• Moreover, a recent study with various malignant tumor cells showed that celecoxib could inhibit the growth of these cells, even though some of these cancer cells didn't even contain COX-2. (wikipedia.org)
  • However, when the ability of all these compounds to kill tumor cells in cell culture was investigated, it turned out that the antitumor potency did not at all depend on whether or not the respective compound could inhibit COX-2, showing that inhibition of COX-2 was not required for the anticancer effects. (wikipedia.org)
  • One of these compounds, 2,5-dimethyl-celecoxib, which entirely lacks the ability to inhibit COX-2, actually turned out to display stronger anticancer activity than celecoxib itself and this anticancer effect could also be verified in highly drug-resistant tumor cells and in various animal tumor models. (wikipedia.org)
  • These alterations may reduce platelet activity and ultimately inhibit platelet aggregation. (hindawi.com)
  • Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. (researchgate.net)
  • A study showed that ganoderic acids C and D isolated from G. lucidum inhibit the release of histamine from mast cells [81] . (researchgate.net)
  • In fact, in addition to their potent vasodilating effect, EETs have potent anti-inflammatory properties, inhibit platelet aggregation, promote fibrinolysis, and reduce vascular smooth muscle cell proliferation. (frontiersin.org)
  • Our experiments involving Rip1-Tag2 mice treated with the LOX inhibitor BAPN showed that BAPN significantly abolished collagen deposition to decrease tumor stiffness and thus inhibit tumor growth. (ijbs.com)
  • This special issue also published an inspiring paper that has investigated the mechanisms of the inhibitory effects of andrographolide, a most active and critical constituent isolated from the leaves of Andrographis paniculata in vascular smooth muscle cells (VSMCs) exposed to a proinflammatory stimulus, tumor necrosis factor- α (TNF- α ). (hindawi.com)
  • Ozone administered at a concentration of between 30 and 55 ug/cc causes the greatest increase in the production of interferon and the greatest output of tumor necrosis factor (TNF) and interleukin 2. (silvermedicine.org)
  • A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. (embl.de)
  • The release of soluble tumour-necrosis factor-alpha (TNF-alpha) from its membrane-bound precursor is one of the most intensively studied shedding events because this inflammatory cytokine is so physiologically important. (embl.de)
  • It neutralizes pathogenic cytokines such as tumor necrosis factor and interleukin-1 as well as superantigens that prevent activation of classes of T lymphocytes. (nursingcenter.com)
  • Hypoxic vascular endothelial cells activate white blood cells, which bind to the endothelium and release directly damaging substances (eg, reactive oxygen species, proteolytic enzymes) and inflammatory mediators (eg, cytokines, leukotrienes, tumor necrosis factor). (msdmanuals.com)
  • Current studies support an association of disorders such as these with chronic inflammation, which appears to decrease with the use of COX-2 inhibitors. (wikipedia.org)
  • The results of this paper suggest that Sanguis draconis may have a therapeutic potential in vascular inflammation due to the decreased levels of oxidative stress, apoptosis, and PARP-1 activation. (hindawi.com)
  • Nitric oxide aids the immune system by increasing white blood cell count, thus aiding in reducing inflammation processes associated with certain autoimmune disorders and helping to reduce allergic reactions from foreign substances like pollen and other environmental irritants. (tvhealth.in)
  • NO has been shown to play an important role in both innate and adaptive immune responses as it serves to regulate inflammation by suppressing cytokine production, dendritic cell maturation, and T-cell proliferation. (tvhealth.in)
  • These increases were not found in PP. Rhythmical behavior of blood flow in malignant tumors is totally different from that in regions with inflammation. (iospress.com)
  • The latest findings indicate that full spectrum grape extract can help support cardiac health by maintaining youthful endothelial function, regulating platelet aggregation, and reducing inflammation. (lifeextension.com)
