Platelet derive fibroblast growth factor 4. Medical search. Frequent questions

It inhibits the three main vascular endothelial growth factor receptors VEGFR1, 2 and 3, as well as fibroblast growth factor receptors (FGFR) 1, 2, 3 and 4, platelet-derived growth factor receptor (PDGFR) alpha, c-Kit, and the RET proto-oncogene. (wikipedia.org)
Lenvatinib inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1-3, fibroblast growth factor (FGF) receptors FGFR1-4, platelet-derived growth factor receptor alpha (PDGFR⍺), stem cell factor receptor (KIT) and rearranged during transfection (RET). (pharmacytimes.com)
By inhibiting these receptors' function, lenvatinib has the potential to inhibit pathogenic angiogenesis, tumor growth, and cancer progression. (pharmacytimes.com)
Yoon S, Tefferi A, Li C: Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow. (karger.com)
Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes. (nature.com)
The drug is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). (dcatvci.org)
Here, we report that normal adult human skin fibroblasts display two isoform-specific, cell surface glycosyl phosphatidylinositol (GPI)-anchored, TGF-beta binding proteins in addition to the type I, II, and III TGF-beta receptors. (eurekamag.com)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)

Platelet-derived growth factor subunit-BB (PDGF-BB). (molvis.org)
Platelets elaborate a number of proinflammatory substances, such as adenosine diphosphate, tissue growth factor beta (TGF-ß), and platelet-derived growth factors (PDGF). (medscape.com)
Our studies also show that these NPs have differential requirements for LIF and ciliary neurotrophic factor (CNTF) and for epidermal growth factor (EGF), fibroblast growth factor (FGF-2) and platelet-derived growth factor (PDGF) for their propagation in vitro. (karger.com)
Platelets are cells derived from the bone marrow containing or producing several biomolecules, such as platelet-derived growth factors (PDGF), interleukin 1, platelet-derived endothelial growth factors, basic fibroblast growth factor, transforming growth factors (TGF-1 and TGF-2), and vascular endothelial growth factors. (termedia.pl)
Platelets release platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-b) from their alpha granules to attract neutrophils and macrophages. (medscape.com)
Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an immunoregulatory Factor Mediates Airway Remodeling and Possible Pharmacological Target. (il-10.com)

Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis. (il-10.com)
Recent studies have shown that cancer-associated fibroblasts (CAFs) and the epithelial-mesenchymal transition (EMT) contribute to invasive and metastatic abilities of ovarian cancer (OC) cells. (oncotarget.com)

Lenvatinib is an oral multi-kinase inhibitor that inhibits mainly vascular endothelial growth factor receptor 1-3, fibroblast growth factor receptor (FGFR) 1-4, platelet-derived growth factor receptor (PDGFR) α, c-KIT, and RET ( 11 ). (spandidos-publications.com)
Dovitinib inhibited vascular endothelial growth factor receptor 1/2, fibroblast growth factor receptor 1/3, platelet-derived growth factor receptor β (PDGFR-β), the phosphorylation of PDGFR-β and extracellular signal-regulated kinase (ERK) in tumors. (lclabs.com)
We have tested simultaneous inhibition of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor receptor signaling by novel indolinone derivatives using 14 myeloid, including 11 human leukemic, cell lines. (nih.gov)
Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)
Once PRP is activated, a large number of growth factors, including platelet-derived growth factor, transforming growth factor-beta, insulin-like growth factor, epidermal growth factor and vascular endothelial growth factor, will be released from the alpha particles in platelets, which have the effect of improving the microenvironment of hair follicles and promoting hair follicle growth. (czkealor.com)
The synthesis of specific extracellular matrix molecules by fibroblasts in the wound is regulated by transforming growth factor-b1 and other factors such as insulin-like growth factor, interleukin 1a and 1b, interleukin-4, and vascular endothelial growth factor. (dentistryiq.com)

Platelet-rich fibrin is a second-generation platelet concentrate, showing a substantial regenerative property with minimal to no inflammatory reactions upon application in defects [10]. (termedia.pl)
Case reports have shown significant results of adding platelet-rich fibrin to bone grafting procedures for bone regeneration in sinus augmentation, cleft reconstruction, and fistula management [11, 12]. (termedia.pl)
Platelet-rich plasma (PRP) is a platelet concentrate extracted from patient blood by centrifugation, containing high concentrations of platelets, white blood cells and fibrin. (czkealor.com)
The clot consists of coagulated blood and aggregated platelets within a cross-linked fibrin network. (dentistryiq.com)
The growth factors and cytokines present in the fibrin clot provide some of the start signals for wound repair. (dentistryiq.com)
Fibrin, along with fibronectin in the clot, acts as a provisional matrix for the influx of monocytes and fibroblasts. (dentistryiq.com)
Plasmin is derived from activated plasminogen in the fibrin clot. (dentistryiq.com)

