• Multidrug resistant (MDR) Klebsiella pneumoniae is a major cause of healthcare-associated infections around the world, with attendant high rates of morbidity and mortality. (ibm.com)
  • In this study, the structures of the polymers were optimized for the treatment of MDR Klebsiella pneumoniae lung infection. (ibm.com)
  • Taken together, pBut_20 is promising for treating MDR Klebsiella pneumoniae lung infection in vivo. (ibm.com)
  • In this study, we report a degradable guanidinium-functionalized polycarbonate with unexpected antimicrobial activity and selectivity towards MDR Klebsiella pneumoniae. (ibm.com)
  • The polymer with optimal composition alleviates Klebsiella pneumonia lung infection without inducing damage to major organs. (ibm.com)
  • Urinary tract infections caused by Escherichia coli, Klebsiella species, Proteus mirabilis, Morganella morganii, Proteus vulgaris and Providencia species (including P. rettgeri). (rxlist.com)
  • Intra-abdominal infections , including peritonitis and intra-abdominal abscess, caused by Escherichia coli, Klebsiella species, Bacteroides species including Bacteroides fragilis, and Clostridium species. (rxlist.com)
  • Antibiotic-resistant strains of the superbug Klebsiella pneumoniae, a pathogen that can cause respiratory and bloodstream infections in humans, are spreading throughout European hospitals. (first4lawyers.com)
  • Certain strains of Klebsiella pneumoniae are resistant to the carbapenem antibiotics that can be the last resort in treating infections. (first4lawyers.com)
  • What is Klebsiella pneumoniae? (first4lawyers.com)
  • Klebsiella pneumoniae is a form of bacteria that lives normally in our intestines. (first4lawyers.com)
  • Klebsiella pneumoniae was responsible for the deaths of 2,094 people in 2015. (first4lawyers.com)
  • If you have suffered a superbug infection in a hospital - from MRSA to Klebsiella pneumoniae - you may be able to get justice for the suffering you have experienced. (first4lawyers.com)
  • Congratulations to Alan Hauser, NU, for his recent publication in Infection and Immunity , "A Genomic Approach to Identify Klebsiella pneumoniae and Acinetobacter baumannii Strains with Enhanced Competitive Fitness in the Lungs During Multi-Strain Pneumonia. (chicagobiomedicalconsortium.org)
  • Klebsiella pneumoniae is the third-most commonly reported infection in a hospital setting, so understanding why certain strains proliferate may help clinicians stem the spread of these bacteria, according to Alan Hauser, MD, PhD , vice chair of Microbiology-Immunology , professor of Medicine in the Division of Infectious Diseases and senior author of the study. (chicagobiomedicalconsortium.org)
  • Klebsiella pneumoniae ( K. pneumoniae ) causes a wide range of infections, including pneumonia, urinary tract infections, bacteremia and liver abscesses, and mainly infects immunocompromised people. (krqe.com)
  • To measure the ability of predatory bacteria to reduce microbial burden in vivo, we introduced sublethal concentrations of Klebsiella pneumoniae into the lungs of rats via intranasal inoculation and followed with multiple doses of predatory bacteria over24 h. (dtic.mil)
  • Three species in the genus Klebsiella are associated with illness in humans: Klebsiella pneumoniae, Klebsiella oxytoca, and Klebsiella granulomatis. (medscape.com)
  • Organisms previously known as Klebsiella ozaenae and Klebsiella rhinoscleromatis are considered nonfermenting subspecies of K pneumoniae that have characteristic clinical manifestations. (medscape.com)
  • This scanning electron micrograph (SEM) reveals some of the ultrastructural morphologic features of Klebsiella pneumoniae. (medscape.com)
  • Twenty ESBL producing strains (15%) including Escherichia coli (n = 9), Klebsiella pneumoniae (n = 7), Klebsiella oxytoca (n = 2) and Enterobacter aerogenes (n = 2) were detected and further analyzed for their resistance transfer features, plasmid profile and nature of the resistance genes. (scielo.br)
  • Foram detectadas vinte cepas produtoras de ESBL, entre as quais Escherichia coli (n=9), Klebsiella pneumoniae (n=7), Klebsiella oxytoca (n=2) e Enterobacter aerogenes (n=2), que foram posteriormente analisadas quanto a suas características de transferência de resistência, perfil plasmidial e natureza dos genes de resistência. (scielo.br)
  • For this study, mice were inoculated with either live Klebsiella pneumoniae bacteria to induce lung infection, or the dead form of the bacteria to induce inflammation. (medicaldesignandoutsourcing.com)
  • Escherichia coli, Klebsiella pneumoniae, Shigella, testing (AST) patterns is the cornerstone of an effective a School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia. (who.int)
  • The selection and diagnostic upper respiratory tract, particularly among criteria for primary and secondary pneumo- patients with chronic obstructive pulmonary nia were a positive chest X-ray and clini- disease, whereas Klebsiella pneumoniae, cal features. (who.int)
  • However, the bacteria may also cause a serious infection of the bloodstream - a condition called bacteremia. (medicalnewstoday.com)
  • Kadouri hopes that one day medical practitioners can use these predator bacteria to supplement antibiotic drugs in treating life-threatening infections. (newswise.com)
