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  • Thrombocytopenic
  • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. (ox.ac.uk)
  • METHODS: In this phase III, randomised, double-blind, placebo-controlled study, adults from 63 sites in 23 countries with chronic idiopathic thrombocytopenic purpura (ITP), platelet counts less than 30 000 per muL of blood, and one or more previous ITP treatment received standard care plus once-daily eltrombopag 50 mg (n=76) or placebo (n=38) for up to 6 weeks. (ox.ac.uk)
  • enough platelets
  • If you don't have enough platelets you may notice signs of bleeding such as nosebleeds, easy bruising, prolonged bleeding from a cut, black or bloody stools, brown or red urine, or tiny pinpoint sized spots on your skin, under your nails or in you gums. (medhelp.org)
  • If you don't have enough platelets, it could be a sign of something serious. (aafp.org)
  • reduce platelet count
  • Either an underlying medical condition is causing the reduced level, or an individual is taking a medication or substance that serves to reduce platelet count. (medicalnewstoday.com)
  • People are usually split up into low and high risk for bleeding/blood clotting groups (based on their age, their medical history, their blood counts and their lifestyles), low risk individuals are usually treated with aspirin, whereas those at high risk are given hydroxycarbamide and/or other treatments that reduce platelet count (such as interferon-α and anagrelide). (wikipedia.org)
  • bloodstream
  • Normally, the spleen filters and removes the waste products and with the overload of unwanted substances in the bloodstream, the spleen will remove blood cells too quickly or store the platelets. (wikipedia.org)
  • thrombotic
  • However, well-documented medical regimens can reduce and control the number of platelets, which reduces the risk of these thrombotic or hemorrhagic events. (wikipedia.org)
  • Medication
  • Doctors are advised to be aware of whether or not a patient has HIV/AIDS or another disease that affects the immune system, is taking a medication that affects the immune system, has cancer, a fever or active untreated tuberculosis, is receiving cancer treatment, or has ever had a low platelet count (a blood disorder). (wikipedia.org)
  • purpura
  • Eltrombopag has been shown to be effective in two major clinical syndromes: idiopathic thrombocytopenic purpura and cirrhosis due to hepatitis C (in which low platelet counts may be a contraindication for interferon treatment). (wikipedia.org)