Pmid blood coagulation factor inhibitors. Medical search. Frequent questions

In 1990 another naturally occurring Xa inhibitor was isolated, tick anticoagulant peptide (TAP) from extracts of the tick Ornithodoros moubata. (wikipedia.org)
e.g., thrombin when bound to thrombomodulin activates protein C. Another example is factor V (FV), which in addition to being a procofactor to FVa has emerged as an anticoagulant. (lu.se)
The anticoagulant properties of FV were discovered during investigations of individual patients and follow the great tradition of bed-to-bench and bench-to-bed research in the coagulation field. (lu.se)
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. (cusabio.com)
This is because Vacutainer test tubes generally contain a powdered anticoagulant to prevent blood from clotting. (wikidoc.org)
Just as adding solvent to any solution will dilute it, adding liquid anticoagulant to blood will dilute it. (wikidoc.org)
and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS. (lookformedical.com)

These factors activate each other in a blood coagulation cascade that occurs through two separate pathways that interact, the intrinsic and extrinsic pathway. (wikipedia.org)
The prothrombin time (PT) and its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) are measures of the extrinsic pathway of coagulation . (wikidoc.org)
This measures the quality of the extrinsic pathway (as well as the common pathway ) of coagulation . (wikidoc.org)
The speed of the extrinsic pathway is greatly affected by levels of factor VII in the body. (wikidoc.org)
Together with factor VIIa, tissue factor forms the tissue factor or extrinsic pathway of coagulation. (wikidoc.org)
Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. (lookformedical.com)
It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation. (lookformedical.com)
FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation. (lookformedical.com)

The discovery of APC resistance, caused by FVLeiden, as a thrombosis risk factor resulted in the identification of FV as an APC cofactor. (lu.se)
We also have collaborative interests in determining structures of protein complexes formed with anti-cancer and anti-thrombosis inhibitors. (nottingham.ac.uk)
We concluded that OC users, and patients with factor V Leiden, the prothrombin G20 120A mutation, and hyperhomocysteinemia are at a significantly increased risk of cerebral vein thrombosis. (greenmedinfo.com)
Levothyroxine administration is associated with altered fibrinolysis and coagulation, indicating it may increase the risk of venous thrombosis. (greenmedinfo.com)
Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as deep vein thrombosis . (wikidoc.org)
8. Acquired hemophilia with thrombosis in a cancer patient: an unusual presentation Maral S, Bakanay SM, Dilek I. Blood Coagul Fibrinolysis. (medipol.com.tr)
In conclusion, in patients with deep vein thrombosis the 4G polymorphism of PAI-1 gene promoter may influence the expression of PAI-1 and it should be taken into consideration as a facilitating condition for pathological fibrinolysis together with other environmental and genetic factors. (unboundmedicine.com)

Factor Xa is an activated serine protease that occupies a key role in the blood coagulation pathway by converting prothrombin to thrombin. (wikipedia.org)
In FV-Short, the truncated B domain exposes a high-affinity binding site for tissue factor pathway inhibitor alpha (TFPIα), and together with protein S a high-affinity trimolecular complex is generated. (lu.se)
The blood coagulation and Protein C pathway. (wikidoc.org)
It is processed to remove the signal peptide , glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form where the chains are linked by a disulfide bridge . (wikidoc.org)
As a cellular receptor for coagulation factor VII (FVII), and its activated form, factor VIIa, tissue factor is part of the coagulation pathway. (adcreview.com)
Thromboplastin defines the cascade that leads to the activation of factor X - the tissue factor pathway. (wikidoc.org)
This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. (wikidoc.org)
This is opposed to the intrinsic (amplification) pathway which involves both activated factor IX and factor VIII . (wikidoc.org)
Both pathways lead to the activation of factor X (the common pathway) which combines with activated factor V in the presence of calcium and phospholipid to produce thrombin (thromboplastin activity). (wikidoc.org)
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. (idrblab.net)
Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. (lookformedical.com)
Storage-stable blood coagulation factor acting in the intrinsic pathway. (lookformedical.com)
Stable blood coagulation factor involved in the intrinsic pathway. (lookformedical.com)

