Platelet aggregation is normal platelet glycoprotein gpiib iiia complex. Medical search. Frequent questions

Activation also induces a conformational change in the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor, giving it high affinity for fibrinogen. (wikipedia.org)
Binding of fibrinogen to GPIIb/IIIa receptors leads to platelet-to-platelet bridges and results in platelet aggregation. (wikipedia.org)
Binding of TRAP-6 to PAR-1 causes a conformational change in the GPIIb/IIIa receptors on platelets, giving them high affinity for fibrinogen. (wikipedia.org)
Glanzmann thrombasthenia (GT) is a rare platelet disorder in which the platelets have qualitative or quantitative deficiencies of the fibrinogen receptor αIIbβ3. (medscape.com)
[ 4 ] With platelet activation, the αIIbβ3 complex shifts into its active configuration, which allows the binding of fibrinogen and/or von Willebrand factor (vWF). (medscape.com)
On resting platelets, GP IIb/IIIa is unable to bind fibrinogen or vWf. (medscape.com)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
Under physiological conditions, the GP IIb/IIIa receptors are present in a low-affinity state and cannot bind to fibrinogen. (aging-us.com)
It is a receptor for fibrinogen and von Willebrand factor and aids in platelet activation. (hemostasis.com)
Platelet activation by ADP (blocked by clopidogrel) leads to a conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. (hemostasis.com)
Once activated, platelets express the GPIIb/IIIa receptor which can then bind with vWF or fibrinogen. (teachmephysiology.com)
Fibrinogen facilitates the formation of crosslinks between platelets, aiding platelet aggregation to form a platelet plug. (teachmephysiology.com)
Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor and other adhesive molecules. (smpdb.ca)
Whatever the initial stimulus, the final common event is a cross-linking of platelets by binding of fibrinogen to a membrane-binding site, glycoprotein IIb/IIIa (GPIIb/IIIa). (justia.com)
Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. (embl.de)
Common (or conventional) coagulation tests (CCT) include prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, D-dimer, and fibrinogen levels. (e-jnc.org)

Ristocetin forms complexes with von Willebrand factor (vWF) that bind to the glycoprotein Ib (GP1b) receptors on platelets, causing platelet activation and aggregation. (wikipedia.org)
Reduced or absent aggregation in response to ristocetin can be caused by a lack of or reduction of vWF, as seen in von Willebrand disease (vWD), or absence or reduction in numbers of GP1b receptors, as in Bernard-Soulier syndrome (BSS). (wikipedia.org)
Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Bitiscetin has recently been shown to induce von Willebrand factor (vWF)-dependent aggregation of fixed platelets (Hamako J, et al, Biochem Biophys Res Commun 226:273, 1996). (ashpublications.org)
V ON WILLEBRAND FACTOR (vWF) is a multimeric glycoprotein (GP) that plays a key role, under high-shear conditions, in the initial attachment of platelets to the extracellular matrix of the endothelial cells after injury of the vessel wall. (ashpublications.org)

Collagen is added to the sample-saline mix, and binds to collagen-receptors on platelets. (wikipedia.org)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
Platelets are activated when brought into contact with collagen (which is exposed when the endothelial blood vessel lining is damaged), thrombin (primarily through PAR -1), ADP receptors (P2Y1 and P2Y12) expressed on platelets, a negatively charged surface (e.g. glass), or several other activating factors. (wikidoc.org)
Other receptors include GPIb-V-IX complex (vWF) and GPVI ( collagen ). (wikidoc.org)
Exposed collagen fibres bind vWF released from the damaged endothelium, which in turn binds to vWF receptors on platelets to promote adhesion. (teachmephysiology.com)
The exposed collagen itself also promotes platelet binding. (teachmephysiology.com)
When a platelet binds to collagen, the glycoprotein IIb/IIIa pathway is activated - a complex system controlled by G-protein coupled receptors (GPCRs). (teachmephysiology.com)
The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. (who.int)
Collagen-induced platelet aggregation was significantly reduced after alum injection. (who.int)
contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
Platelet thrombus on immobilized collagen was quantified using microfluidics platform. (elifesciences.org)
Platelets firmly adhere to the sub-endothelial matrix through the engagement of collagen receptors α2β1 and GPVI (Adhesion) . (biomedcentral.com)
The localization of the binding site of bitiscetin within the A3 domain was further supported by showing that MoAb to vWF, which are specific for this domain and block the interaction between vWF and collagen, are potent inhibitors of the binding of bitiscetin to vWF and consequently of the bitiscetin-induced binding of vWF to platelets. (ashpublications.org)
In this mechanism, vWF acts as a molecular bridge between constituents of the subendothelium, like collagen, and receptors of the platelet membrane, primarily the GPIb. (ashpublications.org)