  • Clinical improvement has been reported independent of the presence or absence of chronic airway infection 11 and with antibiotic levels below the minimum inhibitory concentrations of several pathogenic bacteria 15 . (ersjournals.com)
  • One of Nahm's crucial discoveries was a method to rapidly and inexpensively test whether a vaccine candidate effectively elicits antibodies that can kill the S. pneumoniae bacteria. (sciencedaily.com)
  • S. pneumoniae is a bacteria that can quickly develop antibiotic resistance. (nationalinterest.org)
  • Using a cutting-edge sequencing technique during live mice infections, we discovered the difference in the rafR gene altered how both the mice and the bacteria responded to infection. (nationalinterest.org)
  • Treatments that prevent S. pneumoniae from spreading around the body may be better for preventing disease compared to simply inhibiting or killing the bacteria, as is current practice. (nationalinterest.org)
  • When this bacteria is killed, other deadly bacteria may take its place and spread to sites such as the lungs to cause disease. (nationalinterest.org)
  • The bacteria camp out inside the lungs and cause very gradual changes in the consistency and appearance of phlegm. (kembrel.com)
  • Using population genetics, the authors analyzed the prevalence of pathogenic bacteria in animal models of infection, following inoculation of the animals with single and/or multiple strains of bacteria. (chicagobiomedicalconsortium.org)
  • A genetic population analysis of pneumonia bacteria has given insight into how inter-strain competition affects infectivity, according to a recent Northwestern Medicine study published in Infection and Immunity . (chicagobiomedicalconsortium.org)
  • The lung, for example, is an intricate ecosystem, and the body fights to maintain the natural microbiome in the face of bacteria and viruses invading via saliva and inhalation. (chicagobiomedicalconsortium.org)
  • According to the study, dramatically more KPPR1 bacteria were found in the lungs 20 hours after infection when compared to other strains. (chicagobiomedicalconsortium.org)
  • K. pneumoniae bacteria represents a new target with a high medical need, affecting a large population worldwide, and for which antibiotics offer only a limited therapeutic solution. (krqe.com)
  • Acute lower respiratory tract infections (ALRIs) are common and frequent group of diseases caused by a wide range of pathogens (viruses, bacteria, fungi or parasites) in which the possible anatomic site(s) extend from the trachea to the alveoli. (scirp.org)
  • Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus are predatory bacteria that naturally and obligately prey on other Gram-negative bacteria, and their use has been proposed as a potential new approach to control microbial infection. (dtic.mil)
  • In this study, we examined whether predatory bacteria can reduce bacterial burden in the lungs in an in vivo mammalian system. (dtic.mil)
  • No adverse effects or lung pathology were observed in rats exposed to high concentrations of predatory bacteria at up to 10 days post inoculation. (dtic.mil)
  • Predatory bacteria were able to reduce K. pneumoniae bacterial burden, on average, by more than 3.0 log10 in the lungs of most rats as measured by CFU plating. (dtic.mil)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLEOCIN PHOSPHATE and other antibacterial drugs, CLEOCIN PHOSPHATE should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Atypical bacteria, Chlamydia pneumoniae , and Mycoplasma pneumoniae infections may precede asthma onset or exacerbate asthma, 3 and these bacteria might be involved in chronic asthma. (bmj.com)
  • Half of the mice with the live bacteria were imaged with PET/CT using either 18 F-FDS or 18 F-FDG on days 0, 1, 2 and 3 to monitor disease progression post infection. (medicaldesignandoutsourcing.com)
  • This same technique could potentially be used in patients to identify infection sites and determine the bacterial infection class, so that patients could avoid taking antibiotics that are known to have no effect against specific bacteria. (medicaldesignandoutsourcing.com)
  • The overall goal is to uncover the temporal changes in transcriptional and signaling profiles of the host and bacteria during infection in naïve and vaccinated hosts with an ultimate goal of improving preventative approaches. (leukocytebiology.org)
  • In individuals older than 30 years of age, pneumonia is known to occur as a result of bacteria, especially S. pneumoniae. (natural-homeremedies.com)
  • Clinicians in Pacific island nations are increasingly challenged by patients who have infection due to antimicrobial- resistant bacteria. (who.int)
  • Contamination of stream and tank water with en- of resistant pathogens should inform standard treatment teric bacteria, including Salmonella Typhi, is documented guidelines that are developed in the Pacific region. (who.int)
  • Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. (who.int)
  • When bacteria develop resistance to common antibiotics and treatment fails, harmless infections become life threatening. (lu.se)
  • Sepsis can originate from infections caused by a wide array of pathogens: bacteria, virus, parasites or fungi. (lu.se)