Prothrombin complex concentrate (PCC) for the management of Xa-inhibitor-associated bleeding has been described in small case series and one cohort study. (nih.gov)
The INR was introduced in the early 1980s when it turned out that there was a large degree of variation between the various prothrombin time assays, a discrepancy mainly due to problems with the purity of the thromboplastin (tissue factor) concentrate. (wikidoc.org)
The prothrombin time can be measured roughly on whole blood (which is done in neonates ), but is more commonly measured from blood plasma . (wikidoc.org)
The prothrombin time is the time it takes plasma to clot after addition of tissue factor (obtained from animals). (wikidoc.org)
Factor VII has a short half-life and its synthesis requires vitamin K . The prothrombin time can be prolonged as a result of deficiencies in vitamin K, which can be caused by warfarin , malabsorption or lack of intestinal colonization by bacteria (such as in newborns ). (wikidoc.org)

Heparin targets multiple factors in the blood coagulation cascade, one of them being FXa. (wikipedia.org)
They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins. (lookformedical.com)

Several structures of 'super active' mutants have been solved, [10] which reveal the nature of factor IX activation by other proteins in the clotting cascade. (wikidoc.org)
The coagulation cascade. (wikidoc.org)

A deletion/insertion polymorphism (4G or 5G) in the promoter of the plasminogen activator inhibitor type 1 gene has been suggested to be involved in regulation of the synthesis of the inhibitor, the 4G allele being associated with enhanced gene expression. (unboundmedicine.com)

Amino Acids, Peptides, and Proteins Proteins Blood Proteins Protein S Amino Acids, Peptides, and Proteins Proteins Glycoproteins Protein S Biological Factors Blood Coagulation Factor Inhibitors Protein S, anabolen kopen achteraf betalen. (nourishmialmamedicalnutritiontherapy.com)
The findings show how a crucial enzyme in our blood, known as ADAMTS13, works like a pair of molecular scissors to carefully cut back the clotting effects of a key protein, von Willebrand factor (VWF). (nottingham.ac.uk)
When blood vessels are damaged by a cut or by other types of vascular injury, VWF in blood plasma binds to the site of damage and unravels to form long protein strings that specifically capture specialised blood cells (platelets) to the site of injury. (nottingham.ac.uk)
Deficiency of this protein causes haemophilia B . It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia . (wikidoc.org)
Tissue factor , also called platelet tissue factor , factor III , or CD142 is a protein encoded by the F3 gene , present in subendothelial tissue and leukocytes . (wikidoc.org)

Cytokines are small proteins that can influence the behavior of white blood cells . (wikidoc.org)
Endogenous substances, usually proteins, that are involved in the blood coagulation process. (lookformedical.com)

ii) Determination of the platelet receptor glycoprotein Ib extracellular domain and von Willebrand factor A1 domain structures (iii) determination of the coagulation factor xi structure. (nottingham.ac.uk)
Complete blood cell count: The presence of thrombocytopenia would be a contraindication to the administration of parenteral glycoprotein 2b3a inhibitors. (wikidoc.org)
Tissue factor (TF) a transmembrane glycoprotein with a 219-amino acid extracellular domain, a 23-residue transmembrane region, and a 21-residue intracellular domain. (adcreview.com)
The F3 gene encodes coagulation factor III which is a cell surface glycoprotein . (wikidoc.org)
Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. (lookformedical.com)

Extracellular protease inhibitors that are secreted from FIBROBLASTS. (lookformedical.com)
The crossreactivity was tested by a competitive enzyme immunoassay (50% inhibition) against different aprotinin homologues and two human Kunitz-type protease inhibitors, bikunin and TFPI. (uni-bielefeld.de)

