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  • novel
  • The technical challenge underlying this study was to provide a novel system to detect and/or identify human platelet antigen specific antibodies in human serum. (haematologica.org)
  • acute
  • Acute bouts of high-intensity intermittent exercise (HIIE) or sports are associated with changes in lymphocytes and platelet functions and we hypothesized that the purinergic system is involved with t. (bioportfolio.com)
  • thromboxane
  • Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (bioportfolio.com)
  • Thromboxane-A synthase, an enzyme found in platelets, converts the arachidonic acid derivative prostaglandin H2 to thromboxane. (wikipedia.org)
  • Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation. (wikipedia.org)
  • These "Sticky platelets" secrete several chemicals, including thromboxane A2 that stimulate vasoconstriction, reducing blood flow at the site. (wikipedia.org)
  • activation
  • Although this antibody may also react with the corresponding activation loop phosphotyrosine of other Src family members, it reacted on Western blots of platelet lysates with an apparent single band at ∼60 kD, consistent with Src (unpublished data). (nih.gov)
  • Thus, Src activation takes place in association with αIIbβ3 and at the periphery of spreading platelets. (nih.gov)
  • Reduced β2-GPI is associated with increased platelet aggregation and activation in patients with prolonged isolated thrombocytopenia after allo-HSCT. (bioportfolio.com)
  • Platelet activation is an essential event that is. (bioportfolio.com)
  • Characterization of distinct mechanism of agonist-induced canine platelet activation. (bioportfolio.com)
  • In the resting state the contact between the two protein subunits (necessary for the complex activation)is prevented by aggregin, which disables their contact necessary for the complex activation. (wikipedia.org)
  • granules
  • Activated platelets will release the contents of stored granules into the blood plasma. (wikipedia.org)
  • The granules' contents activate a Gq-linked protein receptor cascade, resulting in increased calcium concentration in the platelets' cytosol. (wikipedia.org)
  • blood vessel
  • The process includes the following steps: Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa). (wikipedia.org)
  • Hemorrhage
  • Moreover, platelet αIIbβ3 levels correlate poorly with hemorrhagic severity, as virtually undetectable αIIbβ3 levels can correlate with negligible bleeding symptoms, and 10%-15% levels can correlate with severe hemorrhage. (wikipedia.org)
  • Surface
  • The surface expression of this complex shows high variability, particularly in relation to the polymorphism of GPIa subunit gene. (wikipedia.org)
  • This may be the surface of a small air bubble or a more complex structure. (wikipedia.org)
  • GPIb
  • The leading role in the elimination of high-stress injury is taken by the GPIb-IX-V complex. (wikipedia.org)
  • GPIbα and GPIbβ are linked by disulfide bridges, while the GPV and GPIX associate non-covalently with the complex. (wikipedia.org)