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  • inhibition
  • Some would add the subsequent clot retraction and platelet inhibition as fourth and fifth steps to the completion of the process and still others a sixth step wound repair. (wikipedia.org)
  • Since PGI2 is primarily produced in a nucleated endothelial cell, the COX inhibition by NSAID can be overcome with time by increased COX gene activation and subsequent production of more COX enzymes to catalyze the formation of PGI2. (wikipedia.org)
  • In contrast, TXA2 is released primarily by anucleated platelets, which are unable to respond to NSAID COX inhibition with additional transcription of the COX gene because they lack DNA material necessary to perform such a task. (wikipedia.org)
  • Platelet inhibition is important to prevent thrombotic episodes or the formation of blood clot and consequently preventing heart attacks and strokes. (wikipedia.org)
  • reactivity
  • In conclusion, high glucose levels enhanced platelet reactivity to agonist stimulation through elevated osmolality. (ovid.com)
  • integrin
  • Suppression of integrin activation: a novel function of a Ras/Raf- initiated MAP kinase pathway," Cell , vol. 88, no. 4, pp. 521-530, 1997. (hindawi.com)
  • fibrinogen
  • High glucose levels enhanced adenosine diphosphate (ADP)- and thrombin receptor-activating peptide (TRAP)-induced platelet P-selectin expression, and TRAP-induced platelet fibrinogen binding. (ovid.com)
  • Superoxide anion scavenging by superoxide dismutase (SOD) attenuated the hyperglycaemic enhancement of platelet P-selectin expression, but did not counteract the enhancement of TRAP-induced platelet fibrinogen binding. (ovid.com)
  • dysfunction
  • These results suggest that hyperglycemia-induced mitochondrial superoxide generation may play an important role in platelet dysfunction observed in patients with diabetes. (diabetesjournals.org)
  • No evidence of platelet dysfunction or an increase in surgical bleeding after administration of inhaled epoprostenol has been found. (wikipedia.org)
  • responses
  • Platelets are key players in inflammatory responses, with platelet activation contributing to the pathogenesis of acute lung injury (ALI) and acute coronary events (ACE) in community-acquired pneumonia. (ersjournals.com)
  • It may therefore be valuable to assess platelet responses mediated by diverse strains of bacteria. (lu.se)
  • CD62P
  • Recombinant Ply was used at pathologically relevant concentrations (10-80 nanograms/mL), while platelet activation was measured flow cytometrically according to the level of expression of P-selectin (CD62P). (ersjournals.com)
  • The influx of extracellular calcium, an event which precedes and is a prerequisite for platelet activation, including upregulation of CD62P, was measured using a Fura-2AM-6-based spectrofluorimetric procedure. (ersjournals.com)
  • Ply-mediated upregulation of expression of CD62P on platelets was associated with increases in the concentrations of cytosolic calcium and attenuated by depletion of calcium from the cell-suspending medium, as well as by exposure of the cells to a pneumolysoid devoid of pore-forming activity. (ersjournals.com)
  • These observations are consistent with Ply-mediated platelet activation involving sub-lytic pore formation, calcium influx, and discharge of CD62P-expressing α-granules. (ersjournals.com)
  • contributes
  • Alteration of platelet function contributes to microthrombus formation and may play an important role in the pathogenesis of diabetic micro- and macroangiopathies. (diabetesjournals.org)
  • vivo
  • There is strong evidence of in vivo interaction between platelets and atherogenic lipoproteins suggesting that atherogenic triglyceride-rich lipoproteins, such as VLDL, that are increased in diabetic dyslipidemia are important in this process. (diabetesjournals.org)
  • No increase in platelet activation was found after ex vivo irradiation of blood samples obtained from healthy controls. (bmj.com)
  • calcium
  • For the intracellular Ca 2+ assay, platelets were loaded with calcium-indicator dyes and the measurements were carried out using a ratiometric method with real-time confocal microscopy. (hindawi.com)
  • Ceramide
  • Moreover, there is also sufficient evidence which implicates ceramide to the activation of the kinase suppressor of Ras (KSR), PKCζ, and cathepsin D. Interestingly, cathepsin D has been proposed as the main target for ceramide formed in organelles called lysosomes, making lysosomal acidic SMase enzymes one of the key players in the mitochondrial pathway of apoptosis. (wikipedia.org)
  • pathway
  • 2.Zhicheng Xiao, Jing Zhang, Xiaogang Peng, Yanjun Dong, Lixin Jia, Huihua Li,Jie Du: The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. (54doctor.net)
  • The activation of the c-Src pathway has been observed in about 50% of tumors from colon, liver, lung, breast and the pancreas. (wikipedia.org)
  • Kinase
  • 10.Xin Xi, Shuang Liu, Hongtao Shi, Min Yang, Yongfen Qi, Jian Wang, Jie Du: Serum-Glucocorticoid Regulated Kinase 1 Regulates Macrophage Recruitment and Activation Contributing to Monocrotaline-Induced Pulmonary Arterial Hypertension. (54doctor.net)
  • cell
  • Platelets, also called thrombocytes, are the smallest cell type in the blood . (thoughtco.com)
  • Activated platelets change their shape and become more round with long, finger-like projections extending from the cell. (thoughtco.com)
  • The decoy platelets were able to compete with normal platelets when binding to cancer cells and were effective in preventing cancer cell extrusion out of a vasculature-emulating microfluidic chip model. (innovations-report.com)
  • Twenty two tests were carried out on homozygous mutant mice and one significant abnormality was observed: females had abnormal complete blood count parameters, including an increased red blood cell distribution width and increased mean platelet volume. (wikipedia.org)
  • count
  • A low platelet count may result from a condition called thrombocytopenia . (thoughtco.com)
  • Other common findings, although not part of the APS classification criteria, are low platelet count, heart valve disease, and livedo reticularis. (wikipedia.org)
  • acid
  • Thromboxane A synthase 1 (platelet) ( THAS ) forms 12-hydroxyheptadeca-5,8,10-trienoic acid and malonic dialdehyde as a byproduct, Thromboxane A(,2 ) [ 38 ], [ 39 ] and Thromboxane B2 . (bio-rad.com)
  • agents
  • Our ability to reverse the platelet inhibiting effects with a simple reintroduction of normal platelets is very encouraging as currently available anti-platelet agents are often difficult to reverse in emergency settings such as severe bleeding," Dr. Papa said. (innovations-report.com)
  • form
  • Megakaryocytes are huge cells that break into fragments to form platelets. (thoughtco.com)
  • The plasmatic form includes two additional identical subunits, FXIII-B, that is released in a calcium-dependent manner upon activation peptide cleavage. (wikipedia.org)
  • cells
  • Furthermore, in a model of metastasis, there was a significant reduction in the burden of established metastatic tumors when cancer cells were introduced simultaneously with platelets and decoys. (innovations-report.com)