Factor IX deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell vectors. (wikidoc.org)
Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding. (wikidoc.org)
Congenital factor XIII deficiency is an inherited bleeding disorder due to reduced levels and activity of factor XIII (FXIII) and characterized by hemorrhagic diathesis frequently associated with spontaneous abortions and defective wound healing. (nih.gov)
Factor XIII deficiency is one of the most rare coagulation factor deficiencies. (nih.gov)
Factor XIII Deficiency: A Review of Clinical Presentation and Management. (nih.gov)
A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder. (lookformedical.com)
Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease). (lookformedical.com)
A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia. (lookformedical.com)
An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. (lookformedical.com)
Deficiency of factor XI is often called hemophilia C. (lookformedical.com)
The classic hemophilia resulting from a deficiency of factor VIII. (lookformedical.com)
The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease. (lookformedical.com)

Djelovanje faktora ometa inhibitor puteva tkivnog faktora (TFPI), koji se oslobađa skoro odmah nakon iniciranja koagulacije. (wikipedia.org)

There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. (wikidoc.org)

[1] In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which results from alternatively spliced tissue factor mRNA transcripts, in which exon 5 is absent and exon 4 is spliced directly to exon 6. (wikidoc.org)

An excess of calcium is added (thereby reversing the effects of citrate), which enables the blood to clot again. (wikidoc.org)
Tissue factor (also known as factor III or thromboplastin ) is added, and the time the sample takes to clot is measured optically. (wikidoc.org)
[1] [2] The condition is caused by occlusion of the hepatic veins (usually due to a blood clot ) that drain the liver . (wikipedia.org)
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. (lookformedical.com)

In 2008 the first direct Xa inhibitor was approved for clinical use. (wikipedia.org)
This study aimed to investigate the preferences for prophylactic treatment among Chinese adult patients with hemophilia A without inhibitors, considering clinical effectiveness, side effects, dosing mode, and dosing frequency. (jmir.org)
Patients demonstrated a clear understanding of benefit-risk trade-offs, exhibiting a willingness to accept an increased risk of developing inhibitors for improved clinical outcomes. (jmir.org)
Auto- and alloantibodies against factor XIII: laboratory diagnosis and clinical consequences. (nih.gov)
7. A Placebo-Controlled, Randomized, Double-Blinded, Cross-Over Phase I Clinical Study to Demonstrate Safety of Ankaferd Blood Stopper Topical Usage In Healthy Volunteers. (medipol.com.tr)

Antistasin is a polypeptide and a potent Xa inhibitor. (wikipedia.org)

On average, ocular blood flow (OBF) is reduced in glaucoma patients in various tissues of the eye. (molvis.org)
Hemorrhagic shock is defined as an acute loss of circulating blood volume leading to inadequate oxygen delivery to tissues. (reliasmedia.com)

2] Based on its high expression on many solid tumors, including cervical cancer, and its rapid internalization, tissue factor was selected as a target for an ADC approach. (adcreview.com)

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These processes result from a complex inflammatory response that is initiated through the innate immune system by interactions between host cells and microbes or endogenous host factors that are released during injury or cell death. (ucsf.edu)
The family of Toll-like receptors (TLRs) recognize different microbial components and endogenous host factors, and are critical in initiating inflammatory responses to infection. (ucsf.edu)
Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. (lookformedical.com)

It is defined as the formation of insoluble fibrin by activated coagulation factors, specifically thrombin. (wikipedia.org)

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. (idrblab.net)

Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics. (nottingham.ac.uk)
[13] Recombinant factor IX is used to treat Christmas disease. (wikidoc.org)

