• Treatment of chondrosarcoma is predominantly surgical because adjuvant chemotherapy and radiotherapy are generally ineffective with the exception of dedifferentiated subtypes [ 11, 18 ]. (lww.com)
  • The primary sites were mainly located on the left side and have more possibility to receive chemotherapy and radiotherapy. (hindawi.com)
  • Despite recent advances in chemotherapy and radiotherapy for CC, surgical resection remains the primary treatment, but there are gender differences in CC treatment choices [ 3 , 4 ]. (hindawi.com)
  • In February 1998 she joined the CRCTU as a Trial Coordinator coordinating a national, multicentre, phase III, trial called SECRAB which was designed to determine the optimal sequence of chemotherapy and radiotherapy in patients with early breast cancer. (birmingham.ac.uk)
  • In 2004, a randomised phase III trial by the European Organisation for Research and Treatment of Cancer (EORTC) and National Cancer Institute of Canada Clinical Trials Group (NCIC) reported improved median and 2-year survival for patients with glioblastoma treated with concomitant and adjuvant temozolomide and radiotherapy. (nih.gov)
  • Adult patients with newly diagnosed glioblastoma were randomly assigned to receive either standard radiotherapy or identical radiotherapy with concomitant temozolomide followed by up to six cycles of adjuvant temozolomide. (nih.gov)
  • Benefits of adjuvant temozolomide with radiotherapy lasted throughout 5 years of follow-up. (nih.gov)
  • The standard of care for patients with newly diagnosed GBM comprises maximum safe resection of the tumor followed by radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy [ 3 , 4 ]. (springer.com)
  • Available prospective randomized clinical trials in the elderly population with glioblastoma have shown that radiotherapy is superior to supportive care only, that single-modality hypofractionated radiotherapy (reduced dose and shorter treatment schedule) is an alternative to single-modality standard fractionated radiotherapy, and that single-agent temozolomide is equivalent to radiotherapy alone. (jnccn.org)
  • Treatment of Glioblastoma Multiforme with Radiotherapy and Concomitant and Adjuvant Temozolomide: Translation of Randomised Controlled Trial Evidence into Routine Clinical Practice. (medscape.com)
  • However, the comparator was external-beam radiotherapy, and the study reaffirmed the role of chemotherapy for treating high risk endometrial cancer," she said. (medscape.com)
  • Objectives Optimal adjuvant treatment for early-stage clear cell and serous endometrial cancer remains unclear. (bmj.com)
  • Methods From April 1998 to January 2020, women with FIGO stage IA-IB clear cell, serous, and mixed endometrial cancer underwent surgery and adjuvant vaginal cuff brachytherapy. (bmj.com)
  • Conclusion Adjuvant vaginal cuff brachytherapy alone without chemotherapy is an appropriate treatment for women with negative peritoneal cytology and small, early-stage clear cell, serous, and mixed endometrial cancer. (bmj.com)
  • In the six trials of interest, a total of 988 patients with locally advanced HNSCC were randomly assigned to receive either accelerated or conventionally fractionated adjuvant radiotherapy. (biomedcentral.com)
  • Compared with the reference RRT combined with neoadjuvant CAB/adjuvant GnRH, risk of Pca death for men treated with CAB/bicalutamide and conventionally fractionated external beam radiotherapy (CF-EBRT) was hazard ratio (HR) 0.73 (95% CI: 0.50-1.04), hypofractionated EBRT (HF-EBRT), HR 1.35 (95% CI: 0.65-2.81) and EBRT with high dose rate brachytherapy (EBRT-HDRBT), HR 0.85 (95% CI: 0.37-1.95). (lu.se)
  • However it is currently not established whether this is also true for the postoperative / adjuvant situation. (biomedcentral.com)
  • In a randomized trial among 300 patients with cervical cancer undergoing postoperative radiation, disease-free survival was similar with image-guided IMRT versus 3D-CRT (77 versus 81 percent), but three-year cumulative incidence of late toxicity was reduced (28 versus 49 percent) [3]. (nursingcenter.com)
  • Patients at high risk for tumor recurrence may benefit from more aggressive altered fractionation schedules in order to reduce the overall time from surgery to completion of radiotherapy. (biomedcentral.com)
  • For this study, Matei and colleagues hypothesized that systemic chemotherapy and tumor volume-directed radiotherapy would improve recurrence-free survival and overall survival in comparison with systemic chemotherapy alone for patients with surgically staged III/IVA uterine cancer. (medscape.com)
  • The mean final Musculoskeletal Tumor Society functional scores were greater after extended intralesional versus resection treatment (29.5 versus 25.1). (lww.com)
  • MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group study 26951. (thieme-connect.de)
