Embryonic stem cells (ESCs) and adult stem cells, are undifferentiated cells which when they divide have the potential to either remain a stem cell or to differentiate into other specialized cells. (wikipedia.org)
Here, we used induced pluripotent stem cell (iPSC) technology and established a 3-dimensional, organoid-like differentiation system (hemanoid) maintaining the structural cellular integrity to evaluate the effect of cytokines on embryonic hematopoietic development. (haematologica.org)
In the current review, we recapitulate the most updated evidence for such a view and summarize our recent findings indicating that magnetic energy and sound vibration can deeply impact onto a coordinated program of gene expression and signaling networks remarkably enhancing the expression of multipotency in embryonic and human adult stem cells, and counteracting stem cell aging and loss of differentiating potential due to geroconversion. (cellr4.org)
We will also report on the possibility of using a magnetic energy to reprogram human adult non-stem somatic cells to an embryonic-like pluripotent state, ensuing into lineages in which these cells would never otherwise appear, including cardiac, neural and skeletal muscle cells. (cellr4.org)
Our data provide a significant advance in the understanding of fetal thymic epithelial development and thus have implications for thymus-related clinical research, in particular research focussed on generating TEC from pluripotent stem cells. (bvsalud.org)
Furthermore, pluripotent stem cell-derived and ex vivo expanded respiratory progenitors offer novel, tractable, high-fidelity systems that allow for mechanistic studies of cell fate decisions and developmental processes. (bvsalud.org)
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells. (amedeo.com)
Indeed, Tbx3 binds highly conserved T-elements to activate the promoters of Eomes, T, Sox17 and Gata6, which are factors essential for mesoderm differentiation and extra embryonic endodermal. (wikipedia.org)
Use of mouse genetic models, including lineage tracing and loss-of-function studies, has elucidated signaling pathways that guide proliferation and differentiation of embryonic lung progenitors as well as transcription factors that underlie lung progenitor identity. (bvsalud.org)
Progenitor3
We identified KDR+/CD34high/CD144+/CD43-/CD45- hemato-endothelial progenitor cells (HEPs) forming organized, vasculature-like structures and giving rise to CD34low/CD144-/CD43+/CD45+ hematopoietic progenitor cells. (haematologica.org)
Current models suggest that within the thymic primordium most TEC exist in a bipotent/common thymic epithelial progenitor cell (TEPC) state able to generate both cTEC and mTEC, at least until embryonic day 12.5 (E12.5) in the mouse. (bvsalud.org)
As our understanding of embryonic progenitor biology deepens, we move closer to the goal of in vitro lung organogenesis and resulting applications in developmental biology and medicine. (bvsalud.org)
Tissue-specific1
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. (bvsalud.org)
Development2
We hypothesized that a high fat diet in non-human primates would induce changes in hepatic chromatin structure resulting in altered expression of fetal genes critical to the development of childhood and adult obesity. (nih.gov)
1 While embryonic macrophages and nucleated red blood cells are generated early in development in the first wave of primitive hematopoiesis, lymphoid cells, definitive erythro-myeloid progenitors and long-term repopulating HSC are only generated at later stages by the definitive hematopoietic program. (haematologica.org)
Human1
The early developmental phase is of critical importance for human health and disease later in life. (mdpi.com)
Show1
Tbx3 null embryos show defects in, among other structures, the heart, mammary glands and limbs and they die in utero by embryonic day E16.5, most likely due to yolk sac and heart defects. (wikipedia.org)