We demonstrate expression of Notch1, its ligand DLL-4 and their respective transcripts in human platelets. (elifesciences.org)
Breton-Gorius,J. and Guichard,J. (1972): Ultrastructural localization of peroxidase activity in human platelets and megakaryocytes. (9dok.net)
1998): Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite. (9dok.net)

Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
Dysfunction or low levels of platelets predisposes to bleeding , while high levels, although usually asymptomatic, may increase the risk of thrombosis . (wikidoc.org)
GP IIb/IIIa receptor activation plays an important role in thrombosis. (aging-us.com)
In thrombosis, platelet activation serves as the initiation factor. (aging-us.com)
Hughes Syndrome/Antiphospholipid syndrome (APS) is a systemic autoimmune, hypercoagulable, thrombo inflammatory, and thrombosis and/or pregnancy complications syndrome caused by the persistent presence of antiphospholipid antibodies (APL) in plasma of patients with vascular thrombosis and/or pregnancy morbidity along with persistent anti-phospholipid antibodies (APLA), including lupus anticoagulant (LA), anti-β2-glycoprotein I (anti-β2GPI) and/or anti-cardiolipin (ACL) antibodies. (endinglines.com)
Blood platelets play an essential role in hemostasis, thrombosis and coagulation of blood. (biomedcentral.com)
High shear stress in stenotic atherosclerotic arteries cause platelet adhesion leading to the development of arterial thrombosis and cardiovascular events[ 15 ]. (biomedcentral.com)
to Platelet adhesion and aggregation are initiating events in arterial thrombosis. (justia.com)
Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. (embl.de)
Inhibition of Notch signaling, too, restrained agonist-induced platelet activation, and significantly impaired arterial thrombosis in mice. (elifesciences.org)
Normal coagulation is a balance between hemostatic and fibrinolytic processes, the loss of which may result in either excessive bleeding or intravascular thrombosis, which defines coagulopathy. (e-jnc.org)
Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. (comprehensivephysiology.com)
Chen,M. and Geng,J.G. (2006): P-Selectin mediates adhesion of leukocytes, platelets and cancer cells in inflammation, thrombosis, cancer growth and metastasis. (9dok.net)
Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integrins. (biomedcentral.com)

In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
Platelet activation results in a morphological change on the membrane surface of the platelet, increasing the surface area and preparing it for aggregation. (teachmephysiology.com)
Particular platelet defects, including unusual platelet morphology, obtained storage space pool disease, platelet membrane abnormalities, and unusual arachidonic acid fat burning capacity, have already been defined [4] previously. (cancercurehere.com)
ADP-induced platelet aggregation is mediated by the P 2T receptor subtype located on the platelet membrane. (justia.com)
Know normal platelet count, increased bleeding time, increased PTT *Captopril is a teratogen *MOA of Amphotericin B  Punches holes in ergosterol of the fungal cell membrane *Tons of biostats. (pdfcoffee.com)
Alternatively, further activation of platelets is associated with microvesiculation as a none-selective mechanism which leads to the loss of membrane- bearing receptors. (biomedcentral.com)

