• Despite prophylactic platelet transfusions, people with blood cancers often bleed, and other risk factors for bleeding such as inflammation and duration of thrombocytopenia should be considered. (wikipedia.org)
  • Several studies have now assessed the benefit of using preventive platelet transfusions in adults with dengue who have profound thrombocytopenia (platelet count (wikipedia.org)
  • The [original] guideline recognized the important role of platelet transfusion in the prevention and treatment of bleeding in patients with treatment-related thrombocytopenia but also sought to avoid the overuse of platelet transfusions by identifying patients who are most likely to benefit," guideline panel chair Charles A. Schiffer, MD, of Wayne State University in Detroit, and co-authors said in the introduction to the updated guideline. (medpagetoday.com)
  • Immune thrombocytopenia (ITP) is a type of platelet disorder . (nih.gov)
  • Platelet transfusion is commonly used to prevent or treat bleeding in people with thrombocytopenia or platelet dysfunction. (atlasofscience.org)
  • We concluded that thrombocytopenia was common after ECC, maximum drop of the platelet counts after ECC was usually seen on the second day after ECC, and platelet counts started to recover on the fifth day after ECC. (nature.com)
  • Platelet transfusion, as the primary treatment for severely low platelet count (thrombocytopenia) or disorders of platelet function, is used extensively in patients with blood system diseases or active hemorrhaging. (blood-genomics.com)
  • This study is investigating the safety and efficacy of platelet transfusion as a treatment for infants with thrombocytopenia. (nih.gov)
  • This study investigates immature platelet counts as a marker for bleeding risk in newborns with thrombocytopenia, compared with platelet counts alone. (nih.gov)
  • Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to chronic bone marrow failure: a meta-analysis and systematic review. (ox.ac.uk)
  • OBJECTIVES: To compare the relative efficacy of different interventions for patients with thrombocytopenia due to chronic bone marrow failure and to derive a hierarchy of potential alternative treatments to platelet transfusions. (ox.ac.uk)
  • SELECTION CRITERIA: We included randomised controlled trials in people with thrombocytopenia due to chronic bone marrow failure who were allocated to either an alternative to platelet transfusion (artificial platelet substitutes, platelet-poor plasma, fibrinogen concentrate, recombinant activated factor VII (rFVIIa), desmopressin (DDAVP), recombinant factor XIII (rFXIII), recombinant interleukin (rIL)6 or rIL11, or thrombopoietin (TPO) mimetics) or a comparator (placebo, standard of care or platelet transfusion). (ox.ac.uk)
  • We suggest that the anti-HIV-1gp120 antiidiotype-like complex contributes to the markedly elevated platelet Ig and C3 level of HIV-1-ITP patients and propose that this may contribute to their thrombocytopenia. (jci.org)
  • Thrombocytopenia commonly seen with PIs is called cyclic thrombocytopenia in which the platelet count usually nadirs around day 11 of the cycle and then improves. (hindawi.com)
  • Although parturients, a cohort of patients that often receives neuraxial anesthesia, are generally in a hypercoagulable state, certain conditions of pregnancy (eg, gestational thrombocytopenia, HELLP [hemolysis, elevated liver enzymes, low platelets] syndrome, and complications of preeclampsia) can increase the incidence of epidural hematoma. (medscape.com)
  • Patient A. In October 2004, a man aged 74 years in Ohio with leukemia received a transfusion consisting of a pool of five platelet unit concentrates. (cdc.gov)
  • Among transfusable blood products, however, platelet concentrates (PCs), which also contain plasma, have a higher frequency of transfusion reactions than red blood cells or fresh frozen plasma. (atlasofscience.org)
  • Platelet concentrates (PCs) are blood components transfused in thrombocytopenic patients, including patients with blood malignancies. (phcogj.com)
  • Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
  • Cytokines released from WBCs during storage, particularly in platelet concentrates, are another possible cause. (msdmanuals.com)
  • PCs contain leukocytes, which can pose potential side effects and activate platelets, reducing the efficacy of platelet transfusion. (phcogj.com)
  • A review in people with blood cancers compared different platelet transfusion doses. (wikipedia.org)
  • this review compares different platelet transfusion doses. (ox.ac.uk)
  • One of the review's included studies reported on transfusion reactions. (wikipedia.org)
  • The PLT-specific critique found many studies adequately reported basics of the PLT product, PLT increment, and transfusion reactions. (ox.ac.uk)
  • Hemolytic transfusion reactions, posttransfusion purpura, febrile nonhemolytic transfusion reactions, and transfusion-related acute lung injury are discussed in Transfusion Reactions . (medscape.com)
  • Transfusion reactions can lead to discomfort for the patient and can even be fatal, albeit rarely. (atlasofscience.org)
