• These factors cause the upregulation of many genes involved in cell proliferation, differentiation, migration and apoptosis (programmed cell death), causing the growth of benign tumors. (wikipedia.org)
  • miR122 is the prevalent miRNA in adult healthy liver and it is responsible for liver stem cell differentiation towards hepatocyte lineage. (oncotarget.com)
  • HCC stem-like cells can be directed towards cell differentiation and tumor dormancy by restoring miR122 expression. (oncotarget.com)
  • In this study, we focused on genes of sphingolipid metabolism and investigated their roles in PrS formation using an in vitro mouse ES cell differentiation system. (bvsalud.org)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. (urat1inhibitor.com)
  • The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. (caister.com)
  • Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
  • This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
  • These cells are the original precursors of various cells in a tumor, whereas other intratumoral cells are limited in terms of their potential for proliferation and pluripotent differentiation. (biomedcentral.com)
  • In addition, normal adult stem cells (ASCs) self-renew, proliferate infinitely, have a multidirectional differentiation potential, similar to that of tumor cells, and can transform more easily into tumor stem cells than non-stem cells [ 20 , 21 ]. (biomedcentral.com)
  • Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
  • The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)
  • Using computational predictions, we revealed that HPV-positive cervical cancers are regulated by transcription factors including, SOX2, E2F, NANOG, OCT4, and MYC, which control various processes such as the renewal of cancer stem cells, and the proliferation and differentiation of tumour cells. (fortuneonline.org)
  • In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
  • It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. (novusbio.com)
  • Disease models for GERD, BE, GVHD, and ulcerative colitis based on three-dimensional human cell and tissue culture systems that recapitulate in vivo growth and differentiation in inflammatory-associated microphysiological environments would enhance our understanding of disease progression and improve our ability to test for disease-prevention strategies. (biomedcentral.com)
  • Differentiation and integration of grafted cells in the host tissue were validated with immunofluorescence staining using human-specific antibodies. (biomedcentral.com)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow hematopoietic stem cells, which can manifest as an increased number of functionally normal platelets, red blood cells (RBCs). (msdmanuals.com)
  • Primary myelofibrosis results from neoplastic transformation of a pluripotent hematopoietic stem cell. (msdmanuals.com)
  • Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
  • As an extension of the phenomenon observed in hematopoietic stem cells giving rise to colonies within the spleen, commonly referred to as "colony-forming units in spleen (CFU-s)", we hypothesize that "colony-forming units in liver (CFU-L)" serves as a reliable indicator of stemness, engraftment, and functionality of hepatocytes. (bvsalud.org)
  • We, therefore, propose that CFU-L can be used to quantify the number of "hepatocytes that engraft and proliferate in vivo" as a quantitative assay for stem cells that utilize colony-forming ability, similar to that observed in hematopoietic stem cells. (bvsalud.org)
  • Krzysztof Szade (PhD) together with Andy Reinisch from the Medical University of Graz were awarded the Mozart grant for their joint project Identifying the hematopoietic and leukemic stem cell niches. (edu.pl)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
  • In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
  • Leukocytic, hematopoietic cells are important in maintaining the body's defense against disease. (justia.com)
  • Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
  • The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
  • In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
  • Restitution of miR122 in BCLC9 cells, decreases cell proliferation rate and reduces significantly tumor size in vivo . (oncotarget.com)
  • Treatment of miR122 positive cells with an inhibitor of TGFBR1 activation, abolished tumor dormancy program and recovered cell proliferation rate through a Smad-independent TGF-β response. (oncotarget.com)
  • Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
  • decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
  • It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
  • HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • chronic myeloid leukemia (cml) is characterized by increased and unregulated proliferation of granulocytic lineage in the bone marrow and presence of these immature myeloid cells in the peripheral blood with presence of philadelphia (ph) chromosome. (liverpool.ac.uk)
  • Immune cells can potentiate oxidative stress, and fibroblasts have the capacity to contribute to advanced growth and proliferation of the epithelium and any resultant cancers. (biomedcentral.com)
  • The T cells also effectively terminate their activation and proliferation as a means of avoiding autoimmunity, resulting in different phenotypes that either further activate Th1 immune responses or suppress via Th2-driven responses. (encyclopedia.pub)
  • PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)
  • Topological manage of p21WAF1/CIP1 expression in normal and neoplastic tissues. (urat1inhibitor.com)