Adjacent platelets are cross-linked through the αIIβ3, resulting in platelet aggregation and hemostasis. (medscape.com)
Normal hemostasis. (medscape.com)
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
Platelets , or thrombocytes , are the cells circulating in the blood that are involved in the cellular mechanisms of primary hemostasis leading to the formation of blood clots . (wikidoc.org)
In other words platelets are corpuscular messengers, or are more than a member of the family providing hemostasis. (biomedcentral.com)
The function of platelets in the maintenance of hemostasis has long been recognized and well defined. (biomedcentral.com)
Choice C is wrong because platelet count measures the number of platelets in the blood, which are involved in primary hemostasis.Platelet count is not affected by warfarin therapy, but it can be decreased by heparin-induced thrombocytopenia (HIT), a rare but serious complication of heparin therapy. (naxlex.com)

When it is added to saline-diluted whole blood in the test cuvette, it stimulates the ADP receptors on platelets, activating the platelets. (wikipedia.org)

The platelet integrin αIIbβ3, also known as the glycoprotein GPIIb/IIIa (CD41/CD61) complex, is essential for normal platelet function. (medscape.com)
Glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. (hemostasis.com)
Microaggregation appeared to be distinct from full aggregation, as it was not inhibited by the addition of CD61, an antibody to the β 3 integrin. (nature.com)
Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
Bombeli,T., Schwartz,B.R., and Harlan,J.M. (1998): Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIb/IIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), α V β 3 -Integrin and GPIbα. (9dok.net)
Platelet integrin α IIb β 3 can also be modulated with a calpain-dependent proteolytic cleavage. (biomedcentral.com)
This triggers potent inside out signals inducing ADP release from dense bodies ( Shape change & agonist release ) as well as activating platelet major integrin α IIb β 3 . (biomedcentral.com)

Recombinant coagulation factor VIIa is approved for bleeding episodes and perioperative management in patients with GT refractory to platelet transfusions, with or without antibodies to platelets. (medscape.com)
Platelets with antibodies on their surface are trapped in the spleen, where they are efficiently removed by splenic macrophages. (medscape.com)
These antibodies may be directed toward viral antigens and then cross-react with platelet antigens. (medscape.com)
These antibodies can also react with the developing megakaryocytes in the bone marrow, leading to decreased production of platelets (ineffective thrombopoiesis). (medscape.com)
The high anti-platelet efficacy of antibodies or antagonists for GPIIb/IIIa is explained by their interference with this final common event. (justia.com)

Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 (PAR-1). (wikipedia.org)
The signal (PAF, or other tissue/cell specific factors) comes from the stimulated (by the e.g., hypophyseal hormones, bacteria, external factors, etc.) organs or cells, and activates platelets. (biomedcentral.com)

The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
Platelets are produced in hematopoiesis by budding off from megakaryocytes . (wikidoc.org)
Platelets originate from megakaryocytes, which are the largest progenitor cells of the bone marrow. (teachmephysiology.com)
In CML, the platelet dysfunction is normally believed to have got comes from a clonal extension of dysfunctional megakaryocytes. (cancercurehere.com)
Bentfeld-Barker,M.E. and Bainton,D.F. (1982): Identification of primary lysosomes in human megakaryocytes and platelets. (9dok.net)

The key role of platelets is their participation in haemostasis through the formation of blood clots at the site of bleeding. (teachmephysiology.com)
This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions. (comprehensivephysiology.com)

This process relies on the destruction of disulfide bonds present on these receptors, such as Cys5-Cys435, Cys663-Cys687, and a third Cys-rich repetitive zone, to be transformed into the ligand-binding, high-affinity state and evoke conformational changes in GP IIb/IIIa receptors [ 10 ]. (aging-us.com)

The platelets adhere to each other via adhesion receptors or integrins , and to the endothelial cells in the wall of the blood vessel forming a haemostatic plug in conjunction with fibrin . (wikidoc.org)
A) Platelets localize to the site of injury, binding to fibrin, and forming a hemostatic plug. (comprehensivephysiology.com)
2006): The influence of fibrin polymerization and platelet-mediated contractile forces on citrated whole blood thromboelastography profile. (9dok.net)
Of note, in a developing thrombus further activation converts platelets from a proaggregatory to a to pro-coagulant phenotype which enables the assembly of the coagulation reaction complexes (the Tenase and Prothrombinase complex) on the cell surface, necessary for thrombin and fibrin generation. (biomedcentral.com)

