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  • ITGA2b
  • Mutations in the ITGA2B gene can also cause another rare bleeding disorder called platelet-type bleeding disorder 16. (nih.gov)
  • Because the mutation that causes this disorder affects only one copy of the ITGA2B gene, some normal integrin is formed and normal platelets produced, which accounts for the mild signs and symptoms in affected individuals. (nih.gov)
  • Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. (wikipedia.org)
  • bind
  • Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by degradating activated factor V). Lupus anticoagulant (LAC) antibodies bind to prothrombin, thus increasing its cleavage to thrombin, its active form. (wikipedia.org)
  • coagulation
  • in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. (wikipedia.org)
  • Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. (wikipedia.org)
  • localization
  • Conclusion Our study provides proof of concept for imaging and localization of tumours by molecular targeting activated platelets. (thno.org)
  • Antibody
  • Here we investigate a unique single chain antibody (scFv), which specifically targets activated platelets, as a novel biotechnological tool for molecular imaging of cancer. (thno.org)
  • The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti-β2-glycoprotein-I (since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a less specific proxy). (wikipedia.org)
  • protein
  • Mammalian epididymial apical protein 1 (EAP I). EAP I is associated with the sperm membrane and may play a role in sperm maturation. (wikipedia.org)
  • coronary
  • The central role of platelet activity in the development of ischemic complications in these settings is highlighted by several studies demonstrating unequivocal clinical benefit derived from therapy with aspirin among patients with unstable angina ( [9-) and those undergoing percutaneous coronary revascularization ( [13, ). (onlinejacc.org)
  • antibodies
  • Binding studies showed a nonsaturable ristocetin binding of VCL to platelets that was blocked by vWF or inhibitory antibodies against GPIb. (ahajournals.org)
  • citation needed] Examples of glycoproteins in the immune system are: molecules such as antibodies (immunoglobulins), which interact directly with antigens. (wikipedia.org)
  • gene
  • Early genes, such as mpl coding for the TPO receptor 9 and the GPIIb gene 10 are first expressed in CD34 + cells, but are still expressed in the late stages leading to platelet production. (bloodjournal.org)
  • 16 In conditional knockout mice in which the thymidine kinase gene was driven by the GPIIb promoter, 17 the administration of gancyclovir led to dramatic reduction in the platelet count. (bloodjournal.org)
  • ristocetin
  • This fragment inhibited ristocetin-induced platelet aggregation with an IC 50 of 0.2 μmol/L and botrocetin-induced aggregation with an IC 50 of 0.08 μmol/L. We studied the antiadhesive profile of VCL by adding it to blood that was circulated over various adhesive surfaces. (ahajournals.org)