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  • 2016
  • In a study published in the Blood for January 2016, the effects of donor characteristics on survival were compared in 10,000 unrelated donor transplantations for hematologic malignancies. (cryo-cell.com)
  • SAN DIEGO, Oct. 05, 2016 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ:FATE), a biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer and immune disorders, announced today that the U.S. Patent and Trademark Office issued U.S. Patent No. 9,452,186 covering enhanced hematopoietic stem cell compositions. (cnbc.com)
  • In 2016, STEMCELL was awarded overall Exporter of the Year, as well as won in the Advancing Technology & Innovation category, while Dr. Eaves won in the Leadership category at the BC Export Awards. (wikipedia.org)
  • therapies
  • We believe this approach, which is backed by our extensive intellectual property, is broadly applicable to the development of hematopoietic cell therapies with novel biological properties and enhanced therapeutic functionality. (cnbc.com)
  • Furthermore, the large experimental matrix generated by testing different cell types cultured with different survival and integration molecules, creates a barrier to the rapid development of candidate therapies. (pnas.org)
  • Adult stem cell-based regenerative therapies are evolving as viable clinical alternatives. (kjim.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • This self-regeneration capacity gives rise to alternatives to classical cellular therapies whereby administration of growth factors such as Thymosin β4 for cell activation and migration are solely necessary. (wikipedia.org)
  • vitro
  • The glycoengineered cells exhibited enhanced tethering and rolling interactions on E-selectin-bearing endothelium under flow conditions in vitro as well as increased BM trafficking and extravasation when transplanted into mice. (jci.org)
  • As a member of the clinical (Director Bayard Clarkson) and laboratory teams (Director Malcolm A.S. Moore), he carried out a systematic analysis of all patients with acute myeloid leukemia (AML) treated at MSKCC, defining the prognostic and predictive parameters of cell cytology, cell growth in vitro and enzymatic markers. (wikipedia.org)
  • These properties can be illustrated with relative ease in vitro, using methods such as clonogenic assays, where the progeny of a single cell is characterized. (wikipedia.org)
  • It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
  • Attempts to create organs in vitro started with one of the first dissociation-reaggregation experiment where Henry Van Peters Wilson demonstrated that mechanically dissociated sponge cells can reaggregate and self-organize to generate a whole organism. (wikipedia.org)
  • In 2009 the Laboratory of Hans Clevers at Hubrecht Institute and University Medical Center Utrecht, The Netherlands showed that single LGR5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. (wikipedia.org)
  • Examples of such cells are CFUs (Colony-forming units - referred to as such because of their ability to form colonies in vitro in artificial media) such as CFU-T. In mice, transplantation of a single pHSC cell can reconstitute a sub-lethally irradiated host (i.e. a mouse that has been irradiated so that all leukocytes are killed) with all these lineages of cells, including all types of lymphocytes via CLPs. (wikipedia.org)
  • self-renewal
  • Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal. (wikipedia.org)
  • This self-renewal demands control of cell cycle as well as upkeep of multipotency or pluripotency, which all depends on the stem cell. (wikipedia.org)
  • The classical definition of a stem cell requires that it possesses two properties: Self-renewal: the ability to go through numerous cycles of cell division while maintaining the undifferentiated state. (wikipedia.org)
  • Symmetric division gives rise to two identical daughter cells, both endowed with stem cell properties, whereas asymmetric division produces only one stem cell and a progenitor cell with limited self-renewal potential. (wikipedia.org)
  • therapeutic
  • Transfusion experts, manufactures of Human Platelet Lysate, scientist who are investigating its therapeutic and cell culture potential, as well as regulators have met and discussed the latest updates in the field. (isbtweb.org)
  • Importantly, these newly patented compositions and methods are independent of the specific modulators used to enhance the cells' biological properties and therapeutic function. (cnbc.com)
  • With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. (mdpi.com)
  • The immunological barriers, such as graft vs . host or required immunosuppression of the host, are of constant consideration in the therapeutic benefits and limitations of stem cell transplantation. (mdpi.com)
  • Nevertheless, these cells are being investigated as the basis for a number of therapeutic applications, including possible treatments for diabetes and Parkinson's disease. (wikipedia.org)
  • This includes cells that naturally secrete the relevant therapeutic factors, or which undergo epigenetic changes or genetic engineering that causes the cells to release large quantities of a specific molecule. (wikipedia.org)
  • There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell plasticity. (wikipedia.org)
  • It is therefore highly hypothetical that cord blood cells kept for autologous use will be of any value in the future" and "the legitimacy of commercial cord blood banks for autologous use should be questioned as they sell a service which has presently no real use regarding therapeutic options. (wikipedia.org)
  • Cord