Keloids are benign hyper proliferative reaction of dermal fibroblasts demonstrated by the excessive deposition of extracellular matrix components, especially collagen, fibronectin, elastin, proteoglycans, and growth factors such as transforming growth factor (TGF) β. (scirp.org)
It was found that the cross-sectional area of hairs in the PRP and PRP&D/P MPs groups was significantly increased, so it was concluded that PRP rich in platelet-derived growth factors regulates cell migration, attachment, proliferation and differentiation, promotes the accumulation of extracellular matrix, and many growth factors positively promote hair growth. (czkealor.com)
During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
The fibroblasts found in the granulation tissue are actively laying down the extracellular matrix. (dentistryiq.com)

and high protein levels of stomatin-like protein 2 and epidermal growth factor receptor ( 17 , 18 ). (spandidos-publications.com)
Among these factors are epidermal growth factor, transforming growth factor alpha, heparin-binding epidermal growth factor, and keratinocyte growth factor. (dentistryiq.com)

These growth factors act on surrounding cells and stimulate chemotaxis of neutrophils, monocytes, and fibroblasts to the area of injury. (medscape.com)
Neutrophils also serve as a source of pro-inflammatory cytokines providing signals that activate adjacent fibroblasts and keratinocytes. (dentistryiq.com)
By day three the neutrophils are phagocytosed either by macrophages or fibroblasts. (dentistryiq.com)
Thus, the wound repair signals initiated by degranulating platelets and neutrophils are maintained by macrophages. (dentistryiq.com)
Eosinophil Production and Function Eosinophils are granulocytes (white blood cells that contain granules in their cytoplasm) derived from the same progenitor cells as monocytes-macrophages, neutrophils, and basophils. (msdmanuals.com)

However, TACE can induce hypoxia and increase the level of VEGF in HCC, which may be the driving factor of tumor growth, progression, and metastasis [ 4 , 5 ]. (hindawi.com)
Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)

Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
In this regard, the growth and proliferation of the neural stem cells in vitro are critical as the number of cells available for transplantation is essential to achieve beneficial effect in replacing injury or loss of the neuronal cells. (biomedcentral.com)

The following CAF-related markers were used: CD10, podoplanin, fibroblast activating protein (FAP), platelet derived growth factor receptor (PDGFRα), PDGFRβ, S100A4 and α-smooth muscle actin (α-SMA). (oncotarget.com)

Among the important functions of the clot are its role as a reservoir of growth factors and cytokines that are released by the degranulation of activated platelets. (dentistryiq.com)
Macrophages continue cleansing the wound and releasing cytokines and growth factors. (dentistryiq.com)
It is a reservoir of cytokines and growth factors, as well as signaling molecules, mitogens, and chemotactic factors. (dentistryiq.com)
Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)

Importantly, dual targeting cholesterol and steroid biosynthesis with simvastatin, commonly prescribed cholesterol synthesis inhibitors, and inhibitors to have the strongest growth inhibitory AKR1C3 effect.From our results we conclude that the CAFS induces upregulation of cholesterol and steroid biosynthesis in PCa cells, driving them to AR targeted therapy resistance. (il-10.com)

Transforming growth factor beta 1 (TGF-β). (molvis.org)
There are explicit indications, however, that transforming growth factor (TGF)-β2 may be involved in the pathogenesis of POAG. (arvojournals.org)
Fibroblasts play a critical role in wound repair and in the development of fibrotic diseases, and transforming growth factor-beta (TGF-beta) has been shown to profoundly modulate fibroblast function. (eurekamag.com)
Joyce ME, Jinngushl S, Bolander ME: Transforming growth factor-beta in the regulation of fracture repair. (medigraphic.com)

Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)

The purpose of this study aimed to investigate the clinicopathologic characteristics of breast cancer according to its cancer-associated fibroblast (CAF) phenotype. (elsevierpure.com)

bFGF is a chemotactic and mitogenic factor for fibroblasts and endothelial cells. (medscape.com)

CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)

