Pmid genetic polymorphisms disease susceptibility. Medical search. Frequent questions

We examined the seven newly identified susceptibility SNPs for interactions with body mass index, smoking status, and report of weekly heartburn or reflux. (who.int)
Single nucleotide polymorphisms (SNPs) are a type of polymorphism that produces a variation in a single base pair. (andrologica.org)
There are works about, how single nucleotide polymorphisms, or SNPs (pronounced «snips»), in the human genome correlate with disease, with drug response, and other phenotypes. (andrologica.org)
The type of polymorphism of SNPs can be detected by various methods and given their great biological importance, they have been used successfully in several studies. (andrologica.org)
Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population. (snpedia.com)
there are other single nucleotide polymorphisms (SNPs) that alters the susceptibility and severity of rheumatoid arthritis (RA) and juvenile idiopathic arthritis. (blogspot.com)
The International HapMap Project has estimated that CNVs constitute approximately 12% of the human genome and involve a greater fraction of nucleotides than single-nucleotide polymorphisms (SNPs). (bio-rad.com)
As with SNPs, consortiums, such as the CNV Project coordinated by the Wellcome Trust Sanger Institute, are studying CNVs in order to investigate a number of questions including the effects of CNVs on gene expression, their roles in disease and human evolution, and their usefulness in mapping lineages. (bio-rad.com)
In this study, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients and controls were genotyped for five immune gene SNPs in tyrosine phosphatase non-receptor type 22 ( PTPN22 , rs2476601), cytotoxic T-lymphocyte-associated protein 4 ( CTLA4 , rs3087243), tumor necrosis factor ( TNF , rs1800629 and rs1799724), and interferon regulatory factor 5 ( IRF5 , rs3807306), which are among the most important risk variants for autoimmune diseases. (phoenixrising.me)

2022. Identification of genetic effects underlying type 2 diabetes in South Asian and European populations. (nih.gov)

http://dx.doi.org/10.1093/schbul/sbn187 PMid:19223657 PMCid:2669580 Fujiwara Y, Yamaguchi K, Tanaka Y, Tomita H, et al. (geneticsmr.com)

Common variants such as single-nucleotide polymorphisms seem to contribute to ASD susceptibility, but, taken individually, their effects appear to be small. (pasteur.fr)
Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome. (snpedia.com)
Rarely occurring genetic variants are hypothesized to influence human diseases, but statistically associating these rare variants to disease is challenging due to a lack of statistical power in most feasibly sized datasets. (icompbio.net)
Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study. (icompbio.net)
Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease. (icompbio.net)
TRPV1 is the target of several novel analgesics drugs under development and therefore, TRPV1 genetic variants might represent promising candidates for pharmacogenetic modulators of drug effects. (researchgate.net)
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. (uni-kiel.de)
On 09/13/17, NIH grant R01 MH101244 "Rare and common variants in complex disease" (4 PIs: Sunyaev/Price/Kraft/Neale) was awarded to Alkes Price as a subcontract with BWH (Shamil Sunyaev)/NIMH. (harvard.edu)

Sometimes they are located very close to mutations or polymorphisms involved in pathogenic processes, which makes them useful as genetic markers. (andrologica.org)
Genetic mutations in inflammasomes were first recognized to result in autoinflammatory diseases, which are characterized by the absence of both autoantibodies and autoreactive-T/B cells. (blogspot.com)
I found some information on genetic mutations that trigger ME when people are exposed to chronic viruses. (phoenixrising.me)
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population. (nel.edu)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

PMID 21245770 ] Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis. (snpedia.com)
PTPN22 mutation gives, 'increased risk of Type 1 Diabetes , rheumatoid arthritis , lupus , Vitiligo and Graves' disease , but a decreased risk of Crohn's disease . (phoenixrising.me)

Wang Z, Lu Y, Fornage M, Jiao L, Shen J, Li Donghui , Wei P . Identification of novel susceptibility methylation loci for pancreatic cancer in a two-phase epigenome-wide association study. (mdanderson.org)