Based on clinical and experimental evidences we propose that platelets modulate the function of hypothalamo-hypophyseal-ovarian system. (biomedcentral.com)

Neither affinity-purified Ab1 nor Ab2 binds to platelets. (jci.org)
However, the combination of Ab1 and Ab2 (preincubated for 2 h at 22 degrees C) binds to platelets in a saturation-dependent manner at an optimum ratio range of 10-20:1. (jci.org)
In the presence of bitiscetin, vWF binds to platelets in a dose-dependent and saturable manner. (ashpublications.org)

The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. (aging-us.com)

The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)
Adhesion receptors promote the adhesion of platelets to other platelets, the vessel wall or leucocytes , depending on the receptor stimulated. (teachmephysiology.com)
The firm adhesion of platelets to the site of injury forms a monolayer which serves as a reactive site for further recruitment of free-flowing platelets. (biomedcentral.com)

While the expression and shedding of pro-inflammatory molecules can induce post-transfusion adverse effects, stored-dependent loss of adhesion receptors by ectodomain shedding or microvesiculation may attenuate post-transfusion adhesive functions of platelets causing their premature clearance from circulation. (biomedcentral.com)

Platelet activation further results in the scramblase -mediated transport of negatively charged phospholipids to the platelet surface. (wikidoc.org)

Platelet activation pathways. (medscape.com)
Through these pathways activated platelets are accumulated in the follicular vessels surrounding the follicle and due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters) locally increase oocyte maturation and hormone secretion. (biomedcentral.com)
A number of converging pathways lead to platelet aggregation. (justia.com)
Thrombin can produce platelet aggregation largely independently of other pathways but substantial quantities of thrombin are unlikely to be present without prior activation of platelets by other mechanisms. (justia.com)

The platelet-activating factor (PAF) is also an important secretory product of platelets mediating the platelet aggregation, inflammation and anaphylaxis[ 13 ] (Table 1 ). (biomedcentral.com)
Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. (comprehensivephysiology.com)

[ 5 ] Acquired Glanzmann thrombasthenia is characterized by anti-αIIbβ3 autoantibodies or paraproteins that block platelet aggregation. (medscape.com)
ITP is caused by autoantibodies to platelets. (medscape.com)
Obtained GT can be an unusual event in colaboration with CML, and it could be caused by the forming of autoantibodies against the GPIIb/IIIa complex [2]. (cancercurehere.com)

Platelets play an important role in the formation of blood clots . (teachmephysiology.com)

The activation of the platelets leads to shape change and degranulation, and the released content of the granules further activates the platelets. (wikipedia.org)
TXA2 increases platelet aggregation, promotes degranulation and stimulates platelet activation. (wikipedia.org)
Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
The contents of the granules are released upon activation of the platelet. (wikidoc.org)
Platelet aggregation is stimulated by thromboxane and α2 receptor -activation, but inhibited by other inflammatory products like PGI2 and PGD2 . (wikidoc.org)
Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)
The mechanism of early activation of GP IIb/IIIa receptors in diabetic conditions remains unknown. (aging-us.com)
Compared with the normal diet group, the diabetic group had significantly increased plasma EMP-PDI content and accelerated platelet activation by increased GP IIb/IIIa expression. (aging-us.com)
In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state. (aging-us.com)
However, diabetic patients have significantly higher platelet aggregation and activation than non-diabetic patients, including those undergoing dual antiplatelet therapy [ 4 - 6 ]. (aging-us.com)
This suggests that the mechanism of platelet activation in the diabetic state has not been fully elucidated. (aging-us.com)
However, the ultimate common pathway of platelet aggregation is the activation of glycoprotein (GP) IIb/IIIa receptors present on platelet surface [ 7 - 9 ]. (aging-us.com)
Platelet activation means their aggregation, sludge formation, furthermore the release of the for-mentioned biologically very powerful factors, which can locally amplify and deepen the tissue specific cell reactions. (biomedcentral.com)
Stehbens and Biscoe, 1967 ), platelet shape change was, and still is, generally regarded to be the initial stage of platelet activation. (nature.com)
The P 2T receptor (also known as P2Y ADP or P2T AC ) is primarily involved in mediating platelet aggregation/activation and is a G-protein coupled receptor which is as yet uncloned. (justia.com)
describes a novel signaling pathway involving Notch1 and its ligand, Δ-like ligand-4 (DLL4) in driving platelet activation and thrombus formation. (elifesciences.org)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
B) Platelet (red)‐neutrophil (green/blue) interactions in suspension after platelet activation. (comprehensivephysiology.com)
In a non-physiological condition, the storage of therapeutic platelets has also shown to be associated with the unwilling activation of platelets which triggers receptors down-regulation via aforementioned different mechanisms. (biomedcentral.com)

