Platelet surface receptors. Medical search. Frequent questions

Using a platelet‑aggregation assay, it was revealed that LGP significantly inhibited platelet aggregation induced by ADP, U46619 and arachidonic acid. (spandidos-publications.com)

This provokes the release of thromboxane A 2 and the secretion of granular contents including ADP and, via these autocrine agents, the subsequent recruitment of additional flowing platelets, which assemble into a growing thrombus via α IIb β 3 -fibrinogen interactions (aggregating platelet population) ( 1 ). (frontiersin.org)
Fibrinogen and vWF bind to the GP IIb-IIIa complex exposed on the activated platelet's surface. (medscape.com)
The platelet integrin GP IIb-IIIa (also referred to as α IIb-β) is a calcium-dependent heterodimer complex that can bind fibronectin, fibrinogen, vWF, and vitronectin. (medscape.com)
On resting platelets, GP IIb/IIIa is unable to bind fibrinogen or vWf. (medscape.com)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. (medlineplus.gov)
Under physiological conditions, the GP IIb/IIIa receptors are present in a low-affinity state and cannot bind to fibrinogen. (aging-us.com)
However, following conformational changes, these receptors are transformed into a high-affinity state wherein they can bind to fibrinogen and promote thrombosis. (aging-us.com)
Fibrinogen binds to the glycoprotein IIb/IIIa complexes of adjacent platelets, connecting them into aggregates. (msdmanuals.com)
Thrombin converts fibrinogen into fibrin monomers, and the fibrin monomers polymerize into fibrin polymers that bind aggregated platelets into platelet-fibrin hemostatic plugs. (msdmanuals.com)
Coagulation factors interact on platelet and endothelial cell surfaces to produce thrombin , which converts fibrinogen to fibrin. (msdmanuals.com)

The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
A history of prolonged bleeding, a prolonged bleeding time, and failure of platelets to aggregate in response to L-epinephrine, adenosine 5'-diphosphate (ADP), collagen, and arachidonic acid are diagnostic of thrombasthenia. (medscape.com)
von Willebrand factor (vWF) binds the exposed collagen and binds GP Ib-IX-V complex on the surface of the platelet. (medscape.com)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. (who.int)
Collagen-induced platelet aggregation was significantly reduced after alum injection. (who.int)
contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
Platelet thrombus on immobilized collagen was quantified using microfluidics platform. (elifesciences.org)
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. (rcsb.org)
1) Immune mediated damage near infected endothelial cells leads to collagen exposure, fibrin deposition, platelet activation, endothelial activation, and release of ultra-high molecular weight vWF from endothelial cells and platelets. (cdc.gov)

The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)
The binding of von Willebrand factor (VWF) to its platelet receptor initiates the primary mechanism for the adhesion of platelets to a site of vascular injury and subsequent platelet activation. (peprotech.com)

These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
Therefore, understanding the molecular mechanisms of platelet activation and identifying novel techniques for platelet inhibition remain critically important. (spandidos-publications.com)
Platelet inhibition is a prerequisite for the prevention of acute or subacute thrombosis in various neurointerventional procedures such as stent placement in atherosclerotic lesions or stent-assisted coiling of aneurysms. (ajnr.org)
DLL-4, in turn, instigated neighbouring platelets to switch to 'activated' phenotype through cleavage of Notch receptor and release of its intracellular domain (NICD), which was averted by inhibition of γ-secretase and phosphatidylinositol-3-kinase (PI3K). (elifesciences.org)
Inhibition of Notch signaling, too, restrained agonist-induced platelet activation, and significantly impaired arterial thrombosis in mice. (elifesciences.org)
2. There was a progressive decline during pregnancy in sensitivity of platelets to inhibition of the arachidonic acid-induced release reaction by agents which act via cyclic AMP. (portlandpress.com)
Inhibition of PDGFRB (PDGFR1, JTK12, CD140B,Beta platelet-derived growth factor) receptor kinase may be useful in the treatment of several tumors. (discoverx.com)
We tested whether low-dose sevoflurane inhalation provides sustained inhibition of detrimental granulocyte-platelet aggregation in humans. (uzh.ch)
Inhibition of granulocyte-platelet aggregates was accompanied by reduced clot firmness 24 h after sevoflurane inhalation compared with control. (uzh.ch)
Gint4.T aptamer is able to specifically bind to the human PDGFRβ ectodomain (Kd: 9.6 nmol/l) causing a strong inhibition of ligand-dependent receptor activation and of downstream signaling in cell lines and primary cultures of human glioblastoma cells. (unina.it)

Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
These genes provide instructions for making the two parts (subunits) of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3). (medlineplus.gov)
integrin αIIbβ3 helps platelets bind together. (medlineplus.gov)
But the long-term congregating the scientists saw in B. cereus -infected mice required vWF-binding by the integrin GpIIb-GpIIIa, which also aids platelet aggregation. (the-scientist.com)
It targets integrin alpha IIb beta3 receptor on the surface of human platelets. (pharmaceutical-technology.com)
The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet. (medlineplus.gov)
Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing. (medlineplus.gov)
The overactive integrin αIIbβ3 binds inappropriately to clotting proteins within the cell during the formation of platelets, causing the platelets to become misshapen and large. (medlineplus.gov)
Because the mutation that causes this disorder affects only one copy of the ITGB3 gene, some normal integrin is formed and normal platelets produced, which accounts for the mild signs and symptoms in affected individuals. (medlineplus.gov)
The antigenic phenotype of OCs and foreign body giant cells (FBGCs) was investigated for the presence of several integrin molecules and other largely platelet-associated antigens involved in cell adhesion reactions. (ox.ac.uk)
CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)

Peripheral versus central venous blood sampling does not influence the assessment of platelet activation in cirrhosis. (harvard.edu)
The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. (revespcardiol.org)

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. (wikipedia.org)
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). (wikipedia.org)
A PDGF receptor that binds specifically to the PDGF-B chain. (wakehealth.edu)
This cleavage results in the creation of a new N-terminal sequence (tethered ligand), which subsequently binds to a site in the second extracellular loop of the same receptor. (enzolifesciences.com)
FIXa on platelets and TF-bearing cells binds with FVIIIa, assembling the FIXa-FVIIIa complex (intrinsic tenase). (merckvetmanual.com)
The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. (ox.ac.uk)
VWF binds to receptors on the platelet surface membrane (glycoprotein Ib/IX). (msdmanuals.com)

The 18A2 monclonal antibody recognizes human CD140b also known as the platelet-derived growth factor receptor, beta polypeptide, PDGFR1, and PDGFRß. (biolegend.com)
Platelet-derived growth factor receptor β (PDGFRβ), a cell-surface tyrosine kinase receptor, is an important hallmark involved in glioma since it influences several cellular processes of tumor biology including proliferation, migration, and angiogenesis. (unina.it)
In addition, Gint4.T aptamer prevents PDGFRβ heterodimerization with and resultant transactivation of epidermal growth factor receptor. (unina.it)
As a result, the combination of Gint4.T and an epidermal growth factor receptor-targeted aptamer is better at slowing tumor growth than either single aptamer alone. (unina.it)

