness, pain, itching, swelling. (wikipedia.org)
  • We have investigated the effects of podophyllotoxin on the dynamic properties of microtubules assembled from pure tubulin dimer. (herts.ac.uk)
  • Treatments for EGWs focus on the removal of visible warts [ 3 ] and can be divided broadly into two categories: provider-administered ablative/cytodestructive therapies (including cryotherapy, laser ablation, and trichloroacetic acid) and patient-administered topical therapies (such as podophyllotoxin, sinecatechins, and imiquimod) [ 10 ]. (hindawi.com)
  • During October 2005-December 2009, the patient received topical and ablative treatments for the warts (salicylic acid, podophyllotoxin, 5-fluoruracil cream, imiquimod 5% cream, cryosurgery, surgical curettage, electrocautery, and CO 2 laser therapy), but clinical improvement was not sustained. (cdc.gov)
  • Teniposide is a semisynthetic derivative of podophyllotoxin. (nih.gov)
  • Semisynthetic derivative of podophyllotoxin. (enzolifesciences.com)
  • A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. (bvsalud.org)
  • Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues. (mcmaster.ca)
  • Syed TA, Lundin S, Ahmad M. Topical 0.3% and 0.5% podophyllotoxin cream for self-treatment of molluscum contagiosum in males. (cdc.gov)
  • Podophyllotoxin , a liquid or cream shaped drugs normally used to treat molluscum contagiosum genital. (markethealthbeauty.com)
  • Podophyllotoxin destabilizes microtubules by binding tubulin and thus preventing cell division. (wikipedia.org)
  • Excess podophyllotoxin causes the complete disassembly of microtubules, through formation of a tubulin-GTP-podophyllotoxin ternary complex with a dissociation rate constant of 160 s-1 at 37 degrees C, similar to that found upon extensive isothermal dilution in this buffer system. (herts.ac.uk)
  • Addition of substoichiometric concentrations of podophyllotoxin causes partial disassembly of microtubules through production of an equivalent amount of the ternary complex. (herts.ac.uk)
  • Microtubule length measurements and incorporation of [3H]GTP-tubulin dimer show that podophyllotoxin can suppress the dynamic instability of tubulin dimer microtubules and that it acts substoichiometrically in so doing. (herts.ac.uk)
  • We interpret the action of substoichiometric podophyllotoxin on microtubule ends in terms of effects on interconversion of growing and shrinking microtubules in a dynamic system in which tubulin-GTP-podophyllotoxin is kinetically analogous to tubulin-GTP in addition and to tubulin-GDP in dissociation. (herts.ac.uk)
  • Podophyllotoxin bears four consecutive chiral centers, labelled C-1 through C-4 in the following image. (wikipedia.org)
  • Mutant Chinese hamster cells resistant to podophyllotoxin are affected in a protein P1 that was later identified as the mammalian HSP60 or chaperonin protein. (wikipedia.org)
  • Mitochondrial binding of a protein affected in mutants resistant to the microtubule inhibitor podophyllotoxin. (mcmaster.ca)
  • Podophyllotoxin-resistant mutants of Chinese hamster ovary cells. (mcmaster.ca)
  • The ability to suppress dynamic instability may be one way in which drugs such as podophyllotoxin, acting at relatively low concentrations, are able to arrest cell growth and development in a selective way, without necessarily affecting the integrity of the major part of the cytoskeletal microtubule network. (herts.ac.uk)
  • Side effects of the use of podophyllotoxin belong to the light, the itching and burning of the skin. (markethealthbeauty.com)
  • Podophyllotoxin was first isolated in pure form in 1880 by Valerian Podwyssotzki (1818 - 28 January 1892), a Polish-Russian privatdozent at the University of Dorpat (now: Tartu, Estonia) and assistant at the Pharmacological Institute there. (wikipedia.org)
  • podophyllotoxin Major changes to the cation or anion paliperidone being directly observed without further manipulation. (drapikowski.pl)