  • With regards to treatment, the role of surgical resection, radiotherapy, chemotherapy, and tumor-treating fields will be presented. (cancernetwork.com)
  • Specific TMT components used in this trial included transurethral resection of bladder tumor, hypofractionated radiotherapy, and gemcitabine chemotherapy. (urologytimes.com)
  • Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. (thieme-connect.de)
  • In a retrospective cohort study reported in the Journal of Clinical Oncology , Tilki et al found that adjuvant radiotherapy was associated with reduced risk for all-cause mortality vs early salvage radiotherapy among men at high risk for disease recurrence following radical prostatectomy. (ascopost.com)
  • These data led to approval by the US Food and Drug Administration (FDA) for adjuvant nivolumab in patients at high risk for recurrence after undergoing radical resection of UC [2]. (nursingcenter.com)
  • 18 F-DCFPyL PET/CT has a significant impact on management intent in patients being considered for salvage radiotherapy after RP with PSA recurrence. (snmjournals.org)
  • Adjuvant radiation therapy should be considered in men with pN1 or [prostatectomy] Gleason score 8 to 10 and pT3/4 PC given the possibility that a significant reduction in all-cause mortality risk exists. (ascopost.com)
  • Carboplatin has also been used for adjuvant therapy of stage 1 seminomatous testicular cancer. (wikipedia.org)
  • A final analysis of data from the NRG258 trial, with a median follow-up of 112 months for overall survival, showed no significant difference between the two arms: the stratified ratio for death comparing chemoradiation therapy vs chemotherapy alone was 1.05 (log-rank two-sided P = .72). (medscape.com)
  • For adjuvant radiation for cervical cancer, newer techniques such as intensity- modulated radiation therapy (IMRT) are being evaluated as less toxic options compared with three-dimensional conformal radiation therapy (3D-CRT). (nursingcenter.com)
  • Dr. Lu-Yao and colleagues looked at the patients who were treated either with prostatectomy plus adjuvant radiation as one group, and compared them to another group who were treated with radiation therapy plus hormone-blocking therapy. (eurekalert.org)
  • Convincing data doexist for the use of adjuvant/neoadjuvant hormonal therapy with external-beam radiation therapy. (cancernetwork.com)
  • BACKGROUND: Oncological outcome after radical radiotherapy (RRT) combined with neoadjuvant and adjuvant androgen suppression therapy (AST) may differ according to type of AST. (lu.se)
  • No difference was found in risk of Pca death for men treated with bicalutamide or GnRH as adjuvant therapy to RRT following neoadjuvant CAB. (lu.se)
  • It is important for patients to obtain as much information as possible about the results of each treatment modality and to obtain more than one opinion on the matter, especially when deciding on surgery versus radiation therapy. (texasoncology.com)
  • 2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
  • Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer. (cdc.gov)
  • Value of therapeutic drug monitoring of endoxifen in Egyptian premenopausal patients with breast cancer given tamoxifen adjuvant therapy: A pilot study. (cdc.gov)
  • As stated by the investigators, "Three randomized trials and an associated meta-analysis found no difference in progression-free survival when comparing adjuvant with early salvage radiotherapy, which can cause many physicians to not offer adjuvant radiotherapy, irrespective of the pathologic findings at radical prostatectomy. (ascopost.com)
  • Accelerated radiotherapy did not improve the loco-regional control ( n = 988, HR = 0.740, CI = 0.48-1.13, p = 0.162), progression-free survival (HR = 0.89, CI = 0.76-1.04, p = 0.132) or overall survival (HR = 0.88, CI = 0.75-1.04, p = 0.148) significantly. (biomedcentral.com)
  • However, among 13 patients whose tumors harbored a platelet-derived growth factor receptor alpha (PDGFRA) D842V mutation, avapritinib improved progression-free survival (median not reached versus 4.5 months). (nursingcenter.com)
  • Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. (thieme-connect.de)
  • 278 (97%) of 286 patients in the radiotherapy alone group and 254 (89%) of 287 in the combined-treatment group died during 5 years of follow-up. (nih.gov)
  • The study cohort consisted of 26,118 men with pT2-4N0 or N1M0 prostate cancer consecutively treated between June 1989 and July 2016 with radical prostatectomy and pelvic lymph node assessment and then followed for potential treatment with adjuvant or early salvage radiotherapy at three German and two U.S. centers. (ascopost.com)
  • Analyses included use of a treatment propensity score to minimize potential treatment selection bias in estimating the causal association of adjuvant vs early salvage radiotherapy on all-cause mortality risk. (ascopost.com)
