Loading...
  • binds
  • Importantly, plectin binds to the integrin alpha6beta4 at the cell surface and to nesprin-3 at the ONM in keratinocytes, suggesting that there is a continuous connection between the nucleus and the extracellular matrix through the IF cytoskeleton. (nih.gov)
  • Plectin binds to hemidesmosomes through association of its actin-binding domain with the first pair of fibronectin type III repeats and a small part of the connecting segment of the integrin-beta4 subunit, the latter (integrin-alpha6,beta4) acting as a receptor for the extracellular matrix component laminin-5. (embl-heidelberg.de)
  • Mutations
  • Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. (genecards.org)
  • 1996
  • 1994) and kidney (Yaoita et al, 1996), plectin expression is prominent in cells forming tissue layers at the interface of tissue and fluid-filled cavities. (thefreelibrary.com)
  • nuclear
  • Overexpression of nesprin-3 results in a dramatic recruitment of plectin to the nuclear perimeter, which is where these two molecules are colocalized with both keratin-6 and -14. (nih.gov)
  • constructs
  • 1993). The expression of mutant forms of plectin in cell lines transiently transfected with cDNA constructs led to the conclusion that the C-terminal globular domain of plectin is involved in the binding to IFs (Foisner et al. (thefreelibrary.com)
  • diseases
  • This work was supported in part by a grant from German Ministry for Education and Research (BMBF) for the "Network for rare diseases: epidermolysis bullosa (grant Nr. 01GM0301, L. B-T.) and muscular dystrophies (grant Nr. 01GM0302, R.S.). The work on plectin mutation analysis was supported by the NIH/NIAMS grant P01-AR38923. (springer.com)
  • cell
  • To study the mechanisms underlying vascular disorders, we established plectin-deficient endothelial cell and mouse models. (biologists.org)
  • Plectin-deficient endothelial cell layers were more leaky and showed reduced mechanical resilience in fluid-shear stress and mechanical stretch experiments. (biologists.org)