The N-terminal EGF domain has been shown to at least in part be responsible for binding tissue factor . (wikidoc.org)
Tisotumab vedotin is an investigational antibody-drug conjugate (ADC) composed of a human antibody targeted to tissue factor (TF), a protease-cleavable linker that covalently attaches the microtubule-disrupting agent monomethyl auristatin E (MMAE) to the antibody. (adcreview.com)
Because of differences between different batches and manufacturers of tissue factor (it is a biologically obtained product), the INR was devised to standardise the results. (wikidoc.org)
Each manufacturer gives an ISI (International Sensitivity Index) for any tissue factor they make. (wikidoc.org)
The ISI value indicates how the particular batch of tissue factor compares to an internationally standardized sample. (wikidoc.org)
[2] Other less common risk factors include systemic diseases such as aspergillosis , Behçet's disease , connective tissue disease , mastocytosis , inflammatory bowel disease HIV infection , sarcoidosis or myeloma . (wikipedia.org)
The best known function of tissue factor is its role in blood coagulation . (wikidoc.org)
Note that one of factor VIIa's domains, GLA domain , binds in the presence of calcium to negatively charged phospholipids , and this binding greatly enhances factor VIIa binding to tissue factor. (wikidoc.org)
Obstructive shock can be defined as physical obstruction to the normal path of blood flow, leading to tissue hypoperfusion. (reliasmedia.com)

Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa. (org.vn)

Factor IX expression increases with age in humans and mice. (wikidoc.org)

2. Continue fluid resuscitation with crystalloids (eg, ~3 mL for every 1 mL blood lost) or colloids (eg, ~1 mL for every 1 mL of blood lost) only until packed red blood cells ( PRBCs ) are available for transfusion (see Shock ). (empendium.com)
Health Care Associated Infection after Red Blood Cell Transfusion. (umaryland.edu)
Viscoelastic testing provides information on the state of a patient's coagulation and helps to direct transfusion with blood components, such as platelets and fresh frozen plasma. (reliasmedia.com)
17. The least incompatible crossmatch red blood cell transfusion by biological compatibility test. (medipol.com.tr)

Directly targeting factor Xa is suggested to be an effective approach to anticoagulation. (wikipedia.org)
Oral factor Xa inhibitors are increasingly used for anticoagulation, but there is no approved reversal agent. (nih.gov)
Having previously fast-tracked this paper to publication in summary form, we now expand on why cimetidine/famotidine (histamine type-2 receptor antagonists), dipyridamole (antiplatelet agent), fenofibrate/bezafibrate (cholesterol/triglyceride-lowering agents), and sildenafil (phosphodiesterase-5 inhibitor) are worth considering for patients with COVID-19 based on their antiviral, anti-inflammatory, renoprotective, cardioprotective, and anticoagulation properties. (jmir.org)

TF is the cell surface receptor for the serine protease factor VIIa. (wikidoc.org)
The complex of TF with factor VIIa catalyzes the conversion of the inactive protease factor X into the active protease factor Xa . (wikidoc.org)
This serves as a (probably rigid) template for factor VIIa binding. (wikidoc.org)

It is found on the surface of many extravascular cells, including vascular smooth muscle cells and adventitial cells , which form an integral part of the blood vessel wall. (adcreview.com)
One such risk factor is a primary vascular dysregulation (PVD) occurring in patients with a disturbed autoregulation, another risk factor is oxidative stress. (molvis.org)
4. The effects of TLR2 activation on the vascular endothelium, including on endothelial inflammatory responses, leucocyte trafficking, coagulation pathways and permeability: Endothelial cell (EC) activation, coagulopathy, and vascular leak contribute to sepsis-induced organ failure. (ucsf.edu)

The heterogeneity of immunological risk factors shown in this study indicates the usefulness of detecting alloimmune factors as well as autoantibodies in patients with RM of unknown etiology. (nel.edu)
Although the etiology of Hashimoto's thyroiditis (HT), a common autoimmune endocrine disease, is unknown, studies suggest a potential association with genetic factors and environmental conditions inducing excessive iodine intake. (medsci.org)
We investigated this cluster to confirm its etiology, describe its magnitude, identify potential risk factors, and make recommendations for control. (who.int)