  • Many inflammation-associated cytokines, including changing development aspect 1, 2, 3, and platelet-derived development factor (PDGF), have already been shown to boost biosynthetic degrees of both versican and HA, while IL-1, and IFN- have already been shown to decrease degrees of versican (85C91). (healthyconnectionsinc.com)
  • The use of steroids to decrease inflammation has been around in veterinary medicine for a long time. (vetbloom.com)
  • The use of exogenous steroids will have the positive effects of decreasing inflammation through the inhibition of prostaglandins and leukotrienes with the result of decreasing pain. (vetbloom.com)
  • The platelet-activating factor (PAF) is also an important secretory product of platelets mediating the platelet aggregation, inflammation and anaphylaxis[ 13 ] (Table 1 ). (biomedcentral.com)
  • Indeed, a number of studies have demonstrated that EET analogs and sEH inhibitors induce vasodilation, lower blood pressure and decrease inflammation. (frontiersin.org)
  • Terrein reduces pulpal inflammation in human dental pulp cells: J.C. Lee, et al. (adipogen.com)
  • The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
  • Vascular endothelial cells serve a key role in the pathogenesis of atherosclerosis by regulating vascular tension, platelet adhesion, inflammation and fibrinolysis ( 5 ). (spandidos-publications.com)
  • Nitric oxide also has anti-tumor effects, inhibiting tumor growth and metastasis resulting from cancerous cells that can no longer be removed surgically. (tvhealth.in)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Versican continues to be suggested to donate to HA fragment activation of macrophages, and improved cancer tumor metastasis through induction from the hyaluronidases (83, 84). (healthyconnectionsinc.com)
  • Osteoclasts are bone-resorbing cells of monocyte/macrophage origin and are culprits of bone destruction associated with osteoporosis, rheumatoid arthritis, and cancer bone metastasis. (koreascience.kr)
  • The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was initially identified as a tumor-related lncRNA, which can control the proliferation and metastasis of lung adenocarcinoma ( 10 ). (spandidos-publications.com)
  • Tumor cells can utilize platelets to promote their own infiltration and hematogenous metastasis, and platelets are activated and aggregated in this process. (qxmd.com)
  • This is of great significance for predicting tumor metastasis before timely treatments. (qxmd.com)
  • Furthermore, our previous study demonstrated that P-selectin deletion inhibited melanoma metastasis by suppressing platelet adhesion and that P-selectin-mediated platelet adhesion promoted intestinal tumor growth in Apc Min/+ mice [ 1 , 2 ]. (ijbs.com)
  • Leukocyte trafficking and localization to parts of irritation mediated by connections with cell-adhesion receptors features as a crucial initiating part of the inflammatory cascade (92). (healthyconnectionsinc.com)
  • Lots of the adhesive properties of HA polymers rely upon the current presence of HA-binding protein, and as well as II, HCs, TSG-6, and versican donate to a powerful extracellular environment with the capacity of directing cell adhesion as well as the creation of inflammatory cytokines. (healthyconnectionsinc.com)
  • It is well known, that platelets have an armament of soluble molecules, factors, mediators, chemokines, cytokines and neurotransmitters in their granules, and have multiple adhesion molecules and receptors on their surface. (biomedcentral.com)
  • Platelets have specialized adhesion mechanisms that make them able to take part in cell-matrix and cell-cell interactions. (biomedcentral.com)
  • High shear stress in stenotic atherosclerotic arteries cause platelet adhesion leading to the development of arterial thrombosis and cardiovascular events[ 15 ]. (biomedcentral.com)
  • A nitric oxide (NO) detection kit was used to determine the concentration of NO. Western blotting analysis was performed to determine the levels of intercellular cell adhesion molecule (ICAM)‑1, vascular cell adhesion molecule (VCAM)‑1, endothelin‑1, caspase‑3, Bax, Bcl‑2, Toll‑like receptor 4 (TLR4), p65 and p‑p65. (spandidos-publications.com)
  • P-selectin, a cell adhesion molecule, is an important member of the selectin family. (ijbs.com)
