• The efficient enzymatic antioxidant system played a critical protective role against the deleterious effects of progressive oxidative stress during ripening. (mendeley.com)
  • This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
  • The Keap1-Nrf2-ARE pathway plays a critical role in the regulation of a comprehensive and protective antioxidant response [ 22 ]. (hindawi.com)
  • Thiols have been shown to play important roles in enzymatic reactions, apoptosis, detoxification and antioxidant protection in the body. (intechopen.com)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • As a potent antioxidant, vitamin C reduces oxidative stress in your body. (foodrevolution.org)
  • Oxidative stress, in which production of highly reactive oxygen species (ROS) and reactive nitrogen species (RNS) overwhelms antioxidant defenses, is a feature of many neurological diseases and neurodegeneration. (unboundmedicine.com)
  • Therefore, study of the protective role of antioxidant compounds on inhibition of the inflammatory response and correcting the fundamental oxidant/antioxidant imbalance in patients suffering from neurodegenerative diseases are important vistas for further research. (unboundmedicine.com)
  • Plays an important role in cardiovascular and nervous system functioning as well as acting as a protective antioxidant. (apexhotels.co.uk)
  • Recent studies have shown that EMF affects cellular stress levels, resulting in the deterioration of various tissues and changes to the concentrations of antioxidant markers in the blood. (martindalesnutrition.com)
  • Glutathione is a powerful antioxidant that shields cells from oxidative damage. (martindalesnutrition.com)
  • Encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. (plurisomes.com)
  • Nrf2 is the cellular defense transcription factor which sets into motion a cascade of antioxidant protective response. (geresdengle.com)
  • Oxidative stress has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease. (ersjournals.com)
  • This model would allow us to test how the elimination of the protective sequestration of DA produces endogenous DA toxicity in DA neurons and how this predisposed condition contributes to the pathogenesis of PD. (michaeljfox.org)
  • These studies aim at advancing our current knowledge on the protective machinery and endogenous detoxification of DA by VMAT2 as well as on a potential role of DA toxicity in the pathogenesis of DA neurons in PD. (michaeljfox.org)
  • This also shows that the thiol state is very important in the pathogenesis of oxidative stress-mediated diseases. (intechopen.com)
  • Family history of acne, oxidative stress, dyslipidemia, and lower dietary fiber intakes may play a role in acne pathogenesis. (magiran.com)
  • 1 Although the pathogenesis of light-induced retinal damage remains unclear, oxidative stress is likely involved. (arvojournals.org)
  • Oxidative stress may play a role in the pathogenesis of this disease. (medscape.com)
  • Recently, clinical trials and preclinical studies have shown that curcumin exerts protective effects against a variety of diseases, including diabetes and its cardiovascular complications. (frontiersin.org)
  • Therefore, it is thought that interventions that can improve thiol status may contribute to the prevention or treatment of oxidative stress-related diseases. (intechopen.com)
  • It's also protective against oxidative stress in the brain , especially when it comes to diseases like Alzheimer's and dementia. (foodrevolution.org)
  • The purpose of this review is to summarize the current evidence in support of this critical role played by oxidative stress of neuronal and glial origin in neurodegenerative diseases. (unboundmedicine.com)
  • Reactive oxygen species are widely believed to be involved in the etiology of many diseases as indicated by the signs of oxidative stress seen in those diseases. (athabascau.ca)
  • Potassium, a mineral from avocados has a protective effect against high blood pressure, heart diseases, circulatory diseases and stroke. (diethealthclub.com)
  • Avocados is also an important source of folate, individuals who consume folate rich diets can have a protective effect against Alzheimer's disease, heart attacks and other fatal heart diseases and stroke. (diethealthclub.com)
  • This is because folate helps to decrease the homocysteine levels in the body, which are considered to play a role in these diseases. (diethealthclub.com)
  • Lutein has a protective effect against prostate cancer and eye diseases like macular degeneration and cataracts. (diethealthclub.com)
  • the vitamin E present in avocados slows the aging process and has a protective effect against various cancers and heart diseases. (diethealthclub.com)
  • We will then examine how the impaired DA sequestration induces oxidative stress inside of the cells that are therefore selectively vulnerable to degeneration. (michaeljfox.org)
  • ABA loss of function mutants exhibit pleiotropic phenotypes and simply applying ABA to plants induces an immediate stress response. (nature.com)
  • Given that ME Research UK-funded work has found high levels of oxidative stress and associated arterial stiffness to be a feature in ME/CFS patients ( read more ), it may be that telomere shortening is intimately linked with ongoing inflammatory processes. (meresearch.org.uk)