  • Chlamydia pneumoniae is a species of Chlamydia, an obligate intracellular bacterium that infects humans and is a major cause of pneumonia. (wikipedia.org)
  • Chlamydia pneumoniae is a small gram-negative bacterium (0.2 to 1 μm) that undergoes several transformations during its life cycle. (wikipedia.org)
  • Chlamydia pneumoniae has also been found in the cerebrospinal fluid of patients diagnosed with multiple sclerosis. (wikipedia.org)
  • Chlamydia pneumoniae infection was first associated with wheezing, asthmatic bronchitis, and adult-onset asthma in 1991. (wikipedia.org)
  • Prevalence and persistence of Chlamydia trachomatis-specific antibodies after occasional and recurrent infections. (ppshp.fi)
  • People with antibodies to Chlamydia pneumoniae , a type of bacterium that can cause chest infections, have an increased risk of lung cancer. (wcrf.org)
  • Respiratory Chlamydia Infection Induce Release of Hepoxilin A3 and Histamine Production by Airway Neutrophils. (umassmed.edu)
  • Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain. (alzforum.org)
  • This letter is in response to the recent article in Journal of Clinical Microbiology (38[2]:881-882, 2000) entitled 'Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's Disease Patients' by Gieffers et al. (alzforum.org)
  • Respiratory specimens were analysed by RT-PCR for rhinovirus, enterovirus and respiratory syncytial virus and by PCR for adenovirus, Chlamydia pneumoniae , Mycoplasma pneumoniae and Bordetella pertussis . (bmj.com)
  • Chlamydia pneumoniae PCR was positive in 11 healthy controls (36.6%), 11 mild asthmatics (20.8%), and 11 moderate asthmatics (22%), and PCR positive asthmatics had lower FEV 1 /FVC than negative cases (78.2% v 80.8%, p = 0.023). (bmj.com)
  • Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. (lu.se)
  • Adenovirus infection did not change the adherence of cells of poorly adhering strains of S. pneumoniae or H. influenzae. (lu.se)
  • MEFOXIN is indicated for the treatment of serious infections caused by susceptible strains of the designated microorganisms in the diseases listed below. (rxlist.com)
  • S. pneumoniae bacterial strains are cloaked by a polysaccharide capsule that protects them from phagocytic cells in the lungs and blood during lung infections. (sciencedaily.com)
  • Unfortunately, S. pneumoniae is a genetically diverse pathogen , which means it has many different strains. (nationalinterest.org)
  • New research published today in Nature Communications Biology by my colleagues and I circumvented these genetic diversity issues by studying closely related strains of S. pneumoniae . (nationalinterest.org)
  • In our previous research , two closely related strains of S. pneumoniae were isolated, one from the blood of a patient and another from the ear. (nationalinterest.org)
  • Notably, strains containing the rafR from the ear sample resulted in more neutrophils, an important immune cell, at the site of infection. (nationalinterest.org)
  • If this raffinose phenomenon proves to be widespread across S. pneumoniae strains, blocking their ability to use raffinose may prevent them from surviving in, and thus invading, the lungs. (nationalinterest.org)
  • What they found is that the disease symptoms would be worse in multi-strain infections but, surprisingly, not because of a potential cooperation between the strains resulting in a uniform strains' growth but because of one strain outcompeting the others. (chicagobiomedicalconsortium.org)
  • There are over 150 distinct strains of K. pneumoniae , many of which can be found in the same hospital or even in the same patient, according to the study. (chicagobiomedicalconsortium.org)
  • They found that one strain of K. pneumoniae , called KPPR1, repeatedly outcompeted the other strains of K. pneumoniae in the models. (chicagobiomedicalconsortium.org)
  • Because KPPR1 faltered outside of the lung environment, the scientists hypothesized that KPPR1 may operate through an indirect mechanism that's only effective in the lungs, such as sequestering an important resource or inducing an immune response that's more deadly to other strains. (chicagobiomedicalconsortium.org)
  • We initially thought that strains would proliferate in the lungs to the same degree whether they were inoculated together as a pool into one mouse or individually into separate mice," Hauser said. (chicagobiomedicalconsortium.org)
  • We were surprised to find that a single strain rapidly and robustly outcompetes the other strains in the pool even though that same strain did not necessarily achieve higher numbers in the lung when inoculated alone. (chicagobiomedicalconsortium.org)
  • Recent studies in Europe and the United States 3 , 4 also revealed the existence of K. pneumoniae strains with an exceptionally high level of antimicrobial resistance, making them even more difficult to treat. (krqe.com)
  • This level of antimicrobial resistance in K. pneumoniae strains had never been observed before. (krqe.com)
  • Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. (nih.gov)
  • S. pneumoniae is the most common bacterial pathogen of community acquired pneumonia in childhood. (nature.com)
  • Macrolide antibiotics are used as first-line agents in the treatment of acute bacterial infections, such as community-acquired pneumonia 1 . (ersjournals.com)