Independently of such activation processes, platelet heterogeneity can be achieved by aging and an accompanied inactivation ( 3 ). (frontiersin.org)
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
Platelet activation and subsequent accumulation at sites of vascular injury are central to thrombus formation, which is considered to be a trigger of several cardiovascular diseases. (spandidos-publications.com)
In conclusion, the data presented here demonstrated that LGP, a natural compound from C. nudiflora Hook, inhibited the development of platelet aggregation and amplification of platelet activation. (spandidos-publications.com)
Upon vascular injury, platelets are exposed to the subendothelium, and several agonists, including adenosine diphosphate (ADP) and thrombin, are generated at the injury site, which can stimulate platelet adhesion, activation and aggregation. (spandidos-publications.com)
The uncontrolled progression of these processes through a series of self-sustaining amplification loops can initiate unrestrained platelet activation and aggregation, and eventually lead to thromboembolic events ( 7 , 8 ). (spandidos-publications.com)
Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets. (harvard.edu)
Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization. (harvard.edu)
Platelet Activation and Reactivity in a Large Cohort of Patients with Gaucher Disease. (harvard.edu)
Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
Platelet activation pathways. (medscape.com)
Steve's research interests focus on mechanisms of platelet activation by tyrosine kinase-linked receptors (notably CLEC-2, FcgammaRIIA, GPVI and PEAR1) and in developing novel antiplatelet agents that target these receptors in thrombi-inflammatory disease. (birmingham.ac.uk)
Steve's undertakes a multi- and inter-disciplinary to investigate the molecular mechanisms underlying platelet activation by tyrosine kinase linked glycoprotein receptors. (birmingham.ac.uk)
Steve uses advanced microscopy (FCS and single molecule), molecular modelling (ODE and agent-based), crystallography, cell line studies and protein phosphorylation to study the mechanisms of receptor activation. (birmingham.ac.uk)
Stehbens and Biscoe, 1967 ), platelet shape change was, and still is, generally regarded to be the initial stage of platelet activation. (nature.com)
Clopidogrel exerts its antiplatelet effect by inhibiting the binding of adenosine diphosphate (ADP) to its receptor (P2Y12) and consequent ADP-mediated platelet activation [ 3 ]. (hindawi.com)
describes a novel signaling pathway involving Notch1 and its ligand, Δ-like ligand-4 (DLL4) in driving platelet activation and thrombus formation. (elifesciences.org)
The toxins blocked both PAF-induced transmembrane uptake of Ca2+ as well as release of Ca2+ from internal stores, and were selective in that activation events after cross-linking of surface IgM were not affected. (jci.org)
Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)
GP IIb/IIIa receptor activation plays an important role in thrombosis. (aging-us.com)
The mechanism of early activation of GP IIb/IIIa receptors in diabetic conditions remains unknown. (aging-us.com)
The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. (aging-us.com)
Compared with the normal diet group, the diabetic group had significantly increased plasma EMP-PDI content and accelerated platelet activation by increased GP IIb/IIIa expression. (aging-us.com)
In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state. (aging-us.com)
However, diabetic patients have significantly higher platelet aggregation and activation than non-diabetic patients, including those undergoing dual antiplatelet therapy [ 4 - 6 ]. (aging-us.com)
This suggests that the mechanism of platelet activation in the diabetic state has not been fully elucidated. (aging-us.com)
In thrombosis, platelet activation serves as the initiation factor. (aging-us.com)
However, the ultimate common pathway of platelet aggregation is the activation of glycoprotein (GP) IIb/IIIa receptors present on platelet surface [ 7 - 9 ]. (aging-us.com)
The identification of the key molecules that accurately regulate the activation of these receptors may provide a novel approach for antiplatelet therapy. (aging-us.com)
In this modality of activation, a specific proteinase cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. (enzolifesciences.com)
This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways 1-3 Different PARs are activated by different proteinases. (enzolifesciences.com)
Aggregation was studied using light-transmission aggregometry and platelet activation using flow cytometry detecting. (lu.se)
Aggregation was studied using light-transmission aggregometry and platelet activation using flow cytometry detecting surface upregulation of CD62P. (lu.se)
Platelets and serum were treated with different inhibitors to determine mechanisms involved in platelet aggregation and activation. (lu.se)
Blockade of the platelet Fc-receptor or enzymatic cleavage of IgG abolished platelet activation and aggregation. (lu.se)
Bacterial activation of platelets through this pathway is common for many bacteria causing IE and could be a potential therapeutic target for the prevention and treatment of this infection. (lu.se)
The Fc-IgG-receptor pathway was shown essential for platelet activation and aggregation. (lu.se)
The interaction of these two molecules initiates a signaling pathway which results in platelet activation and aggregation. (ox.ac.uk)
Phosphorylation of this tyrosine initiates binding of spleen tyrosine kinase (Syk) and triggers further downstream signaling events and ultimately potent platelet activation and aggregation. (ox.ac.uk)
Likely, increased platelet activation leads to an increase of total fibrin formation. (cdc.gov)
Platelets anchored to the vessel wall undergo activation. (msdmanuals.com)
During activation, platelets release mediators of aggregation, including adenosine diphosphate (ADP) from storage granules. (msdmanuals.com)
ADP, thromboxane A2, and other mediators induce activation and aggregation of additional platelets on the injured endothelium. (msdmanuals.com)
Platelet receptors for ADP include the P2Y12 receptor, which sends signals to suppress adenylate cyclase, decreases cyclic adenosine monophosphate (cAMP) levels, and promotes activation of the glycoprotein IIb/IIIa receptor (assembled on the activated platelet surface membrane from glycoproteins IIb and IIIa). (msdmanuals.com)

Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Harvard Catalyst Profiles by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles. (harvard.edu)
[ 4 ] particularly in patients who have developed isoantibodies to the GP IIb-IIIa complex and who are thus refractory to platelet transfusions. (medscape.com)
GT is a rare autosomal recessive disorder whereby the quantity or quality of platelet membrane glycoprotein (GP) IIb-IIIa is abnormal, preventing the aggregation of platelets and subsequent clot formation. (medscape.com)
Approximately 80,000 GP IIb-IIIa receptors are present on the surface of each platelet. (medscape.com)
The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)
The EMP-PDI content and GP IIb/IIIa expression of mice platelets were determined. (aging-us.com)
This process relies on the destruction of disulfide bonds present on these receptors, such as Cys5-Cys435, Cys663-Cys687, and a third Cys-rich repetitive zone, to be transformed into the ligand-binding, high-affinity state and evoke conformational changes in GP IIb/IIIa receptors [ 10 ]. (aging-us.com)
[ 4 ] Patients with type 1, the most severe form of the disease, have less than 5% of the normal amount of GP IIb-IIIa present on their platelets. (medscape.com)

Transcripts/peptides of Notch1 and Delta-like ligand (DLL)-4 were detected in platelets isolated from human blood by RT-qPCR, Western analysis and flow cytometry. (elifesciences.org)
Platelet aggregation, granule secretion and platelet-leukocyte interaction were analyzed by lumi-aggregometry and flow cytometry. (elifesciences.org)
Venous blood samples were collected at baseline before inhalation, immediately after inhalation, and 24 h thereafter, and were used for flow cytometry to determine platelet surface marker (CD41, CD42b, CD62P/P-selectin, and PAC-1) on platelets and granulocytes and for kaolin-induced clot formation, as assessed by thromboelastography. (uzh.ch)
In flow cytometry experiments, platelets were stimulated with arachidonic acid (AA, 30 microM), adenosine diphosphate (ADP, 1 microM), and thrombin receptor agonist peptide-6 (TRAP-6, 6 microM). (uzh.ch)

N-terminal 6His-tagged recombinant, human PDGF receptor β, amino acids 557 end. (discoverx.com)
Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, epidermal growth factor (EGF) and certain lymphokines. (discoverx.com)

Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
Various mechanisms, including endothelial cell nitric oxide and prostacyclin, promote blood fluidity by preventing platelet aggregation and dilating intact blood vessels. (msdmanuals.com)

We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. (frontiersin.org)
Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. (ox.ac.uk)
Our team has identified and studied several haemotoxic venom proteins, including a molecule called snaclec from the venom of the Bitis gabonica rhinoceros that blocks a specific protein on platelets and endothelial cells to induce bleeding. (reading.ac.uk)
Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. (discoverx.com)

Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
This negative surface provides binding sites for enzymes and cofactors of the coagulation system, resulting in the formation of a clot (secondary hemostasis). (medscape.com)
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
Functional coagulation and platelet responses lead to endothelial repair. (cdc.gov)

CD140b is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (biolegend.com)

We'll be discussing endotheliopathy and platelet dysfunction in Lassa fever. (cdc.gov)
Sarah Gregory] Endotheliopathy and platelet dysfunction are outcomes of Lassa fever. (cdc.gov)
Sarah Gregory] Explain to us what endotheliopathy and platelet dysfunction is. (cdc.gov)

This abnormally active protein is unable to reach the surface of the platelet where it is needed to bind to other platelets during clot formation. (medlineplus.gov)
The abnormally shaped platelets have a shortened lifespan, so platelet numbers are often reduced, which impairs clot formation. (medlineplus.gov)
Using the model, the research team successfully demonstrated the role of a bridge between a molecule called von Willebrand Factor and a surface receptor on platelets called glycoprotein Ib-alpha, one of the basic mechanisms underlying venous clot formation. (labmate-online.com)

SBSEC mediates platelet aggregation in an IgG and IgG-Fc-receptor dependent manner. (lu.se)

While most studies to date have focused on the effects of this receptor in platelets, PEAR1 is located in multiple tissues including the endothelium, where it is most highly expressed. (duke.edu)
TM is a cell surface receptor for thrombin, mainly expressed on undamaged endothelium. (merckvetmanual.com)
resting platelets circulate and lower molecular weight vWF multimers are constitutively secreted by the endothelium. (cdc.gov)

According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
Platelets are small, a nucleate blood cells, the major role of which is in hemostasis and thrombosis owing to their capacity to adhere to damaged blood vessels and to accumulate at sites of injury ( 1 ). (spandidos-publications.com)
It has been demonstrated clinically that the use of antiplatelet agents to prevent and/or reverse platelet aggregation is a successful strategy for the prevention of thrombosis ( 7 , 8 ). (spandidos-publications.com)
Although platelets are important in both maintaining healthy blood flow and causing thrombosis, they also play a role in inflammation by interacting with other cells. (reading.ac.uk)