  • Plasma is considered to be candidates for the cause of transfusion reactions and removal of plasma in PCs by washing (Fig. 1) effectively reduces transfusion reactions by some clinical studies. (atlasofscience.org)
  • WPCs were transfused to 86 patients (94.5%) due to recurrent PC-related transfusion reactions that could not be prevented by premedication with antihistamine and hydrocortisone. (atlasofscience.org)
  • Clinical preventative effects by WPCs were achieved in 99.8% of the transfusions, and the recurrent transfusion reactions by WPCs were confirmed in only 2 of 1,206 transfusions. (atlasofscience.org)
  • Subgroup analysis revealed that the preventative effect was not affected by sex, disease, type, or severity of transfusion reactions. (atlasofscience.org)
  • WPCs were therefore safely transfused into patients with a history of severe transfusion reactions such as anaphylaxis and respiratory distress. (atlasofscience.org)
  • WPCs were effective for recurrent transfusion reactions in almost all transfusions. (atlasofscience.org)
  • Anaphylaxis and severe allergic transfusion reactions (ATR) are uncommon complications after blood transfusion. (peertechzpublications.org)
  • Transfusion reactions were analyzed as a secondary outcome. (ox.ac.uk)
  • CONCLUSIONS: No differences were seen in the incremental change in platelet count nor in transfusion reactions when comparing major ABO incompatible platelet transfusions with ABO compatible transfusions in a large study of critically ill children. (ox.ac.uk)
  • Allergic reactions The most common complications of transfusion are Febrile nonhemolytic reactions Chill-rigor reactions The most serious complications, which have very high mortality rates, are Acute hemolytic. (msdmanuals.com)
  • Because fever and chills also herald a severe hemolytic transfusion reaction, all febrile reactions must be investigated as for acute hemolytic transfusion reaction, as with any transfusion reaction. (msdmanuals.com)
  • Decrease transfusion-related complications by using leukocyte-depleted blood products, which have been shown to decrease nonhemolytic febrile reactions, prevent alloimmunization and platelet refractoriness, and prevent cytomegalovirus transmission. (medscape.com)
  • Researchers are looking at the positive effects of platelet transfusion against the negative effects, such as the release of inflammatory molecules and the formation of blood clots. (nih.gov)
  • Data from randomized, controlled trials showed that initiating platelet transfusion at the first sign of bleeding showed similar rates of bleeding with reduced platelet usage, as compared with prophylactic platelet transfusion, authors of the updated guideline wrote in the Journal of Clinical Oncology . (medpagetoday.com)
  • Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation. (ox.ac.uk)
  • Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation. (ox.ac.uk)
  • A recent review of clinical platelet (PLT) studies indicated variability in reporting. (ox.ac.uk)
  • STUDY DESIGN AND METHODS: A systematic MEDLINE search for clinical studies of PLT transfusion was performed to identify articles. (ox.ac.uk)
  • CONCLUSION: Recently published articles of clinical PLT transfusion share common strengths and weaknesses. (ox.ac.uk)
  • The quality of reporting may be improved by providing guidelines to authors and journal editors that list the essential elements of a well-reported clinical study of PLT transfusion. (ox.ac.uk)
  • Development of a web-based clinical decision support application for platelet transfusion management using R and the Tidyverse Blood product transfusion is a high risk and costly medical procedure. (posit.co)
  • Proper management of platelet transfusions is essential to clinical care, particularly for patients who have developed antibodies against specific platelet types due to pregnancy or past transfusions. (posit.co)
  • The team has recently participated in two clinical trials, under the Transfusion Medicine/Hemastasis Clinical Trial Network sponsored by NHLBI, identifying and recruiting eligible patients. (jhu.edu)
  • this was considered to be a high value compared with the transfusion threshold of clinical guidelines. (atlasofscience.org)
  • BACKGROUND: Platelet transfusions are used in modern clinical practice to prevent and treat bleeding in people who are thrombocytopenic due to bone marrow failure. (ox.ac.uk)
  • In the clinical application of platelet transfusion, there are large differences between the treatment's effects on different patients. (blood-genomics.com)
  • Platelets used in clinical therapy include platelets made from whole blood and hemapheresis platelets, and the latter is the main application type used in China. (blood-genomics.com)
  • Platelet transfusion cannot be recommended for this indication in clinical practice. (qxmd.com)
  • STUDY DESIGN AND METHODS: From April 1999 to December 2009, we retrospectively reviewed the clinical and transfusion records of all D- patients who received PLT transfusions from D+ donors at our hospital. (notifylibrary.org)
  • Blood transfusion in clinical medicine / P. L. Mollison, C. P. Engelfriet, Marcela Contreras. (who.int)
