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  • biology
  • They will likely prove to be a game changer in the field of stem cells biology, for regenerative medicine and for our understanding of cancer initiation. (springer.com)
  • Cell Biology International, 37 (9), 875-887. (springer.com)
  • In fact, this window is uniquely mammalian, said Amy Ralston, MSU assistant professor of biochemistry and molecular biology, and lead author on the study. (eurekalert.org)
  • Critical and cutting edge, Protocols for Adult Stem Cells is an essential guide which provides groundbreaking and novel techniques certain to redefine the field of stem cell biology. (worldcat.org)
  • Stem cell biology has been the subject of much recent discussion, but only the totipotent fertilized oocyte and blastomere cells of embryos at the 2- to 8-cell stage are capable of generating a fully viable organism. (ahajournals.org)
  • Advances in reproductive biology have immediate application, not only for the treatment of human infertility and the development of new contraceptive methods, but also for a better understanding of environmental influences on the epigenome and the developmental origins of adult disease. (grantome.com)
  • Proteins
  • The monosaccharide addition of an N -acetylglucosamine to serine and threonine residues of nuclear and cytosolic proteins ( O -GlcNAc) is a posttranslational modification emerging as a general regulator of many cellular processes, including signal transduction, cell division, and transcription. (pnas.org)
  • Here, we unambiguously identify over 60 nuclear proteins as O -GlcNAcylated, several of which are crucial for mouse ESC cell maintenance. (pnas.org)
  • In the colonic mucosa of patients with ulcerative colitis, expression of Cirp correlated significantly with the expression of TNFα, IL23/IL17, antiapoptotic proteins Bcl-2 and Bcl-xL, and stem cell markers such as Sox2, Bmi1, and Lgr5. (aacrjournals.org)
  • fetal
  • Human colon adenocarcinoma cell line HCT116 (ATCC) was maintained in McCoy's 5A Media Modified (Gibco) supplemented with 10% fetal bovine serum (Gibco). (genetics.org)
  • In addition, we are interested in how changes in the early fetal environment - for example, though the diet of the mother - may affect how stem cells may provoke or mitigate chronic diseases such as arthrit is in later life. (southampton.ac.uk)
  • Wilmut I, Schnieke AE, Mcwhir J et al (2007) Viable offspring derived from fetal and adult mammalian cells. (springer.com)
  • regenerate
  • Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs. (springer.com)
  • Our future goal after these two-year pilot studies is to inject the human and mouse SSC-derived neuro-retinal progenitor cells into the retina of a mouse model of retinal degeneration and to analyze the capacity of these cells to regenerate and repopulate the retina. (labome.ru)
  • ASCs have been employed in clinical trials 1 , 2 , and hPSCs have been used extensively to regenerate injured mammalian hearts, including a recent report of non-human primates 3 . (pubmedcentralcanada.ca)
  • Peripheral nerves can regenerate to some extent and this ability is mainly attributable to intrinsic growth capacity of peripheral neurons and the ability of Schwann cells to provide a supportive growth environment [ 8 ]. (hindawi.com)
  • autologous
  • 2017). Vision loss after intravitreal injection of autologous "stem cells" for AMD. (springer.com)
  • Autologous cell therapy - A therapy using cells derived from a patient's own body. (perfusecell.com)
  • This approach is of paramount importance since human testicular biopsies may allow the cell-based, autologous organ therapy without the ethical and immunological problems associated with human embryonic stem cells, in the absence of genetic modification and retroviral infection. (labome.ru)
  • This offers a Schwann cell-rich autologous material to bridge the interstump gap and serves to guide regenerating axons. (hindawi.com)
  • Until now, autologous skin grafting remains a Development of cell therapy for burn wound healing standard practice in treating severe burns. (deepdyve.com)
  • However, its Cell therapy which also called cellular therapy or effectiveness is often challenged in treating severe burn cytotherapy involves delivering an autologous or allo- patients with limited donor sites for skin graft harvest- genic cellular component into a patient to repair or re- ing. (deepdyve.com)
  • tives for autologous skin grafts including allogeneic skin, Skin as the multi-functional and protective barrier in xenografts and synthetic skin substitutes have been widely human contains essential stem cell population and vari- adopted in burn wound care [3, (deepdyve.com)
  • germ
  • We have successfully isolated and cultured the adult human spermatogonial stem cells for the first time and under defined culture conditions, we have reprogrammed the SSCs to pluripotent stem cells capable of differentiating into all three germ layers. (labome.ru)
  • We have reprogrammed the SSCs to pluripotent stem cells capable of differentiating into all three germ layers. (labome.ru)