  • 4] H influenzae and M catarrhalis are of increasing importance in both community acquired pneumonia (CAP) and acute exacerbation of chronic bronchitis (AECB) while the importance of S pneumoniae is declining. (bionity.com)
  • Community Acquired Pneumonia (CAP) is an infection that begins outside the hospital or is diagnosed within 48 hours after admission to the hospital [ 3 ]. (alliedacademies.org)
  • Progressive reduction in potency of antibiotics capable of treating MDR K. pneumoniae infections - including lung infection - as a consequence of escalating drug resistance provides the motivation to develop drug candidates targeting MDR K. pneumoniae. (ibm.com)
  • Antibiotics are often needed to treat bacterial infections. (medlineplus.gov)
  • However, antibiotics such as erythromycin, azithromycin, or doxycycline may be given for more serious symptoms associated with pneumonia and ear infections. (healthychildren.org)
  • Most people fully recover from this infection, even when antibiotics are not used. (healthychildren.org)
  • In a study available online and in a future issue of the Journal of Infectious Diseases , researchers at UT Southwestern show that mice infected with a type of severe bacterial pneumonia and subsequently treated with steroids and antibiotics recovered faster and had far less inflammation in their lungs than mice treated with antibiotics alone. (news-medical.net)
  • The new findings not only suggest that giving antibiotics with steroids can help individuals with pneumonia get better faster, but also suggest a potentially more effective therapy for someone in the midst of an asthma attack due to M pneumoniae infection. (news-medical.net)
  • You are more at risk of infection if you have been taking antibiotics on a long-term basis, which have resulted in a weakened immune system. (first4lawyers.com)
  • Antibiotics are often thought to be the first line treatment in lower respiratory tract infections however as discussed later these are not indicated in viral infections. (bionity.com)
  • Pneumonia is an inflammation of the lungs importance with the introduction of potent involving the alveolar ducts and alveolar antibiotics and the proliferation of inten- sacs and associated with acute respiratory sive care units. (who.int)
  • This condition is caused by repeated damage to the distal bronchi from inflammation or infection. (medscape.com)
  • But it turns out you need the antibiotic to kill the bug and the steroid to make the inflammation in the lung from the infection get better. (news-medical.net)
  • In the current study, mice infected with the M pneumoniae bacterium were treated daily with a placebo, an antibiotic, a steroid, or a combination of the antibiotic and steroid in order to investigate the effect on M pneumoniae -induced airway inflammation. (news-medical.net)
  • The inflammation in their lungs got significantly better. (news-medical.net)
  • But from there, S. pneumoniae can spread into the lungs, blood and brain, or more locally into the ear, to cause diseases such as pneumonia, bacteremia , meningitis and otitis media (middle ear inflammation). (nationalinterest.org)
  • Chronic inflammation may also play a role in the development of lung cancer, with cancerous changes occurring as a response to exposure to irritants and repeated injury. (wcrf.org)
  • Prof. Boyton works on the molecular immunology of infectious, allergic and autoimmune inflammation through patient based studies and TCR, HLA class II, lung targeted, inducible (Cre/Lox) and reporter transgenic models. (imperial.ac.uk)
  • Our findings hold such great implications as to how inflammation in the AD brain may be triggered by infection with C. pneumoniae that we must demand that studies to replicate and/or validate our first report should be performed with the rigor and comparable techniques that will provide data that can truly be compared and analyzed. (alzforum.org)
  • Rickinson, A.B. (2014) Co-Infections, Inflammation, and Oncogenesis: Future Directions for EBV Research. (scirp.org)
  • Researchers at the University of Louisville , Kentucky, have demonstrated that a new radiotracer, 2- 18 F-fluorodeoxysorbitol ( 18 F-FDS), can identify and track bacterial infection in lungs better than current imaging methods and is able to differentiate bacterial infection from inflammation. (medicaldesignandoutsourcing.com)
  • He points out, " 18 F-FDG PET, a widely commercially available imaging agent, is capable of imaging infection, but it cannot distinguish infections from other pathologies such as cancer and inflammation. (medicaldesignandoutsourcing.com)
  • There are still no specific imaging agents that can differentiate bacterial infection from sterile inflammation at an early stage. (medicaldesignandoutsourcing.com)
  • While both 18 F-FDS and 18 F-FDG effectively tracked the degree of bacterial infection measured by bioluminescent optical imaging, only 18F-FDS was able to differentiate lung infection from lung inflammation. (medicaldesignandoutsourcing.com)
  • 18 F-FDS whole-body PET/CT imaging in mice has shown to be a unique imaging technique that could differentiate infection from inflammation. (medicaldesignandoutsourcing.com)