Our results indicated that the prevalence of the minor allele (T) of the polymorphism rs35705950 in healthy Chinese subjects was approximately 0.66%, which was lower than that described in the Caucasian population. (nih.gov)
0.001) between both self-rating and interview-based adult ADHD assessments and the rs1801260 polymorphism with at least one T-mutation being the risk allele. (snpedia.com)
Common allele of the CYP19 tetranucleotide TTTA repeat polymorphism in this population of Han Chinese women was 11R. (nel.edu)
The most common allele of the tetranucleotide TTTA repeat polymorphism in the forth intron of CYP19 gene in Han Chinese women is 11R, which was different with the previous study in European Caucasians. (nel.edu)

http://dx.doi.org/10.1016/j.neulet.2009.11.017 PMid:19913597 Fatemi SH and Folsom TD (2009). (geneticsmr.com)

Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)
2018). Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. (harvard.edu)
2018). Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. (harvard.edu)
2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
2018) Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. (harvard.edu)

A pilot study of the association between genetic polymorphisms involved in estrogen signaling and infant male genital phenotypes. (snpedia.com)

PMID 19336565 ] Folate Intake, Methylenetetrahydrofolate Reductase Polymorphisms, and Breast Cancer Risk in Women from the Malmo Diet and Cancer Cohort. (snpedia.com)
2. Mercke Odeberg J, Andrade J, Holmberg K, Hoglund P, Malmqvist U, Odeberg J*. UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females. (uit.no)

The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. (nih.gov)

The renin-angiotensin system genes exhibit three common polymorphisms: the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme ( ACE ) gene, the M235T polymorphism of the angiotensinogen gene ( AGT ), and the A1166C polymorphism of the angiotensin II type 1 receptor gene ( AT1-receptor ). (molvis.org)

doi: 10.18502/ijaai.v22i3.13050.ABSTRACTCoronavirus disease 2019 (COVID-19), described as World War 3, is the current worldwide health challenge and nearly all countries have so far faced this disaster. (medworm.com)
doi: 10.18502/ijaai.v22i3.13052.ABSTRACTThe Coronavirus Disease 2019 (COVID-19) pandemic has been the most significant health concern in recent years, with respiratory symptoms being the most prominent. (medworm.com)

They are used for clinical purposes such as the possibility of transplants, the genetic instability of tumors, etc. (andrologica.org)
Genetic and clinical risk prediction model for postoperative atrial fibrillation. (icompbio.net)
Harmonizing the Collection of Clinical Data on Genetic Testing Requisition Forms to Enhance Variant Interpretation in Hypertrophic Cardiomyopathy (HCM): A Study from the ClinGen Cardiomyopathy Variant Curation Expert Panel. (mayo.edu)
Baudhuin LM , De Backer J, Ingles J, Milewicz DM, Tybjaerg-Hansen A. The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective. (mayo.edu)
The diagnosis of axSpA relies on the recognition of a clinical pattern of the disease, based on clinical, laboratory and imaging features. (bmj.com)
The impact of the osteopathic approach on chronic disease and elderly care: Proposals should explore the impact of the osteopathic approach on chronic disease and elderly care through clinical, translational or basic science research. (osteopathic.org)
Single nucleotide polymorphisms and long term clinical outcome in renal transplant patients. (uni-kiel.de)
Clinical and genetic analysis of a Chinese pedigree affected with Smith-Lemli-Opitz syndrome]. (nih.gov)
The distinction between acquired and inherited disease may present a clinical challenge, but more than 80% of cases are acquired. (medscape.com)

The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans. (snpedia.com)
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. (snpedia.com)

Interleukin 12B rs3212227 and rs6887695 single nucleotide polymorphisms are associated with the susceptibility to preeclampsia: Genetic, haplotype and bioinformatics analysis. (nih.gov)
Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. (snpedia.com)

Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear. (who.int)
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. (benthamscience.com)
The associations between PD-1 polymorphisms and genetic susceptibility of chronic HBV infection were analyzed usng the family-based association analysis method. (wjgnet.com)
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. (uni-kiel.de)

Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling. (uni-kiel.de)

BACKGROUND: Important risk factors for esophageal adenocarcinoma and its precursor, Barrett's esophagus, include gastroesophageal reflux disease, obesity, and cigarette smoking. (who.int)
However, some of them confer a risk for a disease such as diabetes or heart disease, obesity, hypertension and psychiatric disorders, for example. (andrologica.org)
PMID 18071340 ] Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. (snpedia.com)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
Twelve obesity-susceptibility loci were genotyped or imputed in 111,421 participants. (lu.se)

Failure to confirm influence of methyltetrahydrofolate reductase (MTHFR) polymorphisms on age at onset of Huntington disease. (snpedia.com)
PMID 17301261 ] Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women. (snpedia.com)

Polymorphisms can have different functional significance, depending on whether they affect a coding region of the genome, a regulatory region or a non-coding region. (andrologica.org)
PMID 19760036 ] Potentially functional polymorphisms in ESR1 and breast cancer risk: a meta-analysis. (snpedia.com)
Evidence indicates that the CYP19 gene is a positional and functional candidate for genetic study in polycystic ovarian syndrome (PCOS). (nel.edu)
As a human geneticist and bioinformatician, Dr. Bush's research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research. (icompbio.net)
The method adds a large amount of genetic information as a basis for complete analysis of TRPV1 ion channel genetics and its functional consequences. (researchgate.net)

PMID 28651127 ] Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: A case-control study. (snpedia.com)

This CYP19 tetranucleotide TTTA repeat polymorphism is an ethnic and racial variant and moderately contributes to the pathogenesis of PCOS in the population of Han Chinese women. (nel.edu)
A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease. (icompbio.net)
A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. (lu.se)
PMID 21736789 ] A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population. (snpedia.com)

Genetic variation in VEGF family genes and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. (snpedia.com)
Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms. (snpedia.com)
NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)

Vitamin D receptor gene FokI polymorphisms and tuberculosis susceptibility: a meta-analysis. (vitamindwiki.com)
Several diseases protect themselves by deactivating the Vitamin D receptor. (vitamindwiki.com)
Databases including PubMed and Embase were searched for genetic association studies of FokI polymorphism of vitamin D receptor (VDR) and TB. (vitamindwiki.com)
Association of vitamin D receptor BsmI rs1544410 and ApaI rs7975232 polymorphisms with susceptibility to adolescent idiopathic scoliosis: A systematic review and meta-analysis. (vitamindwiki.com)
Purpose:This meta-analysis was performed to clarify whether the two single nucleotide polymorphisms (ApaI and BsmI) in vitamin D receptor (VDR) gene conferred susceptibility to adolescent idiopathic scoliosis (AIS). (vitamindwiki.com)

PMID 17428266 ] CLOCK 3111 T/C SNP was associated with activity levels in the second part of the day, neuropsychological performance and BOLD fMRI correlates (interaction of genotype and moral valence of the stimuli). (snpedia.com)
Regarding the angiotensin-converting enzyme insertion/deletion polymorphism, our findings suggest that the II genotype could be a risk factor for NAION in younger male patients when compared to all cases and controls (p=0.033, odds ratio=5.71, confidence interval=1.152¨C28.35 and p=0.03, odds ratio=5.33, confidence interval=1.17¨C24.31 respectively). (molvis.org)
rs1799750 in MMP1 might be a risk factor for rheumatic heart disease in a Han population in Southern China, and individuals carrying the 2G/2G genotype are likely more susceptible to rheumatic heart disease. (cusabio.com)