  • From early techniques that measured overall DNA methylation levels to enzyme-associated techniques that interrogated methylation at a single CpG dinucleotide to present day assays that catalogue the methylation of every cytosine in the genome, technical advancement progressively has brought increasing clarity to our understanding of the complex epigenomes of normal and neoplastic cells. (esmed.org)
  • It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
  • A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
  • The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
  • The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
  • ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
  • Inflammation initiated by an immune response targets epithelial cells, leading to cytotoxic effects, and is a key driver of several disease conditions in the gastrointestinal (GI) tract [ 1 ]. (biomedcentral.com)
  • Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and epithelial ovarian cancer (EOC). (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • The development of the inflammatory process is regulated by specialized endothelial cells that control the recruitment of leukocytes from the blood into the lymphoid tissues. (edu.pl)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
  • Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
  • Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
  • Improved models based on human cells and tissues are urgently needed to understand pathogenesis as well as to explore novel therapeutic strategies. (biomedcentral.com)
  • Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)
  • Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1. (ox.ac.uk)
  • Over the past 10 years we have been witness to an explosion of investigation into the epigenetic basis of cancer, and application of the powerful genome-wide DNA methylation profiling techniques to be reviewed have yielded critical insights into the organization of the cancer methylome with its broad regions of hypomethylation and foci of hypermethylation resulting in critical differences in gene expression and chromosomal stability compared to normal cells. (esmed.org)
  • Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
  • Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation. (stanford.edu)
  • Benign tumors have relatively well differentiated cells. (wikipedia.org)
  • According to the hypothesis, only a small group of stem cell-like tumor cells can form new tumors. (biomedcentral.com)
  • This leads to the activation of genes and the production of proteins that increase cell growth. (wikipedia.org)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • It was reported that a human being protein comprising five WD40 repeat domains can stabilize ORC binding to chromatin by interacting with ORC and modulating the chromatin association of ORC in human being cells [12], suggesting that WD40 repeat proteins play important roles in human being DNA replication. (irjs.info)
  • BCLC9-miR122 cells down-regulate expression of MYC, KLF4, FOXM1, AKT2 and AKT3 genes and up-regulate FOXO1 and FOXO3A gene expression. (oncotarget.com)
  • These insights, in turn, have prompted novel, testable hypotheses, to be discussed, pertaining to fundamental aspects of cancer biology including the potential stem cell/progenitor cell origins of cancer and the plasticity of gene expression that may underlie tumor heterogeneity and tumor progression. (esmed.org)
  • The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • Infiltrating immune cells and stromal components of tissue including fibroblasts contribute to dynamic changes occurring in tissue related to disease development. (biomedcentral.com)
  • Cancer cells also recruit and alter nearby stromal cells to aid the tumour cells in avoiding immune detection and destruction [ 16 ] [ 17 ] . (encyclopedia.pub)
  • A benign tumor is a mass of cells (tumor) that does not invade neighboring tissue or metastasize (spread throughout the body). (wikipedia.org)
  • However, obtaining primary neuronal cells from adult tissue is difficult and faces major ethical issues in clinical practice. (hindawi.com)
  • Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • Errors arising in stem and progenitor cells have a much greater influence on the tissue in which they are found than errors arising in postmitotic differentiated cells. (biomedcentral.com)
  • Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. (lookformedical.com)
  • Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)
  • Treatment is often supportive, but Janus kinase 2 ( JAK2 ) inhibitors, such as ruxolitinib , fedratinib , pacritnib, or momelotinib may decrease symptoms, and stem cell transplantation may be curative. (msdmanuals.com)
  • Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
  • this limitation has been overcome via ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, to produce large quantities of these cells as an attractive source for cellular transplantation [ 16 - 18 ]. (hindawi.com)
  • This protein activates two transcription factors: T-cell factor (TCF) and lymphoid enhancer factor (LEF). (wikipedia.org)
  • Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
  • As cells undergo oncogenesis, neoantigens are released and captured on major histocompatibility complex (MHC)/ human leukocyte antigen (HLA) of dendritic cells (DCs) that subsequently mature and migrate to central lymphoid organs. (encyclopedia.pub)
  • Few areas showed islands and sheets of epidermoid cells, intermediate cells with minimal cellular atypia, and few mitotic figures. (bvsalud.org)
  • Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
