• Platelet-derived growth factor (PDGF)-BB has been identified as important factor in pathogenesis of Graves' ophthalmopathy (GO). (eur.nl)
  • The aim of this study was to investigate the effect of PDGF-BB on adipocyte differentiation by orbital fibroblasts. (eur.nl)
  • Adipogenesis was induced by culturing orbital fibroblasts in differentiation medium, either in the presence or absence of PDGF-BB. (eur.nl)
  • It enhanced IL-6 production early during differentiation, but the effect of PDGF-BB on adipogenesis was independent of autocrine IL-6 signaling as it was not abrogated by IL-6-receptor-a neutralizing antibody. (eur.nl)
  • Common genes implicated in fibrosis are Transforming Growth Factor-Beta (TGF-β), Connective Tissue Growth Factor (CTGF), Epidermal Growth Factor Receptor (EGFR), Interleukin-13 (IL-13), Platelet-Derived Growth Factor (PDGF), Wnt/β-catenin signaling pathway. (wikipedia.org)
  • The aim of this study was to investigate the effect of PDGF-BB on adipocyte differentiation by orbital fibroblasts.METHODS: Orbital fibroblasts from five healthy controls and nine GO patients were collected. (eyehospital.nl)
  • Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells. (biomedcentral.com)
  • Neutralising antibodies against PDGFRs were shown to block signalling through PDGFRα and PDGFRβ receptors, reduce human PDGF-AA and PDGF-BB-induced collagen gel remodelling in dermal fibroblasts, and reduce migration stimulated by all PDGF ligands in human dermal and lung fibroblasts. (biomedcentral.com)
  • PDGF-AA is a potent mitogen for cardiac fibroblasts and has been shown to be critical in lung alveolar myofibroblast development and alveogenesis[ 13 , 14 ]. (biomedcentral.com)
  • Platelets are cells derived from the bone marrow containing or producing several biomolecules, such as platelet-derived growth factors (PDGF), interleukin 1, platelet-derived endothelial growth factors, basic fibroblast growth factor, transforming growth factors (TGF-1 and TGF-2), and vascular endothelial growth factors. (termedia.pl)
  • The PQ+PFD 200 group was selected to further explore the pathological changes of lung tissue, the contents of hydroxyproline and malondialdehyde in lung tissue were determined.And the tumor necrosis factor (TNF) -α, interleukin (IL) -6, transforming growth factor (TGF) -β1, fibroblast growth factor (FGF) -B, platelet-derived growth factor (PDGF) -AB, insulin-like growth factor (IGF) -1 and PQ concentrations in serum and lung tissue were determined. (bvsalud.org)
  • PDGF is a protein that regulates cell growth and division. (dvcstem.com)
  • Platelets release platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-b) from their alpha granules to attract neutrophils and macrophages. (medscape.com)
  • Finally, MWCNTs induced the production of fibrogenic growth factors TGFbeta1 and PDGF that function as paracrine signals to promote the transformation of lung fibroblasts into myofibroblasts, a key molecular step in the development of lung fibrosis. (cdc.gov)
  • Yoon S, Tefferi A, Li C: Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow. (karger.com)
  • Lenvatinib inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1-3, fibroblast growth factor (FGF) receptors FGFR1-4, platelet-derived growth factor receptor alpha (PDGFR⍺), stem cell factor receptor (KIT) and rearranged during transfection (RET). (pharmacytimes.com)
  • By inhibiting these receptors' function, lenvatinib has the potential to inhibit pathogenic angiogenesis, tumor growth, and cancer progression. (pharmacytimes.com)
  • Platelet-derived growth factors (PDGFs) acting via their tyrosine kinase receptors are major mitogens for many cell types of mesenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs)[ 1 - 4 ]. (biomedcentral.com)
  • Elevations of cytokines, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha, have all been noted. (medscape.com)
  • Apratoxin A inhibits Janus kinase (JAK)/STAT signaling through rapid down-regulation of interleukin 6 signal transducer (gp130). (aspetjournals.org)
  • Interleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 patients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response. (dirjournal.org)
  • Continuous interleukin-6 application in vivo via macroencapsulation of interleukin-6-expressing COS-7 cells induces massive gliosis. (uni-bielefeld.de)
  • Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. (uni-bielefeld.de)
  • Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury. (uni-bielefeld.de)
  • Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress. (uni-bielefeld.de)
  • Interleukin-6, a mental cytokine. (uni-bielefeld.de)
  • OBJECTIVE@#To investigate the effect of electroacupuncture (EA) at Neiguan (PC 6) on myocardial fibrosis in spontaneously hypertensive rats (SHRs), and to explore the contribution of interleukin-1 β (IL-1 β), insulin-like growth factor 1 (IGF-1), and transforming growth factor β 1 (TGF- β 1) to the effects. (bvsalud.org)