Recently, genome-wide association studies have identified seven germline single-nucleotide polymorphisms (SNP) that are associated with risk of Barrett's esophagus and esophageal adenocarcinoma. (who.int)
2010). An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population. (geneticsmr.com)
Our autopsy study showed direct association between severe cerebral β-amyloid angiopathy and microinfarct burden in Alzheimer's disease brains. (mahidol.ac.th)
PMID 20600471 ] Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder. (snpedia.com)
We examined the association of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene, of the M235T polymorphism of the angiotensinogen gene, and of the A1166C polymorphism of the angiotensin II type 1 receptor gene with NAION. (molvis.org)
Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease. (who.int)
PMID 17372038 ] Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene. (snpedia.com)
PMID 18449864 ] Association study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders. (snpedia.com)
For MMP-1(-1607) 1G/2G, a significant association was observed using the recessive genetic model. (cusabio.com)
To ascertain the association with ETM2, we performed a genetic analysis of three polymorphic loci, etm1231, etm1234, and etm1240, located within the ETM2 candidate region in 61 Czech patients with a family history of ET and 68 healthy controls. (nel.edu)
Evaluation of the association between the CYP19 Tetranucleotide (TTTA)n polymorphism and polycystic ovarian syndrome(PCOS) in Han Chinese women. (nel.edu)
The present study aims to evaluate the association between tetranucleotide TTTA repeat polymorphism in the CYP19 gene and PCOS among Han Chinese women. (nel.edu)
Hao C, Zhang N, Qu Q, Wang X, Gu H, Chen Z. Evaluation of the association between the CYP19 Tetranucleotide (TTTA)n polymorphism and polycystic ovarian syndrome(PCOS) in Han Chinese women. (nel.edu)
SecureMA: protecting participant privacy in genetic association meta-analysis. (icompbio.net)
Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. (icompbio.net)
Data were extracted by two independent authors and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of the association between VDR FokI gene polymorphism and TB risk. (vitamindwiki.com)
Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population. (nih.gov)
Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus. (nih.gov)
Databases, including PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database, were systematically searched, and eligible case-control studies that explored the association of VDR (BsmI and ApaI) and the susceptibility to AIS were selected. (vitamindwiki.com)
Methods: A comprehensive literature search in five online databases (PubMed, EMBASE, ISI Web of Science, CNKI, and Wanfang) was performed to identify studies that analyzed the association between VDR gene polymorphisms and risk of AIS. (vitamindwiki.com)
A statistically significant association was observed between BsmI polymorphism and AIS (OR 1.90, 95% CI 1.32, 2.62). (vitamindwiki.com)
In subgroup analysis by ethnicity, the association between BsmI polymorphism and AIS was significant in Asians (OR 2.06 , 95% CI 1.56, 2.73) but not in Caucasians (OR 0.70, 95% CI 0.23, 2.19). (vitamindwiki.com)
Moreover, no evidence of association between BMD and the two VDR gene polymorphisms was detected. (vitamindwiki.com)
To investigate the association between the programmed death-1(PD-1) polymorphisms and genetic susceptibility of chronic hepatitis B virus (HBV) infection in Chinese patients. (wjgnet.com)
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. (uni-kiel.de)
Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures. (uni-kiel.de)

Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. (nih.gov)

AIS is the most common spinal deformity disease, yet its etiology remains uncertain. (vitamindwiki.com)
however, we could not draw a definitive conclusion for Caucasian populations, as no studies have been conducted in this group to determine the role of the VDR ApaI polymorphism in AIS etiology and development. (vitamindwiki.com)
VDR BsmI was significantly associated with AIS susceptibility in the overall and Asian populations, while the VDR ApaI polymorphism only played a key role in AIS etiology and development in Asian populations. (vitamindwiki.com)

We recruited 405 patients with interstitial lung diseases (ILD), including 165 IPF patients and 2043 healthy controls, for genotyping the MUC5B gene in the Chinese population. (nih.gov)
PMID 21982816 ] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population. (snpedia.com)
Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. (nih.gov)
Synthesis of the available studies suggests that homozygosity for the FokI polymorphism of the VDR gene might be associated with an increased TB risk, especially in the East and Southeast Asian population. (vitamindwiki.com)