  • Several factors are believed to inhibit the proper functioning of stem cells as the donor ages, making the young stem cells in cord blood a beneficial source when HLA-matching is equal. (cryo-cell.com)
  • Cord blood stem cells have not been exposed to factors that inhibit proper function as with older stem cells from other sources. (cryo-cell.com)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • However MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
  • The policy of the American Academy of Pediatrics states that "private storage of cord blood as 'biological insurance' is unwise" unless there is a family member with a current or potential need to undergo a stem cell transplantation. (wikipedia.org)
  • The American Society for Blood and Marrow Transplantation and the American Congress of Obstetricians and Gynecologists also encourage public cord banking and discourage private cord blood banking. (wikipedia.org)
  • This is why cord blood cells are currently used to treat blood and immune system related genetic diseases, cancers, and blood disorders. (wikipedia.org)
  • An adequate cord blood collection requires at least 75mL in order to ensure that there will be enough cells to be used for a transplantation. (wikipedia.org)
  • blood vessels
  • In 1917, Florence Sabin first observer of blood vessels and red blood cells in the yolk sac of chick embryos occur in close proximity and time. (wikipedia.org)
  • clinical
  • ProTmune™ is an investigational programmed cellular immunotherapy undergoing clinical development for the prevention of acute graft-versus-host disease and cytomegalovirus infection in patients undergoing allogeneic hematopoietic cell transplantation. (cnbc.com)
  • This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential. (mdpi.com)
  • Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Hematology
  • Allen C. Eaves (born 1941) was the founding Director of the Terry Fox Laboratory for Hematology/Oncology Research, which over a 25 year period (1981-2006) he grew into an internationally recognized[citation needed] centre for the study of leukemia and stem cell research. (wikipedia.org)
  • At Freiburg University Medical Center he became the director of the Department for Medicine I, Oncology, Hematology and Stem Cell Transplantation. (wikipedia.org)
  • isolate
  • Additionally, it now appears possible to identify and isolate specific ESC-derived cardiac progenitors (ESC-CPs) ( 9 - 11 ), opening the possibility of using progenitor cells for cardiac cell therapy, as has been explored using pancreatic endoderm progenitors for the generation of insulin responsive islet-like cells ( 12 , 13 ). (pnas.org)
  • It should also be possible to isolate stem cells from the transplanted individual, which can themselves be transplanted into another individual without HSCs, demonstrating that the stem cell was able to self-renew. (wikipedia.org)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • MSCs
  • MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. (wikipedia.org)
  • citation needed] Bone marrow was the original source of MSCs, and still is the most frequently utilized. (wikipedia.org)
  • Australian company Cynata claims the ability to mass-produce MSCs from induced pluripotent stem cells obtained from blood cells. (wikipedia.org)
  • Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (wikipedia.org)
  • Originally it was proposed that the MSCs were discarded from the embryo at the end of their life cycle but since the cells remained viable in the amniotic fluid and were able to proliferate in culture this hypothesis was overturned. (wikipedia.org)
  • Comparison of amniotic fluid-derived MSCs to bone-marrow-derived ones showed that the former has a higher expansion potential in culture. (wikipedia.org)
  • patients
  • This study is being done to test if it is safe to give stem cells to adult patients with Cystic Fibrosis (CF). The kind of stem cells we are studying are called allogeneic human mesenchyma. (bioportfolio.com)
  • The Company's hematopoietic cell therapy pipeline is comprised of NK- and T-cell immuno-oncology programs, including off-the-shelf product candidates derived from engineered induced pluripotent cells, and immuno-regulatory programs, including product candidates to prevent life-threatening complications in patients undergoing hematopoietic cell transplantation and to promote immune tolerance in patients with autoimmune disease. (cnbc.com)
  • Allogeneic hematopoietic cell transplantation is frequently used to treat malignant and non-malignant conditions, and many patients lack a human leukocyte antigen (HLA) matched related or unrelated donor. (bioportfolio.com)
  • A total of nine decompensated cirrhotic patients were randomized into three groups: group 1 (n = 3) was control group, group 2 (n = 3) received granulocyte-colony stimulating factor (G-CSF) mobilization for 3 days, and group 3 (n = 3) received G-CSF mobilized PBMCs by leukapheresis and PBMC transplantation through ultrasound-guided percutaneous portal vein puncture. (kjim.org)
  • Autologous PBMC transplantation through ultrasound-guided percutaneous portal vein puncture could be considered as a safe alternative treatment for decompensated cirrhotic patients. (kjim.org)
  • A human study of IL-7 in patients with cancer demonstrated that administration of this cytokine can transiently disrupt the homeostasis of both CD8+ and CD4+ T cells with a commensurate decrease in the percentage of CD4+CD25+Foxp3+ T regulatory cells. (wikipedia.org)
  • This technique has also been proposed as an alternative source of human organs for future transplantation into human patients. (wikipedia.org)