PMCIDReceptorsMitogen-activatKinaseMutationsProtease-activatedGrowing cellsInflammasomeProteinMechanically activatedDopamineERK1Anti-inflammatoryHepatocellular carcinomaSTINGPeroxisomeThrombinInhibitorMelanomaEnzymesSensorCell

PMCID1

• PMID: 22679108, PMCID: PMC3422428 *Manuscript selected as a highlighted article by AACR. (bu.edu)

Receptors2

• A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. (wjgnet.com)
• In previous work from our laboratories (PMIDs 26092994 , 24152160 , 21270400 ) we found that environmental allergens, including cockroach- and barn-derived particulates, contain proteolytic enzymes that contribute to lung inflammation by cleaving and activating proteinase-activated receptors (PARs). (cdc.gov)

Mitogen-activat1

• We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)

Kinase11

• PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception. (iasp-pain.org)
• The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. (iasp-pain.org)
• Using primary cultures of sensory neurons, it was demonstrated that crotalphine increases the level of activated ERK1/2 and JNK-MAPKs and this increase is dependent on the activation of protein kinase Cζ (PKCζ). (iasp-pain.org)
• The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
• TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
• A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet-Induced Weight Loss. (diabetesjournals.org)
• This has led to the development of a range of ERK1/2 inhibitors (ERKi) that either inhibit kinase catalytic activity (catERKi) or additionally prevent the activating pT-E-pY dual phosphorylation of ERK1/2 by MEK1/2 (dual-mechanism or dmERKi). (babraham.ac.uk)
• We have previously shown that budding yeast Mak11, whose homologues in other eukaryotes were described as modulating a p21-activated protein kinase function, accumulates in Rlp24-associated pre-60S complexes when their maturation is impeded in Saccharomyces cerevisiae. (pasteur.fr)
• Woolson, H. D. , Thomson, V. S. , Rutherford, C. , Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. (gla.ac.uk)
• The inhibitory effect of cAMP could not be reversed by inhibition of cAMP-dependent protein kinase (PKA) but was blocked by depletion of the alternative intracellular cAMP sensor exchange protein activated by cAMP 1 (Epac1), which is also required to observe SOCS-3 accumulation in response to cAMP. (gla.ac.uk)
• Mostajeran M, Wetterling F, W Blixt F, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)

Mutations4

• Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway. (nih.gov)
• Somatic activating mutations in MAP2K1 cause melorheostosis. (nih.gov)
• Melanoma in particular exhibits a high incidence of activating BRAF and NRAS mutations and such cells are addicted to the activity of these mutant oncoproteins. (babraham.ac.uk)
• RefAuthors Friedman, E., Gejman, P. V., Martin, G. A., McCormick, F. RefTitle Nonsense mutations in the C-terminal SH2 region of the RefTitle GTPase activating protein (GAP) gene in human tumours. (lu.se)

Protease-activated1

• The protease-activated thrombin receptor-1 (PAR-1) can be activated by both the tethered ligand exposed by thrombin cleavage and a synthetic peptide having the tethered ligand sequence (thrombin receptor agonist peptide or TRAP). (nih.gov)

Growing cells1

• Per usual in non-apoptotic growing cells caspase activated dnase is held in check inactivated in the cytoplasm thanks to the association with its inhibitor, inhibitor of caspase-activated DNase (ICAD) also known as DNA fragmentation factor 45 kDa (DFF45). (wikipedia.org)

Inflammasome1

• An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. (nih.gov)

Protein5

• Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene. (wikipedia.org)
• Activated protein C-protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). (wikipedia.org)
• Another complex related to APC-PCI is the activated protein C-α1-antitrypsin (APCAT) complex. (wikipedia.org)
• Role of mitogen-activated protein kinases in endothelin ETB receptor up-regulation after organ culture of rat mesenteric artery. (lu.se)
• We identify the SUMO ligase Protein Inhibitor of Activated STAT1 (PIAS1) as a constituent PML-NB protein. (gla.ac.uk)

Mechanically activated3

• Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice. (iasp-pain.org)
• Here, we show that deletion of the mechanically activated and rapidly adapting Piezo2 channel in a portion of the low-threshold mechanoreceptors and a majority of the IB4-positive nociceptors impairs touch but sensitizes mechanical pain in mice. (iasp-pain.org)
• Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons. (ohsu.edu)

Dopamine1

• Locomotion activates PKA through dopamine and adenosine in striatal neurons. (ohsu.edu)

ERK11

• Here, we biochemically demonstrated that the systemic crotalphine activates ERK1/2 and JNK and decreases the phosphorylation of p38 in the lumbar spinal cord. (iasp-pain.org)

Anti-inflammatory2

• This study investigated conversion of n-3 DPA, and examined the anti-inflammatory effects of n-3 DPA on activated macrophages. (unboundmedicine.com)
• These results demonstrate that n-3 DPA exhibits anti-inflammatory effects in activated RAW264.7 cells, which are independent of DHA conversion. (unboundmedicine.com)

Hepatocellular carcinoma1

• Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling. (wjgnet.com)

STING1

• Activated STING in a vascular and pulmonary syndrome. (nih.gov)

Peroxisome1

• Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)

Thrombin1

• These results suggest that although both agonists can activate PAR-1, there are profound differences in the ability of thrombin and TRAP to activate PAR-1. (nih.gov)

Inhibitor1

• Preliminary work using in-gel zymography demonstrated the presence of multiple serine proteinase inhibitor-sensitive enzymes in hog barn dust extract (HDE: PMID 26092994 ). (cdc.gov)

Melanoma1

• PAX3 and SOX10 activate MET receptor expression in melanoma. (bu.edu)

Enzymes3

• Because these HDE enzymes were blocked by alkylation of the active serine in many of the proteinases with PMSF and related agents, we reasoned that an activity-based serine proteinase probe (ABP: PMID 16554154 ) would also be able to alkylate the enzymes in the HDE. (cdc.gov)
• Using this novel approach (PMID 21270400 ), we ABP-biotinylated the enzymes in HDE with ABPs selective for tryptic, chymotryptic, and elastase enzymes, respectively. (cdc.gov)
• that are bactericidal by unknown mechanisms but perhaps by activating autolytic enzymes that destroy the cell wall in some bacteria. (msdmanuals.com)

Sensor1

• Indeed, the NLRP1 sensor is activated upon cleavage by the SARS-CoV-2 3CL protease NSP5 in lung epithelial cells [2]. (invivogen.com)

Cell2

• Caspase-3 is activated in the apoptotic cell. (wikipedia.org)
• Transcription Factor CTCFL Promotes Cell Proliferation, Migration, and Invasion in Gastric Cancer via Activating DPPA2. (nih.gov)