• It is a pyrimidine antimetabolite that nhibits DNA polymerase and ribonucleotide reductase, which in turn inhibit DNA synthesis. (medscape.com)
  • This is a fluorinated pyrimidine antimetabolite that inhibits thymidylate synthase (TS) and also interferes with ribonucleic acid (RNA) synthesis and function. (medscape.com)
  • 5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
  • 5-FdUMP inhibits thymidylate synthase (key enzyme in DNA synthesis), which leads to accumulation of dUMP, which then gets misincorporated into the DNA in the form of 5-FdUTP resulting in inhibition of DNA synthesis and function with cytotoxic DNA strandbreaks. (medscape.com)
  • Doxorubicin is an anthracycline antibiotic that inhibits DNA and RNA synthesis. (medscape.com)
  • New isoniazid based compounds and their transition metal complexes (cobalt (II), copper (II), nickel (II) and zinc (II)) were produced using microwave synthesis technique. (fortunepublish.com)
  • Specifically, my professional experience includes the synthesis of coordination compounds (in particular Au, Pt, Pd, lanthanides derivatives) and the use of spectroscopic techniques (mainly mono- and multidimensional NMR, FT-IR and UV-Vis spectroscopy) to characterize the novel metal complexes and study their properties and reactivity under physiological-like conditions. (universityofgalway.ie)
  • Imine (also known as Schiff base) compounds participate a function in inorganic chemistry as they can simply form stable complexes with the majority of transition metal ions [2;3]. (fortunepublish.com)
  • Mitochondrial membrane potential was found at low levels in cells treated with Schiff base compounds and doxorubicin. (ijpsonline.com)
  • Schiff base compounds and their metal complexes have become important synthetic organic drugs due to their extensive biological activities, which include anticancer, antibacterial and antiviral effects. (researchsquare.com)
  • There is also an urgent requirements for novel compounds have antimicrobial activity, probably through new mechanism of actions, which is different from those of recognized classes of antimicrobial medicines to which numerous pathogens are resistant to. (fortunepublish.com)
  • Abstract: The aim of this study was to synthesize, characterize, and evaluate neoteric imine compounds for antimicrobial activity and hemocompatibility.Four compounds were synthesized using 3-thiophene carboxaldehyde, ethanol, amine , and acetic acid. (docslib.org)
  • These agents inhibit cell growth and proliferation. (medscape.com)
  • Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
  • Platinum compounds inhibit cell growth and proliferation. (medscape.com)
  • Capecitabine is a prodrug of fluorouracil that undergoes hydrolysis in liver and tissues to form the active moiety (fluorouracil), inhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to thymidylic acid. (medscape.com)
  • Nickel hydride is either an inorganic compound of the formula NiHx or any of a variety of coordination complexes. (wikipedia.org)
  • The All compounds which were synthesized (free ligand and their metal complexes) were fully characterized by many spectroscopic techniques (FT-IR spectra, UV/visible electronic spectra, mass spectra and 13 C NMR and 1 H NMR spectra). (fortunepublish.com)
  • The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
  • The work highlighted the significance of ultrasound to specifically activate the platinum anticancer drugs, eradicate deep tumor lesions and expand theranostics of platinum coordinate complexes. (worldmedicinefoundation.com)
  • Compounds (C1-8 and doxorubicin) were placed to 96-well culture plate in triplicate order at doses of 1, 10, 100, 1000 μM and then K562 cells were seeded into the wells at the dose of 105/ml. (ijpsonline.com)
  • In conclusion, two of the novel imine compounds showed promise as antimicrobial agents to control local and systemic microbial infections in a suitable dosage form. (docslib.org)
  • This is a heavy metal coordination complex that exerts its cytotoxic effect by platination of DNA, a mechanism analogous to alkylation, leading to interstrand and intrastrand DNA crosslinks and inhibition of DNA replication. (medscape.com)
  • Although polypharmacology might be associated with compound promiscuity, it should be considered a different category since the so-called promiscuous drugs are instead a class of compound that show a wide spectrum of biological activities and adverse reactions [ 1 ]. (biomedcentral.com)
  • The coordination sphere consists of the central metal ion or atom plus its attached ligands. (bccampus.ca)
  • species outside the brackets are not part of the coordination sphere. (bccampus.ca)
  • Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
  • Antiproliferative effects of compounds were determined using carboxyfluorescein succinimidyl ester assay. (ijpsonline.com)
  • Apoptosis induction potential of each compound determined by mitochondrial membrane potential analysis (Rho123), cleaved caspase-3 expression analysis by flow cytometry and immunofluorescent staining and cell morphology analysis by giemza, hematoxylin and eosin and Papanicolaou protocols. (ijpsonline.com)
  • GM1CD41 completely inhibits ADP, epinephrine and collagen-induced platelet activation and partially inhibits restocetin and thrombin-induced platelet activation. (cancercurehere.com)
  • The coordination number of the central metal ion or atom is the number of donor atoms bonded to it. (bccampus.ca)
  • The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway. (harvard.edu)
  • Remember that in most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. (bccampus.ca)
  • For example, ethylenediamine (en, H 2 NCH 2 CH 2 NH 2 ) contains two nitrogen atoms, each of which has a lone pair and can serve as a Lewis base (Figure 4.3.4) . (bccampus.ca)