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Once blood products are available, they are the best resuscitative fluid to use in hemorrhagic shock. (empendium.com)

It is an essential part of hemostasis and works by stopping blood loss from damaged blood vessels. (wikipedia.org)
The complex reactions of blood coagulation are balanced by several natural anticoagulants resulting in tuned hemostasis. (lu.se)

Furthermore, we observed that treatment with ERK5 inhibitor reduces inflammation, coagulopathy, and mortality in LPS-treated mice, but conversely increases mortality and bacteremia in a cecal ligation and puncture model of sepsis. (ucsf.edu)
Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. (lookformedical.com)

In many diseases clots can continue to grow and prevent blood from flowing properly, leading to serious complications. (nottingham.ac.uk)
These findings suggest that LA could be considered an additional factor in the onset and/or progression of diabetic complications, acting as a link between the immunological and haemostatic systems in the pathogenesis of diabetic microangiopathy. (nih.gov)
technical factors, likely related to specific expertise or approach of the endoscopist and center, are also significant risk factors for overall complications. (koreamed.org)
In turn, the ERCP case volume of the endoscopists or medical centers, when examined, has almost always been a significant factor in complications by both univariate or multivariable analysis. (koreamed.org)

Preeclampsia, a pregnancy-related condition marked by dangerously high blood pressure. (adam.com)

It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin. (lookformedical.com)

In our early studies we found that bacterial lipoprotein TLR2 agonists are shed by bacteria into human serum in vitro and into the blood of septic mice and rats in vivo. (ucsf.edu)

The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. (wikidoc.org)

Inhibition of factor Xa leads to antithrombotic effects by decreasing the amount of thrombin. (wikipedia.org)
It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin. (lookformedical.com)

Today there are four factor Xa inhibitors marketed: rivaroxaban, apixaban, edoxaban and betrixaban. (wikipedia.org)

Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. (wikipedia.org)

The Pharmacology of TNF Inhibitors - August 17, 2001. (powershow.com)

Polly , a transgenic cloned Poll Dorset sheep carrying the gene for factor IX, was produced by Dr Ian Wilmut at the Roslin Institute in 1997. (wikidoc.org)
Gene amplification, overexpression and hyperactivity of the epidermal growth factor receptor (EGFR) is frequently observed in non-small cell lung cancer (NSCLC), head and neck cancer (HNSCC), breast and colorectal cancer (CRC). (wisc.edu)

For example, the heart rate may appear to stabilize between class II and III because of vagal activity caused by paradoxical activation of the Bezold-Jarisch reflex, a cardioinhibitory reflex causing hypotension, peripheral vasodilation, and bradycardia, at around 30% blood loss. (reliasmedia.com)
158 non-pregnant women with recurrent implantation failures after IVF/ET procedures were tested for peripheral blood autoimmune profile. (nel.edu)

This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII . (wikidoc.org)
Having recently published a short summary of our thesis [ 2 ], the current paper expands on why cimetidine or famotidine (histamine type-2 receptor antagonists), dipyridamole (antiplatelet agent), fenofibrate or bezafibrate (cholesterol/triglycerides-lowering agents), and sildenafil (phosphodiesterase-5 inhibitor) are worth considering for patients with COVID-19. (jmir.org)

Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. (wikidoc.org)

Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. (lookformedical.com)

2. The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: a case report.Yıldız, A., Şahin, O., Yayar, O., Öztürk, Ç. (medipol.com.tr)

Functional coagulation tests such as the TEG may provide valuable information when resuscitating the hemorrhaging patient, especially if there is any concern for an underlying coagulopathy. (umaryland.edu)

We have characterized the effects of bacterial lipoproteins on monocytes, macrophages, and endothelial cells, and have done extensive work on the effects of TLR2 activation on coagulation and permeability in vitro and in vivo. (ucsf.edu)