  • Growth of cancer cells is regulated by the balance between cell proliferation and apoptosis, which is a normal physiological process serving to eliminate unwanted cells and maintain homeostasis in healthy tissue. (nutraculture.com)
  • Typically this expansion originates in the bone marrow though, rarely, MM can develop as a result of the systemic proliferation of a solitary plasma cell tumour. (ctvrc.ca)
  • Terrein inhibits keratinocyte proliferation via ERK inactivation and G2/M cell cycle arrest: D.S. Kim, et al. (adipogen.com)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • These enzymes convert molecules such as nitrate and arginine into NO. The NO molecule then interacts with specific proteins on the surface of cells known as receptors which trigger various cellular responses depending on the type of receptor it binds to. (tvhealth.in)
  • Versican itself is normally with the capacity of binding to several cell surface area receptors present on leukocytes through connections also mediated by CS stores, including both L- and P-selectins and Compact disc44 (93C95). (healthyconnectionsinc.com)
  • Furthermore, mast cells and H1 receptors have not been the primary sites of antipruritic action of this extract. (researchgate.net)
  • Nevertheless, their distinctive armament of soluble mediators as well as the presence of surface receptors suggests that platelets must have further roles in several physiological and pathophysiological regulatory processes[ 14 ]. (biomedcentral.com)
  • Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. (embl.de)
  • Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. (embl.de)
  • Some of these mediators bind to cell surface receptors and activate nuclear factor kappa B (NF κ B), which leads to production of additional cytokines and nitric oxide (NO), a potent vasodilator. (msdmanuals.com)
  • 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
  • These processes cause immune system cells to release inflammatory mediators called cytokines, which in their own turn produce changes in the walls of blood vessels, eventually resulting in accumulation of diseased tissue known as plaques. (lifeextension.com)
  • Through these pathways activated platelets are accumulated in the follicular vessels surrounding the follicle and due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters) locally increase oocyte maturation and hormone secretion. (biomedcentral.com)
  • In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis (break- down). (silvermedicine.org)
  • In MM the malignant plasma cells over produce a single type of immunoglobulin, typically IgG or IgA. (ctvrc.ca)
  • In fungi, ozone inhibits cell growth at certain stages. (silvermedicine.org)
  • Ozone inhibits tumor metabolism. (silvermedicine.org)
  • Recent studies have shown that P-selectin deletion inhibits tumor growth in Rip1-Tag2 mice by suppressing platelet accumulation in tumor tissues. (ijbs.com)
  • Production of prostacyclin, a platelet aggregation inhibitor, and a vasodilator, is also induced by ozone. (silvermedicine.org)
  • Collagen-induced platelet aggregation inhibitor [11]. (adipogen.com)
  • A new terrein glucoside, a novel inhibitor of angiogenin secretion in tumor angiogenesis: M. Arakawa, et al. (adipogen.com)
  • Not only is it the site of production of many of the coagulation factors, including the vitamin K-dependent factors, fibrinogen and factor VIII (endothelial cells in the liver, not hepatocytes) and inhibitors (protein C, protein S, antithrombin), but it is also responsible for clearance and degradation of factors, factor-inhibitor complexes and D-dimer/FDPs. (eclinpath.com)
  • Liver disease can be associated with impaired coagulation factor and inhibitor production, production of abnormally functioning clotting factors, increased consumption of factors by initiation of DIC, and abnormal platelet number or function. (eclinpath.com)
  • For example, decreased production of coagulation factors is offset by decreased inhibitor production and profibrinolytic forces are balanced by antifibrinolytic mediators. (eclinpath.com)
  • This paper showed that Sanguis draconis attenuated high-glucose induced cell toxicity, nitrite, lipid peroxidation, and reactive oxygen species (ROS) formation in HUVEC. (hindawi.com)
