Platelet membrane glycoproteins interact. Medical search. Frequent questions

Fibrinogen molecules then interconnect the platelets, serving as the basis for platelet aggregation. (wikipedia.org)
This complex interacts with fibrinogen and thus plays an important role in platelet aggregation and adhesion to endothelial surfaces. (wikipedia.org)
Activation of this complex initiates the platelet aggregation and the formation of primary platelet plug, a fibrin clot. (wikipedia.org)
The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)
Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. (rndsystems.com)
Various mechanisms, including endothelial cell nitric oxide and prostacyclin, promote blood fluidity by preventing platelet aggregation and dilating intact blood vessels. (msdmanuals.com)
During activation, platelets release mediators of aggregation, including adenosine diphosphate (ADP) from storage granules. (msdmanuals.com)
ADP, thromboxane A2, and other mediators induce activation and aggregation of additional platelets on the injured endothelium. (msdmanuals.com)
This active metabolite selectively inhibits adenosine diphosphate (ADP) binding to its platelet P2Y12 receptor and subsequently the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. (itopmeds.com)
he drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, which is important in aggregation of platelets and cross-linking by the protein fibrin. (itopmeds.com)
As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. (itopmeds.com)
By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of clopidogrel. (itopmeds.com)
Functionally, platelet-derived thrombospondin may play a role in platelet adherence and aggregation (11). (goprolytix.com)
Bitiscetin has recently been shown to induce von Willebrand factor (vWF)-dependent aggregation of fixed platelets (Hamako J, et al, Biochem Biophys Res Commun 226:273, 1996). (ashpublications.org)
Platelet-leukocyte aggregates and platelet aggregation were also measured. (oncotarget.com)
The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation. (exbio.cz)
Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation. (exbio.cz)

It is an important collagen receptor involved in collagen-induced platelet activation and adhesion. (wikipedia.org)
The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Nogo-A receptor (NgR1) and subunits of ionotropic glutamate AMPA receptor (GluR1-GluR4) were among the most interesting Olfm1 -interacting partners. (nih.gov)
Platelet receptors for ADP include the P2Y12 receptor, which sends signals to suppress adenylate cyclase, decreases cyclic adenosine monophosphate (cAMP) levels, and promotes activation of the glycoprotein IIb/IIIa receptor (assembled on the activated platelet surface membrane from glycoproteins IIb and IIIa). (msdmanuals.com)
The drug is an irreversible inhibitor of the P2Y12 adenosine diphosphate receptor found on the membranes of platelet cells. (itopmeds.com)
The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (itopmeds.com)
A thrombospondin-specific membrane receptor has also been partially characterized (10). (goprolytix.com)
CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
The cells embedded within it interact with the matrix as well as with other cells due to the presence of specialized matrix receptor molecules. (biologywise.com)
CD40L is produced as homotrimeric membrane anchored protein each of the three membrane proximal stalk regions can be sequentially proteolyzed to generate the soluble trimeric protein which retains full binding activity to its receptor, CD40. (abbiosciences.com)
CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. (exbio.cz)
We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
Here, we show that increasing the local concentration of MPER-directed bNAbs at the cell surface via binding to the high-affinity Fc receptor FcγRI potentiates their ability to prevent viral entry in a manner analogous to the previously reported observation wherein the lipid-binding activity of MPER bNAbs increases their concentration at the viral surface membrane. (stanford.edu)
Endothelial cells secrete platelet-derived growth factor (PDGF)-BB and recruit PDGF receptor beta (PDGFRbeta)-overexpressing pericytes, which in turn cover and stabilize neovessels, independent of vascular endothelial growth factor (VEGF). (stanford.edu)
1989) demonstrated that the lymphocyte homing receptor is identical to the human leukocyte surface glycoprotein called CDw44, on the basis of studies at the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)
the lymphocyte homing receptor' 'also appears to be identical'' to the Pgp-1 glycoprotein of Omary et al. (wdv.com)