They are cysteine proteinase inhibitors. (lookformedical.com)

At the site of injury, where there is an exposure of blood under the endothelium, the platelets gather and immediately form a plug. (wikipedia.org)
conclude that residues 88 to 109 of the second EGF domain mediate binding to platelets and assembly of the factor X activating complex. (wikidoc.org)
CBC = hemoglobin 127g/L, platelets 260 x 109/L, white blood cells 7 x 109/L. (mcgill.ca)

TNF inhibitors may increase the risk of skin cancer, particularly non-melanoma skin cancers like squamous cell carcinoma. (powershow.com)
Diabetes, age over 65, and prior dye load within the past 24 hours are risk factors for the development of post procedure renal insuffiency. (wikidoc.org)
Among the samples from patients who underwent ≥5 RM, positive levels of TNFα were the most frequently observed risk factor (up to 27%) (p=0.05). (nel.edu)
Increased intraocular pressure (IOP) is a major risk factor for glaucomatous damage. (molvis.org)
Nevertheless, there is little doubt that other risk factors besides IOP are involved. (molvis.org)
Increased intraocular pressure (IOP) is a major risk factor for glaucomatous damage and it is well established that an IOP reduction improves, on average, the prognosis of all types of glaucoma. (molvis.org)
An important non-genetic risk factor is the use of estrogen-containing forms of hormonal contraception , which is implicated in 22% of cases of Budd-Chiari syndrome. (wikipedia.org)
A matched case-control study was conducted to identify the risk factors. (who.int)
The study found that patients prioritized reducing annual bleeding times and avoiding the risk of developing inhibitors over treatment process attributes. (jmir.org)
Perforation occurs primarily after sphincterotomy, or endoscope-related, but risk factors are more difficult to determine. (koreamed.org)
Although relevant studies are heterogeneous and sometimes omit potentially key risk factors, several patterns are apparent. (koreamed.org)
5. Infections in patients with lymphoma: An analysis of incidence, relationship and risk factors. (medipol.com.tr)
Objective: To investigate risk factors for early mortality (EM) in patients with newly diagnosed multiple myeloma (NDMM) and to build an EM-predictive model. (bvsalud.org)
Methods: In a cohort of 275 patients with NDMM, risk factors for EM at 6, 12, and 24 months after diagnosis (EM6, EM12, and EM24, respectively) were determined to establish a model to predict EM. (bvsalud.org)
Factors such as distance from an infected person, the number of infected people in the room, the duration of time spent with infected people, the size of the air space, aerosol-generating activity (eg, singing, shouting, or exercising), ventilation in the location, and the direction and speed of airflow can contribute to this risk. (msdmanuals.com)
Based on the procedure type and duration, age, and presence of additional risk factors, a risk of venous thromboembolism (VTE) is determined. (medscape.com)

Organisms1

Diseases7

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes7

Information Science2

Anticoagulant7

Extrinsic pathway8

Thrombosis7

Pathway13

Prothrombin5

Heparin2

Cascade2

Plasminogen activator1

Protein5

Proteins2

Glycoprotein5

Protease inhibitors2

Deficiency12

TFPI1

Extracellular1

MRNA1

Clot4

Clinical5

Polypeptide1

Tissues2

Tumors1

20211

Endogenous3

Fibrin1

Proteases1

Recombinant2

Tissue9

Characterization1

Humans1

Transfusion4

Anticoagulation3

VIIa3

Vascular3

Etiology3

20233

Hemorrhagic shock1

Hemostasis2

Inflammation2

Complications4

Preeclampsia1

Inactivator1

Serum1

Proteolysis1

Thrombin2

Apixaban1

Rivaroxaban1

20011

Gene2

Peripheral2

Receptor2

Cascades1

Platelet1

Hemophilia1

Coagulopathy1

Vitro1

Cysteine1

Platelets3

Risk16