  • An ever growing body of evidence shows that components of red grapes can have powerful effects on vascular health, reducing platelet aggregation and lipid peroxidation while improving endothelial function. (lifeextension.com)
  • Oxygenation of the tissues increases as the arterial partial pressure increases and viscosity decreases. (silvermedicine.org)
  • How this process occurs is multi-factorial including more than simply sensory blockade decreasing substance P release and edema, but also by diminishing the actions of polymorphonuclear (PMN) cells and related release of inflammatory mediators and oxygen free radicals, as well as by decreasing microvascular permeability and albumin extravasation in some tissues. (vetbloom.com)
  • internal or external triggers and/or stimuli may complement and connect regulatory pathways aimed towards target tissues and/or cells. (biomedcentral.com)
  • Some studies have shown that many types of tumors are stiffer than adjacent tissues and that tumor ECM stiffness is strongly correlated with solid tumor progression and aggression [ 5 , 6 ]. (ijbs.com)
  • A paper in this special issue investigates the effect of Antrodia camphorata, a rare Taiwanese medicinal mushroom that is popularly known as "niu cheng zhi" in Taiwan, on inflammatory arterial thrombosis-mediated platelet activation and also the pivotal role of protein kinase C in this situation was investigated. (hindawi.com)
  • Lowering Blood Pressure - Nitric oxide can decrease arterial stiffness making it easier for the heart to pump blood throughout the body. (tvhealth.in)
  • The antifungal properties of nitric oxide are being explored for their potential use as an anticancer agent due to its ability to affect cancer cell metabolism and growth rate through numerous pathways such as apoptosis induction, mTOR pathway blockage, autophagy activation, and cell cycle arrest at G1 phase with strong cytotoxicity effects towards tumor cells. (tvhealth.in)
  • Nutraculture™ Phycocyanin™ induces apoptosis in the existing and proliferating cancer cells and being a natural antioxidant, it also helps getting rid of any cancer promoting oxidative stress. (nutraculture.com)
  • It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)
  • This protection has been credited with preventing medication-induced liver and kidney damage, heart muscle damage following heart attack, and inducing programmed cell death (apoptosis) in a variety of human cancer cells. (lifeextension.com)
  • In other cells, apoptosis may be augmented, increasing cell death and thus worsening organ function. (msdmanuals.com)
  • Research progress on the correlation between platelet aggregation and tumor progression. (qxmd.com)
  • However, more and more studies have confirmed that platelets also have an important relationship with tumor progression. (qxmd.com)
  • It has been shown that MYL9 promotes cancer cell migration and is implicated in tumor development and progression. (cusabio.com)
  • To explore the role of P-selectin in tissue stiffness, we demonstrated that tumor progression in Rip1-Tag2 mice was correlated with tissue stiffness using immunofluorescence and histological staining. (ijbs.com)
  • HT-29 cells showed the second-highest level of CXCL10 secretion. (bslonline.org)
  • No significantly measurable level of CXCL10 secretion was detected in HCT116 cells. (bslonline.org)
  • The signal (PAF, or other tissue/cell specific factors) comes from the stimulated (by the e.g., hypophyseal hormones, bacteria, external factors, etc.) organs or cells, and activates platelets. (biomedcentral.com)
  • The researchers concluded that even a single dose of grape seed extract can minimize after-meal oxidant stress, both by decreasing oxidants and by increasing the blood's own antioxidant capacity. (lifeextension.com)
  • Antioxidant agent that enhances osseointegration by decreasing the level of ROS and having a potentially synergistic effect on osteoblast differentiation [13]. (adipogen.com)
  • Furthermore, this paper found that Sanguis draconis increased the expression of Bcl-2 and decreased Bax protein expression. (hindawi.com)
  • Though, high globulin levels can result in platelets becoming coated in protein (globulin), which decreases platelet aggregation ability. (ctvrc.ca)
  • 3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
  • Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
  • This importance is focussed on the target binding site - epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. (preprints.org)
  • Versican, in either unchanged or fragmented forms filled with the G3 domains, can boost tumor cell migration, development, and angiogenesis (80C82). (healthyconnectionsinc.com)
  • Localized folate and vitamin alcoholicвЂ"its relationship to medical and haematological abnormaliВ- B-12 deп¬Ѓciency in squamous cell lung cancer is related to global ties, liver illness and folate stores. (ehd.org)
  • This interaction enables the recruitment of T cells to the inflamed lung, which is significant in understanding immune responses [1] . (cusabio.com)
  • 1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
  • No increase in lung tumors was observed at 10 or 50 mg/m3. (who.int)
  • Bleeding is the result of thrombocytopathy (platelet dysfunction). (ctvrc.ca)
  • In recent years, studies on anti-tumor pharmacodynamics have found that one of its active components, the small molecule ophiopogonin, has a relatively strong anticancer effect.In vitro studies on anti-tumor effect showed that the compound could improve the therapeutic effect and patients' vital signs by inhibiting tumor vascular growth, regulating and enhancing cellular immune function, etc. (rainwoodbio.com)
  • Matrix assisted laser desorption ionization (MALDI) mass spectrometry is commonly used to analyze biological molecules such as proteins, peptides and lipids from cells or tissue. (koreascience.kr)
  • Platelet activation means their aggregation, sludge formation, furthermore the release of the for-mentioned biologically very powerful factors, which can locally amplify and deepen the tissue specific cell reactions. (biomedcentral.com)
  • Furthermore, we showed that P-selectin deficiency significantly decreased tissue stiffness by inhibiting lysyl oxidase (LOX) expression. (ijbs.com)
  • Further study demonstrated that P-selectin-mediated platelet accumulation increases tissue stiffness mainly by increasing LOX expression and thus promotes tumor growth. (ijbs.com)
  • The reason for its use is the higher number of platelets, which is an important source of growth factors, such TGF- β1, that hypothetically possess a stimulating effect on regulation and differentiation in mesenchymal tissue repair 10 . (bvsalud.org)
  • In addition, an interesting piece of work in this special issue examined the effect of an ethanolic extract of Sanguis draconis , a kind of dragon's blood resin that was obtained from Daemonorops draco (Palmae), on human umbilical vein endothelial cells (HUVEC) under high-glucose stimulation. (hindawi.com)
  • This study aimed to evaluate whether and how P-selectin affects tumor stiffness in Rip1-Tag2 mice. (ijbs.com)
  • Cancer is the uncontrolled growth of cells in the body, which is caused by the stepwise accumulation of mutations that affect cell growth control, differentiation and survival. (nutraculture.com)
  • CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)
  • Conversely, high levels of von Willebrand factor and FVIII are seen in human patients with liver disease, since both of these are produced in endothelial cells, not hepatocytes, and increase as acute phase proteins in humans (Lisman and Porte 2010). (eclinpath.com)
  • Ozone also causes an increase in the NADH reducing process and helps to oxidize cytochrome C. There is a stimulation of the production of the enzymes which act as free radical scavengers and cell wall protectors: glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase. (silvermedicine.org)
  • Granules merge with channels of the canalicular system after platelet stimulation and evacuate their contents[ 8 - 10 ]. (biomedcentral.com)
  • Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release potent soluble regulatory factors. (embl.de)
  • Inactivation of the gene in mouse cells caused a marked decrease in soluble TNF-alpha production. (embl.de)
  • B-cells are responsible within the immune system for producing antibodies. (ctvrc.ca)
  • There is limited research on the potential use of alum for treating tumors, but it has been investigated for its ability to enhance the immune system and act as an adjuvant in cancer immunotherapy. (aahari.com)