  • In metazoan, all cell types, with the exception of mature germ cells, contain the same genetic information within the species. (stembook.org)
  • Embryos
  • Hence could replace the use of embryonic stem cells (ESC), and may overcome the various ethical issues regarding the use of embryos in research and clinics. (frontiersin.org)
  • The cells of mammalian embryos get to make a different first choice - to become the protective placenta or to commit to forming the baby. (eurekalert.org)
  • Second, they are created by embryos during this crucial four-day window of a mammalian pregnancy. (eurekalert.org)
  • Embryos make pluripotent stem cells with 100 percent efficiency," she said. (eurekalert.org)
  • However, the use of ES cells requires the destruction of the embryos and creates ethical issues and concerns. (labome.ru)
  • They are collected from the inner cell mass of embryos in the blastocyst or morula stage of development. (blogspot.com)
  • Unfortunately, stem cells can't be extracted from embryos without destroying the latter. (blogspot.com)
  • Many scientists question why the destruction of embryos during the extraction of stem cells draws such vociferous protests when fertility clinics routinely dispose of extra embryos as medical waste. (blogspot.com)
  • Moreover, stem cells, pluripotent cells, gametes and early embryos provide important models for basic research aimed at understanding epigenetics, the developmental origins of adult disease, environmental perturbation of the epigenome, nuclear programming and cell cycle regulation, as well as transcriptional, translational, and post-translational control mechanisms. (grantome.com)
  • populations
  • Stem cell therapy for SCI is based on a strategy to treat the injuries and to restore lost functions by replacing lost or damaged cell populations [ 3 ]. (hindawi.com)
  • Defective apoptosis of inflammatory cell populations seems to be a relevant pathogenetic mechanism in refractory IBD. (aacrjournals.org)
  • loss of the progenitor cell populations that are essential for regenerating and restoring the structures and func- Review tions . (deepdyve.com)
  • gene
  • Consequently, considerable effort has been expended to understand the gene expression networks that control cell division, differentiation, and migration. (genetics.org)
  • Simply put, this gene could determine the source of stem cells in mammals. (eurekalert.org)
  • In fact, Sox2 may be the pre-pluripotent gene. (eurekalert.org)
  • The gene appears to help coordinate the cells that make the fetus and the other cells that establish the pregnancy and nurture the fetus. (eurekalert.org)
  • Here we examine the differences between these two cell-types by sequencing their RNA contents and subsequently reconstructing and comparing their gene expression profiles. (pubmedcentralcanada.ca)
  • We have therefore identified, for the first time, distinct gene expression dynamics during erythroblast differentiation from hiPSCs which may cause reduced proliferation and enucleation of hiPSC-derived erythroid cells. (biomedcentral.com)
  • ES cells provide a unique system for the genetic manipulation and the creation of knockout strains of mice through gene targeting. (ahajournals.org)
  • For instance, a subpopulation of germinal cells express a gene called nanos-2 , which is involved in regulating gamete production across multiple taxa. (elifesciences.org)
  • This review examines the role of key transcription factors in various stem cell types, and emphasizes on their control of downstream gene expression, which ultimately contributes to cellular function. (stembook.org)
  • Other components of the post-transcription machinery are also involved in augmenting the overall levels of gene transcripts in the cell. (stembook.org)
  • We have demonstrated that pluripotent stem cells can be directly gene. (bio-medicine.org)
  • gametogenesis
  • Here we provide evidence that MYST4, a known HAT, may be involved in early mammalian gametogenesis. (biomedcentral.com)
  • This application requests partial funding for the 18th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 21-26, 2011 at Waterville Valley Resort in Waterville Valley New Hampshire. (grantome.com)
  • The objective of the Gordon Conference on Mammalian Gametogenesis and Embryogenesis is to provide a forum for the exchange of the latest advances in the field, as well as to promote discussion and debate by providing a relaxed setting that fosters interaction. (grantome.com)
  • MSCs
  • In this review, we provide an overview of different types of MSCs that have been isolated and characterized from several origins such as dental pulp, exfoliated deciduous teeth, the periodontal ligament, the dental follicle, the dental papilla, oral mucosa, and gingiva, with the focus on the potential clinical applications for each type of dental stem cell. (springer.com)
  • Besides the mechanisms underlying the trophic, anti-inflammatory, and immunomodulatory effects, another important action of MSCs that has been debated over the past decade is the broad spectrum of differentiation beyond the boundaries of tissue stem cells. (mdpi.com)