Adherent, activated platelets recruit additional platelets to the growing thrombus ( 5 , 6 ). (spandidos-publications.com)
Once activated, platelets have two major mechanisms to recruit additional platelets to the growing hemostatic plug. (medscape.com)

Platelet aggregometry is a standard clinical technique that measures the in vitro aggregability of platelets in response to agonists by using the amount of light transmitted through platelet-rich plasma (PRP) ( Holmsen, 1987 ). (nature.com)
Severe abnormalities in platelet function, such as Bernard-Soulier syndrome, Glanzmann's thrombasthenia, or platelet storage-pool deficiency, are characterized by the inability of platelets to aggregate in response to certain agonists. (nature.com)
Our study presents compelling evidence in support of non-canonical juxtacrine Notch signaling within platelet aggregates that synergizes with physiological agonists to generate occlusive intramural thrombi. (elifesciences.org)
6) Our in vitro aggregation studies show that platelets in the presence of the aggregation inhibitor become activated and change shape in response to platelet agonists but fail to maintain the aggregated state. (cdc.gov)

The amount of granulocyte-platelet aggregates increased upon agonist stimulation. (uzh.ch)
Low-dose sevoflurane inhalation reduced ADP-induced CD62P expression on platelets 24 h after inhalation, and inhibited the formation of granulocyte-platelet aggregates under stimulation with AA and ADP after 1 and 24 h, and with TRAP-6 after 24 h compared with control. (uzh.ch)
Under these conditions, platelets adhere to the damaged intima and form aggregates. (msdmanuals.com)

Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Kupffer cells collect von Willebrand Factor (vWF), a free-floating blood glycoprotein, on their surface. (the-scientist.com)
The association of CD42b/GP1Ba with GP1Bb (covalently) and platelet glycoproteins IX and V (non‐covalently) forms the von Willebrand factor receptor. (peprotech.com)
Mutations in von Willebrand factor and to a lesser extent, CD42b/GP1Ba, that affect the binding of VWF to the GP1B receptor are the primary cause of the hereditary bleeding disorder known as Type 2 von Willebrand disease (VWD). (peprotech.com)
In the 1970s, the molecular defect was shown to involve the absence of a platelet membrane glycoprotein (GPIb/IX/V) complex which is the receptor for von Willebrand factor (vWF). (medscape.com)
Initial platelet adhesion is to long strings of von Willebrand factor (VWF) that have been previously secreted by, and anchored to, stimulated endothelial cells. (msdmanuals.com)

Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)

Mutations in this gene cause platelet glycoprotein deficiency. (thermofisher.com)
Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7. (thermofisher.com)
The deficiency is uniformly present throughout the platelet population and is present in endothelial cells and precursor megakaryocytes. (medscape.com)

We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations. (frontiersin.org)
Two different platelet receptors-already known to be important in platelets' ability to staunch bleeding-mediated the two types of interactions the researchers saw. (the-scientist.com)

Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function. (harvard.edu)
Thus, the release reaction and prostaglandin synthesis act to consolidate the initial hemostatic plug by promoting the participation of other platelets in the growing hemostatic plug. (medscape.com)
The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
GpIb and GpIIb are "carrying members of the hemostatic repertoire of platelets-but here they fulfill an innate immune function"-highlighting platelets' dual role, said Guy Zimmerman , an immunologist at the University of Utah, who did not participate in the study. (the-scientist.com)
Platelet dysfunction can lead to weaker hemostatic plugs which then leave fibrin more susceptible to cleavage by plasmin. (cdc.gov)

These interactions further activate platelets. (medscape.com)
Though previous research had demonstrated that bacteria can activate platelets, "this work emphasizes that platelets play a day-to-day role in innate immune defense by helping remove bacteria in the liver. (the-scientist.com)

Understanding the role of platelets in human health and disease is critical for the development of new treatments for a range of conditions, including heart disease, stroke, and inflammatory disorders. (reading.ac.uk)

There was no PVR cell surface expression on platelets and extremely low levels on polymorphonuclear leukocytes. (nih.gov)

The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
GPIb/IX/V complex is located in the platelet cytoskeleton and hence is also essential to the production of platelets from the megakaryocytes in the bone marrow (which explains the large size and decreased numbers of platelets in this syndrome). (medscape.com)