  • International guidelines recommend that platelets transfusions are given to people with reversible bone marrow failure to reduce the risk of spontaneous bleeding when the platelet count is less than 10 x 109/L. If the person is well using a higher platelet count threshold does not reduce the risk of bleeding further. (wikipedia.org)
  • BACKGROUND: Current guidelines recommend that platelets (PLTs) from D- donors should be given to D- patients. (notifylibrary.org)
  • The evidence is very uncertain about the effect of platelet transfusions prior to surgery for people with a low platelet count on the all-cause mortality, the number of participants with bleeding events after surgery, serious surgery-related or transfusion-related adverse events. (wikipedia.org)
  • Researches on the molecular basis or the curative effect of platelet transfusion are increasing, such as the relationship between platelet-activating factors, tissue factors, thrombopoietin, membrane glycoprotein and platelet activation, and their influence on the curative effect of platelet transfusion, the inhibition of antiplatelet therapy in platelet activation, and platelet signal transduction pathways and their significance in the curative effect of platelet transfusion. (blood-genomics.com)
  • This article aims to review the research progress on the curative effect of platelet transfusion and its molecular mechanisms. (blood-genomics.com)
  • Refractoriness to platelet transfusion (an increase in the platelet count after platelet transfusion that is significantly lower than expected [e.g. (medscape.com)
  • DHTRs and refractoriness to platelet transfusions are discussed in this article. (medscape.com)
  • Higher platelet transfusion thresholds have been used in premature neonates, but this has been based on limited evidence. (wikipedia.org)
  • The objectives are as follows: To determine whether different platelet transfusion thresholds for administration of prophylactic platelet transfusions (platelet transfusions given to prevent bleeding) affect the efficacy and safety of prophylactic platelet transfusions in preventing bleeding in patients with haematological disorders after chemotherapy with or without stem cell transplantation. (ox.ac.uk)
  • Refractoriness to granulocyte transfusion involves either HLA or granulocyte-specific antibodies and is similar to platelet refractoriness, except that refractoriness to granulocyte transfusion results in the patient failing to respond clinically to the infused granulocytes. (medscape.com)
  • You also may have a blood test to check for the antibodies that attack platelets. (nih.gov)
  • By providing platelets that avoid a patient's known antibodies, improved patient outcomes and better inventory management of a rare blood product are achieved. (posit.co)
  • Immune or nonimmune factors, such as platelet-specific antibodies, platelet gene analysis and matches, and auxiliary treatment, may affect the curative effect, and even result in ineffective platelet transfusion. (blood-genomics.com)
  • Adults undergoing hematopoietic stem-cell transplants (HSCT) may safely delay platelet infusion until the first sign of bleeding, as opposed to prophylactic infusion, according to an updated guideline for platelet transfusion in patients with cancer. (medpagetoday.com)
  • In addressing a half dozen other issues posed for consideration, the panel made no substantive changes to existing recommendations for platelet transfusion for patients with cancer. (medpagetoday.com)
  • Whereas viscoelastic testing and transfusion algorithms may be considered, in general, evidence informing indications for plasma and platelet transfusions in neonatal and pediatric patients undergoing cardiac surgery with cardiopulmonary bypass or those requiring extracorporeal membrane oxygenation support is lacking. (nih.gov)
  • Platelet services are available to help ensure optimal responses to platelet transfusions in sensitized patients. (actscorp.org)
  • The platelet transfusion coordinators order inventory based on projected usage, designate selected products for immunized patients, and monitor the use of all platelet products within the Institution. (jhu.edu)
  • The platelet transfusion coordinators provide coverage 24/7, screening requests for and assigning platelet products to patients as needed. (jhu.edu)
  • Approximately 3,000 different patients are transfused platelet products in this institution per year. (jhu.edu)
  • Patients displayed mostly hematological diseases and had a median of 48 transfusion histories. (atlasofscience.org)
  • However, platelet values at 24 hours could be evaluated in only 36 patients, and 11 patients had risk factors for platelet transfusion refractoriness such as bleeding and infections. (atlasofscience.org)
  • Our objective was to observe the effects of extracorporeal circulation (ECC) with different time on platelet count in patients undergoing cardiac surgery. (nature.com)
  • However, there are few studies on the effects of ECC time on platelet count in patients after cardiac surgery, especially the effects of different ECC time on postoperative platelet count has not been reported. (nature.com)