  • An active nature product of Asian herb medicine, curcumin, shows many protective effects, including against inflammatory and oxidative stress conditions. (thieme-connect.com)
  • Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor that is upregulated in times of oxidative stress. (hindawi.com)
  • As shown in Figure 1 , in the absence of oxidative stress, Kelch-like ECH-associated protein 1 (Keap1) keeps Nrf2 sequestered in the cytosol, where it mediates proteasomal degradation of Nrf2 [ 25 - 27 ]. (hindawi.com)
  • Proposed molecular mechanisms of oxidative stress-induced Nrf2 activation. (hindawi.com)
  • This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
  • The gene Nrf2 is known to affect immune function and stress response in adults, but research on the effects of this gene in infants and children has been explored less. (sciencedaily.com)
  • To better understand the role of Nrf2 during development and clarify how ultrafine particles affect health, researchers exposed both unmodified animal models and those that have had the Nrf2 genes knocked out to fresh, filtered air and air containing ultrafine particles like those found in diesel exhaust, a common pollutant in urban areas. (sciencedaily.com)
  • Exposure to pollution had no notable effects in unmodified animal models, which may indicate Nrf2 playing some protective role during pregnancy. (sciencedaily.com)
  • Researchers propose that diabetes progression can be suppressed by a reversal of oxidative state with the addition of Nrf2 activators. (geresdengle.com)
  • Pluripotent neurotrophic factor that plays a role in neuronal differentiation and survival. (plurisomes.com)
  • In this paper, we make the case that mitochondrial dysfunction could play an important role in the pathophysiology of depression. (frontiersin.org)
  • This activates cascade of events which, in the end, affects oxidative status of the cells and provides robust protection against oxidative challenge. (springer.com)
  • ROS and RNS can also indirectly contribute to tissue damage by activating a number of cellular pathways resulting in the expression of stress-sensitive genes and proteins to cause oxidative injury. (unboundmedicine.com)
  • however, the exact ways pollutants have these effects and the roles of genes related to immune function and stress response are not fully understood. (sciencedaily.com)
  • The researchers also analyzed lung and liver tissue from the offpsring to measure differences in certain immune markers and expression of genes related to oxidative stress response. (sciencedaily.com)
  • This highlights a need for further research into the roles of genes on immune and stress response and how those genes interact with environmental factors. (sciencedaily.com)
  • It is known that thiols are one of the main protective mechanisms of the body against oxidative stress. (intechopen.com)
  • The aquatic to terrestrial transition must have posed a significant challenge to algae and environmental differences required the adaptive evolution of protective mechanisms enabling them to become high-light and desiccation tolerant and sessile at the water surface. (nature.com)
  • Our previous studies demonstrated its protective effect in early experimental diabetic retinopathy (DR), but the molecular and cellular mechanisms are largely unknown. (molvis.org)
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
  • the higher the cellular oxidative stress levels the greater the degree of shortening ( read more ). (meresearch.org.uk)
  • Cyclic AMP was a major molecule of interest, which played an important role as second messenger, contributing to signal transduction in the regulation of cellular function by peptide hormones. (novapublishers.com)
  • Plays a central role in DNA repair by facilitating cellular responses to DNA damage. (plurisomes.com)
  • Oxidative stress can denature lipids and proteins [ 10 , 12 - 14 ], as well as induce DNA and RNA fragmentation [ 15 - 17 ], leading to cell dysfunction, injury, and death. (hindawi.com)
  • Plasmalogens may also play important roles in interactions between lipids and proteins, the transmission of chemical signals in cells, and the fusion of cell membranes. (medlineplus.gov)
  • After subsequent studies, regucalcin has been established to play a pivotal role in maintaining cell homeostasis and protecting it from disorders in various types of cells and tissues. (novapublishers.com)
  • For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. (hindawi.com)
  • The effects of oxidative stress occur as a result of peroxidative damage of the macromolecule and membranes of the cells and with the disruption of metabolic activities in the components of the cells in living organisms. (intechopen.com)
  • This study aims to investigate the protective effects and mechanism of Pts against acetaminophen (APAP)-induced hepatotoxicity in vivo . (karger.com)
  • This study aimed to investigate the in vitro and in vivo protective effects of DHEA against high glucose-induced oxidative stress in tenocytes and tendons. (biomedcentral.com)
  • Melatonin is a hormone that minimizes the effects of oxidative stress. (martindalesnutrition.com)
  • When exposed to mobile phone radiation, a group of rats experienced decreased adverse effects after being treated with vitamins C and E. These two vitamins worked together synergistically to reduce the oxidative stress caused by cell phone radiation. (martindalesnutrition.com)