BACKGROUND: Periodontal disease is a major complication of type 1 diabetes mellitus (T1DM). (afpm.org.my)

In children, asthma is the most prevalent chronic disease. (medworm.com)
Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. (nih.gov)
Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan. (nih.gov)
A, were genotyped in 539 patients with chronic HBV infection and 353 other family members (HbsAg-) from 256 nuclear families using polymerase chain reactiorestriction fragment length polymorphisms assay. (wjgnet.com)
The data demonstrated that PD-1.1 and PD-1.2 polymorphisms are not associated with chronic HBV infection in Chinese patients. (wjgnet.com)
It is a chronic inflammatory disease with a predilection for involving the axial skeleton. (bmj.com)
He has authored 20 original peer-reviewed papers relating to the use of osteopathic manipulation for pneumonia, chronic obstructive lung disease, influenza vaccine, improving immune function, applications of osteopathic philosophy, falls prevention, leg length discrepancies and, most recently, leg edema. (osteopathic.org)

Polymorphism in maternal LRP8 gene is associated with fetal growth. (snpedia.com)
PMID 21837769 ] A cis-acting regulatory variation of the estrogen receptor alpha (ESR1) gene is associated with hepatitis B virus-related liver cirrhosis. (snpedia.com)
PMID 22869321 ] Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals. (snpedia.com)

PMID 22925497 ] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease. (snpedia.com)
Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity and mortality worldwide. (bvsalud.org)
Traditional in vitro models for studying vascular diseases have limitations, as they do not fully recapitulate the complexity of the in vivo microenvironment. (bvsalud.org)
Organ-on-a-chip systems have emerged as a promising approach for modeling vascular diseases by incorporating multiple cell types, mechanical and biochemical cues, and fluid flow in a microscale platform. (bvsalud.org)
This review provides an overview of recent advancements in engineering organ-on-a-chip systems for modeling vascular diseases, including the use of microfluidic channels, ECM (extracellular matrix) scaffolds, and patient-specific cells. (bvsalud.org)
We also discuss the limitations and future perspectives of organ-on-a-chip for modeling vascular diseases. (bvsalud.org)

Single nucleotide polymorphisms in the TG gene were associated with the development of Hashimoto's disease and Graves' disease, the intractability of Graves' disease, and the levels of TG mRNA expression, serum TG, and serum anti-thyroglobulin antibody. (cusabio.com)
Single nucleotide polymorphisms occur when a single nucleotide (a building block of DNA) is replaced by another. (andrologica.org)
An example of these markers is the single nucleotide polymorphism of the beta-globin gene, which allows prenatal diagnosis of sickle cell disease. (andrologica.org)
SNP, or single nucleotide polymorphisms, are responsible for a large part of the diversity of the human genome. (andrologica.org)
Therefore, we hypothesized that the CLOCK 3111T/C single nucleotide polymorphism (SNP) might have adverse effects on the regulation of gastric motility. (snpedia.com)
It can screen thousands of polymorphisms in a single run with a resolution of 10KB. (geneticeducation.co.in)
Single nucleotide polymorphisms (SNP) in various genes have been described to be associated with susceptibility to autoimmune disease. (phoenixrising.me)

The presence of CNVs contributes to genetic variability among individuals within a species. (bio-rad.com)
Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes. (cdc.gov)

PMID 18385916 ] Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk. (snpedia.com)
Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer. (snpedia.com)
DNA from multiple viral species is associated with Alzheimer's disease risk. (icompbio.net)
In the present study, a meta-analysis was performed to assess the relationship between VDR FokI gene polymorphism and the risk of TB. (vitamindwiki.com)
Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study. (who.int)

DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. (nih.gov)

http://dx.doi.org/10.1159/000113436 PMid:9276194 Glatt SJ, Faraone SV and Tsuang MT (2003). (geneticsmr.com)

Since NAION may occur when compromised watershed microcirculation is combined with insufficient autoregulation of systematic circulation, polymorphisms of genes involved in systematic circulation, such as the RAAS genes, may be associated with NAION occurrence. (molvis.org)

Cerebral β-amyloid angiopathy is common in elderly individuals, especially those affected with Alzheimer's disease. (mahidol.ac.th)

Animal models developed to study these genes should lead to a better understanding of the diversity of the genetic landscapes of ASD. (pasteur.fr)
This study aimed to determine the effects of genetic polymorphisms in PkDBPαII to immune responses in animal models. (afpm.org.my)
The aim of this study was to determine whether VDR BsmI rs1544410 and ApaI rs7975232 polymorphisms are correlated with AIS. (vitamindwiki.com)

NAION occurrence was not associated with the M235T polymorphism of the angiotensinogen gene and the A1166C polymorphism of the angiotensin II, type 1 receptor gene. (molvis.org)

1997). Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases. (geneticsmr.com)

Our findings provide further evidence of genetic heterogeneity for ET. (nel.edu)

Genetic differences in human circadian clock genes among worldwide populations. (snpedia.com)

One hundred three patients with pneumonia and 360 patients with autoimmune diseases (ADs) were recruited as disease controls. (nih.gov)
However, there is increasing attention being placed on genetic polymorphisms that are involved in the components of inflammasomes, and these have implications for innate immunity and the natural history of autoimmune diseases. (blogspot.com)
For example, IL-1β and IL-18 further perpetuate Th17 responses and endothelial cell damage, which potentiate a number of autoimmune diseases, including synovitis in RA, cardiovascular disease, and systemic lupus erythematosus (SLE). (blogspot.com)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (snpedia.com)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)

In this update, the author discusses advancements in the epidemiology, diagnosis, treatment, and prognosis of patients with arterial ischemic stroke and cerebral venous thrombosis associated with genetic and acquired thrombophilia, including the antiphospholipid antibody syndrome. (medlink.com)

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline. (umassmed.edu)
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. (umassmed.edu)
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates. (umassmed.edu)

Effect of the Concentration Levels of Growth Hormone and Insulin-like Growth Factor I on the Polymorphisms of the Il12p40 Gene in Lung Cancer Patients. (nih.gov)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
5 6 Patients with nr-axSpA represent early forms of axSpA, in a disease continuum, in which some, but not all, eventually progress to r-axSpA. (bmj.com)
Dr. Yee's previous research focused on neurologic prognostication in patients with critical brain disease. (osteopathic.org)
ZNF133 Is Associated with Infliximab Responsiveness in Patients with Inflammatory Bowel Diseases. (uni-kiel.de)

Anatomy5

Organisms11

Diseases25

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology3

Phenomena and Processes82

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena1

Information Science8

Named Groups4

Health Care23

Geographicals11

SNPs9

20221

PMCID1

Variants10

Mutations5

Rheumatoid arthritis2

Loci for pancreatic cancer1

Allele4

10.10161

20185

Phenotypes1

Cohort2

Promoter polymorphism1

Common polymorphisms1

20192

Clinical9

Methylenetetrahydrofolate reductase2

Haplotype2

Associations4

Locus1

Obesity5

MTHFR2

Functional5

Haplotypes1

Variant4

Genetics3

Vitamin D recept5

Genotype3

Association26

Cytokine1

Etiology3

Population4

Type 1 diabet1

Chronic7

Gene is associated3

Vascular6

Single7

Contributes2

Risk5

Human leukocy1

10.11591

Genes involved1

Affected with Alzheimer's disease1

Study3

Receptor gene1

19971

Heterogeneity1

Populations1

Autoimmune diseases3

Diabetes2

Epidemiology1

Plasmodium3

Patients5