Inhibition of COX1, as with acetylsalicylic acid, and inhibition or absence of GPIIb/IIIa receptor, as seen in Glanzmann's thrombasthenia, will reduce platelet aggregation in response to arachidonic acid. (wikipedia.org)
COLtest is sensitive to inhibition of COX1 and GPIIb/IIIa and to Glanzmann's thrombasthenia. (wikipedia.org)
Obtained Glanzmann's thrombasthenia (GT) is certainly a uncommon bleeding disorder seen as a abrupt starting point of moderate-to-severe bleeding propensity and extended bleeding period but with regular platelet count number and regular or decreased platelet glycoprotein (GP) appearance. (cancercurehere.com)
Severe abnormalities in platelet function, such as Bernard-Soulier syndrome, Glanzmann's thrombasthenia, or platelet storage-pool deficiency, are characterized by the inability of platelets to aggregate in response to certain agonists. (nature.com)

Nonetheless, physiological thrombus formation (mural thrombi) is tightly regulated to avoid excessive platelet accumulation at the injury site and vascular obstruction, the principal pathological process causing heart attacks and ischaemic stroke [ 5 ]. (biomedcentral.com)
Figure 1 demonstrates different steps of platelet tethering, adhesion, aggregation and thrombus formation. (biomedcentral.com)

It also secretes e.g. platelet-derived growth factor (PDGF). (wikidoc.org)

Strikingly, prevention of DLL-4-Notch1 interaction by a blocking antibody abolished platelet aggregation and extracellular vesicle shedding induced by thrombin. (elifesciences.org)

Platelets contain two unique types of granules: alpha granules and dense granules. (medscape.com)
It is well known, that platelets have an armament of soluble molecules, factors, mediators, chemokines, cytokines and neurotransmitters in their granules, and have multiple adhesion molecules and receptors on their surface. (biomedcentral.com)
Granules merge with channels of the canalicular system after platelet stimulation and evacuate their contents[ 8 - 10 ]. (biomedcentral.com)
Ultrastructural features of a discoid platelet showing α‐granules, mitochondrion, the marginal microtubule band, and open canicular system. (comprehensivephysiology.com)

This is corroborated from the observation that utilizing tyrosine kinase inhibitors H 89 dihydrochloride irreversible inhibition for use in individuals with CML could improve platelet dysfunction [5]. (cancercurehere.com)
It has now been found that certain compounds within the scope of International Patent Application WO 9905143 but not specifically disclosed therein exhibit high potency combined with surprisingly high metabolic stability and bioavailibility, such that the predicted therapeutic dose for prolonged inhibition of aggregation in man shows advantage. (justia.com)
DLL-4, in turn, instigated neighbouring platelets to switch to 'activated' phenotype through cleavage of Notch receptor and release of its intracellular domain (NICD), which was averted by inhibition of γ-secretase and phosphatidylinositol-3-kinase (PI3K). (elifesciences.org)

Platelets contain a number of integrins and cell adhesion molecules on their surface which bind to both leukocytes and endothelial cells (green). (comprehensivephysiology.com)
PEG-precipitable complexes bind to platelets in a saturation-dependent manner. (jci.org)
Thus, our data support the hypothesis that an interaction between the A1 and A3 domains exists that may play a role in the function of vWF by regulating the ability of the A1 domain to bind to platelet GPIb. (ashpublications.org)