  • The synthesis of specific extracellular matrix molecules by fibroblasts in the wound is regulated by transforming growth factor-b1 and other factors such as insulin-like growth factor, interleukin 1a and 1b, interleukin-4, and vascular endothelial growth factor. (dentistryiq.com)
  • It stimulates proliferation, cytokine, and hyaluronan production, and thyrotropin receptor expression by orbital fibroblasts. (eur.nl)
  • In vitro , PDGFR isoforms have been shown to be potent activators of fibroblast proliferation, migration and survival[ 10 ]. (biomedcentral.com)
  • Asbestos-activated macrophages produce a variety of growth factors, including fibronectin, platelet-derived growth factor, insulinlike growth factor, and fibroblast growth factor, which interact to induce fibroblast proliferation. (medscape.com)
  • IL-6 is a cytokine that plays an essential role in the immune response and can stimulate hematopoietic stem cell proliferation. (dvcstem.com)
  • While these factors don't directly activate stem cells, they can create an environment conducive to stem cell health and proliferation. (dvcstem.com)
  • It was found that the cross-sectional area of hairs in the PRP and PRP&D/P MPs groups was significantly increased, so it was concluded that PRP rich in platelet-derived growth factors regulates cell migration, attachment, proliferation and differentiation, promotes the accumulation of extracellular matrix, and many growth factors positively promote hair growth. (czkealor.com)
  • Several growth factors seem to be key players in regulating the proliferation of keratinocytes in healing wounds. (dentistryiq.com)
  • The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or a growth factor. (medscape.com)
  • Ebola RNA persistence in semen of Ebola virus disease lyzed cytokine levels in serum samples from 6 travelers to survivors--preliminary report. (cdc.gov)
  • Once PRP is activated, a large number of growth factors, including platelet-derived growth factor, transforming growth factor-beta, insulin-like growth factor, epidermal growth factor and vascular endothelial growth factor, will be released from the alpha particles in platelets, which have the effect of improving the microenvironment of hair follicles and promoting hair follicle growth. (czkealor.com)
  • Most recently,[7] significant elevations in vascular endothelial growth factor (VEGF) levels have been noted. (medscape.com)
  • We have tested simultaneous inhibition of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor receptor signaling by novel indolinone derivatives using 14 myeloid, including 11 human leukemic, cell lines. (nih.gov)
  • VEGFR, vascular endothelial growth factor receptor. (aspetjournals.org)
  • The changes in vascular endothelial growth factor-A after TARE may help with the ear-ly identification of non-responders to the treatment. (dirjournal.org)
  • Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)
  • Vascular endothelial growth factor (VEGF) plays a significant role in both physiologic and pathologic angiogenesis and plays a part in improved permeability across both blood-retinal and blood-brain barriers. (molecularcircuit.com)
  • Dovitinib inhibited vascular endothelial growth factor receptor 1/2, fibroblast growth factor receptor 1/3, platelet-derived growth factor receptor β (PDGFR-β), the phosphorylation of PDGFR-β and extracellular signal-regulated kinase (ERK) in tumors. (lclabs.com)
  • The review focuses on the role of APC-derived EVs in regulating the transformation of macrophage phenotype, shaping foam cells, driving autophagy and/or inhibiting apoptosis of Th4 + cells, T regulatory cells, endothelial and smooth muscle cells (SMCs), as well as in facilitating oxidative stress in vasculature. (bmrat.org)
  • They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)
  • Macrophages continue to emit growth factors to attract fibroblasts and usher in the next phase of wound healing (see Table below). (medscape.com)
  • By day three the neutrophils are phagocytosed either by macrophages or fibroblasts. (dentistryiq.com)
  • Macrophages continue cleansing the wound and releasing cytokines and growth factors. (dentistryiq.com)
  • Thus, the wound repair signals initiated by degranulating platelets and neutrophils are maintained by macrophages. (dentistryiq.com)
  • MWCNT stimulated the secretion of a panel of inflammatory cytokines and chemokines (TNFalpha, IL-1beta, IL-6, IL-10 and MCP1) from macrophages (Raw264.7) by activating the canonical NF-kappaB signaling pathway. (cdc.gov)
  • Eosinophil Production and Function Eosinophils are granulocytes (white blood cells that contain granules in their cytoplasm) derived from the same progenitor cells as monocytes-macrophages, neutrophils, and basophils. (msdmanuals.com)
  • It shares about 30% homology with members of the fibroblast growth factor receptor/platelet-derived growth factor receptor superfamily, and contains a single putative transmembrane domain and a conserved intracellular tyrosine kinase domain, whereas lacks an extracellular domain for binding specific ligands [ 8 ]. (biomedcentral.com)