The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
The effect of ICA on the growth and proliferation of the neural stem cells was evaluated by 5-ethynyl-2-deoxyuridine (EdU) labeling of proliferating cells, and photomicrographic images of the cultured neural stem cells. (biomedcentral.com)
The present study showed that icariin promotes the growth and proliferation of neural stem cells from rat hippocampus in a dose-dependent manner. (biomedcentral.com)
This study evidently demonstrates the potentiating effect of ICA on neural stem cell growth and proliferation, which might be mediated through regulation of cell cycle gene and protein expression promoting cell cycle progression. (biomedcentral.com)
Exploring the effect of pharmacological manipulation, such as usage of traditional medicine, on the growth and proliferation of neural stem cells is thus valuable towards the development of the stem cells therapies of the neurodegenerative disorders. (biomedcentral.com)
Several growth factors seem to be key players in regulating the proliferation of keratinocytes in healing wounds. (dentistryiq.com)

Macrophages continue to emit growth factors to attract fibroblasts and usher in the next phase of wound healing (see Table below). (medscape.com)

Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)

Basic fibroblast growth factor (bFGF). (molvis.org)
These cells debride the wound on the microscopic level and produce a wide variety of important substances, such as IL-1 and basic fibroblast growth factor (bFGF). (medscape.com)

Despite similar oncogenic pathway alterations in both SUVmax groups of FL samples, 4 out of 5 cases harboring the infrequent FOXO1 transcription factor mutation were seen in FL patients with SUVmax >14.5. (bvsalud.org)
for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)

Therefore, it was suggested that growth factors released from platelets may act on the stem cells of the hair follicle bulge to stimulate stem cell differentiation and promote the formation of neovascularization. (czkealor.com)

Hormonal factors (eg, estrogen, progesterone) have been studied extensively as risk factors for meningiomas because of the striking predominance of meningiomas in women. (medscape.com)

Modification in growth factors, excessive collagen, genetic and immunological factors contribute in keloid formation. (scirp.org)
As wound healing progresses, the provisional matrix is replaced by a new, collagen-rich matrix synthesized by fibroblasts migrating into the wound. (dentistryiq.com)
Sarkar MR, Augat P, Shefelbine SJ, et al: Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold. (medigraphic.com)

We further performed haemostasis and platelet depletion tests in the R6/2 HD mouse model. (bmj.com)
We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)

Other common side effects included decreased appetite, hypotension (low blood pressure), thrombocytopenia (low blood platelet count), nausea, muscle and bone pain. (wikipedia.org)
Design and Methods The expression of hypoxia-inducible factor protein was examined in patients' bone marrow biopsy specimens using immunohistochemistry. (haematologica.org)
Bone regeneration is required to treat these defects, provide support for dental implants, jaw reconstruction after cystic lesion removal, cleft repair, etc. [3, 4]. (termedia.pl)

This plug acts as a lattice for the aggregation of platelets, the most common and "signature" cell type of the early inflammatory phase. (medscape.com)
For example, thromboxane A2 mediates vasoconstriction and platelet aggregation. (medscape.com)
Causative factors for keloid are increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression. (scirp.org)

In the second stage of the inflammatory phase, leukocytes supplant platelets as the dominant cell type, attracted by chemotaxis. (medscape.com)
The inflammatory phase begins at the time of injury and lasts 2-4 days. (medscape.com)
The inflammatory type had high expression of FAPα and NG2 with low podoplanin, while normal-like type showed low expression of prolyl 4-hydroxylase and S100A4. (elsevierpure.com)
Cytokine profiling reveal a high number of pro-inflammatory factors, pro-migratory and pro-angiogenic in the supernatant CAF. (il-10.com)

The phase begins with hemostasis and formation of the platelet plug. (medscape.com)

The eosinophils were stained positively to platelet-derived growth factor receptor-β. (karger.com)

Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. (lclabs.com)
CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice. (lclabs.com)

Methods We assessed the functional status of platelets by performing ELISA, western blot and RNA sequencing in a cohort of 71 patients and 68 age- and sex-matched healthy control subjects. (bmj.com)

Injury to vascular tissue initiates the extrinsic coagulation cascade by releasing intracellular calcium and tissue factor that activate factor VII . (medscape.com)
Understanding how the body repairs damaged tissue and what factors influence the wound healing process helps the surgeon ensure an acceptable outcome from surgery. (medscape.com)
The platelets injected into the tissue can secrete a variety of growth factors upon activation, the most important of which are the following. (czkealor.com)
Studies have shown that when purified growth factors were deposited in granulation tissue, the wounds showed accelerated granulation tissue formation and wound healing (Lynch et al. (dentistryiq.com)

In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. (lclabs.com)

Primary normal human-derived bronchial epithelial cells (NHBEs) were exposed to ABS filament emissions in an ALI for 4hours. (cdc.gov)