  • He adds, "The interpretation of CT appearances of lung disorders can be complex if a differential diagnosis needs to distinguish between inflammation and infection. (medicaldesignandoutsourcing.com)
  • The National Heart, Lung and Blood Institute states that when pneumonia occurs, it causes the air sacs to be filled with fungi and viruses, thereby leading to inflammation, leading to the build-up of mucus and fluid in the airways. (natural-homeremedies.com)
  • This results in bacterial dissemination to the lungs, pulmonary inflammation, and obvious signs of illness that can progress to lethality. (lu.se)
  • It has also become apparent the importance of atypical pathogens such as C pneumoniae, M pneumoniae and L pneumophila, in CAP. (bionity.com)
  • Persistent clinical symptoms were more commonly associated with atypical bacterial infections. (bmj.com)
  • March 2000 (community-acquired pneumo- pneumoniae is the primary cause of atypical nia cases). (who.int)
  • C. pneumoniae infection triggers acute wheezing, if it becomes chronic then it is diagnosed as asthma. (wikipedia.org)
  • These observations suggest that acute C. pneumoniae infection is capable of causing protean manifestations of chronic respiratory illness which lead to asthma. (wikipedia.org)
  • While often used as a synonym for pneumonia , the rubric of lower respiratory tract infection can also be applied to other types of infection including lung abscess , acute bronchitis , and emphysema . (bionity.com)
  • There are a number of acute and chronic infections that can affect the lower respiratory tract, the focus of this paper is to look at the two most common infections, Bronchitis and Pneumonia, as identified by the Therapeutic guidelines. (bionity.com)
  • Acute bronchitis can be defined as acute bacterial or viral infection of the larger airways in healthy patients with no history of recurrent disease. (bionity.com)
  • As information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the pandemic continued to be shared, it was clear that the virus could be detected in other specimen types during an active infection. (bepress.com)
  • Pneumonia is one form of Acute Lower Respiratory Infection (ALRI) that affects the lungs. (alliedacademies.org)
  • The World Health Organization (WHO) defines pneumonia as a form of acute respiratory infection that affects the lungs [ 2 ]. (alliedacademies.org)
  • In order to contribute to reduction of morbidity and mortality due to low acute respiratory infections in pediatrics, the objective of this study was to determine the epidemiological profile and to identify the factors favoring and those associated with the risk of deceased. (scirp.org)
  • The term ALRI included: acute broncho-pneumonia for bacterial infections, bronchiolitis for viral infections, pneumonia and pleuro-pneumonia. (scirp.org)
  • Viral respiratory infections are considered the most common precipitating factors of acute asthma and have been shown to be associated with over 80% of asthma exacerbations in school children. (bmj.com)
  • He received an award for the period of 2018-2020 for the project "Carbapenem-Resistant K. Pneumoniae Genomic Biomarkers that Predict Poor Outcomes. (chicagobiomedicalconsortium.org)
  • The polymer with ethyl spacer between the quanidinium group and the polymer backbone (pEt_20) showed excellent in vivo efficacy for treating MDR K. pneumoniae-caused peritonitis in mice. (ibm.com)
  • Non-lethal S. pneumoniae pneumonia was established by intranasal inoculation of neonatal (1-week-old) female BALB/c mice with D39. (nature.com)
  • S. pneumoniae pneumonia mice were supplemented with or without all-trans retinoic acid 24 hours after infection. (nature.com)
  • We stated that serum vitamin A levels in neonatal S. pneumoniae pneumonia mice were lower than 0.7µmol/L from day 2-7 post infection, while pulmonary vitamin A productions were significantly lower than those in the control mice from day 7-28 post infection. (nature.com)
  • In this study, we established a neonatal non-lethal S. pneumoniae pneumonia mice model and monitored vitamin A levels in lung, serum and liver until early adulthood. (nature.com)
  • When infecting mice lungs with S. pneumoniae through their nose, we found the blood sample remained in the lungs, causing invasive disease. (nationalinterest.org)
  • Investigators showed higher rates of infection in experimental mice deficient in the genes that control expression of these 2 agents. (medscape.com)
  • Mice were inoculated with dead K. pneumoniae (10^8 CFU/mL). (medicaldesignandoutsourcing.com)
  • The other half were screened by bioluminescent imaging, and mice with visible infection were selected for follow-up PET/CT scans with 18 F-FDS. (medicaldesignandoutsourcing.com)
  • In this model, mice are first intranasally inoculated with biofilm-grown pneumococci to establish asymptomatic carriage, followed by IAV infection of both the nasopharynx and lungs. (lu.se)
  • Ng notes, "Bacterial infection represents a threat to human health, including hospital-acquired, implant-related, and multidrug-resistant infections. (medicaldesignandoutsourcing.com)
  • Without treatment, most severe infections are deadly. (medlineplus.gov)
  • Subsequent studies of bronchoalveolar lavage fluid from pediatric patients with asthma and also other severe chronic respiratory illnesses have demonstrated that over 50 percent had evidence of C. pneumoniae by direct organism identification. (wikipedia.org)
