• It has been suggested that synemin could function as a linker between different cytoskeletal components based on the fact that it interacts with several proteins involved in the organization of the costameres, neuromuscular and myotendinous junctions within striated muscle cells. (biomedcentral.com)
  • The analysis resulted in 4 pathways in addition to ERBB2 signaling (EGFR, integrin, MYC signaling, and PI3K signaling that contained many of the oncogene interacting proteins. (rug.nl)
  • Proteins interacting with HDPs were identified by co-immunoprecipitation coupled with mass spectrometry. (biomedcentral.com)
  • Spectrin, the major component of the erythroid membrane skeleton, is a long, asymmetrical rodlike protein that interacts with several other proteins to form a two-dimensional membrane skeleton. (embl.de)
  • Many molecules have been reported to associate with desmin, such as other IF proteins (including members of the membrane dystroglycan complex), nebulin, the actin and tubulin binding protein plectin, the molecular motor dynein, the gene regulatory protein MyoD, DNA, the chaperone alphaB-crystallin, and proteases such as calpain and caspase. (biologicalworld.com)
  • The possibility that intermediate filaments interact directly with peripheral membrane proteins and membrane lipids will also be addressed. (biologicalworld.com)
  • Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
  • Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. (wikipedia.org)
  • In muscle, plectin binds to the periphery of Z-discs, and along with the intermediate filament protein desmin, may form lateral linkages among neighboring Z-discs. (wikipedia.org)
  • Plectin has been revealed to localize to the desmosomes and in vitro studies have shown that it can form bridges between the desmosome protein, desmoplakin and intermediate filaments. (wikipedia.org)
  • Although normally a cytoplasmic protein, plectin is expressed on the cell membrane in pancreatic ductal adenocarcinoma (PDAC) and can therefore be used to target PDAC cells. (wikipedia.org)
  • Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION. (bvsalud.org)
  • Plectin for instance contains interaction domains for both IFs and microtubules (Wiche et al. (biongenex.com)
  • This page leads you to internet information about microtubules (MTs) and factors that interact with them. (uni-osnabrueck.de)
  • These globular domains are responsible for connecting plectin to its various cytoskeletal targets. (wikipedia.org)
  • Role of plectin in cytoskeleton organization and dynamics" (abstract). (wikipedia.org)
  • 2004 APC directly interacts with IFs and controls their organization Rilmenidine during cell migration. (biongenex.com)
  • In cardiac muscle and skeletal muscle, plectin is localized to specialized entities known as Z-discs. (wikipedia.org)
  • In hemidesmosomes plectin has been shown to interact with the integrin β4 subunits of the hemidesmosome plaque and function in a clamp-like manner to link the intermediate filament cytokeratin to the junction. (wikipedia.org)
  • To understand the molecular basis for spectrin's mechanical properties, one must determine how spectrin subunits interact with each other. (embl.de)
  • In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. (wikipedia.org)
  • The current investigation aims at identifying interacting partners of HDPs in the rpAD brains to unravel the pathological involvement of HDPs in the rapid progression. (biomedcentral.com)
  • The structure of plectin is thought to be a dimer consisting of a central coiled coil of alpha helices connecting two large globular domains (one at each terminus). (wikipedia.org)
  • Through the use of gold-immunoelectron microscopy, immunoblotting and immunofluorescence experiments plectin has been found to associate with all three major components of the cytoskeleton. (wikipedia.org)
  • By holding these different networks together, plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues. (wikipedia.org)
  • Mutations that prevent the cell from making any functional plectin tend to cause more severe signs and symptoms, while mutations that reduce the amount of plectin or alter the protein's structure usually cause milder signs and symptoms. (medlineplus.gov)
  • A shortage of functional plectin disrupts the attachment of the epidermis to underlying skin layers, making the skin less resistant to friction and minor trauma. (medlineplus.gov)
  • A shortage of functional plectin in muscle tissue affects critical structures needed for muscle tensing (contraction), which leads to muscle weakness and atrophy. (medlineplus.gov)
  • In summary, the analysis of the different genetic models indicated that a functional plectin is required for the proper function of striated and simple epithelia, cardiac and skeletal muscle, the neuromuscular junction, and the vascular endothelium, recapitulating the symptoms of humans carrying plectin mutations. (nih.gov)
  • The PLEC gene mutations responsible for EB-PA change the normal structure and function of plectin. (medlineplus.gov)
  • Plectin also functions to link cytoskeleton to intercellular junctions, such as desmosomes and hemidesmosomes, which link intermediate filament networks between cells. (wikipedia.org)
  • In hemidesmosomes plectin has been shown to interact with the integrin β4 subunits of the hemidesmosome plaque and function in a clamp-like manner to link the intermediate filament cytokeratin to the junction. (wikipedia.org)
  • In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. (wikipedia.org)
  • Through the use of gold-immunoelectron microscopy, immunoblotting and immunofluorescence experiments plectin has been found to associate with all three major components of the cytoskeleton. (wikipedia.org)
  • Role of plectin in cytoskeleton organization and dynamics" (abstract). (wikipedia.org)
  • Within cells, plectin interacts with several molecules that make up the cell's structural framework (the cytoskeleton). (medlineplus.gov)
  • Artemin also down-regulated the expression of genes related to cell adhesion and matrix assembly, including biglycan, plectin, nestin, neuronatin and the neuron-glia-CAM-related cell adhesion molecule, which is functionally relevant to neurite elongation in DRG neurons. (yonsei.ac.kr)
  • As part of these structures, plectin plays a critical role in anchoring the outer layer of the skin (the epidermis) to underlying layers. (medlineplus.gov)
  • Plectin can exist in cells as several alternatively-spliced isoforms, all around 500 kDa and >4000 amino acids. (wikipedia.org)
  • By holding these different networks together, plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues. (wikipedia.org)
  • Plectin is expressed in nearly all mammalian tissues. (wikipedia.org)
  • The exact function of plectin in different tissues is unclear. (medlineplus.gov)
  • UT-A1 was found to interact with UT-A3, although quantitative proteomics revealed that most UT-A1 molecules in the cell are not bound to UT-A3. (nih.gov)
  • 20. Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions. (nih.gov)
  • Z bands function as Inbjudan av talare till konferernsen "intermediära filament (nanofilament) i on Astrocyte Intermediate Filaments (Nanofilaments) and Astrocyte Function in The plakin family of cytolinkers interacts with intermediate filaments (IFs) through plakin repeat domain (PRD) and linker modules. (netlify.app)
  • In cardiac muscle and skeletal muscle, plectin is localized to specialized entities known as Z-discs. (wikipedia.org)
  • In addition, in HEK293 cells transfected with HA-Ubc9, we found that -tubulin could be coimmunoprecipitated with Ubc9, the unique E2 enzyme for SUMOylation (Physique?1C), indicating that -tubulin interacts with the SUMOylation machinery. (colinsbraincancer.com)