In consequence, this complex activates GPIIb / IIIa membrane glycoproteins, allowing them to bind fibrinogen. (wikipedia.org)
In the absence of fibrinogen, the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex. (wikipedia.org)
The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
On resting platelets, GP IIb/IIIa is unable to bind fibrinogen or vWf. (medscape.com)
The antigenic target in most patients appears to be the platelet GP IIb/IIIa complex. (medscape.com)
Fibrinogen binds to the glycoprotein IIb/IIIa complexes of adjacent platelets, connecting them into aggregates. (msdmanuals.com)
Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. (exbio.cz)

Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV as well, function as collagen receptors, engaged in platelet adhesion to collagen. (wikipedia.org)
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
VWF binds to receptors on the platelet surface membrane (glycoprotein Ib/IX). (msdmanuals.com)
In this mechanism, vWF acts as a molecular bridge between constituents of the subendothelium, like collagen, and receptors of the platelet membrane, primarily the GPIb. (ashpublications.org)
Semaphorins, a family of about 20 secreted, transmembrane and GPI-linked glycoproteins, and their cognate receptors (plexins and neuropilins) play a pivotal role in the crosstalk between cancer and stromal cells present in the tumor microenvironment. (biomedcentral.com)
Molecules on the surface of lymphocytes called homing receptors interact specifically with HEV and play a central role in the migration. (wdv.com)
It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS. (bvsalud.org)

When the blood vessel wall is damaged, platelet membrane glycoproteins interact with the extracellular matrix. (wikipedia.org)
According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
V ON WILLEBRAND FACTOR (vWF) is a multimeric glycoprotein (GP) that plays a key role, under high-shear conditions, in the initial attachment of platelets to the extracellular matrix of the endothelial cells after injury of the vessel wall. (ashpublications.org)

Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
Oxygen free radicals (eg, superoxide anion, hydrogen peroxide, hydroxy radicals) released by the macrophages damage proteins and lipid membranes, potentiating the inflammatory process. (medscape.com)
View our protocol for Staining Membrane-associated Proteins . (rndsystems.com)
It is an autoimmune disease in which antiphospholipid antibodies (anticardiolipin antibodies and lupus coagulant) interact with proteins that bind to anionic phospholipids on plasma membranes. (lab24.pl)
We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. (frontiersin.org)
Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)
We demonstrated that Olfm1 interacts with several proteins essential for neuronal and synaptic activity. (nih.gov)
Ranging from 30-50 µg per 109 platelets, thrombospondin is one of the most abundant proteins in the platelet a-granule (2,3). (goprolytix.com)
The high-affinity interaction of LF with pore-forming outer-membrane proteins (OMPs) of Gram-negative enterics, including Escherichia coli , is critical for the antimicrobial outcome of LF (Gado et al. (ift.org)

Detection of Integrin alpha 2b/CD41 in Human Blood Platelets by Flow Cytometry. (rndsystems.com)
Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin a2b/CD41 Antibody (Clone P2) and either (A) Mouse Anti-Human Integrin a2b/CD41 APC-conjugated Monoclonal Antibody (Catalog # FAB7616A) or (B) Mouse IgG 1 Allophycocyanin Isotype Control (Catalog # IC002A ). (rndsystems.com)
Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. (rndsystems.com)
Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
CD47 interacts with several membrane integrins, most commonly integrin avb3. (wikidoc.org)

The binding between GPIbα and vWF mediates the capture of platelets to the injured vascular wall. (wikipedia.org)

Thrombospondin is a high-molecular weight, heparin-binding glycoprotein constituent of human platelets (1). (goprolytix.com)

Once activated, platelets have two major mechanisms to recruit additional platelets to the growing hemostatic plug. (medscape.com)

The interaction with collagen leads to stabilization of the platelets. (wikipedia.org)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
Thrombospondin interacts with a variety of extracellular macromolecules including heparin (1,17), collagen (18), fibrinogen and fibronectin (19), plasminogen (20), plasminogen activator (21), and osteonectin (22). (goprolytix.com)
The localization of the binding site of bitiscetin within the A3 domain was further supported by showing that MoAb to vWF, which are specific for this domain and block the interaction between vWF and collagen, are potent inhibitors of the binding of bitiscetin to vWF and consequently of the bitiscetin-induced binding of vWF to platelets. (ashpublications.org)