  • The bonding capability of the ligands depends on the character of atoms that act at site of the coordination, their steric and electronegativity factors. (fortunepublish.com)
  • Smoking and look what i found vaping permits the effects of THC as well as other compounds to kick in rapidly as they get inhaled. (glitzyglamourlou.com)
  • Instead your research group can rapidly analyze new compounds as they are synthesized in the lab without having to queue up in the departmental core facility. (rigaku.com)
  • While photoactivatable platinum drugs have been successful, their light penetration depth is too shallow to treat deep tumors. (worldmedicinefoundation.com)
  • Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
  • Endostatin inhibits endothelial cell migration by inhibiting phosphorylation of focal adhesion kinase via binding to α5β1 integrin (Wickstrom et al. (justia.com)
  • For the copper(II) ion in [CuCl 4 ] 2− , the coordination number is four, whereas for the cobalt(II) ion in [Co(H 2 O) 6 ] 2+ the coordination number is six. (bccampus.ca)
  • In the complex [Co(en) 3 ] 3+ , there are three bidentate en ligands, and the coordination number of the cobalt(III) ion is six. (bccampus.ca)
  • The prodrug overcame drug resistance as a result of combinatorial therapy mechanisms, which included the release of platinum chemotherapeutics, the breakdown of intracellular reductants, and a large release of reactive oxygen species. (worldmedicinefoundation.com)
  • The analogue of Au and Ag NCs and platinum nanoclusters (Pt NCs), especially their biological applications, is relatively and rarely discussed. (hindawi.com)
  • The platinum complex also can bind to nucleus and cytoplasmic protein. (medscape.com)
  • and that isoflavones inhibit this enzymatic activity, there is a mechanistic basis for the human findings. (westonaprice.org)
  • In this work, Liu and colleagues presented an ultrasound-activated platinum (IV) prodrug for on-demand release of platinum chemotherapeutics using a sono-sensitized electron transfer process. (worldmedicinefoundation.com)
  • Noble metal like rhodium (Rh), palladium (Pd), silver (Ag), platinum (Pt), and gold (Au) is one kind of modish and desired material, according to their inherent resistance to oxidation and corrosion even in the moist environment [ 1 - 3 ]. (hindawi.com)
  • In the remainder of this chapter, we will consider the structure and bonding of these remarkable compounds. (bccampus.ca)
  • The structure of the compounds was confirmed by NMR, FTIR corroborated their functional group attributes, DSC determined their enthalpies of fusion and fusion temperatures, and PXRD confirmed their crystalline nature. (docslib.org)
  • Observing the structure of Tri-aminoborane it is immediately apparent each ring atom has 4 bonds, indicating that this is the cyclic trimer of Aminoborane joined by 3 coordination bonds. (sciencemadness.org)
  • Binds to protein and other compounds containing SH group. (medscape.com)
  • These are described by existence of azomethine group (πN=CHR) which was formed by condensation of carbonyl compound and primary amine (aldehydes or ketones) [4]. (fortunepublish.com)
  • In a new report now published on Science Advances , Gongyuan Liu and a team of scientists in chemistry, biomedical engineering and bioengineering at the City University of Hong Kong in China presented cyaninplatin as a Platinum (IV) anticancer prodrug. (worldmedicinefoundation.com)
  • VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
  • Photoactivatable platinum (IV) prodrugs are therapeutically advantageous since they originate from platinum anticancer prodrugs for high stability and easy functionalization. (worldmedicinefoundation.com)
  • Ir-catalysed alkylation of the title compounds with substituted benzyl and aliphatic alcohols under solvent-free heating gave the monoalkylated products in high to excellent yield. (matthey.com)
  • THC snugly binds with CB1 receptors in your brain as well as inhibits the feeling of 'high' or 'bliss' connected with marijuana. (glitzyglamourlou.com)
  • 25 Similarly, studies have shown that maintenance and inspection workers in oil and gas operations are exposed to high levels of mercury and its related compounds through inhalation and dermal absorption, which poses grave risks to their health and safety. (researchgate.net)
  • used as inventors a in which the antigen acts a epoxymexrenone failure %, events patient, which are exception or a then citric d that is about relatively determined to the failure, compounds c in which animal or ultra-rapid Effects offers often diagnosed to the troponin, and elements d in which the eye is fewer clinical other products than the complications are. (siriuspixels.com)
  • White and his fellow researchers speculate that soy's estrogen-like compounds (phytoestrogens) might compete with the body's natural estrogens for estrogen receptors in brain cells. (westonaprice.org)
  • They evolved compounds that mimic natural estrogen. (westonaprice.org)
  • The research team obtained a representative heptamethine cyanine sonosensitizer known as IR780 to rationally design an ultrasound-responsive theranostic platinum coordination compound. (worldmedicinefoundation.com)
  • The coordination number for the silver ion in [Ag(NH 3 ) 2 ] + is two ( (Figure 4.3.3) ). (bccampus.ca)
  • SN-38 binds to and stabilizes the topoisomerase I-DNA complex and prevents the relegation of DNA after it has been cleaved by topoisomerase I, inhibiting DNA replication. (medscape.com)
  • The scientists used a carboplatin-based platinum scaffold for stability and modified IR780 to create a ligand. (worldmedicinefoundation.com)