  • The purpose of this study was to conduct a retrospective study to observe the effects of ECC with different time on platelet count in patients undergoing cardiac surgery, so as to provide reference for improving the prognosis of patients undergoing cardiac surgery. (nature.com)
  • Hospitals of Karachi were flooded with dengue patients as the incursion of mosquitoes triggered the outbreak of dengue virus in the city, however unnecessary transfusion of platelets in dengue patients has been reported in the city, Geo News reported. (noor.news)
  • Meanwhile, it is reported that some private hospitals in the city, for the lust of money are transfusing platelets unnecessarily to dengue patients against the direction of the World Health Organisation (WHO). (noor.news)
  • Dr Darnaz also directed the authorities concerned that platelets be transfused to dengue patients, only if it ranges below 20 thousand or the patient starts bleeding. (noor.news)
  • This activity will focus on recommendations for plasma and platelet transfusions in patients with cirrhosis and examine strategies for optimizing platelet inventory in a hospital blood bank. (cap.org)
  • Patients with cirrhosis are often transfused with platelets and plasma, yet the optimal role of these blood products is often poorly understood by ordering providers. (cap.org)
  • This activity reviews the variety of plasma and platelet products available for transfusion, explores the role of plasma and platelet transfusion in stable, nonbleeding patients with cirrhosis, and discusses options to maintain a platelet inventory that is adequate to support their patients’ needs while minimizing wastage of unused units. (cap.org)
  • Describe the role of plasma and platelet transfusions in stable, nonbleeding patients with cirrhosis. (cap.org)
  • PATIENTS: Children (3 d to 16 yr old) were enrolled if they received a platelet transfusion during one of the predefined screening weeks. (ox.ac.uk)
  • Prediction of Mid-term Platelet Transfusion in Stable Trauma Patients Using Rotational Thromboelastometry. (bvsalud.org)
  • TEM International GmbH, Munich, Germany ) is a global coagulation test that guides evidence-based platelet transfusion in trauma patients . (bvsalud.org)
  • We evaluated ROTEM parameters for predicting mid-term (five days) platelet transfusion in trauma patients . (bvsalud.org)
  • FIBTEM and EXTEM can reliably predict mid-term platelet transfusion in trauma patients . (bvsalud.org)
  • Variability in the Use of Platelet Transfusion in Patients with Intracerebral Hemorrhage: Observations from the Ethnic/Racial Variations of Intracerebral Hemorrhage Study. (wakehealth.edu)
  • To reduce morbidity and mortality as a result of uncontrolled hemorrhage, patients needing a massive transfusion, specifically addressed in detail later in this chapter, must be quickly identified so that immediate interventions can prevent the development of the lethal triad of coagulopathy, hypothermia, and acidosis. (medscape.com)
  • The most common situations are for patients receiving chemotherapy, requiring surgery (especially cardiac surgery) or having experienced severe haemorrhage (e.g. from pregnancy or childbirth, trauma, largely from road traffic accidents, or severe anaemia in the young, often caused by malaria), often being combined with other blood products such as fresh frozen plasma (FFP) and red blood cells (RBCs) in a massive transfusion protocol. (nhsbt.nhs.uk)
  • Platelet transfusions from D+ donors to D- patients: a 10-year follow-up study of 1014 patients. (notifylibrary.org)
  • We thus decided to extend these findings by examining anti-D alloimmunization at our institution, where PLT transfusions from D+ donors are transfused to D- patients because of logistic constraints. (notifylibrary.org)
  • RESULTS: Our series comprises 1014 D- patients who received 5128 PLT transfusions from D+ donors (89% were pooled PCs). (notifylibrary.org)
  • We had 315 (31.1%) patients who had a blood sample to analyze the presence of anti-D 4 or more weeks after the first D+ PLT transfusion with a median follow-up of 29 weeks (range, 4-718 weeks). (notifylibrary.org)
  • Patients should also be treated (eg, with acetaminophen ) before future transfusions. (msdmanuals.com)
  • Guidelines for transfusion in patients with MDS and bone marrow failure are as follows. (medscape.com)
  • Patients with congestive heart failure may not tolerate the same degree of anemia as young patients with normal cardiac function, and slow or small-volume (eg, packed RBCs) transfusions with judicious use of diuretics should be considered. (medscape.com)
  • Patients with low-risk or intermediate-1-risk MDS typically have long-term survival and may receive multiple RBC transfusions. (medscape.com)
  • These patients may develop transfusion-induced iron overload and can incur significant damage of the liver, heart, pancreas, and other tissues. (medscape.com)
  • Platelet transfusion is beneficial to stop active bleeding in thrombocytopenic patients, but the life span for transfused platelets is only 3-7 days. (medscape.com)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)