  • Thus, we evaluated the protective effects of ω-3 supplementation on hepatotoxicity and nephrotoxicity induced by multiple DOX administrations in rodents. (bvsalud.org)
  • In this study, we investigated the effects of exposure of mice to waterpipe smoke on oxidative stress in lungs and liver and the effects of selenium administration before smoke exposure on the oxidative stress. (who.int)
  • Histological examinations of lungs and liver confirmed the protective actions of selenium against the effects of exposure to waterpipe smoke. (who.int)
  • Administration of low level of selenium, 1.78 µg selenium/kg body weight as sodium selenite, exerted protective effects against oxidative stress induced by exposure to waterpipe smoke. (who.int)
  • As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)
  • Data from in vitro , ex vivo and in vivo studies indicate two sorts of effect of oxidative stress relevant to COPD. (ersjournals.com)
  • Both in vitro and in vivo experiments have demonstrated that oxidative stress may cause alterations in essential components of the lung, contributing to pathological abnormalities and functional changes (table 2 ⇑ ) 6 , 7 . (ersjournals.com)
  • To condense evidence about risk and protective factors for childhood asthma and/or wheezing disorders occurred in the first 1,000 days of life. (bvsalud.org)
  • Structural changes to essential components of the lung are caused by oxidative stress, contributing to irreversible damage of both parenchyma and airway walls. (ersjournals.com)
  • Attenuation of oxidative stress would be expected to result in reduced pulmonary damage and a decrease in local infections, contributing to attenuation of the progression of COPD. (ersjournals.com)
  • In the present study, we investigated whether Sirtuin Type 1 (Sirt1), a class III histone deacetylase, mediates the retinal protective effect of HRS in rats with light-induced retinal damage. (arvojournals.org)
  • Glycation leads next to Advanced Glycation End Products (AGES) .AGES are extremely destructive oxidative and become a significant source of continuous oxidative stress and leads to DNA damage and destruction to the affected cells. (geresdengle.com)
  • Vitamin C is part of your external defense system as well, as it plays a primary role in the health and integrity of your skin. (foodrevolution.org)
  • [ 7 ] Full-length human ferritin heavy chain protein (FTH1), which has a DNA-protective role in the nucleus, has been identified as an interacting protein partner for ALADIN in vitro. (medscape.com)
  • Decreased estrogen as experienced by post-menopausal women increases the risk of knee osteoarthritis as estrogen is protective of bone health specifically reducing oxidative stress to the cartilage. (clevelandclinic.org)
  • These findings suggest that oxidative stress is involved in disease progression. (medscape.com)
  • Methylglyoxal is the most powerful precursor of AGES, and is believed to play a significant role in the progression of Alzheimer's Disease. (geresdengle.com)
  • Several reviews have summarised the available data on the presence (table 1 ⇓ ) and consequences (table 2 ⇓ ) of oxidative stress in the lungs of "healthy" smokers and smokers with COPD 1 - 5 , 9 . (ersjournals.com)
  • Ca 2+ in the emulsions [ 8 ] and the lipid-peroxidation can play a role in the aging processes of colloid systems like oil-containing TPNs, this property of olive oil can be of importance in case of kinetic/physical stability of all-in-one nutrient mixtures however, we did not study the details of aging process itself in this experiment. (biomedcentral.com)
  • This study aimed to investigate the protective mechanism of a GLP-1R agonist E4 against early DR in Goto-Kakizaki (GK) rats. (molvis.org)
  • The necessity of Sirt1 for the retinal protective effect of HRS was investigated using the Sirt1 activator resveratrol, the Sirt1 inhibitor EX-527, and short interfering RNAs. (arvojournals.org)
  • Additionally, the retinal protective effect of HRS was inhibited by both the Sirt1 inhibitor EX-527 and Sirt1 targeted short interfering RNAs. (arvojournals.org)
  • Previous studies have demonstrated that curcumin at a dose of 100 mg/kg orally in mice and 60 mg/kg in rats reduced concentration of tumor necrosis factor (TNF)-α and inhibited oxidative stress in cisplatin-induced nephrotoxicity [ 7 ] [ 8 ]. (thieme-connect.com)
  • The pathway responsible for reducing most methemoglobin (95%-99%) back to hemoglobin is the NADH-dependant methemoglobin reductase system, in which the enzyme cytochrome-b5 reductase plays a crucial role in a transfer of electrons from NADH to methemoglobin. (medscape.com)
  • 3] As discussed in Interpretation, methemoglobinemia results from either an overproduction of methemoglobin that exceeds these protective pathways or a defect in the pathways themselves. (medscape.com)
  • Under oxidative-stressed conditions, cysteine residues of Keap1 are oxidized, forming a disulfide bridge. (hindawi.com)
  • The emerging role of redox-sensitiveNrf2-Keap1 pathway in diabetes. (geresdengle.com)
  • Considering the inconsistency of the few previous reports, the present study aimed to determine the levels of vitamin D, adiponectin, oxidative stress, lipid profile and nutrient intakes in females with acne. (magiran.com)