The test can be used to diagnose platelet disorders, monitor antiplatelet therapy, and is also investigated as a potential predictor of transfusion requirements and bleeding risk in cardiac surgery. (wikipedia.org)
Patients with GT who are bleeding require platelet transfusion. (medscape.com)
With the extension of ECC time, the drop in platelet counts is more pronounced, the volume of perioperative blood loss and blood products transfusion are more, and the recovery level and speed of platelet counts is lower. (nature.com)
It then highlights the crucial role of ectodomain shedding and microvesiculation in the propagation of "platelet storage lesion" which may affect the post-transfusion efficacy of platelet components. (biomedcentral.com)

The result is the secretion of ADP and thromboxane A2 which subsequently activate other platelets. (teachmephysiology.com)
The limited anti-thrombotic efficacy of aspirin may reflect the fact that it blocks only one source of ADP which is that released in a thromboxane-dependent manner following platelet adhesion (see e.g. (justia.com)

Major cell adhesion molecule interactions include (platelet‐leukocyte) P‐selectin‐PSGL‐1 and GP1bα‐Mac‐1. (comprehensivephysiology.com)

Adenosine diphosphate (ADP) is a platelet agonist. (wikipedia.org)
Platelets have abundant surface receptors , classified into agonist and adhesion receptors. (teachmephysiology.com)
Platelets were activated with ADP, thrombin, or the thrombin receptor agonist peptide SFLLRN (TRAP 1-6 ). (nature.com)

The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
Once activated, they release a number of different coagulation factors and platelet activating factors. (wikidoc.org)

Nurden provides reported that platelet glycoprotein dysfunction and signaling defects might occur in myeloproliferative neoplasms (MPNs), including CML [3]. (cancercurehere.com)

Thus, Notch pathway can be a potential anti-platelet/anti-thrombotic therapeutic target. (elifesciences.org)

This normally induces a strong platelet aggregation, and low or absent aggregation can be caused by the earlier mentioned conditions vWD and BSS. (wikipedia.org)

It was suggested that this optical effect was caused by the morphological change of platelets from discs to spherical cells with pseudopodia ( Latimer et al, 1977 ). (nature.com)

This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with each other to form an aggregate (see image below). (medscape.com)
Knockin of human VWF exon 28 and crossbreeding with hGPIbα Tg generated a humanized mouse model of platelet GPIbα-VWFA1 interaction. (ashpublications.org)
Platelet aggregation, granule secretion and platelet-leukocyte interaction were analyzed by lumi-aggregometry and flow cytometry. (elifesciences.org)
A) EM image of an inflamed mouse cremaster venule, demonstrating platelet‐neutrophil‐endothelial cell interaction. (comprehensivephysiology.com)

The instrument detects change in electrical impedance when platelets aggregate on metal electrodes in the test cuvette. (wikipedia.org)
This test can detect if vWF shows a stronger than normal tendency to aggregate platelets, which can be seen in a subtype of vWD called vWDIIb. (wikipedia.org)
When the complex functions abnormally, platelets cannot aggregate, which leads to increased bleeding. (medscape.com)

The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)

This property let platelets arrest bleeding and promote vessel repair. (biomedcentral.com)
Although the process of platelet adhesion to the sub-endothelial surface may have an important role to play in the repair of damaged vessel walls, the platelet aggregation that this initiates can precipitate acute thrombotic occlusion of vital vascular beds, leading to events with high morbidity such as myocardial infarction and unstable angina. (justia.com)

Antiplatelet drugs like clopidogrel and prasugrel irreversibly inhibit the ADP receptor P2Y12, leading to a decreased ADP-induced platelet aggregation. (wikipedia.org)
Clopidogrel is an antiplatelet drug that inhibits the ability of platelets to clump together as part of a blood clot.It is used to prevent recurrent stroke and other cardiovascular events in people who are at high risk. (naxlex.com)
Choice A is correct because taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) while on clopidogrel can increase the risk of bleeding.These drugs also affect platelet function and can interfere with the action of clopidogrel. (naxlex.com)

Platelets also adhere to endothelial cells and help capture flowing leukocytes from the circulation. (comprehensivephysiology.com)