  • There is little evidence for the use of preventive platelet transfusions in people with chronic bone marrow failure, such as myelodysplasia or aplastic anemia. (wikipedia.org)
  • Multiple guidelines recommend prophylactic platelet transfusions are not used routinely in people with chronic bone marrow failure, and instead an individualised approach should be taken. (wikipedia.org)
  • PLTVXM queries information on available/pending platelet inventory (and eligible donors) from reports that run in our institutional reporting tool Tableau® via a Tableau Server REST API. (posit.co)
  • Patient B. In December 2004, a man aged 79 years in Utah received a transfusion of pheresis platelets for thromobocytopenia after coronary artery bypass surgery. (cdc.gov)
  • He underwent an immediate splenectomy with massive transfusion: 9 packed red blood cells units, 7 fresh frozen plasma units, and 1 whole blood platelet pool. (cdc.gov)
  • [ 1 ] Massive transfusion protocols (MTPs) should be institutionally monitored by a blood utilization committee that can track initiation, cessation, component wastage, storage of blood products outside of the blood bank, transport standards, and compliance with applicable Food and Drug Administration (FDA) standards. (medscape.com)
  • The American Red Cross is the Institution's primary platelet supplier, providing the majority of the more than 18,000 pheresis platelets transfused each year at a cost of nearly $600 each. (jhu.edu)
  • Since pheresis platelets expire five days after collection, this leaves roughly three days to transfuse the product. (jhu.edu)
  • OBJECTIVES: To determine whether different doses of prophylactic platelet transfusions (platelet transfusions given to prevent bleeding) affect their efficacy and safety in preventing bleeding in people with haematological disorders undergoing myelosuppressive chemotherapy with or without haematopoietic stem cell transplantation (HSCT). (ox.ac.uk)
  • Bleeding disorders can also result from a problem with the number or function of platelets. (medlineplus.gov)
  • Bone marrow disorders, such as leukemia and lymphoma , can also affect how many platelets the body can produce. (medicalnewstoday.com)
  • Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. (qxmd.com)
  • Platelet transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet therapy might reduce death or dependence by reducing the extent of the haemorrhage. (qxmd.com)
  • We aimed to investigate whether platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet therapy use. (qxmd.com)
  • stratified by hospital and type of antiplatelet therapy) to receive either standard care or standard care with platelet transfusion within 90 min of diagnostic brain imaging. (qxmd.com)
  • Platelet transfusion seems inferior to standard care for people taking antiplatelet therapy before intracerebral haemorrhage. (qxmd.com)
  • There is now evidence that using a high platelet count threshold (50 x 109/L) increases the risk of death or bleeding compared to a lower platelet count threshold (25 x 109/L) in premature neonates. (wikipedia.org)
  • To present the recommendations and consensus statements with supporting literature for plasma and platelet transfusions in critically ill neonates and children undergoing cardiac surgery with cardiopulmonary bypass or supported by extracorporeal membrane oxygenation from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. (nih.gov)
  • A panel of nine experts developed evidence-based and, when evidence was insufficient, expert-based statements for plasma and platelet transfusions in critically ill neonates and children following cardiopulmonary bypass or supported by extracorporeal membrane oxygenation. (nih.gov)
  • A total of 143 (36%) respondents reported they were aware that bacterial contamination of platelets is one of the most common infectious risks of transfusion therapy. (cdc.gov)
  • Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children. (nih.gov)
  • Effects of ABO Matching of Platelet Transfusions in Critically Ill Children. (ox.ac.uk)
  • OBJECTIVES: To determine if transfusing ABO compatible platelets has a greater effect on incremental change in platelet count as compared to ABO incompatible platelets in critically ill children. (ox.ac.uk)
  • Studies in larger, prospectively enrolled cohorts should be performed to validate whether ABO matching for platelet transfusions in critically ill children is necessary. (ox.ac.uk)
  • With the extension of ECC time, the drop in platelet counts is more pronounced, the volume of perioperative blood loss and blood products transfusion are more, and the recovery level and speed of platelet counts is lower. (nature.com)
  • Perform complete blood counts and platelet counts. (nih.gov)
  • Some people have low platelet counts due to genetic factors. (medicalnewstoday.com)
  • Low platelet counts affect close to 10% of pregnant people at the time of birth. (medicalnewstoday.com)
  • Time course of liver blood test results from a vere acute respiratory distress syndrome developed, and the trauma patient in France who was transfused with an HEV- patient was treated with venovenous extracorporeal mem- contaminated blood platelet pool on day 5 posttrauma. (cdc.gov)
