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  • disorders
  • Metabolic/storage disorders e.g. leukodystrophies,mucopolysaccharidoses as Hurler disease;Stem cell defects e.g.reticular agenesis, among many other rare similar conditions. (clinicaltrials.gov)
  • hiPSC-derived
  • Following up on this discovery, the researchers tested a rocking-bag-based bioreactor followed by a new microfluidic system with a flow chamber and multiple pillars, but these devices generated fewer than 20 platelets per hiPSC-derived megakaryocyte. (phys.org)
  • However, it remains elusive to which extent patient-specific hiPSC-derived cells functionally resemble their native counterparts. (jove.com)
  • Here, we generated a hiPSC model of the primary platelet disease Glanzmann thrombasthenia (GT), characterized by dysfunction of the integrin receptor GPIIbIIIa, and compared side-by-side healthy and diseased hiPSC-derived platelets with peripheral blood platelets. (jove.com)
  • Both GT-hiPSC-derived platelets and their peripheral blood equivalents showed absence of membrane expression of GPIIbIIIa, a reduction of PAC-1 binding, surface spreading and adherence to fibrinogen. (jove.com)
  • We demonstrated that GT-hiPSC-derived platelets recapitulate molecular and functional aspects of the disease and show comparable behavior to their native counterparts encouraging the further use of hiPSC-based disease models as well as the transition towards a clinical application. (jove.com)
  • progenitor cells
  • We also optimise culture conditions and develop ex vivo expansion strategies to amplify the HSCs and short-term repopulating progenitor cells in vitro , that allow generation of clinically significant number of cells from the limited number of cells present in the available samples. (genelon.in)
  • This combination of constitutively expressed adhesion molecules may thus constitute a BM-specific recruitment pathway for progenitor cells analogous to the vascular addressins that direct selective lymphocyte homing to lymphoid organs. (rupress.org)
  • However, little is known about the adhesion pathways that are involved in the homing of hematopoietic stem cells and hematopoietic progenitor cells (HPCs) from the blood to the BM. (rupress.org)
  • PBSC
  • Evaluate the effectiveness of TXA127 in accelerating the time to initial platelet recovery following PBSC transplant with a limited number of CD34+ cells, defined as CD34+ cell concentrations ≥1.5 x 106 and ≤5.0 x 106 CD34+ cells/kg. (clinicaltrials.gov)
  • Koji Eto
  • The discovery of turbulent energy provides a new physical mechanism and ex vivo production strategy for the generation of platelets that should impact clinical-scale cell therapies for regenerative medicine," says senior study author Koji Eto, part of the Center for iPS Cell Research and Application at Kyoto University. (phys.org)
  • Kyoto University
  • Researchers at the Center for iPS Cell Research and Application at Kyoto University in Japan presented data here at a meeting of the American Society of Hematology showing they were able to create the cells in the laboratory and confirm they had the same life span as normal human platelets when infused in mice. (blogspot.com)
  • therapies
  • A meta-analysis was performed on relevant published evidence evaluating re-injury 24 months after stem cell-based [17.6% of the SL and 14.3% of the SDFT group ( n = 89)] versus conventional therapies. (frontiersin.org)
  • The goal for her cardiovascular platelet laboratory is to identify the etiology of platelet dysfunction in many disease states and apply methods that may improve this dysfunction that can eventually be translated to therapies for patients with cardiovascular disease. (hopkinsmedicine.org)
  • injuries
  • We are committed to improving the body's ability to heal using the most advanced stem cell and platelet solutions to treat pain from common injuries and overcome degenerative conditions, allowing patients to regain focus on achieving personal goals. (regenexx.com)
  • Dr. Centeno is one of the few physicians in the world with extensive experience in the culture expansion of and clinical use of adult stem cells to treat orthopedic injuries. (regenexx.com)
  • acute
  • Adipose stem cells are an attractive and abundant stem cell source with therapeutic applicability in diverse fields for the repair and regeneration of acute and chronically damaged tissues. (caringmedical.com)