  • The fibroblasts found in the granulation tissue are actively laying down the extracellular matrix. (dentistryiq.com)
  • In this study, we used PDGFR-specific neutralising antibodies to dissect out receptor-specific signalling events in fibroblasts in vitro , to further understand key cellular processes involved in wound healing and tissue repair. (biomedcentral.com)
  • Recent studies have attempted to dissect PDGFR-specific events using genetically defined mouse embryonic fibroblasts (MEFS) expressing PDGFRα, PDGFRβ, both or neither[ 20 ]. (biomedcentral.com)
  • Fibrin, along with fibronectin in the clot, acts as a provisional matrix for the influx of monocytes and fibroblasts. (dentistryiq.com)
  • Platelet-rich fibrin is a second-generation platelet concentrate, showing a substantial regenerative property with minimal to no inflammatory reactions upon application in defects [10]. (termedia.pl)
  • Case reports have shown significant results of adding platelet-rich fibrin to bone grafting procedures for bone regeneration in sinus augmentation, cleft reconstruction, and fistula management [11, 12]. (termedia.pl)
  • Platelet-rich plasma (PRP) is a platelet concentrate extracted from patient blood by centrifugation, containing high concentrations of platelets, white blood cells and fibrin. (czkealor.com)
  • The clot consists of coagulated blood and aggregated platelets within a cross-linked fibrin network. (dentistryiq.com)
  • The growth factors and cytokines present in the fibrin clot provide some of the start signals for wound repair. (dentistryiq.com)
  • Plasmin is derived from activated plasminogen in the fibrin clot. (dentistryiq.com)
  • A high-quality PRP system can concentrate platelets 6-10 times greater than what is usual in blood. (regenvet.com)
  • CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)
  • EGF is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. (dvcstem.com)
  • Stimulates growth. (cdc.gov)
  • Activation of this factor occurs in the stromal cells, tumor cells, and invading immune cells within the tumor microenvironment. (surgicalneurologyint.com)
  • It is a reservoir of cytokines and growth factors, as well as signaling molecules, mitogens, and chemotactic factors. (dentistryiq.com)
  • FGF is particularly important for the growth and differentiation of neural stem cells. (dvcstem.com)
  • Therefore, it was suggested that growth factors released from platelets may act on the stem cells of the hair follicle bulge to stimulate stem cell differentiation and promote the formation of neovascularization. (czkealor.com)
  • Although, a list of contributing factors such as sickle cell anaemia, use of steroids, femoral neck fractures are involved in the loss of osteogenic cells via obstructing blood supply especially in the greater trochanteric region[ 1 , 2 ]. (ijpsonline.com)
  • Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
  • It's crucial for the growth of specific types of stem cells, including epidermal and neural stem cells. (dvcstem.com)
  • It's particularly important for the growth of mesenchymal stem cells, which can differentiate into a variety of cell types, including bone, cartilage, and fat cells. (dvcstem.com)
  • Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
  • Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
  • Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
  • Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
  • 3 - 5 CXCL12 is highly expressed by MM plasma cells, 6 and circulating levels of CXCL12 are higher in the peripheral blood of MM patients than in age-matched normal donors and MGUS patients. (haematologica.org)
  • 6 Recent animal studies involving systemic injection of labeled MM plasma cells have also demonstrated that blocking the CXCL12/CXCR4 axis leads to a 20% reduction in bone marrow tumor burden. (haematologica.org)
  • 12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
  • Furthermore, dovitinib significantly inhibited the growth of primary cells from 8p11 myeloproliferative syndrome (EMS) patients dose-dependently. (lclabs.com)
  • Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. (lclabs.com)
  • The COL4A1-VEGFD fusion leads to production of mature VEGFD after proteolytic processing, which may act as an autocrine growth factor for tumour cells. (cusabio.com)
  • Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine (see the image below). (medscape.com)
  • Primary normal human-derived bronchial epithelial cells (NHBEs) were exposed to ABS filament emissions in an ALI for 4hours. (cdc.gov)
  • Our objective was to observe the effects of extracorporeal circulation (ECC) with different time on platelet count in patients undergoing cardiac surgery. (nature.com)
  • However, there are few studies on the effects of ECC time on platelet count in patients after cardiac surgery, especially the effects of different ECC time on postoperative platelet count has not been reported. (nature.com)