  • About 20 people die yearly in the US as a result of acute hemolytic transfusion reaction. (msdmanuals.com)
  • ABO incompatibility is the most common cause of acute hemolytic transfusion reaction. (msdmanuals.com)
  • and platelet transfusions compared to alternative treatments. (ox.ac.uk)
  • Supportive therapy, including transfusions of the cells that are deficient (ie, red blood cells [RBCs], platelets), and treatment of infections are the main treatments. (medscape.com)
  • isolates from the patient's blood and the platelet bag were indistinguishable by pulsed-field gel electrophoresis (PFGE). (cdc.gov)
  • A primary responsibility of the Service is to monitor correct use of platelet products in order to keep outdating to a minimum, while maintaining an inventory that can support patient's needs yet respond to unexpected emergencies. (jhu.edu)
  • Strong correlations (r>0.7) were noted between platelet count and EXTEM (A5, A10, and A15) or PLTEM (A5), platelet function (per platelet count ) and EXTEM (A10 and A15), and fibrinogen levels and all FIBTEM parameters . (bvsalud.org)
  • FIBTEM, EXTEM, and PLTEM parameters correlate with conventional coagulation tests ( platelets and fibrinogen ). (bvsalud.org)
  • There is no randomised controlled trial evidence for artificial platelet substitutes, platelet-poor plasma, fibrinogen concentrate, rFVIIa, rFXIII or rIL6 or rIL11, antifibrinolytics or DDAVP in this setting. (ox.ac.uk)
  • The use of PMEA-coated circuit is associated with retainment of perioperative plasma proteins levels and may help to reduce transfusion of platelet products in TAR in comparison with the heparin-coated circuit. (elsevierpure.com)
  • point to the importance of evidence-based transfusion practice. (medpagetoday.com)
  • In spite of widespread use, data supporting specific practice paradigms for whole blood and component therapy transfusion are lacking, the notable exception being in the primary treatment of hemorrhagic shock. (medscape.com)
  • Prompt and sustainable termination of IAH may require therapeutic combination of transfusion, anti-microbial chemotherapy, and immune modulation therapy. (bvsalud.org)
  • Platelet transfusion, also known as platelet concentrate, is used to prevent or treat bleeding in people with either a low platelet count or poor platelet function. (wikipedia.org)
  • A review in people with blood cancers receiving intensive chemotherapy or a stem cell transplant found that overall giving platelet transfusions when the platelet count is less than 10 x 109/L reduced the number of bleeding events and days with significant bleeding. (wikipedia.org)
  • Two reviews in people with blood cancers receiving intensive chemotherapy or a stem cell transplant found that overall giving platelet transfusions when the platelet count is less than 10 x 109/L compared to giving platelet transfusions when the platelet count is less than 20 or 30 x 109/L had no effect on the risk of bleeding. (wikipedia.org)
  • In people with a low platelet count, prophylactic platelet transfusions do not need to be given prior to procedures that have a low risk of causing bleeding. (wikipedia.org)
  • Guidelines recommend that it is safe to perform central venous catheter insertion when the platelet count is 20 x 109/L or above. (wikipedia.org)
  • The evidence for this is based on observational studies in which bleeding occurred due to procedure error rather than due to the platelet count. (wikipedia.org)
  • In ITP, your blood does not clot as it should, because you have a low platelet count. (nih.gov)
  • When you have a low platelet count, you may have trouble stopping bleeding. (nih.gov)
  • This test measures your platelet count and the number of other blood cells in your blood. (nih.gov)
  • Most people who have chronic ITP can stop treatment at some point and maintain a safe platelet count. (nih.gov)
  • Treatment depends on your platelet count and whether you have any symptoms. (nih.gov)
  • In mild cases, you may not need any treatment, and your provider will monitor your condition to make sure that your platelet count does not become too low. (nih.gov)
  • If your ITP was caused by an infection, treating the infection may help increase your platelet count and lower your risk of bleeding problems. (nih.gov)
  • Primary outcome was the platelet count before operation (T 1 ), at the end of operation (T 2 ), on the first day (T 3 ), the second day (T 4 ) and the fifth day after operation (T 5 ). (nature.com)
  • Does your infant have a low platelet count? (nih.gov)
  • To participate in this study, your child must be younger than 6 months old and have a low platelet count (less than 100 × 109/L). This study takes place in Boston, Massachusetts. (nih.gov)
  • To participate in this study, you must have a newborn who is less than 32 weeks' gestational age, has a birth weight greater than 500 grams, and has a platelet count less than 100 × 109/L. This study takes place in multiple locations in the United States, the Netherlands, and Sweden. (nih.gov)