A lack of platelet cohesion leads to prolonged or spontaneous bleeding episodes experienced by people with Glanzmann thrombasthenia. (medlineplus.gov)
Defective platelet adhesion is demonstrated by the lack of platelet aggregation in response to ristocetin, an antibiotic that normally causes platelets to aggregate. (medscape.com)

Exclusion criteria were the following: 1) unclear antiplatelet medication history, 2) platelet count lower than 150 × 10 3 /μL, and/or 3) hematocrit level lower than 33% at the time of admission. (ajnr.org)

Mechanisms of Stimulus-Response Coupling in Platelets. (wikipedia.org)
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
To the best of our knowledge, this is the first study that reports on platelet interactions of SBSEC-isolates other than Streptococcus gallolyticus subspecies gallolyticus as well as the first study to report of mechanisms of platelet interaction of SBSEC-isolates. (lu.se)

Thrombin activates the receptor on the surface of platelets inducing platelet aggregation, granular secretion, and procoagulant activity. (enzolifesciences.com)
The TF-bearing cells and platelet surfaces act as the main cellular surfaces for assembly of the procoagulant complexes. (merckvetmanual.com)

1. Platelet behaviour in vitro in relation to cyclic AMP was studied longitudinally during pregnancy and in the same women when they were not pregnant. (portlandpress.com)

As a result, platelets cannot clump together to form a blood clot, leading to prolonged bleeding. (medlineplus.gov)

The identity of the growth factor bound to the receptor determines whether the functional receptor is a homodimer or heterodimer composed of both PDGFR-α and -β. (biolegend.com)
Cell-free human cytomegalovirus (HCMV) may be inhibited by a soluble type of the mobile HCMV-receptor PDGFRα , resembling neutralization by antibodies . (aetox.com)

We demonstrate expression of Notch1, its ligand DLL-4 and their respective transcripts in human platelets. (elifesciences.org)
CD42b, also known as GP1Ba (GP1B alpha, Glycoprotein 1Ba) is a single pass transmembrane glycoprotein that functions as the key ligand binding subunit of the GP1B platelet surface receptor. (peprotech.com)
Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets. (ox.ac.uk)

PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)
this method is widely used to assess the functional status of platelets. (nature.com)
Existence of functional Notch signaling in enucleate platelets remains elusive. (elifesciences.org)

Platelets were activated with ADP, thrombin, or the thrombin receptor agonist peptide SFLLRN (TRAP 1-6 ). (nature.com)
Synthetic peptide corresponding to aa 61-76 of human PAR-1 (proteinase-activated receptor-1). (enzolifesciences.com)
Our research group is mainly focusing on the interplay of different circulating molecules and receptors involved in inflammation, such as formyl peptide and toll-like receptors, on the surface of platelets, monocytes, and neutrophils, and how they control multicellular interactions and complex functions during the inflammatory responses. (reading.ac.uk)

CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. (thermofisher.com)

Scientists found that in the livers of mice, platelets collaborated with specialized white blood cells to capture and engulf blood-borne bacteria, and this interaction helped protect the animals from bacterial infection. (the-scientist.com)
The notion that platelets may cooperate with other cells to clear blood-borne bacteria came from observations in the liver, said study lead Paul Kubes , an immunologist at the University of Calgary. (the-scientist.com)
But when mice were infected with certain types of bacteria-either Bacillus cereus or methicillin-resistant Staphylococcus aureus (MRSA), though not methicillin-susceptible S. aureus -the platelets formed long-term interactions with the Kupffer cells, engulfing the bacteria snagged from the blood. (the-scientist.com)
Unlike wild type mice, mice lacking GpIb also couldn't clear bacteria from their blood within 4 hours, suggesting that the platelets' ability to interact with Kupffer cells was integral to fighting bacterial infection. (the-scientist.com)
In some sepsis cases, they found, the bacteria win out and platelet levels plummet. (news-medical.net)
In laboratory experiments, the researchers worked out what's likely happening: Platelets secrete antimicrobial peptides that help the immune system destroy staph bacteria. (news-medical.net)
Mice with staph sepsis and treated with either ticagrelor or oseltamivir maintained more platelets and had less bacteria in their blood. (news-medical.net)
While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this respect. (lu.se)
The capacity for bacteria-induced platelet aggregation was also shown to be transferable between donors through serum. (lu.se)
IMPORTANCE The capacity of bacteria to activate and aggregate platelets is believed to contribute to the pathogenesis of IE. (lu.se)
It adds SBSEC to a group of bacteria that activate and aggregate platelets via the platelet Fc-receptor. (lu.se)

