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  • ependymal cells
  • Szabolcsi V, Celio MR. De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair. (novusbio.com)
  • Originated from ependymal cells which are found lining the ventricular cavities and the central canal of the spinal cord. (statpearls.com)
  • GFAP
  • In a study published in Glia, Dr Marco Celio (University of Fribourg, Switzerland) employed Novus' GFAP antibody (clone 5C10) for Immunohistochemistry Whole-Mount (IHC-WhMt) on ependymal-cell islands in organotypic hippocampal slice cultures/OHSC of C57BL/6 mice at DIV7 and they noticed that GFAP co-express with ependymal marker S100 beta but not with calcium-binding protein parvalbumin/PV (a marker of GABAergic neuron). (novusbio.com)
  • Although, pilocytic astrocytoma is GFAP positive, it almost never stains. (theveganapprentice.com)
  • Grading
  • Established in 1993 in an effort to eliminate confusion regarding diagnoses, the WHO system established a four-tiered histologic grading guideline for astrocytomas that assigns a grade from 1 to 4, with 1 being the least aggressive and 4 being the most aggressive. (bestclinic.co.in)
  • Cerebellar
  • Anzilotti S, Tornincasa M, Gerlini R. Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype. (novusbio.com)
  • The tumors are usually found on the left cerebellar hemisphere, and consist of abnormal hypertrophic ganglion cells that are somewhat similar to Purkinje cells . (wikipedia.org)
  • lesions
  • A subset of low-grade astrocytomas may have features of high-grade lesions including endothelial proliferation and necrosis, although they remain slow growing and well circumscribed. (medscape.com)
  • heterogeneous
  • Low-grade astrocytomas are a heterogeneous group of intrinsic central nervous system (CNS) neoplasms that share certain similarities in their clinical presentation, radiologic appearance, prognosis, and treatment. (medscape.com)
  • molecular
  • Pediatric low-grade astrocytomas exhibit markedly different molecular alterations, clinical course, and treatment than their adult counterpart. (medscape.com)