  • When S. pneumoniae produces a severe infection of the lungs, it is called pneumonia. (medicalnewstoday.com)
  • Mefoxin (cefoxitin) is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms. (rxlist.com)
  • Although antimicrobials remain the primary therapy for M pneumoniae infection, there have been several reports in recent years about physicians adding steroids to the treatment regimen of patients with severe cases, Dr. Hardy said. (news-medical.net)
  • It is harmless when restricted to the intestines, but if they spread to another part of the body, they can cause severe infections. (first4lawyers.com)
  • Because CLEOCIN PHOSPHATE therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate, as described in the INDICATIONS AND USAGE section. (nih.gov)
  • 1 In that study picornaviruses (mostly rhinoviruses) accounted for two thirds of the viral infections, with coronavirus causing less severe asthma exacerbations than other respiratory viruses. (bmj.com)
  • Pneumonia is a lung infection that can range from mild to so severe that you have to go to the hospital. (webmd.com)
  • S. pyo- dialysis unit and other surgical wards who genes may cause a variety of illnesses from developed pneumonia after 48 hours after very common ones such as pharyngitis admission (hospital-acquired pneumonia to less common severe infections includ- cases). (who.int)
  • By separating carriage and disease into distinct steps and providing the opportunity to analyze the genetic variants of both the pathogen and the host, this S. pneumoniae/IAV co-infection model permits the detailed examination of the interactions of an important pathobiont with the host at different phases of disease progression. (lu.se)
  • This investigation was aimed at dissecting the mechanisms of C. pneumoniae pathogenesis by multivariate analysis of challenge experiments in a mouse model of C. pneumoniae lung infection. (auburn.edu)
  • Pathogenesis: how does lung cancer develop? (wcrf.org)
  • The fundamental question is what role C. pneumoniae plays in the pathogenesis of Alzheimer's disease. (alzforum.org)
  • The air sacs in the lungs, known as alveoli, become filled with fluid and pus and reduce the ability of the lungs to their job. (cdc.gov)
  • Pneumonia is a serious infection of the small bronchioles and alveoli that can involve the pleura. (bionity.com)
  • Air enters the lung through the trachea which divides into two main bronchi, each of which is subdivided into several bronchioles which terminate in clusters of alveoli. (wcrf.org)
  • Pneumonia is an infection of the small air sacs of the lungs (alveoli) and the tissues around them. (msdmanuals.com)
  • It happens when an infection causes the air sacs in your lungs (your doctor will call them alveoli) to fill with fluid or pus. (webmd.com)
  • Rhinovirus, C pneumoniae , and B pertussis are found in the sputum or pharyngeal swab specimens of asthmatic subjects without concurrent symptoms of infection or asthma exacerbation, as well as in some healthy controls. (bmj.com)
  • To help determine the role of bacterial coinfection in the current influenza pandemic, CDC examined postmortem lung specimens from patients with fatal cases of 2009 pandemic influenza A (H1N1) for bacterial causes of pneumonia. (cdc.gov)
  • It is important to use appropriate antibiotic selection based on the infecting organism and to ensure this therapy changes with the evolving nature of these infections and the emerging resistance to conventional therapies. (bionity.com)
  • We are sure that the original observations of C. pneumoniae in atherosclerosis were received skeptically, but this organism is now being fully investigated for its role in that disease. (alzforum.org)
  • Although nearly 20% of all cancers are caused by an infection of a microbe, the amount of evidence and information regarding the mechanisms associated with oncogenesis varies dramatically from one organism to the next. (scirp.org)
  • Overview of Parasitic Infections A parasite is an organism that lives on or inside another organism (the host) and benefits (for example, by getting nutrients) from the host at the host's expense. (msdmanuals.com)
  • Having a range of symptoms that can develop slowly or within 24 hours, the danger is that the tiny air sacs within your lungs dangerously fill with fluids, compromising your ability to respire. (iflscience.com)
  • The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)
  • In the first section, infections of the lung are discussed, with a focus on bronchiectasis, lung abscess, and pneumatocele. (medscape.com)
  • Complications after surgical resection for lung abscess are infrequent and include atelectasis, bronchopleural fistula, and wound infection. (medscape.com)
  • Lung abscess, when a pocket of pus forms inside or around your lung. (webmd.com)
  • and Acinetobacter, which in its drug-resistant form can produce extremely hard-to-treat infections in wounds. (newswise.com)
  • C. pneumoniae infection increases adherence of macrophages to endothelial cells in vitro and aortas ex vivo. (wikipedia.org)
  • This increases the air pressure in the shampoo bottle, which is transferred back to the lungs, preventing them from collapsing. (iflscience.com)