  • progenitor cell
  • 1 As development proceeds and a stem cell becomes committed to a specific lineage or decreases its proliferative potential, it is usually described as a progenitor cell. (ahajournals.org)
  • 4. The method of claim 1 , wherein the device comprises a plurality of welds for maximizing surface area to volume ratio of the human PDX1-positive pancreatic progenitor cell population in the device. (google.es)
  • 12. The method of claim 1 , wherein providing a human PDX1-positive pancreatic progenitor cell population comprises thawing a cell population. (google.es)
  • 13. The method of claim 1 , wherein providing a human PDX 1-positive pancreatic progenitor cell population further comprises enriching the cell population for PDX1/NKX6.1 co-positive pancreatic progenitor cells. (google.es)
  • 14. The method of claim 1 , wherein providing a human PDX1-positive pancreatic progenitor cell population further comprises enriching the cell population for PDX1/NKX6.1 co-positive pancreatic progenitor cell by contacting the cell population with an antibody that binds to CD142 antigen and enriching for said CD142 binding cells. (google.es)
  • lineage
  • IL23 has been shown to promote the expansion of a distinct lineage of T H 17 cells that are characterized by production of a number of specific cytokines not produced by T H 1 or T H 2 cells, including IL17A, IL17F, IL21, and IL22 ( 5 ). (aacrjournals.org)
  • bone
  • Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population? (springer.com)
  • Discovery of self-renewal by any living cell was one of the major breakthrough reported by Till and McCulloch (1961) who while subjecting the mice with lethal doses of radiation followed by injection of bone marrow cells found that these cells formed clumps due to cells cloned from them which was the main reason of survival of the mice ( Till and McCulloch, 1961 ). (frontiersin.org)
  • A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors. (springer.com)
  • mammals
  • O -GlcNAcylation of the mammalian Ph homolog, PHL3, and a second mammalian PcG protein homolog, YY1, extends the relationship between OGT and PcG to mammals ( 19 - 21 ). (pnas.org)
  • clinical
  • Sources of dental stem cells and their multilineage differentiation capability and potential clinical applications for regenerative and immunomodulatory therapy. (springer.com)
  • Recent clinical trials have confirmed the safety of stem cell delivery to the heart with promising but variable results. (pubmedcentralcanada.ca)
  • We also discuss some of the biological, practical, ethical, and commercial considerations in using these different stem cells for future clinical application. (hindawi.com)
  • More evidence from large, randomly controlled trials is also needed to understand the clinical impact of cell therapy in burns. (deepdyve.com)
  • types
  • The differentiation of cells into distinct cell types, each of which is heritable for many generations, underlies many biological phenomena. (pubmedcentralcanada.ca)
  • White and opaque cells of the fungal pathogen Candida albicans are two such heritable cell types, each thought to be adapted to unique niches within their human host. (pubmedcentralcanada.ca)
  • Using the new annotation, we compared differences in transcript abundance between the two cell types with the genomic regions bound by a master regulator of the white-opaque switch (Wor1). (pubmedcentralcanada.ca)
  • We also find that 5′ and 3′ UTRs of mRNAs in the circuit are unusually long and that 5′ UTRs often differ in length between cell-types, suggesting UTRs encode important regulatory information and that use of alternative promoters is widespread. (pubmedcentralcanada.ca)
  • Likewise there has also been increased interest in the use of pluripotent stem cells capable of differentiating into multiple cell types. (hindawi.com)
  • They can be classified into two types: adult stem cells and embryonic stem cells. (blogspot.com)
  • This review discusses our current understanding of mammalian nephrogenesis: the contributing cell types and the regulatory processes at play. (ca.gov)
  • In this review, we discuss the different stem cell types that are showing promise for nervous system tissue engineering in the context of peripheral nerve injury. (hindawi.com)
  • organism
  • The ability to chronicle transcription-factor binding events throughout the development of an organism would facilitate mapping of transcriptional networks that control cell-fate decisions. (genetics.org)
  • Adherent - micro-organism with affinity to anchor, adhered onto a surface, such as immobilised cells or stem cells or micro-organisms in general adhering to a surface. (perfusecell.com)
  • Bacteria - robust micro-organism with strong cell wall, fast growing with often 20 minute doubling time, high oxygen demand, product are often intracellular, limited in ability to produce molecules larger than 50 kDa, can not produce fully humanized antibodies. (perfusecell.com)