While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
The role of hypoxia-inducible factors-1 and -2 in the regulation of CXCL12 expression was examined using over-expression and short hairpin RNA knockdown constructs, electrophoretic mobility shift assays and chromatin immunoprecipitation. (haematologica.org)
12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Finally, we show that LIF increases the expression of the core transcription factors: Klf4, Fbx15, Nanog, Sox2 and c-Myc. (karger.com)
High expression of α-SMA was a distinctive feature in subgroup 4, and expression of podoplanin and α-SMA characterized subgroup 5. (oncotarget.com)

Oncogene activation is therefore generally only tumorigenic when it is coupled with inactivation or inhibition of oncogene-induced pro-apoptotic or senescence pathways [ 4 ]. (biomedcentral.com)

Furthermore, dovitinib significantly inhibited the growth of primary cells from 8p11 myeloproliferative syndrome (EMS) patients dose-dependently. (lclabs.com)
Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. (lclabs.com)
Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
Although, a list of contributing factors such as sickle cell anaemia, use of steroids, femoral neck fractures are involved in the loss of osteogenic cells via obstructing blood supply especially in the greater trochanteric region[ 1 , 2 ]. (ijpsonline.com)
In addition, the definition of TGF-beta receptor profiles in human skin fibroblasts provides important information for studying their alterations in these cells in various skin diseases. (eurekamag.com)

Shiang R, Thompson LM, Zhu YZ: Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. (medigraphic.com)
Other cytogenetic abnormalities include rearrangement of the gene for fibroblast growth factor receptor 1 ( FGFR1 ) or Janus kinase 2 ( PCM1-JAK2 ). (msdmanuals.com)

Lenvatinib is available as 4 mg and 10 mg capsules packaged in cartons of 6 cards. (pharmacytimes.com)
For example, if the daily dosage of lenvatinib is 24 mg, the appropriate carton would contain 6 cards, each with ten 10 mg capsules and five 4 mg capsules per card. (pharmacytimes.com)
50% of patients receiving lenvatinib therapy experience tumor growth or metastasis within 1 year, highlighting the need to address acquired resistance as a critical clinical challenge. (spandidos-publications.com)
To elucidate the factors associated with acquired resistance to lenvatinib, a lenvatinib‑resistant HCC cell line (JHH‑7_LR) was established by exposing a lenvatinib‑sensitive HCC cell line, JHH‑7, to lenvatinib. (spandidos-publications.com)
In contrast, tumor growth or metastasis occurs in more than 50% of patients who receive lenvatinib therapy within 1 year ( 7 ), and the development of acquired resistance is a crucial clinical problem to be resolved ( 12 ). (spandidos-publications.com)

A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. (lookformedical.com)
the platelet derived growth factor receptor alpha (PDGFRÎ±), KIT, and RET. (dcatvci.org)

Eicosanoids mediate activity influencing platelet plug formation, vascular permeability, and cellular chemotaxis to influence wound healing. (medscape.com)

The underlying molecular mechanisms and the responsible pathogenic factors leading to these changes in outflow resistance remain unknown. (arvojournals.org)

The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient's likelihood of benefitting from treatment with KEYTRUDA, including exploring several different biomarkers. (pipelinereview.com)
Inhibiting HMGCS2 and AKR1C3 resulted in a significant growth retardation of spheroids co-culture as well as a variety of castration and enzalutamide resistant cell lines in 2D and 3D cultures, underlining their alleged role in PCa. (il-10.com)
Role of Exposure and Risk Factors adult-onset nonoccupational asthma. (cdc.gov)

In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. (biomedcentral.com)
We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. (biomedcentral.com)
Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. (medscape.com)
Cell death & disease , Vol. 11 , Issue 4 , pp. 284 , ( 2021 ) ( PubMed ). (antibodies-online.com)

Anatomy35

Organisms11

Diseases12

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Receptors8

PDGF6

Cancer-associated fibroblasts2

Vascular endoth6

Fibrin7

Extracellular matrix4

Epidermal growth2

Neutrophils5

VEGF2

Vitro2

PDGFR1

Cytokines4

CAFS1

Transforming4

Microenvironment1

Phenotype1

Chemotactic1

Regulates cell1

Proliferation6

Macrophages1

Progression1

BFGF2

Pathway2

Stimulate1

Estrogen1

Collagen3

Depletion2

Bone3

Aggregation3

Inflammatory4

Hemostasis1

Positively1

Multiple myeloma6

ELISA1

Tissue4

Receptor kinase1

Epithelial cells1

Expression5

Inhibition1

Cells5

Gene2

Lenvatinib5

Alpha2

Chemotaxis1

Molecular1

Role3

Cell5