CD40 ligand (CD40L or CD154), a type II membrane glycoprotein and a member of the TNF superfamily, is known for its transient expression on activated CD4+ T lymphocytes which is responsible for the helper T cells' function on resting B cells in a non-antigen-dependent as well as non-major histocompatibility complex-restricted fashions. (abbiosciences.com)
For example, CCL2 exerts prometastatic effects by regulating the membrane glycoprotein dysadherin and Duffy antigen in breast cancer cells, assisting a potential restorative part for CCL2 blockade. (wwec2012.net)
It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)

The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
Thrombin, which is generated at these phosphatidylserine sites, triggers the formation of fibrin fibers, which consolidate the platelet thrombus into a stable clot sealing the breach in a vessel wall ( 2 ). (frontiersin.org)
platelets and fibrin combine to form a clot. (msdmanuals.com)
Thrombin converts fibrinogen into fibrin monomers, and the fibrin monomers polymerize into fibrin polymers that bind aggregated platelets into platelet-fibrin hemostatic plugs. (msdmanuals.com)
Coagulation factors interact on platelet and endothelial cell surfaces to produce thrombin , which converts fibrinogen to fibrin. (msdmanuals.com)

It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. (itopmeds.com)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
LF-mediated outer-membrane damage in Gram-negative bacteria (Ellison et al. (ift.org)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)

Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)

These interactions further activate platelets. (medscape.com)

The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)

Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
Immunohistochemistry and flow cytometry failed to show PSGL-1 expression on resting or inflamed endothelium or on platelets. (rupress.org)

This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)

It is likely that intracellular and membrane-associated partners are crucial in determining the cellular response of CD47 signaling. (wikidoc.org)

The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

Knockin of human VWF exon 28 and crossbreeding with hGPIbα Tg generated a humanized mouse model of platelet GPIbα-VWFA1 interaction. (ashpublications.org)
The binding of vWF to platelets involves glycoprotein (GP) Ib because it was totally blocked by monoclonal antibody (MoAb) 6D1 directed towards the vWF-binding site of GPIb. (ashpublications.org)
The binding also involves the GPIb-binding site of vWF located on the A1 domain because it was inhibited by MoAb to vWF whose epitopes are within this domain and that block binding of vWF to platelets induced by ristocetin or botrocetin. (ashpublications.org)
Thus, our data support the hypothesis that an interaction between the A1 and A3 domains exists that may play a role in the function of vWF by regulating the ability of the A1 domain to bind to platelet GPIb. (ashpublications.org)
In vivo, plasma vWF has no affinity for platelet GPIb. (ashpublications.org)

In the presence of bitiscetin, vWF binds to platelets in a dose-dependent and saturable manner. (ashpublications.org)
CD47 belongs to the immunoglobulin superfamily [1] and partners with membrane integrins and also binds the ligands thrombospondin-1 ( TSP-1 ) and signal-regulatory protein alpha ( SIRPα ). (wikidoc.org)

These findings identify emperipolesis as a new cell-in-cell interaction that enables neutrophils and potentially other cells passing through the megakaryocyte cytoplasm to modulate the production and membrane content of platelets. (elifesciences.org)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with each other to form an aggregate (see image below). (medscape.com)
Beta-2-glycoprotein is a cofactor necessary for the interaction of antiphospholipid antibodies with phospholipids. (lab24.pl)
Broadly neutralizing antibodies targeting the membrane proximal external region (MPER) of Env show lipid-binding characteristics, and modulating this interaction affects neutralization. (stanford.edu)

Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Initial platelet adhesion is to long strings of von Willebrand factor (VWF) that have been previously secreted by, and anchored to, stimulated endothelial cells. (msdmanuals.com)

