Platelet activating factor. Medical search. Frequent questions

The pathway to apoptosis can be inhibited by negative feedback from PAF acetylhydrolase (PAF-AH), an enzyme that catabolizes platelet-activating factor. (wikipedia.org)
Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease. (nih.gov)
Activity and distribution of plasma platelet-activating factor acetylhydrolase in women with gestational diabetes mellitus and their neonates. (nih.gov)

The PAFAH1B1 gene (also known as LIS1 ) provides instructions for making a protein that is one part (subunit) of a complex called platelet activating factor acetyl hydrolase 1B (PAFAH1B). (medlineplus.gov)
[ 4 , 5 ] The primary site for the synthesis of subunit A in plasma factor XIII seems to exist in cells that originate in the marrow. (medscape.com)

We have previously identified a novel complex between the platelet-derived growth factor (PDGF)β receptor and the sphingosine 1-phosphate receptor-1 (S1P1). (strath.ac.uk)
These findings are the first to report that a GPCR inverse-agonist reduces growth factor-induced receptor tyrosine kinase signaling, fundamentally broadening their mechanism of action. (strath.ac.uk)
Previous studies from ours and other groups have established that through its ability to act as a pro-oxidative stressor, UVB generates oxidized glycerophosphocholine (Ox-GPC) lipids with Platelet-activating Factor-receptor (PAF-R) agonist activity. (wright.edu)
The Human Platelet activating factor receptor ELISA kit can be used to identify samples from the human species. (elisakit.cc)
Platelet activating factor receptor can also be called PTAFR. (elisakit.cc)
SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets. (elisakit.cc)
The team collected bovine serum albumin fraction V (FV-BSA), ADP, PAF, collagen, and thrombin receptor activating peptide (TRAP) along with a recombinant HEK293-derived SARS-CoV-2 S receptor-binding domain (RBD) protein. (sepoy.net)
However, little is known about the role of PAF/platelet-activating factor receptor (PAF-R) in Parkinson's disease. (korea.ac.kr)
The capacity of pneumococci to adhere to and infect lower airway cells is mediated by host-expressed platelet-activating factor receptor (PAFR). (cdc.gov)

These findings reinforce the view that the pulmonary effects of platelet-activating factor are mediated through different pathways. (ersjournals.com)
The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factors. (nih.gov)
The purpose of this study was to investigate the effects of heparin on the haemodynamic changes which were induced by platelet-activating factor in the pulmonary and systemic circulation in pigs. (uaeu.ac.ae)
Platelet-activating factor caused a dose dependent pulmonary artery hypertension, associated with an initial systemic hypotension followed by systemic hypertension. (uaeu.ac.ae)
The pulmonary and systemic circulation responded differently to platelet-activating factor after giving heparin. (uaeu.ac.ae)
While heparin ameliorated the platelet-activating factor-induced pulmonary hypertension, it did not affect the changes in the systemic circulation. (uaeu.ac.ae)

These developments led to the finding that macrophages produce PAF and that macrophages play an important function in aggregation of platelets and liberation of their inflammatory and vasoactive substances. (wikipedia.org)

Aspirin, glycoprotein (GP) IIb/IIIa inhibitors, and clopidogrel have an inhibitory effect on platelet activation and aggregation. (medscape.com)
Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm. (chop.edu)

Scholars@Duke publication: In vitro effects of recombinant activated factor VII on thrombin generation and coagulation following inhibition of platelet procoagulant activity by prasugrel. (duke.edu)
In the current study we evaluated whether recombinant activated factor VII may reverse prasugrel induced effects and increase thrombin generation in an in vitro model. (duke.edu)
METHODS: The effect of prasugrel active metabolite, PAM (R-138727), was evaluated on platelet aggregation, thrombin generation, and rotational thromboelastometry parameters using blood from 20 healthy volunteers. (duke.edu)
Treatment with recombinant activated factor VII restored all three parameters of thrombin generation towards baseline. (duke.edu)
When recombinant activated factor VII and ADP were combined they had a greater effect on thrombin parameters than either drug alone. (duke.edu)
CONCLUSIONS: Recombinant activated factor VII restores thrombin generation in the presence of PAM. (duke.edu)
Platelets play a crucial role in thrombosis and homeostasis and their aggregation has been widely reported among coronavirus disease 2019 (COVID-19) patients as a response to collagen, thrombin, and adenosine diphosphate (ADP). (sepoy.net)
During thrombus formation, circulating prothrombin is activated to the active clotting factor, thrombin, by activated platelets. (medscape.com)
Fibrinogen is activated to fibrin by the newly activated thrombin. (medscape.com)
Also known as fibrin-stabilizing factor, the 320,000-Dalton glycoprotein is activated by thrombin in the presence of calcium and has a plasma half-life of approximately 10 days. (medscape.com)
Thrombin cleavage of the Arg 37 -Gly 38 bond in the A chain, causing the release of an M r 4500 activation peptide, is the key step in the activation of plasma factor XIII. (medscape.com)
When activated by thrombin, factor XIIIa forms an insoluble clot by causing cross-linkage between fibrin molecules. (medscape.com)