  • while this machinery was originally identified by its ability to allow cells to survive starvation via lysosomal degradation to recycle cellular components, it has recently become apparent that it also is used by cells to secrete cytoplasmic constituents. (liverpool.ac.uk)
  • We applied functional pathway analysis to show that HPV-positive cancers are characterised by perturbations of numerous cellular processes, predominantly in those linked to the cell cycle, mitosis, cytokine and immune cell signalling. (fortuneonline.org)
  • Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
  • Unlike normal cells, cancer cells reprogram cellular energetics as a result of oncogenic transformations [ 4 ]. (biomedcentral.com)
  • and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
  • These cells secrete immune inhibitory growth factors and cytokines, including vascular endothelial growth factor (VEGF), which is primarily produced by microglia, myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs). (encyclopedia.pub)
  • TREM2 - triggering receptors expressed on myeloid cells 2. (actanaturae.ru)
  • The neoplastic transformation of cells and inflammation are processes that contribute to tumor initiation. (ox.ac.uk)
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
  • We reported that silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, as cell viability was increased and apoptosis rate was decreased. (molcells.org)
  • Furthermore, the ability of Myc HLH/LZ mutants to bind DNA and activate transcription in collaboration with Max correlates closely with their neoplastic transforming activity in higher eukaryotic cells. (ox.ac.uk)
  • Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. (hindawi.com)
  • Mitochondria are the energy producing organelles in eukaryotic cell providing ATP through oxidative phosphorylation (OXPHOS). (hindawi.com)
  • The course and physiological effects of the interaction of leukocytes with vascular wall cells have been studied for years and relatively well understood. (edu.pl)
  • Butcher: A molecular map of murine lymph node blood vascular endothelium at single cell resolution Nat Commun 2020 Jul 30;11:3798. (edu.pl)
  • Understand the evaluation algorithms and evidence-based treatment options for vascular, neurodegenerative and neoplastic disorders. (barrowneuro.org)
  • The establishment of ERα + luminal breast cancer cell lines has turned out to be a challenging task for reasons not entirely clear. (nature.com)
  • Studies on the transcriptomic profiles of the clonal luminal breast cancer cell lines suggest that these cell lines do not recapitulate well the established luminal tumor subtype 7 . (nature.com)
  • Therefore, widespread use of few ERα + luminal cell lines generate an information bias towards the specific clonal genetic makeup of these cell lines and their other attributes, which may not possibly apply to luminal ERα + breast cancer in general. (nature.com)
  • The primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to produce excessive collagen. (msdmanuals.com)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • Exceptions to this rule may indicate malignant transformation. (wikipedia.org)
  • In this study, we investigated the effect of the BET inhibitor JQ-1 on malignant transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 P+ cells. (ox.ac.uk)
  • Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? (biomedcentral.com)
  • Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. (biomedcentral.com)
  • Moreover, malignant transformation cannot be accurately predicted in individual patients using either technique [ 6 , 7 ]. (biomedcentral.com)
  • The ERα + phenotype is not stable in cultured cells for reasons not fully understood. (nature.com)
  • About 80% of all newly diagnosed breast cancers have luminal cell phenotype and they express estrogen receptor (ERα). (nature.com)
  • 2012. "Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. (esmed.org)
  • This immunosuppressive helper T cell phenotype can be further induced by the zinc-finger transcription factor GATA3, which regulates Th2 cytokine expression [ 9 ] . (encyclopedia.pub)
  • Also, melanomas frequently show a spindled cell phenotype when they involve this area. (basicmedicalkey.com)
  • Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)
  • Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
  • In this category of experimentation, besides the use of locally delivered trophic factors (such as brain-derived neurotrophic factor (BDNF)-, glial cell line-derived neurotrophic factor (GDNF)-, and fibroblast growth factor (FGF)-peptides or growth factors-gene-encoding vectors) [ 8 ], regionally grafted fetal or embryonic stem cell-derived neuronal precursors are frequently used [ 9 - 18 ]. (biomedcentral.com)
  • We studied the effects of restoring miR122 expression in a distinctive cell line derived from human HCC-BCLC9 cells-with a solid stem-like cell profile, high tumor initiating ability and undetectable miR122 expression. (oncotarget.com)
  • We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
  • Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
  • Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
  • 34. Saito S, Sawai K, Murayama Y, Fukuda K, Yokoyama K. Nuclear transfer to study the nuclear reprogramming of human stem cells. (urat1inhibitor.com)
  • Human amnion-derived cells as a reputable supply of stem cells. (urat1inhibitor.com)
  • lymphoblastoid cell lines (lcls) transformed by epstein-barr virus (ebv) serve as an unlimited resource of human genomic dna. (liverpool.ac.uk)
  • 2006. "let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. (esmed.org)