  • The primary outcome was the incremental change in platelet count. (ox.ac.uk)
  • Hemoglobin and platelet count showed similar time-course curves. (elsevierpure.com)
  • Conduct baseline laboratory testing: complete blood count (CBC) with platelets, serum hepatic panel, and serum creatinine. (nih.gov)
  • A doctor can diagnose thin blood by looking at platelet numbers in a complete blood count or CBC. (medicalnewstoday.com)
  • However, sometimes treating the underlying cause may not change the platelet count, and the blood will remain thin. (medicalnewstoday.com)
  • If VITT is suspected , perform immediate CBC with platelet count and imaging for thrombosis based on symptoms. (hematology.org)
  • an estimated one in 1,000--3,000 platelet units are contaminated with bacteria, resulting in transfusion-associated sepsis in many recipients ( 2 ). (cdc.gov)
  • This report summarizes two fatal cases of transfusion-associated sepsis in platelet recipients in 2004 and describes results of a 2004 survey of infectious-disease consultants regarding their knowledge of transfusion-associated bacterial infections and the new AABB standard. (cdc.gov)
  • The occurrence of the acquired immunodeficiency syndrome (AIDS) in intravenous (IV) drug users, blood transfusion recipients, and persons with hemophilia indicates that parenteral transmission of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) occurs via infectious blood or blood products (1). (cdc.gov)
  • Currently available practices have nearly eliminated these risks for transfusion recipients and persons with hemophilia (2,3). (cdc.gov)
  • Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (msdmanuals.com)
  • Supportive care includes transfusion of RBCs or platelets. (medscape.com)
  • Genotyping confirmed HEV in a transfused platelet pool and the donor. (cdc.gov)
  • TA-GVHD is a condition in which donor T-cells mount an immune response against the transfusion recipient's lymphoid tissue. (businesswire.com)
  • The requisite documentation for platelet product reservation or donor recruitment is then autogenerated using institutional form templates. (posit.co)
  • We report a successful ABO-incompatible living donor liver transplantation in a patient with hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma who had a history of platelet transfusion-related anaphylaxis. (peertechzpublications.org)
  • The areas under the curve for FIBTEM, EXTEM, and PLTEM predicting platelet concentrate transfusion of >12 U at mid-term were 0.915-0.923, 0.878-0.896, and 0.551-0.735, respectively. (bvsalud.org)
  • The retrieved data is processed by a published algorithm implemented in R and incorporates user input to present sortable tables of patient-specific compatible platelet inventory (and donors) for consideration. (posit.co)
  • Blood donors and their donated blood are rigorously screened, and so the frequency of disease transmission through transfusion is low, although tragically marred by recent scandals in the 1980s when strict screening and testing for infectious agents was less common. (nhsbt.nhs.uk)
  • RhIG was not administered after the transfusion of PCs from D+ donors. (notifylibrary.org)
  • As part of his job, he processed platelets pooled from individual donors for transfusion. (cdc.gov)
  • It is not known whether any of the individual platelet donors or the patient with leukemia had HTLV-III infection. (cdc.gov)
  • Cerus currently markets and sells the INTERCEPT Blood System for both platelets and plasma in the United States, Europe, the Commonwealth of Independent States, the Middle East and selected countries in other regions around the world. (businesswire.com)
  • Normal blood clotting involves blood particles, called platelets, and as many as 20 different plasma proteins that layer over the platelets. (medlineplus.gov)
  • This analytic observational study with a cross-sectional design was carried out on PCs obtained from platelet-rich plasma (PRP-PC). (phcogj.com)
  • Compare and contrast the various types of plasma that are available for transfusion. (cap.org)
  • Blood contains four main components: plasma, red blood cells, white blood cells, and platelets. (medicalnewstoday.com)
  • Factors affecting transfusion of fresh frozen plasma, platelets, and red blood cells during elective coronary artery bypass graft surgery. (nataonline.com)
  • From 2019 to 2021, the median price hospitals paid per unit of leukoreduced red blood cells, leukoreduced and pathogen-reduced apheresis platelets, and fresh frozen plasma increased. (cdc.gov)
  • Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integrins. (biomedcentral.com)
  • It is often given at the same time as the RBC transfusion, which is ineffective. (medscape.com)
  • Allogeneic blood transfusion is an essential component of medical care. (medscape.com)
  • Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
  • Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)
  • In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
  • Platelets can be produced either from whole blood or by apheresis. (wikipedia.org)