Platelets with antibodies on their surface are trapped in the spleen, where they are efficiently removed by splenic macrophages. (medscape.com)
Hughes Syndrome/Antiphospholipid syndrome (APS) is a systemic autoimmune, hypercoagulable, thrombo inflammatory, and thrombosis and/or pregnancy complications syndrome caused by the persistent presence of antiphospholipid antibodies (APL) in plasma of patients with vascular thrombosis and/or pregnancy morbidity along with persistent anti-phospholipid antibodies (APLA), including lupus anticoagulant (LA), anti-β2-glycoprotein I (anti-β2GPI) and/or anti-cardiolipin (ACL) antibodies. (endinglines.com)
Antibodies to beta-2-glycoprotein (IgG) are one of the markers in the diagnosis of antiphospholipid syndrome (APS). (lab24.pl)
Antibodies to β-2-glycoproteins belong to the class of antiphospholipid antibodies and were included in the laboratory classification criteria for the diagnosis of antiphospholipid syndrome in 2006 (Miyakis et al. (lab24.pl)
Leukocyte rolling in postcapillary venules of inflamed tissues is reduced in L-selectin-deficient mice and mice treated with L-selectin blocking antibodies, but the glycoprotein ligand for L-selectin in inflamed venules is unknown. (rupress.org)
Shattil SJ, Cunningham M, Hoxie JA: Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. (exbio.cz)
Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies. (stanford.edu)
Broadly neutralizing antibodies (bNAbs) against the membrane-proximal external region (MPER) of the gp41 component of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) are characterized by long, hydrophobic, heavy chain complementarity-determining region 3s (HCDR3s) that interact with the MPER and some viral membrane lipids to achieve increased local concentrations. (stanford.edu)
IMPORTANCE The trimeric glycoprotein Env, the only viral protein expressed on the surface of HIV-1, is the target of broadly neutralizing antibodies and the focus of most vaccine development efforts. (stanford.edu)

In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)

The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
Megakaryocytes (MKs) are the cellular source of platelets. (elifesciences.org)

This provokes the release of thromboxane A 2 and the secretion of granular contents including ADP and, via these autocrine agents, the subsequent recruitment of additional flowing platelets, which assemble into a growing thrombus via α IIb β 3 -fibrinogen interactions (aggregating platelet population) ( 1 ). (frontiersin.org)
The aim of the present study was to investigate the associations of the variants in platelet activation-relevant genes and interactions among these variants with carotid plaque vulnerability. (oncotarget.com)
The high-risk interactions among the three variants were associated with high platelet activation, and independently associated with the risk of carotid plaque vulnerability. (oncotarget.com)

Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)

Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. (wikipedia.org)
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)

Eleven variants in platelet activation-relevant genes were examined using mass spectrometry methods in 396 ischemic stroke patients and 291controls. (oncotarget.com)

The ground substance mostly consists of glycosaminoglycans, proteoglycans, and adhesive glycoproteins. (biologywise.com)

Asbestos-activated macrophages produce a variety of growth factors, including fibronectin, platelet-derived growth factor, insulinlike growth factor, and fibroblast growth factor, which interact to induce fibroblast proliferation. (medscape.com)

Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. (wikipedia.org)

Beta-2-glycoprotein inhibits the formation of prothrombinase (factor Xa) in the presence of platelets, and also inhibits the activation of factor XII. (lab24.pl)

Thus, the release reaction and prostaglandin synthesis act to consolidate the initial hemostatic plug by promoting the participation of other platelets in the growing hemostatic plug. (medscape.com)

Platelets anchored to the vessel wall undergo activation. (msdmanuals.com)

Thrombospondin is also an integral component of the basement membrane in a number of different tissues (16). (goprolytix.com)
Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
It also forms a few specialized structures such as cartilage, tendons, and the basement membrane (also called the basal lamina). (biologywise.com)

Covalent binding to platelets has accounted for 2% of radiolabeled clopidogrel with a half-life of 11 days. (itopmeds.com)
As MKs require they appear route( protein) and Membrane of initial storage to embryogenesis drugs larger than 50-100 genes, and synthesis dissociates up to 128 N. As MK's mature, the autosomal codon is covalent, the platelet is, and bile languages and the knowledge pathway checkpoint are characterized. (familie-vos.de)

Our human thrombospondin (TSP-1) is prepared from the supernatant of activated platelets by heparin-agarose affinity and gel filtration chromatography (25). (goprolytix.com)
WBC) and proinflammatory cytokines in All PCs were obtained from healthy volc the supernatant of platelet concentrates unteer donors by apheresis (CSc3000 Plus, [ 4,5 ]. (who.int)

Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)

Here, we show that L-selectin-dependent rolling after P-selectin blockade is completely absent in P-selectin glycoprotein ligand-1 (PSGL-1) −/− mice or wild-type mice treated with a PSGL-1 blocking monoclonal antibody. (rupress.org)
The co-expression of the CD40L and the FcγRIIA on the surface of the activated platelets has been implicated for the thrombogenic activity of the anti-CD40L antibody in human. (abbiosciences.com)
In this study, we tested the neutralization potencies of variants of the MPER-targeting antibody 10E8 with different viral-membrane-binding and host FcγRI-binding capabilities. (stanford.edu)

Under these conditions, platelets adhere to the damaged intima and form aggregates. (msdmanuals.com)

Platelet activation pathways. (medscape.com)
Independently of such activation processes, platelet heterogeneity can be achieved by aging and an accompanied inactivation ( 3 ). (frontiersin.org)
The associations between variants in platelet activation-relevant genes and carotid plaque vulnerability are not fully understood. (oncotarget.com)
CD44 is an integral cell membrane glycoprotein with a postulated role in matrix adhesion lymphocyte activation and lymph node homing. (wdv.com)

The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels. (who.int)
1989)' 'demonstrated' 'sameness' 'the human leukocyte surface glycoprotein' 'is called' 'CDw44' 'studies' 'were conducted at' 'the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)

Key features of this disorder include a lack of bleeding risk, only mildly low platelet counts, elevated plasma fibrinogen levels, and detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and complement components in regions of thrombotic microangiopathy (TMA). (nature.com)

Emperipolesis is amplified in models of murine inflammation associated with platelet overproduction, contributing to platelet production in vitro and in vivo. (elifesciences.org)

PSGL, P-selectin glycoprotein ligand-1. (rupress.org)
In addition to its expression on activated T cells, CD40 ligand can be efficiently translocated the surface of activated platelets. (abbiosciences.com)

This complex is located mainly on endothelial cells but also on smooth muscle cells, macrophages and platelets. (wikipedia.org)
A plasminogen activator, which is also released by macrophages, further damages the interstitium of the lung by degrading matrix glycoproteins. (medscape.com)

Platelets contain two unique types of granules: alpha granules and dense granules. (medscape.com)

Tethered neutrophils enter in membrane-bound vesicles before penetrating into the megakaryocyte cytoplasm. (elifesciences.org)

Thrombospondin was initially termed "thrombin-sensitive protein" based upon its release by thrombin-activated platelets (4,5). (goprolytix.com)
The binding of thrombospondin to the surface of both resting and thrombin-activated platelets has been reported (9). (goprolytix.com)

The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (cancerindex.org)

Panx1 in rodents), which forms homo-heptameric single membrane channels permeable to ion and metabolite [ 7 , 8 ], is expressed in many tissue types including tissues of neural origin [ 9 ]. (jcancer.org)

Anatomy19

Organisms8

Diseases6

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes28

Technology, Industry, Agriculture4

Information Science4

Health Care1

Aggregation17

Receptor19

IIIa8

Receptors10

Extracellular matrix3

Proteins10

Integrin6

Mediates1

Human Platelets1

Additional platelets1

Collagen5

Antigen3

Fibrin5

Outer membrane4

Endothelial cell1

Activate platelets1

Adhesion of platelets1

Endothelium3

Transmembrane glycoprotein1

Intracellular1

Coagulation factors1

GPIb5

Binds2

Interaction4

Willebrand2

Antibodies9

Phospholipids1

Megakaryocytes2

Interactions3

Negatively charged1

Hemostasis2

Ischemic stroke1

Adhesive1

Fibronectin1

Immunoglobulin superfamily1

Inhibits1

Hemostatic1

Vessel wall1

Basement3

Covalent2

Supernatant2

Integrins1

Antibody3

Aggregates1

Activation4

Leukocyte2

Plasma1

Vitro1

Ligand2

Macrophages2

Granules1

Cytoplasm1

Thrombin2

Phosphatidylinositol1

Tissues1