  • Current research in our lab aims to further characterize the platelet-monocyte interaction during acute viral infection with the goals of establishing methods of pharmacologically manipulating this association, and establishing how platelet binding to a monocyte influences the monocyte's susceptibility to lentiviral infection and the monocyte's interactions with endothelium. (hopkinsmedicine.org)
  • Dr. Williams' research focuses on platelet physiology particularly as it relates to acute coronary syndromes and depression. (hopkinsmedicine.org)
  • coronary
  • Through funding by the National Heart Lung and Blood Institute, we have performed candidate gene analysis, linkage studies, whole genome association studies, and now whole genome sequencing in about 2000 healthy subjects from families with early onset coronary artery disease. (hopkinsmedicine.org)
  • Researchers
  • A team of Japanese researchers has worked out a method to produce a large volume of cells from which blood platelets can be derived outside the human body, using artificially created stem cells. (jagran.com)
  • Medical Xpress)-A team of Canadian researchers has found that platelets in mice liver collaborate with special types of white blood cells to help capture bacteria. (medicalxpress.com)
  • A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) describes the biology behind why muscle stem cells respond differently to aging or injury. (medicalxpress.com)
  • After thoroughly testing various devices, the researchers discovered that large-scale production of high-quality platelets was possible using a bioreactor called VerMES. (phys.org)
  • significantly
  • The discovery of the crucial role of turbulence in platelet production significantly extends past research showing that shear stress from blood flow is also a key physical factor in this process," Eto says. (phys.org)
  • Platelets are known to participate in innate immunity through cytokine signaling and direct interactions with other cells, and the platelet has the potential to significantly influence disease outcomes. (hopkinsmedicine.org)
  • endothelial
  • Selectin-independent rolling was mediated by α4 integrins, which interacted with endothelial vascular cell adhesion molecule (VCAM)-1. (rupress.org)
  • Parallel contribution of the endothelial selectins and VCAM-1 is not known to direct blood cell trafficking to other noninflamed tissues. (rupress.org)
  • HPCs were also shown to bind to P-selectin (( 13 )), although the expression of P-selectin on BM endothelial cells has not been described. (rupress.org)
  • Recent data suggest that E-selectin is constitutively expressed on endothelial cells of human and murine hematopoietic tissues (( 8 ), ( 14 )), but the role of E-selectin in HPC homing has not been addressed. (rupress.org)
  • shelf life
  • The supply of donated platelets , which have a short shelf life and must be kept at room temperature, is often insufficient to meet clinical needs. (medicalxpress.com)
  • One factor that contributes to this problem is the short shelf-life of some blood components. (phys.org)
  • vessel
  • When a dose was given to a mouse, a clot was formed in a damaged blood vessel and bleeding was arrested, according to the team. (jagran.com)
  • In response to blood vessel damage, von Willebrand factor (vWF) binds to the exposed extra cellular matrix, recruits platelets to the site of injury, and activates platelets, which promotes thrombis formation. (medicalxpress.com)
  • In normal clotting, platelets (cells that cause the blood to clot) stick together and form a plug at the site of an injured blood vessel, allowing the injured site to heal. (blogspot.com)
  • They are also thought to stimulate angiogenesis (new blood vessel formation), which provides blood flow to assist in hair growth. (yahoo.com)
  • Subsequently, leukocytes migrate through the blood vessel wall and enter the extravascular tissue. (rupress.org)
  • function
  • Platelets, whose primary function is to prevent bleeding, are vital for treating various forms of trauma and blood diseases. (medicalxpress.com)
  • To develop a quantitative approach to personalized risk assessment for stroke and dementia based on patent-specific heart anatomy, function and blood flow. (hopkinsmedicine.org)
  • It is known that L-selectin is expressed on the majority of HPCs (( 9 )-( 11 )), but its function on these cells is unclear. (rupress.org)
  • mice
  • They then tested the functionality of the cultured platelets by infusing them into immunodeficient mouse models and confirmed they had the same life span as human platelets infused in mice. (blogspot.com)
  • Specifically, both types of platelets promoted blood clotting and reduced bleeding times to a comparable extent after ear vein incisions in rabbits and tail artery punctures in mice. (phys.org)