  • Availability of iron increases host susceptibility to K pneumoniae infection. (medscape.com)
  • Clinical signs and symptoms consistent with influenza o Having clinical signs and symptoms consistent with influenza increases the pre-test probability of influenza virus infection, which increases the reliability of a positive RIDT result. (cdc.gov)
  • Whether neonatal S. pneumoniae pneumonia induced asthma was associated with vitamin A levels remains unclear. (nature.com)
  • The aim of this study was to investigate the effects of neonatal S. pneumoniae pneumonia on vitamin A expressions, to explore the effects of vitamin A supplement after neonatal S. pneumoniae pneumonia on adulthood asthma development. (nature.com)
  • Our data suggest that neonatal S. pneumoniae pneumonia induce serum vitamin A deficiency and long-time lung vitamin A reduction, vitamin A supplement after neonatal S. pneumoniae pneumonia inhibit the progression of asthma by altering CD4 + T cell subsets. (nature.com)
  • The prevention and treatment of asthma induced by S. pneumoniae pneumonia is crucial, while it remains indistinctly. (nature.com)
  • Whether neonatal S. pneumoniae pneumonia promoted adulthood allergic asthma was associated with vitamin A levels remains unclear. (nature.com)
  • We also explored the effects of vitamin A supplement after neonatal S. pneumoniae pneumonia on the development of adulthood allergic asthma. (nature.com)
  • This infection often causes wheezing in children with asthma or reactive airways. (healthychildren.org)
  • Respiratory infections are well known triggers of asthma exacerbations, but their role in stable adult asthma remains unclear. (bmj.com)
  • Positivity is associated with lower lung function and more frequent asthma symptoms. (bmj.com)
  • The aetiology of asthma involves interactions between genetic susceptibility, allergen exposure, and external aggravating factors such as air pollution, smoking and respiratory infections. (bmj.com)
  • Both clinical and experimental evidence suggest an important role for respiratory infections as triggers of asthma attacks in adults and in children. (bmj.com)
  • Thumerelle et al 2 confirmed the high incidence of viral infections (especially enteroviruses or rhinoviruses) in children admitted to hospital with an asthma exacerbation. (bmj.com)
  • In research into the association between C. pneumoniae infection and atherosclerosis and coronary artery disease, serological testing, direct pathologic analysis of plaques, and in vitro testing suggest infection with C. pneumoniae is a significant risk factor for development of atherosclerotic plaques and atherosclerosis. (wikipedia.org)
  • Objective: We sought to assess the effect of mild steel welding fumes (MS-WF) on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a mouse model. (cdc.gov)
  • In most cases, the bronchitis and upper respiratory tract illnesses associated with M pneumoniae infections are mild and get better on their own without antibiotic treatment. (healthychildren.org)
  • 6] Most often it is caused by viral infection and hence antibiotic therapy is not indicated in immunocompetent individuals. (bionity.com)
  • An antibiotic may be needed to treat an underlying bacterial infection. (kembrel.com)
  • Doctors call it the "last hope" antibiotic because it is used to treat patients who are critically ill with infections which have become resistant to nearly all other drugs. (thebureauinvestigates.com)
  • Discussion meeting issue, 'Immunity, infection, migration and human evolution' organised and edited by Danny Altmann, Francois Balloux and Rosemary Boyton. (imperial.ac.uk)
  • A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions. (ersjournals.com)
  • As proven clinical data accumulate over time, 18 F-FDS PET/CT could become a new clinical standard for confirming bacterial infection in the lungs or other sites. (medicaldesignandoutsourcing.com)
  • This research highlights how this single difference in the gene increased neutrophil levels during infection, preventing S. pneumoniae from causing invasive disease. (nationalinterest.org)
  • Recent data from preclinical studies suggest a role for neutrophil myeloperoxidase and lipopolysaccharide-binding protein in host defense against K pneumoniae infection. (medscape.com)
  • Seventeen percent of those with invasive pneumococcal disease had evidence of pandemic H1N1 infection and up to 62 percent of cases of pneumococcal pneumonia may have been associated with pandemic H1N1, based on their presenting symptoms. (cdc.gov)
  • The symptoms and treatment of the infection depend on its location. (first4lawyers.com)
  • In her book 'Handbook of Pathophysiology', Dr. Elizabeth Corwin states that pneumonia is an infection that affects the lungs and lower respiratory tract and triggers symptoms of coughing. (natural-homeremedies.com)
  • However, due to th e limited sensitivities and predictive values of RIDTs, negative results of RIDTs do not exclude influenza virus infection in patients with signs and symptoms suggestive of influenza. (cdc.gov)
  • Infection with viruses such as influenza A and B, respiratory syncytial virus, coronavirus, adenoviruses, and parainfluenza viruses may lead to pneumonia. (momjunction.com)