  • Research has indicated that it is not less effective than adjuvant radiotherapy for this treatment, while having fewer side effects. (wikipedia.org)
  • Adjuvant radiotherapy in the treatment of invasive intraductal papillary mucinous neoplasm of the pancreas: an analysis of the surveillance, epidemiology, and end results registry. (duke.edu)
  • When radiation is delivered after surgery is performed, it is called adjuvant (additional) treatment. (medlineplus.gov)
  • Extended Intralesional Treatment versus Resection of Low-gra. (lww.com)
  • The need for segmental resection versus intralesional treatment of low-grade chondrosarcomas of the appendicular skeleton remains controversial. (lww.com)
  • Extended intralesional treatment of Grade I intracompartmental chondrosarcomas of the long bones of the appendicular skeleton therefore appears safe with improved functional scores and decreased complications versus segmental resection and reconstruction. (lww.com)
  • New insights have been gained particularly in anaplastic glioma, primary CNS lymphoma as well as brain metastases by answering the basic question about the optimal place for radiotherapy in the treatment of these diseases. (thieme-connect.de)
  • Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
  • Post-orchiectomy primary treatment for pure seminoma includes surveillance, radiotherapy, 0r chemotherapy. (medscape.com)
  • NPC is mainly treated by RT and is profoundly radiosensitive and radiotherapy treatment is the spine of treatment for all stages of NPC without far off metastases. (intechopen.com)
  • At a time when modern radiation treatment like intensity-modulated radiotherapy (IMRT) are accomplishing great good local control, distant metastases are getting to be the transcendent design of treatment failure, particularly in patients with locally progressed illness. (intechopen.com)
  • However, if SBRT is an equally promising treatment option if applied in the adjuvant or salvage setting after RPE remains unknown. (bvsalud.org)
  • aTTom - adjuvant Tamoxifen Treatment Offer more? (birmingham.ac.uk)
  • We provide evidence to support that adjuvant compared with early salvage radiotherapy may lower the risk of death in men with adverse pathology at radical prostatectomy. (ascopost.com)
  • Analyses were performed to assess the effect of different definitions of adverse pathology on all-cause mortality risk-eg, exclusion of pN1 disease and exclusion of early salvage radiotherapy patients with persistent postsurgery prostate-specific antigen level. (ascopost.com)
  • Among the 933, 109 received adjuvant radiotherapy, 379 received no radiotherapy, and 445 received early salvage radiotherapy. (ascopost.com)
  • On multivariate analysis, compared with early salvage radiotherapy, men receiving adjuvant radiotherapy had significantly lower risk of all-cause mortality both when patients with pN1 disease were included (adjusted hazard ratio [HR] = 0.61, 95% confidence interval [CI] = 0.41-0.89, P =.01) and when those with pN1 disease were excluded (HR = 0.31, 95% CI = 0.12-0.78, P = .01). (ascopost.com)
  • Compared with early salvage radiotherapy, no significant differences in all-cause mortality risk were observed among patients receiving no radiotherapy when pN1 disease was included (HR = 1.09, 95% CI = 0.88-1.36, P = .42) or excluded (HR = 1.14, 95% CI = 0.83-1.57, P = .42). (ascopost.com)
  • Compared with early salvage radiotherapy, no significant difference in risk for all-cause mortality was observed among men receiving adjuvant radiotherapy (HR = 0.78, 95% CI = 0.50-1.22, P = .28) or no radiotherapy (HR = 1.07, 95% CI = 0.93-1.23, P = .33). (ascopost.com)
  • Salvage radiotherapy, most commonly to the prostate bed, results in 5-y biochemical control of 56% ( 3 ). (snmjournals.org)
  • Failure after salvage radiotherapy is most likely due to disease outside the prostate bed, which can include the pelvic lymph nodes, paraaortic lymph nodes, and distant metastases. (snmjournals.org)
  • Adjuvant radiotherapy in advanced head and neck squamous cell cancer (HNSCC) reduces the risk of local-regional failure and most likely increases the survival rate. (biomedcentral.com)
  • Accelerated radiotherapy does not result in a significant improvement of loco-regional control or overall survival in high-risk patients. (biomedcentral.com)
  • We investigated whether adjuvant radiotherapy (RT) improved cancer-specific survival (CSS) and overall survival (OS) among patients undergoing surgical resection for invasive IPMN. (duke.edu)
  • CONCLUSION: On propensity-score-adjusted analysis, adjuvant RT was associated with improved survival in selected subsets of patients with invasive IPMN, particularly those with T3/T4 tumors and LN involvement. (duke.edu)