  • This review found no difference in the number of people who had clinically significant bleeding between platelet transfusions that contained a small number of platelets (low dose - 1.1 x 1011/m2) and those that contained an intermediate number of platelets (intermediate dose - 2.2 x 1011/m2). (wikipedia.org)
  • Within the Johns Hopkins Hemapheresis and Transfusion Service (commonly referred to as "HATS"), a specialized team of nine people, known as the Platelet Transfusion Service, manages the Institution's pheresis platelet inventory and relevant patient data. (jhu.edu)
  • Both preparation and preservation methods can affect the quality of platelets and influence the therapeutic effect. (blood-genomics.com)
  • In a non-physiological condition, the storage of therapeutic platelets has also shown to be associated with the unwilling activation of platelets which triggers receptors down-regulation via aforementioned different mechanisms. (biomedcentral.com)
  • Platelet transfusion strategies are driven by either the need to stop active bleeding (therapeutic) or to prevent its occurrence in at-risk groups (prophylactic). (nhsbt.nhs.uk)
  • Repeat cycles every 6 weeks upon hematologic recovery (ANC at least 1,000/μL and platelets at least 50,000/μL) for a minimum of 4 cycles. (nih.gov)
  • While the expression and shedding of pro-inflammatory molecules can induce post-transfusion adverse effects, stored-dependent loss of adhesion receptors by ectodomain shedding or microvesiculation may attenuate post-transfusion adhesive functions of platelets causing their premature clearance from circulation. (biomedcentral.com)
  • Title : Impact of the COVID-19 pandemic on blood donation and transfusions in the United States in 2020 Personal Author(s) : Basavaraju, Sridhar V.;Free, Rebecca J.;Chavez Ortiz, Joel L.;Stewart, Phylicia;Berger, James;Sapiano, Mathew R. P. (cdc.gov)
  • Platelet increase 24 hours after WPC transfusion was observed at a median of 3.5 (range, −13 to 53.6) × 10 9 /L, lower than those reported in previous studies. (atlasofscience.org)
  • the median (interquartile range) change for ABO-identical transfusions was 28 × 10 cells/L (8-68 × 10 cells/L), for transfusions with major incompatibility 26 × 10 cells/L (7-74 × 10 cells/L), and for transfusions with minor incompatibility 54 × 10 cells/L (14-81 × 10 cells/L) (p = 0.37). (ox.ac.uk)
  • The nucleic acid targeting mechanism of action of the INTERCEPT treatment is designed to inactivate established transfusion threats, such as Hepatitis B and C, HIV, West Nile Virus and bacteria, as well as emerging pathogens such as chikungunya, malaria and dengue. (businesswire.com)
  • Other modes of transmission for dengue virus are less common but include vertical transmission from a mother to a baby, blood transfusion or organ transplantation, needle stick, mucocutaneous exposure, or hospital or laboratory accidents, breast milk, and rarely, sexual transmission. (cdc.gov)
  • Bacterial infections are relatively more common with platelets as they are stored at warmer temperatures. (wikipedia.org)
  • To reduce this risk, AABB (formerly the American Association of Blood Banks) adopted a new standard on March 1, 2004, that requires member blood banks and transfusion services to implement measures to detect and limit bacterial contamination in all platelet components ( 3 ). (cdc.gov)
  • Health-care providers should be aware of the new standard and the need for bacterial testing of platelets to improve transfusion safety. (cdc.gov)
  • However, health-care providers also should be able to diagnose transfusion-associated infections, because even when testing complies with the new standard, false negatives can occur and fatal bacterial sepsis can result. (cdc.gov)
  • Before transfusion, the pooled platelet unit had been tested for bacterial contamination with a reagent strip test (Multistix ® , Bayer Diagnostics, Tarrytown, New York) to determine the pH level, a means for detecting the presence of bacteria. (cdc.gov)
  • Before transfusion, platelets from the unit bag were tested for bacterial contamination with liquid culture media (BacT/Alert ® , BioMerieux Inc., Durham, North Carolina) by using 4 mL in a standard aerobic blood culture bottle and were found to be negative after 5 days' incubation. (cdc.gov)
  • To assess clinician experience with transfusion-associated bacterial infections and knowledge of the new AABB standard, the Infectious Diseases Society of America (ISDA) conducted a survey of infectious-disease consultants in the United States. (cdc.gov)
  • We have also participated in national meetings and have authored a paper related to bacterial contamination of platelet products that will be published in December 2009. (jhu.edu)
  • We describe HEV infection in a previously healthy man in France who received massive transfusions of blood, plas- ma, and platelets after a traumatic skiing accident. (cdc.gov)
  • reported recent travel to HEV endemic areas or intake of This case describes HEV infection acquired by an uncooked or poorly cooked pork or game meat in the 3 immunocompetent patient through transfusion of a con- months before the accident. (cdc.gov)
  • Employ strategies to maintain adequate platelet inventory while minimizing wastage. (cap.org)