  • The rate of degradation increases with decreasing pH. (rxlist.com)
  • Peripheral blood is collected from the blood vessels, mainly from the capillaries, arteries and veins, and analyzed for the formed blood elements such as red and white blood cells, platelets and plasma. (nytimes-se.com)
  • Long-term suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expression: S.H. Park, et al. (adipogen.com)
  • NO also helps to improve endothelial cell integrity, which improves cellular metabolism and normalizes blood pressure levels. (tvhealth.in)
  • Once perfusion declines and oxygen delivery to cells is inadequate for aerobic metabolism, cells shift to anaerobic metabolism with increased production of carbon dioxide and elevated blood lactate levels. (msdmanuals.com)
  • We use continuous wavelet analysis (WA) of Laser Doppler Flux (LDF) time series measured in basal cell carcinomas (BCC) and plaque psoriasis (PP) in order to investigate the rhythmical behavior of blood flow in tumor or inflammatory associated neoangiogenesis. (iospress.com)
  • The same cascade causes platelets, the tiny cell-like fragments responsible for blood clotting, to cluster together (aggregate) excessively, increasing the risk of clot formation that can produce ischemic heart attacks and strokes. (lifeextension.com)
  • Eating fresh ginger in high doses can have blood-thinning effects by preventing platelets from sticking together. (mskcc.org)
  • In circulatory disease, a clumping of red blood cells hinders blood flow through the small capillaries and decreases oxygen absorption due to reduced surface area. (silvermedicine.org)
  • Ozone causes an increase in the red blood cell glycolysis rate. (silvermedicine.org)
  • cytogenetic examination of nucleated blood cells. (nytimes-se.com)
  • Blood from patients treated with IVIG is reported to have increased suppressor CD8-positive T-cells. (nursingcenter.com)
  • Mechanisms may involve decreased circulating volume, decreased cardiac output, and vasodilation, sometimes with shunting of blood to bypass capillary exchange beds. (msdmanuals.com)
  • Non-survivors (n=54, 42%) presented significant alterations in hematological and coagulation parameters at admission, such as increased in white blood cells (WBC), neutrophil, and band cell counts, as well as elevated prothrombin time (PT), activated partial thromboplastin time, and D-dimer levels. (bvsalud.org)
  • During follow-up, the same group presented a gradual increase in D-dimer and PT levels, accompanied by a reduction in PT activity, hemoglobin, and red blood cell count (RBC). (bvsalud.org)
  • Severe liver disease resulting in synthetic liver failure can produce coagulation abnormalities from decreased production of coagulation factors. (eclinpath.com)
  • Platelets are generally considered as the main functional unit of the coagulation system. (qxmd.com)
  • In human patients, abnormal carboxylation of vitamin K-dependent enzymes (resulting in decreased enzyme activity) has been documented in patients without evidence of cholestasis. (eclinpath.com)
  • Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
  • MDA was significantly decreased in the colon of groups fed bilberry alone (p = 0.030) and in combination with L. plantarum HEAL19 (p = 0.021) compared to the IR-control but not in chokeberry-fed groups. (biomedcentral.com)
  • These results indicate that P-selectin deletion significantly decreases tumor stiffness in Rip1-Tag2 mice by inhibiting LOX expression. (ijbs.com)
  • Leukocytes and platelets adhere to the endothelium, and the clotting system is activated with fibrin deposition. (msdmanuals.com)
  • This property let platelets arrest bleeding and promote vessel repair. (biomedcentral.com)
  • Cholestatic liver disease can result in a lack of vitamin K, with decreased production of vitamin K-dependent enzymes (factors II, FVII, IX and X) and a vitamin K-responsive coagulopathy. (eclinpath.com)
  • These toxins bind to globotriaosylceramide (Gb3), a glycolipid receptor molecule on the surface of endothelial cells in the gut, kidney, and, occasionally, other organs. (medscape.com)
  • By disrupting the interaction between MYL9 and CD69, researchers found that it can potentially boost the anti-tumor immune response, make MYL9 an attractive target for cancer immunotherapy [2] . (cusabio.com)