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  • tissue
  • The compilation of contributions is unique as there is yet no similar comprehensive overview combining stem cell research with preclinical and clinical evaluation as well as engineering of tissue patches for transplantation. (springer.com)
  • self-renewal
  • Epigenetic regulators, including histone deacetylases (HDACs), have been shown to coordinate with cell-intrinsic transcription factors and various signaling pathways to regulate stem cell pluripotency, self-renewal, and fate determination. (hindawi.com)
  • Epigenetic control, including histone modification, has been shown to play an important role in regulating both stem cell self-renewal and pluripotency [ 2 - 5 ]. (hindawi.com)
  • colonies
  • This protocol is designed to passage stem cell colonies cultured in a 6 cm dish, using EDTA Dissociation Reagent to detach the cell colonies. (atcc.org)
  • state
  • I conclude that in the current state of knowledge, stem cell research needs to continue and be allowed to unfold as the narrative of a story. (jhu.edu)
  • research
  • There is hardly an area of research developing so quickly and raising so many promises as stem cell research. (springer.com)
  • To facilitate research on differentiated cell types and other biomedical investigations, the Aging Cell Repository offers human induced pluripotent stem cell (hiPSC) lines. (coriell.org)
  • Validating cell line quality is critical to stem cell research. (thermofisher.com)
  • Human stem cell research is a new field with much promise, but progress towards a clinical setting has been complicated by scientific and ethical challenges. (jhu.edu)
  • I argue that a new approach is needed to deal with the serious uncertainties and indeterminate probabilities intrinsic to stem cell research and decision-making surrounding it. (jhu.edu)
  • lines
  • These advances in reprogramming will enable the creation of patient-specific stem cell lines to study various disease mechanisms. (hindawi.com)