The composition of the Podocalyxin transmembrane protein consists of acidic residues from position 162-192, many polar residues at positions 200-219, 230-267, and 554-568, as well as containing both basic and acidic residues from position 590-605. (wikipedia.org)
Endoglycan, also named Podocalyxin-like 2 protein, is a type I transmembrane glycoprotein. (rndsystems.com)
CD341
It belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology. (rndsystems.com)
Protein2
Podocalyxin is important for us to potentially provide a better understanding of cancer development and its aggressiveness through induced cell migration and the invasion from interacting with the actin-binding protein EZR. (wikipedia.org)
They also discovered that the location of the apical domain is dependent on a direct link between Rab35 and another apical protein, Podocalyxin, which is already known to control polarity and is involved in tumor progression. (pasteur.fr)
Urinary3
Introduction：To observe the effects of metformin on urinary excretion of MIF, CD74 and podocalyxin in type 2 diabetics and to explore its possible renoprotective mechanisms. (viamedica.pl)
The amount of macrophage migration inhibitory factor(MIF) and CD74 in serum, urinary MIF to creatine ratio(UMCR), urinary CD74 to creatine ratio(UCCR), urinary albumin to creatine ratio(UACR) and urinary podocalyxin to creatine ratio (UPCR) were determined. (viamedica.pl)
Urinary podocalyxin positive-element occurs in the early stage of diabetic nephropathy and is correlated with a clinical diagnosis of diabetic nephropathy. (viamedica.pl)
Podocyte1
Substance containing sialic acid such as podocalyxin on the podocyte surface may be stained. (elsevierpure.com)
Marker1
Podocalyxin is also known as TRA-1-60 and is a marker of pluripotent stem cells. (wikipedia.org)
Progression1
network malware: Podocalyxin in Breast Cancer Progression. (cutechabeads.com)
Expression3
Rat podocalyxin.Kobayashi T.Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells.Takeda T., Go W.Y., Orlando R.A., Farquhar M.G.Mol. (joplink.net)
Co-Expression of Ezrin-CLIC5-Podocalyxin is associated with migration and invasiveness in hepatocellular carcinoma. (bashanfoundation.org)
Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes. (psu.edu)
Mouse1
Staining of a mixture of normal human iPSC and the murine C2C12 cell line with Anti-Human TRA-1-60 (Podocalyxin) PerCP-eFluor® 710 (Product # 46-8863-82) and Mouse IgG2b kappa Isotype Control, PE (Product # 12-4732-82) (left) or Anti-Human PCDH1 (Protocadherin 1) PE (right). (thermofisher.com)
Cell2
At the cellular level podocalyxin has also been shown to regulate the size and topology of apical cell domains and act as a potent inducer of microvillus formation. (wikipedia.org)
The TRA-1-60 antigen is a sialylated epitope on the same keratan sulfate core molecule, podocalyxin, as 4 other distinct antigens on tumor-derived cell lines, TRA-1-81, GCTM2, K4, and K21. (bdbiosciences.com)
Found1
Discussion Podocalyxin has been found to possess post a few translational modification events and likely has more to be discovered. (wikipedia.org)
Control1
La liberación de estas citocinas es particularmente importante para el desarrollo de la respuesta inmune adaptativa, la reconstitución celular después del trasplante de médula haploidéntico, y en el control del crecimiento tumoral. (biocrucesbizkaia.org)
PODXL4
Podocalyxin, also known as Podocalyxin-like protein-1 (PCLP1 or PODXL), is a type I transmembrane glycoprotein. (novusbio.com)
Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane protein that has been demonstrated to be an independent factor of poor prognosis in colorectal cancer (CRC). (nih.gov)
h-PODXL to measure podocalyxin in human tissue/urine. (cychem-bio.com)
Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane glycoprotein belonging to the CD34 family. (cgp60474.com)
Pancreatic Cancer1
Depletion of podocalyxin in a hemispleen mouse model of pancreatic cancer diminished liver metastasis without altering primary tumor size. (healthdisparitiesks.org)
Podocytes6
Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. (wikipedia.org)
Podocalyxin is a major sialoprotein in the podocytes of the kidney glomerulus and is also expressed by both endothelium and multipotent hematopoietic progenitors. (novusbio.com)
This image shows podocalyxin expression (yellow) on podocytes and glomerular endothelia, as well as the surrounding peritubular capillaries in a mouse cortical kidney section (captured at 20X magnification). (portlandpress.com)
This study examined whether the highly conserved cytoplasmic tail of podocalyxin also contributes to the unique organization of podocytes by interacting with the cytoskeletal network found in their cell bodies and foot processes. (embl-heidelberg.de)
By immunocytochemistry, it was shown that podocalyxin and the actin binding protein ezrin are co-expressed in podocytes and co-localize along the apical plasma membrane, where they form a co-immunoprecipitable complex. (embl-heidelberg.de)
These data indicate that in podocytes, podocalyxin is complexed with ezrin, which mediates its link to the actin cytoskeleton. (embl-heidelberg.de)
Nephrin1
The expression of nephrin, Wilms tumor 1 (WT1), and podocalyxin mRNA varied among the clones, which may be due to transformation and/or cloning. (nih.gov)
Sialomucin1
It was postulated previously and confirmed recently that podocalyxin, a sialomucin, plays a major role in maintaining the urinary space open by virtue of the physicochemical properties of its highly negatively charged ectodomain. (embl-heidelberg.de)
Cytoplasmic1
Thus, in addition to its ectodomain, the cytoplasmic tail of podocalyxin also likely contributes to maintaining the unique podocyte morphology. (embl-heidelberg.de)
Protein Expression1
the onset of FSGS, and perhaps other podocytopathies, may be affected by alterations in podocalyxin protein expression. (portlandpress.com)
Glomerular1
The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin. (embl-heidelberg.de)
Collectively1
First a sequence of transient adhesive relationships happens under shear push between adhesion molecules constitutively indicated on circulating lymphocytes (L-selectin) and their ligands [CD34 GlyCAM-1 podocalyxin Sgp200 collectively known as peripheral node addressin (PNAd) and identified by the mAb MECA-79] on specialized high endothelial venules (HEV)67. (immune-source.com)
Knockout1
CRISPR/Cas9 knockout of podocalyxin causes junctional organization defects in podocyte-like cells. (nature.com)
Organization1
Once formed, podocalyxin/ezrin complexes are very stable, because they are insensitive to actin depolymerization or inactivation of Rho kinase, which is known to be necessary for regulation of ezrin and to mediate Rho-dependent actin organization. (embl-heidelberg.de)
Expression1
19. Podocalyxin expression in malignant astrocytic tumors. (nih.gov)
Human1
In direct ELISAs and Western blots, less than 1% cross‑reactivity with recombinant human (rh) Podocalyxin and rhEndoglycan is observed. (novusbio.com)
Mouse1
Detects mouse Podocalyxin in direct ELISAs and Western blots. (novusbio.com)
Levels1
the uEVS were then resuspended in PBS and stored in LowBind tubes at -80°C. uEV protein levels were quantified by BCA and levels of Tamm-Horsfall protein, albumin, podocalyxin, TSG-101, and CD9 were quantified by Western blot after concentration using Amicon Ultra-0.5 ml Centrifugal Filters 10k. (nih.gov)
Cells1
Sialylated, O-glycosylated glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and the affinity of the binding may be pivotal to the metastatic spread of colon carcinoma cells. (wikipedia.org)