Both hemostasis and thrombosis depend on the coagulation cascade, vascular wall integrity, and platelet response. (medscape.com)
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. (chop.edu)
Factor XIII, an enzyme that cross-links fibrin, belongs to the blood coagulation system. (medscape.com)

Fas-Induced Apoptosis Increases Hepatocyte Tissue Factor Procoagulant Activity in Vitro and in Vivo. (chop.edu)

Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis. (wikipedia.org)
Platelet-activating factor (PAF) is a potent proinflammatory mediator that induces systemic and respiratory effects in normal control subjects and asthmatics. (ersjournals.com)
1. This study analyses whole blood in acutely unclipped one-kidney, one-clip (1K,1C) hypertensive rats for the presence of platelet-activating factor (PAF), a potent vasodilator and a putative mediator of the rapid blood pressure (BP) fall seen after unclipping. (portlandpress.com)
The potential role of platelet-activating factor (PAF)-acether and of IL-5 as an eosinophil-proliferating, activating, and/or recruiting mediator in asthma led us to study the effects of human (h) rIL-5 (hrIL-5) and PAF-acether, alone or combined, on isolated guinea pig eosinophils. (pasteur.fr)
Platelet-activating factor (PAF), a potent mediator of inflammatory and immune responses, plays various roles in neuronal functions. (korea.ac.kr)
Platelet-activating factor (PAF) is a proinflammatory mediator that may influence neuronal activity in the enteric nervous system (ENS). (edu.au)

Platelet-activating factor (PAF) stimulates human B cells, resulting in elevation of intracellular calcium and the release of inositol phosphates. (jci.org)
Platelets alone aggregated and showed intracellular Ca2+ movement only when exposed to PAF. (nih.gov)

IL-4 is a potent lymphoid cell growth factor which stimulates the growth and activation of certain B cells and T cells. (biolegend.com)

Platelet activating factors (PAFs) are a family of ether lipids with properties that suggest a major role in inflammation. (jamanetwork.com)

6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. (sigmaaldrich.com)
A series of aryl phosphoglyceride (3, 19-61) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. (sigmaaldrich.com)

150,000 platelets per microliter of blood), consistent with a condition known as thrombotic thrombocytopenia, with platelet nadir counts ranging from 10,000 to 127,000 during their hospitalizations. (cdc.gov)

Platelet-leukocyte interaction could have physiopathological relevance and constitutes a new model for studying old and new platelet inhibitory drugs. (nih.gov)

Dangerous internal bleeding can occur when your platelet count follows below 10,000 or below 10 platelets per microliter. (cdc.gov)

Additionally, we evaluated the effects of adenosine diphosphate (ADP) and recombinant activated factor VII on restoring these parameters towards baseline values. (duke.edu)
Treatment with either recombinant activated factor VII or ADP restored these values towards baseline. (duke.edu)
In the present study, researchers evaluated the effect of the COVID-19 messenger ribonucleic acid (mRNA) vaccine on the human platelet-rich plasma (hPRP) aggregation response and whether a recombinant SSARS-CoV-2 S protein could modulate hPRP aggregation induced by PAF. (sepoy.net)

UVB Generates Microvesicle Particles via Platelet-activating Factor-re" by Jeffrey B. Travers, Christine M. Rapp et al. (wright.edu)

Addition of platelets at different times after leukocyte activation resulted in progressively reduced cytoplasmic Ca2+ increase. (nih.gov)
Cell-free supernatants prepared from FMLP-stimulated leukocytes were able to induce platelet aggregation, thromboxane B2 generation, and Ca2+ mobilization, although at a reduced degree as compared with intact leukocyte addition. (nih.gov)