  • The increase in adherence of S. pneumoniae could be inhibited by the DNA synthesis inhibitor cytosine arabinofuranoside, which is known to block the late phase of the adenovirus infection. (lu.se)
  • The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and development of novel anti-infectives. (frontiersin.org)
  • The "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) project is part of the European Innovative Medicines Initiative (IMI) Antimicrobial Resistance (AMR) Accelerator. (frontiersin.org)
  • Surgical intervention for bronchiectasis is reserved for children with localized disease and indolent, recurring infections, hemoptysis, persistent chest pain, and other indicators suggesting the failure of medical treatment. (medscape.com)
  • Fluid buildup between the layers of tissue that line your lungs and chest cavity. (webmd.com)
  • However, a majority of lower income countries do not have microbiological diagnostic testing for prompt, reliable confirmation of bloodstream infection and identification of AMR. (who.int)
  • The Innovative Medicines Initiative-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium is establishing a validated and globally harmonized preclinical model to increase reproducibility and more reliably translate results from animals to humans. (frontiersin.org)
  • People with lung adenocarcinomas may have an associated history of chronic lung disease, such as scleroderma, rheumatoid disease, sarcoidosis or tuberculosis. (wcrf.org)
  • If you have chronic lung disease, you may be used to seeing brown phlegm. (kembrel.com)
  • These findings confirm that bacterial lung infections are occurring among patients with fatal cases of 2009 pandemic influenza A (H1N1) and underscore both the importance of pneumococcal vaccination for persons at increased risk for pneumococcal pneumonia and the need for early recognition of bacterial pneumonia in persons with influenza. (cdc.gov)
  • Specimens were received from 77 patients who had 2009 pandemic influenza A (H1N1) virus infection confirmed before death (N = 41) or after death (N = 36). (cdc.gov)
  • One meta-analysis of serological data comparing prior C. pneumoniae infection in patients with and without lung cancer found results suggesting prior infection was associated with an increased risk of developing lung cancer. (wikipedia.org)
  • In high-risk patients (alcoholics and septicemics), the mortality rate associated with this kind of infection is between 50 and 100% 1 . (krqe.com)
  • The incidence of K. pneumoniae resistances is evaluated between 90-100,000 patients in the US and EU5 2 , mainly in Urinary Tract infections and Respiratory Tract infections. (krqe.com)
  • It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections. (nih.gov)
  • Standard Precautions include a group of infection prevention practices that apply to all patients, regardless of suspected or confirmed infection status, in any setting in which healthcare is delivered ( Table 4 ). (cdc.gov)
  • Infection control problems that are identified in the course of outbreak investigations often indicate the need for new recommendations or reinforcement of existing infection control recommendations to protect patients. (cdc.gov)
  • As there is no previous study of pneu- ondary pneumonia, which occurs when the monia in Basra, Iraq, this study of patients host or lungs are diseased or weakened, admitted to wards in Basra city centre was hospital-acquired nosocomial pneumonia carried out to investigate the profile of pneu- and aspiration pneumonia [4]. (who.int)
  • The remaining 29 patients were pneumonia in young adults and children, those admitted to the intensive care unit, the second only to S. pneumoniae [9]. (who.int)
  • 2023. Data from all hospitalized patients with culture-confirmed infection were analyzed. (who.int)
  • Pulmonary edema is another condition in which there is fluid build-up in the lungs. (momjunction.com)
  • However, pulmonary edema is not caused by infection. (momjunction.com)
  • Early in the 2009 influenza A (H1N1) virus pandemic, CDC provided guidelines for submission of tissue specimens for evaluation of influenza virus infections. (cdc.gov)
  • However, RIDTs have limited sensitivity to detect influenza virus infection and negative test results should be interpreted with caution given the potential for false negative results. (cdc.gov)
  • On rare occasions, youngsters may develop croup and a sinus infection (sinusitis). (healthychildren.org)
  • PHAXIAM is a biopharmaceutical company developing innovative treatments for resistant bacterial infections, which are responsible for many serious infections. (krqe.com)
  • Pneumonia is also one of the most common serious infections in children and infants. (msdmanuals.com)
  • The term "typical" CAP refers to a bacterial pneumonia caused by pathogens such as S pneumoniae , H influenzae , and M catarrhalis . (medscape.com)
  • Confirmed fatal cases of 2009 pandemic influenza A (H1N1) were defined as influenza-like illness or postmortem findings suggestive of viral pneumonia and laboratory-confirmed 2009 pandemic influenza A (H1N1) virus infection by real time reverse transcriptase-- polymerase chain reaction (rRT-PCR). (cdc.gov)
  • Immunoglobulins play a major role in the immune response , which protects against illness and infection. (medlineplus.gov)