Drugs that inhibit the GPIIb/IIIa receptor, e.g. eptifibatide, can also reduce or eliminate the ADP-induced platelet response. (wikipedia.org)
The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban. (hemostasis.com)
Eptifibatide is a Platelet Aggregation Inhibitor that is FDA approved for the treatment of acute coronary syndrome ( ACS ), percutaneous coronary intervention ( PCI ). (wikidoc.org)

These interactions further activate platelets. (medscape.com)
Platelets have specialized adhesion mechanisms that make them able to take part in cell-matrix and cell-cell interactions. (biomedcentral.com)
Examples of adhesive interactions between platelets (red) and leukocytes (blue). (comprehensivephysiology.com)
Adhesive interactions between activated platelets and neutrophils. (comprehensivephysiology.com)

We have purified bitiscetin from Bitis arietans venom and investigated the mechanism whereby it promotes a form of vWF that is reactive with platelets. (ashpublications.org)

Platelet-derived extracellular vesicles were documented with Nanoparticle Tracking Analyzer. (elifesciences.org)

This was also seen when preactivated platelets, which cannot undergo further morphological changes, were used, and when platelets were activated in the presence of shape-change inhibitors such as cytochalasin D and vincristine. (nature.com)

Once activated, platelets have two major mechanisms to recruit additional platelets to the growing hemostatic plug. (medscape.com)
Therefore we suggest that platelets are not only a small participant but may be the conductor or active mediator of this complex regulatory system which has several unrevealed mechanisms. (biomedcentral.com)
Platelets interact with leukocytes through both adhesive mechanisms as well as release of cytokines/chemokines. (comprehensivephysiology.com)
In its first part, the review presented here aims to describe the mechanisms involved in down-regulation of platelet adhesion receptors. (biomedcentral.com)

Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. (jci.org)

A defect in either glycoprotein can lead to a bleeding disorder. (medscape.com)

The normal platelet count is 150-400 x 10 9 /L. Although they are primarily found in the bloodstream, up to 30% of platelets are transiently sequestered within the spleen , ready for rapid mobilisation. (teachmephysiology.com)

This leads to a release of arachidonic acid, which is converted to the potent platelet activator TXA2. (wikipedia.org)

These phospholipids provide a catalytic surface (with the charge provided by phosphatidylserine and phosphatidylethanolamine ) for the tenase and prothrombinase complexes. (wikidoc.org)

this method is widely used to assess the functional status of platelets. (nature.com)
Existence of functional Notch signaling in enucleate platelets remains elusive. (elifesciences.org)
Selected examples of proinflammatory effects of platelets resulting in functional consequences on leukocytes. (comprehensivephysiology.com)

Genetic Heterogeneity of Platelet-Type Bleeding Disorders Inherited platelet disorders are a heterogeneous group of bleeding disorders affecting platelet number, function, or both. (nih.gov)

Anatomy16

Organisms10

Diseases22

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes41

Information Science3

Health Care2

Fibrinogen16

Willebrand5

Collagen14

Human platelets3

Thrombosis14

Membrane6

Hemostasis8

Receptors on platelets1

Integrin7

Antibodies5

Activates platelets2

Megakaryocytes5

Role of platelets2

Conformational1

Fibrin4

Modulate1

Binds to platelets3

Changes in platelet1

Adhesion of platelets3

Functions of Platelets1

Negatively charged phospholipids1

Pathways4

Inflammation3

Autoantibodies3

Blood clots1

Activation19

Glanzmann's4

Thrombus formation2

PDGF1

Blocking antibody1

Granules4

Inhibition3

Bind3

Transfusion4

Thromboxane2

GP1b1

Agonist3

Coagulation factors2

Nurden1

Pathway1

Induces1

Morphological change1

Interaction4

Aggregate3

Mediates1

Vessel2

Clopidogrel3

Adhere1

Eptifibatide3

Interactions4

Promotes1

Extracellular1

Inhibitors1

Mechanisms4

Arterial1

Defect1

Primarily1

Arachidonic acid1

Prothrombinase1

Functional3

Disorders1