  • Our study suggests that removing the prostate followed by adjuvant radiotherapy is associated with greater overall survival in men with prostate cancer. (eurekalert.org)
  • Ten-year survival for tumors of at least 3.5 cm was 56.9% versus 86.6% for those with smaller tumors (HR 2.9, 95% CI 1.4 to 5.8, p≤0.01). (bmj.com)
  • Ten-year survival for positive/suspicious cytology was 50.9% versus 77.4% (HR 2.2, 95% CI 0.9 to 5.4, p=0.09). (bmj.com)
  • Larger tumors or positive/suspicious cytology are at increased risk for relapse and worse survival, and should be considered for additional upfront adjuvant treatments, such as platinum-based chemotherapy. (bmj.com)
  • There was no difference in rates of ongoing pain for mastectomy vs. breast conserving surgery, but women who had mastectomy had a higher risk of moderate to severe pain as opposed to lighter pain. (ourbodiesourselves.org)
  • This includes patients with muscle-invasive or node-positive disease after receiving neoadjuvant chemotherapy, or those with extravesicular extension or node-positive disease who did not receive neoadjuvant chemotherapy and were ineligible for or refused adjuvant cisplatin-based chemotherapy. (nursingcenter.com)
  • Time-to-event end points are the most frequent primary end points in phase III oncology trials, both in the adjuvant and advanced settings. (medscape.com)
  • End points that assess the time from random assignment to the occurrence of clinically relevant events are widely used in oncology trials and are the most frequent primary end points in phase III trials, both in the adjuvant and the advanced settings. (medscape.com)
  • We report outcomes for women with surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I clear cell, serous, and mixed endometrial cancers following adjuvant vaginal cuff brachytherapy with or without chemotherapy. (bmj.com)
  • The primary objective was to determine the effectiveness of adjuvant vaginal cuff brachytherapy and to identify surgicopathological risk factors that could portend towards worse oncological outcomes. (bmj.com)
  • Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. (bvsalud.org)
  • A descriptive cross over study of women treated by radiotherapy at the Douala General Hospital from October 2020 to January 2021 was conducted. (bvsalud.org)
  • Adjuvant RT was administered to 31.8% (n=309) of patients. (duke.edu)
  • Paker, N., Tekdos, D., Kesiktas, N., and Soy, D. Comparison of the therapeutic efficacy of TENS versus intra-articular hyaluronic acid injection in patients with knee osteoarthritis: a prospective randomized study. (webmd.com)
  • Patients who underwent radiotherapy with 6-mo PSA response data are presented. (snmjournals.org)
  • Eighty-six patients underwent 18 F-DCFPyL-guided radiotherapy. (snmjournals.org)
  • Dr. Pinnix's ultimate aspiration is to advance the clinical outcomes of patients afflicted with Hodgkin's and Non-Hodgkin's lymphoma via the minimization of normal tissue toxicity related to radiotherapy. (mdanderson.org)
  • Three publications included patients without prior radiotherapy and the remaining eight patients with prior radiotherapy . (bvsalud.org)
  • Twenty-eight patients were identified who received SBRT after a median prior external beam radiotherapy dose of 50.4 Gy. (ku.edu)
  • Subgroup analysis demonstrated improved outcomes with the use of adjuvant chemotherapy in patients with large tumors or positive/suspicious cytology. (bmj.com)
  • Patients were not eligible to enroll if they had prior radiotherapy for RCC, or brain or bone metastatic lesions. (urologytimes.com)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
  • The SSI risk was higher after bilateral compared with unilateral mastectomy with (11.4% vs. 9.4%, p =0.001) and without (6.1% vs. 4.7%, p =0.021) immediate reconstruction. (cdc.gov)
  • When adjuvant radiation is indicated for cervical cancer, we suggest image-guided IMRT, but 3D-CRT is an acceptable alternative. (nursingcenter.com)
  • Men who received the combination of surgery and radiotherapy had higher rates of erectile dysfunction (28 percent vs 20 percent) and higher rates of urinary incontinence (49 percent vs 19 percent). (eurekalert.org)
  • Risk of Pca death was increased for men with monotherapy neo-/adjuvant bicalutamide in combination with CF-EBRT or EBRT-HDRBT. (lu.se)
  • This is probably due to a better understanding of the risk factors associated with the disease, its genomic landscape, advances in radiotherapy technology, and development of effective systemic agents. (hkmj.org)
  • Adjuvant chemotherapy is used after other treatments to shrink remaining cancer cells. (healthline.com)
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
  • The role of radiotherapy is controversial in both the adjuvant (post-operative) and definitive (unresectable localized disease) settings. (ku.edu)