  • Here we display that hIPI3 also has important functions in the initiation of DNA replication TMC353121 in human being cells. (irjs.info)
  • The development of physiologically relevant, human cell-based culture systems is therefore a major focus of our research. (biomedcentral.com)
  • In summary, this work to develop advanced human cell-based models of inflammatory conditions will greatly improve our ability to study, prevent, and treat GERD, BE, GVHD, and inflammatory bowel disease. (biomedcentral.com)
  • Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. (biomedcentral.com)
  • Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. (biomedcentral.com)
  • Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
  • Generation of induced pluripotent stem cells from bovine embryonic fibroblast cells. (urat1inhibitor.com)
  • Materials and Methods Mammalian cell tradition and harvest HeLa, HEK 293T and A549 cells [13, 14] were cultured in Dulbeccos Modified Eagles Medium (pH7.4) with 10% (v/v) Fetal Bovine Serum at 37C. (irjs.info)
  • 37. Walensky LD, Gavathiotis E. BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. (urat1inhibitor.com)
  • The work presents a molecular map of blood vessels in the lymph nodes and defines the subpopulations of endothelial cells involved in leukocyte recruitment. (edu.pl)
  • 27. Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. (urat1inhibitor.com)
  • BAX-induced cell death might not JNK2 Molecular Weight require interleukin 1 beta-converting enzyme-like proteases. (urat1inhibitor.com)
  • It will quite effectively cater to the needs of molecular biologists, molecular geneticists, cell and molecular biologists, animal, plant, and crop geneticists, synthetic biologists, biotechnologists, and researchers involved with the fields of stem cell and molecular aspects of cancer research. (caister.com)
  • 4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
  • Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. (stanford.edu)
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
  • These lymphocytes successfully eliminate the genetically unstable tumour cells with intrinsically high immunogenicity [ 4 ] through a series of successive stages [ 5 ] . (encyclopedia.pub)
  • In contrast, the diversity of blood endothelial cells (BECs) and their origin during inflammatory angiogenesis were not fully characterized so far. (edu.pl)
  • The study uses scRNA-seq to define and characterize different subsets of blood endothelial cells in the mouse lymph node. (edu.pl)
  • Persistent stem cells in the oral epithelium of adults are the only cells that can accumulate sufficient mutations for OSCC to develop [ 18 , 19 ]. (biomedcentral.com)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
  • In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)
  • Abstract The candida Ipi3p is required for DNA replication and cell viability in Ipi1-3p have been found to be required for cell viability and for processing of the ITS2 sequences from 35S pre-rRNA in pre-60S ribosomal particles [8, 9]. (irjs.info)
  • the tumor derives from the precursors of plasmacytoid dendritic cells (ie, plasmacytoid monocytes). (medscape.com)
  • efficient and reliable establishment of lymphoblastoid cell lines by epstein-barr virus transformation from a limited amount of peripheral blood. (liverpool.ac.uk)
  • the protocol that is widely used to establish lcls involves peripheral blood mononuclear cell isolation by density gradient centrifugation, however, that method requires as much as 5 ml of peripheral blood. (liverpool.ac.uk)
  • When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
  • The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
  • The cells were analyzed by circulation cytometry for monitor cell cycle progression. (irjs.info)
  • 2022, suggests that the colonies generated by isolated hepatocytes likely originate from a single cell. (bvsalud.org)
  • Oct4 expression will not be essential for mouse somatic stem cell self-renewal. (urat1inhibitor.com)
  • True stem cells are both pluripotent-that is they can give rise to all cell types-and capable of self-renewal. (justia.com)
  • In vivo, stable ERα expression has been reported in patient-derived xenograft (PDX) models, especially in tumor cells introduced via intraductal transplantations 8 , 9 and these findings have suggested a strong microenvironment-dependent dynamic component in the regulation of ERα expression. (nature.com)
  • In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
  • A variety of benign fibrous lesions that may or may not be neoplastic can be found within the upper aerodigestive tract and have been termed "fibromas. (basicmedicalkey.com)
  • The use of cell lines as "biological minipumps" to chronically deliver antinociceptive molecules into the pain-processing centers of the spinal cord represents a newly developed technique for the treatment of pain [ 3 ]. (hindawi.com)
  • Immunocytochemistry/ Immunofluorescence: CDP/CUTL1 Antibody (2A10) [H00001523-M01] - Analysis of monoclonal antibody to CUTL1 on HeLa cell. (novusbio.com)
  • A) HeLa cells were arrested in the G1/S transition with Mimosine (T1), released into S phase and harvested every 2 hrs for 8 hrs (T2CT5). (irjs.info)
  • C) HeLa cells were caught the Rabbit polyclonal to Aquaporin2 G1/S transition with Mimosine (T1), released and harvested every 3 hrs for 6 hrs (T2 and T3). (irjs.info)
  • Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (mdwiki.org)
  • ebv reactivation in latently infected b cells is essential for persistent infection whereby b cell receptor (bcr) activation is a physiologically relevant stimulus. (liverpool.ac.uk)