  • Studies have found vitamin C to play a role in preventing heart disease, primarily by managing blood pressure . (foodrevolution.org)
  • In this way vitamin E was shown to play a protective role, as oxidized LDL is believed to be a major player in terms of promoting atherosclerosis, the build up of fatty plaques in the arteries, and in cardiovascular disease in general, the researchers said. (nutraingredients.com)
  • Known as the 'anti-stress vitamin', B5 plays a role in the production of adrenal hormones and neurotransmitters, as well as helping to convert the food you eat into energy you can use. (apexhotels.co.uk)
  • It plays important roles in immune system function and collagen formation, making this vitamin critical to wound repair and maintaining healthy bones, cartilage, teeth, and gums. (lifestylemarkets.com)
  • Liposomal Vitamin C eliminates this absorption problem by enclosing vitamin C within a protective phospholipid bilayer. (lifestylemarkets.com)
  • Intake of fish oil, zinc and vitamin E during pregnancy appear as protective factors, as well as breastfeeding, fish intake in the first two years, and BCG vaccination. (bvsalud.org)
  • Interestingly, the intracellular reoxidation of cell-permeable nitroxide probe 3CP was observed for the first time in fruits or any other plant tissue, and its intensity is herein proposed as a reliable indicator of oxidative stress during ripening. (mendeley.com)
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
  • They are also abundant in myelin, which is the protective substance that covers nerve cells. (medlineplus.gov)
  • Younger healthy cells produce larger quantities of protective substances. (life-enthusiast.com)
  • Also supports healthy brain functioning, enhances memory and protects cells from oxidative stress. (apexhotels.co.uk)
  • In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
  • Objectives Mesenchymal stem cells (MSCs) play an important role in the development and growth of tumor cells. (immune-source.com)
  • Folic Acid plays a significant role in pregnancy as it helps with infant brain development and the formation of new cells. (martindalesnutrition.com)
  • Owing to oxidative stresses, methemoglobin is always being produced within red blood cells, but its levels are kept low by enzymic pathways that work to reduce the molecule. (medscape.com)
  • Interference with or elimination of the protective mechanism by VMATs may also enable us to directly test the role of DA toxicity in neural degeneration. (michaeljfox.org)
  • A better understanding of the pharmacological role of curcumin on diabetes and DCM can provide clinical implications for the intervention of the onset and development of diabetes and DCM. (frontiersin.org)
  • FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. (wikipedia.org)
  • Several studies have demonstrated the protective capabilities of Melatonin on organs exposed to electromagnetic fields (EMF). (martindalesnutrition.com)
  • Systematic reviews with meta-analysis, or meta-analysis of observational and interventional studies on risk or protective factors for childhood asthma/wheeze, emphasizing the period between the conception and two first years of age, were included. (bvsalud.org)
  • Living organisms are frequently exposed to oxidative stress and toxic insults, like radiation, UV light, air pollution, toxins and others. (springer.com)
  • other components of the diet (other nutrients, phytochemicals and dietary fiber) likely play a significantly greater role The possible benefits of supplements are discussed. (athabascau.ca)
  • As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
  • In the multivariate analysis, a family history of acne and increased malondialdehyde levels were risk factors for acne, whereas a higher fiber intake was protective. (magiran.com)
  • Balances blood sugar levels, lowers stress hormones, encourages bett er quality sleep whilst lift ing energy and mood. (apexhotels.co.uk)
  • The phytohormone abscisic acid (ABA) plays a role in stresses that alter plant water status and may also regulate root gravitropism and hydrotropism. (nature.com)
  • Organ and tissue pathologies are known to occur when oxidative stress is excessive in the body. (intechopen.com)
  • The 'Body & Bubbles' package comprises a 25-minute Yu Back, Neck and Shoulder Massage, where expert therapists will target key stress points with long, slow strokes to leave guests feeling completely relaxed and reinvigorated, followed by bubbles with benefits in the tranquil surroundings of the Yu Spa. (apexhotels.co.uk)
  • Also, statins seem to have a protective role against telomere shortening, and lifestyle factors may have an important role to play. (meresearch.org.uk)
  • Using of this type of melanin could play an important role through the biological needs and/or could pave the way as an active field of research including biochemistry, biomedical, dermatological, cosmetic therapies and microbiological points of view, as well as health care industry. (alliedacademies.org)
  • Since 2001, more epidemiological evidence has come to light suggesting that these other nutrients may play a role in eye health. (nutritionaloutlook.com)
  • Conversely, HRS decreased Bcl2-associated X protein expression, cleaved caspase-3, and oxidant-stress product malondialdehyde (MDA) in a Sirt1-dependent manner. (arvojournals.org)
  • Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes. (biomedcentral.com)