  • The purpose of this study was to conduct a retrospective study to observe the effects of ECC with different time on platelet count in patients undergoing cardiac surgery, so as to provide reference for improving the prognosis of patients undergoing cardiac surgery. (nature.com)
  • CONCLUSION@#EA at bilateral PC 6 could ameliorate cardiac fibrosis in SHRs, which might be mediated by regulation of 1L-1 β/IGF-1-TGF- β 1-MMP9 pathway. (bvsalud.org)
  • Hyalocytes were stained with phalloidin, showing the cell shape and cytoskeletal changes after 6 days of exposure to the different treatments (doses are indicated in the Methods section). (molvis.org)
  • METHODS: Orbital fibroblasts from five healthy controls and nine GO patients were collected. (eyehospital.nl)
  • Methods We assessed the functional status of platelets by performing ELISA, western blot and RNA sequencing in a cohort of 71 patients and 68 age- and sex-matched healthy control subjects. (bmj.com)
  • Therefore, the development of methods to improve the regenerative potential of non-vascularized bone graft (NVBG) are currently on the rise [6]. (termedia.pl)
  • Methods: In April 2017, male 6-8 week-old Wistar rats were selected, and PQ was administered intraperitoneally at one time. (bvsalud.org)
  • Design and Methods The expression of hypoxia-inducible factor protein was examined in patients' bone marrow biopsy specimens using immunohistochemistry. (haematologica.org)
  • In acute myeloid leukemia (AML), receptor tyrosine kinase ligands promote growth and survival and contribute to AML-associated marrow neoangiogenesis. (nih.gov)
  • Receptor protein tyrosine kinases (RPTKs) are important regulators of intracellular signaling pathways mediating diverse cellular and developmental processes and their dysregulation are closely related with the development of cancer [ 6 , 7 ]. (biomedcentral.com)
  • Modification in growth factors, excessive collagen, genetic and immunological factors contribute in keloid formation. (scirp.org)
  • After 8-weeks EA treatment at PC 6, histopathologic changes of collagen type I (Col I), collagen type 1 (Col 1) and the levels of IGF-1, 1L-1 β, TGF- β 1, matrix metalloproteinase (MMP)-2 and MMP-9 were examined in myocardial tissure respectively. (bvsalud.org)
  • As wound healing progresses, the provisional matrix is replaced by a new, collagen-rich matrix synthesized by fibroblasts migrating into the wound. (dentistryiq.com)
  • Other cytogenetic abnormalities include rearrangement of the gene for fibroblast growth factor receptor 1 ( FGFR1 ) or Janus kinase 2 ( PCM1-JAK2 ). (msdmanuals.com)
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
  • Protein/calorie deficiencies inhibit hair growth. (cdc.gov)
  • Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family. (bvsalud.org)
  • To analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttrium- 90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients. (dirjournal.org)
  • Short-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. (dirjournal.org)
  • Short-term changes in angiogenesis factor levels fluctuate with different amplitudes at different times. (dirjournal.org)
  • The cause of this undesirable development in HCC patients depends on many factors, and hypoxia caused by tissue embolization may trigger angiogenesis. (dirjournal.org)
  • 9,10 In randomized controlled cohort studies, it was determined that the release of angiogenesis factors after TACE increased, and this escalation was associated with survival duration. (dirjournal.org)
  • 13,14 In line with these findings, understanding the short-term serial changes of angiogenesis factors after TARE is important for developing different treatment strategies (for example, TARE combined with systemic anti-angiogenic therapies) to prevent possible rapid progression after TARE. (dirjournal.org)
  • The aim of this study was to analyze the short-term changes in angiogenesis factors after TARE with Yttrium-90-loaded resin microspheres and their relationship with the radiological response. (dirjournal.org)
  • Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
  • Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)
  • 6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)
  • APC-derived EVs act as triggers of angiogenesis, neovascularization and inflammation through their participation in microvascular inflammation, angiogenesis, development of atherosclerotic plaques, and modulation of their instability. (bmrat.org)
  • Conclusion Taken together, our results provide a better understanding for the impact of mHtt on platelet function. (bmj.com)
  • In conclusion, platelet rich plasma has been demonstrated by multiple high level studies to be as effective or superior to hyaluronic acid injections for knee arthritis. (regenvet.com)
  • Inhibits growth of hair and follicle. (cdc.gov)
  • Inhibits growth. (cdc.gov)
  • Causative factors for keloid are increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression. (scirp.org)
  • While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