Patients with fewer platelets were more likely to die of staph sepsis than patients with higher platelet counts. (news-medical.net)

Refractory bleeding in individuals with thrombasthenia requires the transfusion of normal platelets. (medscape.com)

Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. (bvsalud.org)

Glanzmann thrombasthenia (GT) is one of several inherited disorders of platelet function, which also include Bernard-Soulier syndrome , as well as deficiencies of platelet adhesion, aggregation, and secretion. (medscape.com)

Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells. (ox.ac.uk)

Twenty-six isolates of the four most common species and subspecies of SBSEC identified in bacteremia were collected, and interactions with platelets were investigated in platelet rich plasma (PRP) from three donors. (lu.se)
1 vol % end-tidal) inhibits agonist-induced granulocyte-platelet interactions 24 h after administration and thus counteracts thromboinflammatory processes. (uzh.ch)

The human leukocyte platelet-activating factor receptor. (wikipedia.org)
Since oxidative stress in airway cells increases platelet-activating factor receptor (PAFR) expression, and PAFR is co-opted by pneumococci to adhere to host cells, we hypothesised that E-cigarette vapour increases pneumococcal adhesion to airway cells. (ersjournals.com)
To establish firm adhesion, pneumococci co-opt host-expressed platelet-activating factor receptor (PAFR), and then use the receptor as a Trojan horse to enter airway cells as the receptor is internalised [ 7 ]. (ersjournals.com)
Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. (jci.org)
Platelet-activating factor (PAF) stimulates human B cells, resulting in elevation of intracellular calcium and the release of inositol phosphates. (jci.org)
Below are the most recent publications written about "Receptor, Platelet-Derived Growth Factor beta" by people in Profiles. (wakehealth.edu)
Factor VIIa bound to TF on the cell surface activates Factor IX to Factor IXa and Factor X to Factor Xa. (merckvetmanual.com)
Activated factor IX (IXa), complexed with activated factor VIII (VIIIa) on a phospholipid membrane surface, activates factor X, and activity normally expressed on the surface of activated platelets. (medscape.com)
Platelets express a receptor/binding protein for factor IXa that promotes assembly of the IXa/VIIIa complex. (medscape.com)

This allows crosslinking of platelets and formation of a clot. (medscape.com)

Use human leukocyte antigen (HLA)-matched platelets whenever possible to prevent alloimmunization complications. (medscape.com)
The CD14 antigen is a glycosyl-phosphatidylinositol-linked single-chain surface membrane glycoprotein with a molecular weight of 53-55 kDa. (beckman.com)
Note: subjects with serologic evidence of prior vaccination to HBV (i.e. hepatitis B surface (HBs) antigen negative-, anti-HBs antibody positive and anti-hepatitis B core (HBc) antibody negative) or positive anti-HBc antibody from intravenous immunoglobulins (IVIG) or patients who have past exposure to HepB (HepB Surface Antigen negative but core antibody positive and DNA negative) who do not require treatment may participate. (who.int)

Anatomy26

Organisms6

Diseases15

Chemicals and Drugs136

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Inhibited platelet aggregation1

FIBRINOGEN11

Collagen11

Adhesion of platelets2

Inhibition10

Integrin12

Assessment of platelet2

Binds7

Growth factor r4

Activation44

IIIa10

Flow cytometry4

PDGF2

Endothelial cell2

Proteins4

Coagulation5

Tyrosine1

Endotheliopathy and Platelet Dysfunction3

Clot formation3

Mediates1

Endothelium3

Thrombosis4

Recruit additional platelets2

Agonists4

Aggregates3

Willebrand6

P2Y121

Deficiency3

Different platelet2

Hemostatic5

Activate platelets2

Role of platelets1

Expression on platelets1

Megakaryocytes in the bone ma2

Lack of platelet2

Antiplatelet1

Mechanisms3

Procoagulant2

Vitro1

Form a blood clot1

PDGFR2

Ligand3

Functional3

Peptide3

Scavenger receptor1

Bacteria11

Higher platelet1

Normal platelets1

Bind1

Secretion1

Extracellular matrix1

Interactions2

Factor9

Formation of a clot1

Antigen3