  • The role of hypoxia-inducible factors-1 and -2 in the regulation of CXCL12 expression was examined using over-expression and short hairpin RNA knockdown constructs, electrophoretic mobility shift assays and chromatin immunoprecipitation. (haematologica.org)
  • This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research. (ersjournals.com)
  • BO and its clinical correlate bronchiolitis obliterans syndrome (BOS) affect up to 50-60% of patients who survive 5 yrs after surgery, irrespective of the type of transplant procedure 1 , 4 - 6 . (ersjournals.com)
  • These small molecules have contributed to our understanding of the physiopathological relevance of the ET axis and the beginning of translation of this information into clinical trials [ 5 , 6 ]. (biomedcentral.com)
  • Raeissadat SA, Rayegani SM, Hassanabadi H, Fathi M, Ghorbani E, Babaee M, Azma K. Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial). (regenvet.com)
  • FGF is a family of growth factors involved in a wide variety of processes, including the regulation of cell growth, wound healing, and embryonic development. (dvcstem.com)
  • Neutrophils also serve as a source of pro-inflammatory cytokines providing signals that activate adjacent fibroblasts and keratinocytes. (dentistryiq.com)
  • Hormonal factors (eg, estrogen, progesterone) have been studied extensively as risk factors for meningiomas because of the striking predominance of meningiomas in women. (medscape.com)
  • These insults result in repeated cycles of hepatocyte injury, death and repair that eventually lead to the premature senescence of the liver [ 6 ]. (biomedcentral.com)
  • Platelet rich plasma (PRP) is plasma with many more platelets than what is typically found in blood. (regenvet.com)
  • How do you decide between injection of hyaluronic acid or platelet rich plasma? (regenvet.com)
  • Kanchanatawan W, Arirachakaran A, Chaijenkij K, Prasathaporn N, Boonard M5, Piyapittayanun P, Kongtharvonskul J. Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee. (regenvet.com)
  • Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. (regenvet.com)
  • Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. (regenvet.com)
  • PRP was first used in surgical patients in 1977 with good efficacy, and in 2011, the International Society of Cellular Medicine launched the Guidelines for the Application of Platelet Rich Plasma. (czkealor.com)
  • The advent of platelet-rich plasma (PRP) for hair loss has more than given patients a new treatment option that is widely recognized for both its efficacy and safety. (czkealor.com)
  • Dovitinib significantly inhibited KMS-11-luc tumor growth and improved animal survival at doses that inhibited FGFR3 signaling in KMS-11-luc tumors in vivo. (lclabs.com)
  • Understanding how the body repairs damaged tissue and what factors influence the wound healing process helps the surgeon ensure an acceptable outcome from surgery. (medscape.com)
  • As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. (medscape.com)
  • Studies have shown that when purified growth factors were deposited in granulation tissue, the wounds showed accelerated granulation tissue formation and wound healing (Lynch et al. (dentistryiq.com)
  • There are explicit indications, however, that transforming growth factor (TGF)-β2 may be involved in the pathogenesis of POAG. (arvojournals.org)
  • Autogenous bone grafts are bone transplantation using bone with a donor site from the same individual, with or without vascularization [6, 7]. (termedia.pl)
  • Vascularized bone-graft are generally used to treat defects bigger than 6 cm because of their perceived benefit of lower resorption rate and higher success rate [8]. (termedia.pl)
  • The method is to inject PRP locally into the dermis of the scalp in the area of hair loss, once/month, with certain efficacy seen in 3~6 consecutive injections. (czkealor.com)
  • Other evidence to substantiate the implication of gender-specific hormones comes from data showing increased growth of meningiomas during pregnancy and size changes with menses. (medscape.com)
  • Platelet-derived growth factor-BB enhances adipogenesis in orbital fibroblasts, and, thus, may contribute to adipose tissue expansion in GO. (eur.nl)
  • Stem cell activation can be influenced by various lifestyle factors. (dvcstem.com)
  • Most of these tumors produce 5-hydroxytryptamine, which, in physiologic conditions, is taken up and stored in the platelets while the excesses are inactivated in the liver and lung and transformed into 5-hydroxyindoleacetic acid (5-HIAA). (medscape.com)
  • CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice. (lclabs.com)
  • [ 6 ] In addition, although data regarding the association between MUC5B promoter polymorphism and idiopathic pulmonary fibrosis appear to be clear, the data are mixed about the MUC5B promoter variant being a potential genetic risk factor for asbestosis. (medscape.com)
  • HIFs are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. (dvcstem.com)
  • Promoter analyses revealed increased hypoxia-inducible factor-2 binding to the CXCL12 promoter under hypoxic conditions. (haematologica.org)