It is concluded that furosemide is not effective in protecting against platelet-activating factor challenge in patients with asthma despite its potential inhibition of leukotriene synthesis. (ersjournals.com)

Furthermore, various studies have reported stimulation of tumor necrosis factor-α (TNF-α), platelet factor 4 (PF4), interleukin 1β (IL-1β), and IL-8 from platelets by the SARS-CoV-2 S protein. (sepoy.net)
Tissue Factor-positive Tumor Microvesicles Activate Platelets and Enhance Thrombosis in Mice. (chop.edu)

It had no effect on the platelet-activating factor- induced systemic hypotension or hypertension. (uaeu.ac.ae)

Increasing numbers of CD19 + CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia. (nih.gov)
Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay. (nih.gov)
And thrombocytopenia is a condition in which you have low blood platelet count, defined as less than 150. (cdc.gov)
So, the discussion around this issue or awareness of this issue originated from reports of a rare but serious condition following AstraZeneca's COVID-19 vaccine, and this condition initially recognized was CVST in the presence of thrombocytopenia, so, blood clots in the brain with low platelets. (cdc.gov)
In these cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets (thrombocytopenia). (cdc.gov)
Based on studies conducted among the patients diagnosed with immune thrombotic thrombocytopenia after the AstraZeneca COVID-19 vaccine in Europe, the pathogenesis of these rare and unusual adverse events after vaccination may be associated with platelet-activating antibodies against platelet factor-4 (PF4), a type of protein. (cdc.gov)

The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells in vivo, allowing those cells to produce the proteins that led to more bone production. (sciencedaily.com)
This fusion gene encodes for the FIP1L1-PDGFR alpha protein, the constitutively activated tyrosine kinase activity that induces eosinophilia. (medscape.com)

In a recent study published in the IUBMB journal, researchers assessed the association between platelet-activating factor (PAF) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein. (sepoy.net)
Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor? (sepoy.net)
The influence of the SARS-CoV-2 S protein on platelet aggregation induced by agonists was assessed by preincubating the platelets in the presence of the viral S protein, while different amounts of platelet agonists were added. (sepoy.net)
In some of the tests, the S protein was added when the agonist-induced aggregation occurred or before the secondary wave of platelet aggregation induced by the agonists. (sepoy.net)
The team also observed that incubation of the platelets from unvaccinated individuals for 10 minutes with the viral S protein did not stimulate hPRP aggregation. (sepoy.net)
Components of the clotting and fibrinolytic system, along with multiple adhesive and contractile proteins, are additional factor XIIIa protein substrates. (medscape.com)
Anti-heat shock protein 10 IgG in chronic spontaneous urticaria: Relation with miRNA-101-5p and platelet-activating factor. (cdc.gov)

In the absence of the B-chain, the elevation of intracytoplasmic Ca 2+ during platelet activation causes the zymogen to assume an active configuration. (medscape.com)

Several cellular factors are responsible for thrombus formation. (medscape.com)
Platelets migrate to the area of injury, where they secrete several cellular factors and mediators. (medscape.com)
In platelets, a nonproteolytic process activates cellular factor XIII. (medscape.com)

Screening for factor XIII, also known as fibrin-stabilizing factor, is performed when its absence is suspected. (medscape.com)
By crosslinking fibrin to alpha 2-antiplasmin, factor XIIIA also protects fibrin from fibrinolysis. (medscape.com)
Fibrin strands form a net that entraps more platelets and blood cells, producing a clot that plugs the break. (msdmanuals.com)

[ 1 ] Plasma factor XIII also plays a role in wound healing and tissue repair, and the enzyme is essential in maintaining pregnancy. (medscape.com)
The enzyme is very specific for monocytes and macrophages, so identification and classification of malignant diseases involving these cells can be carried out by determining whether or not factor XIII is present. (medscape.com)

Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer. (chop.edu)

The team also collected blood samples as an anticoagulant in trisodium citrate and platelet-rich plasma (PRP) via centrifugation. (sepoy.net)

[ 6 ] Although a clot will form if factor XIII is absent, it will not be adequate for hemostasis. (medscape.com)

Human platelets were loaded with aequorin, a Ca2(+)-sensitive photoprotein, and tested in the platelet-ionized calcium aggregometer for simultaneous recording of platelet aggregation and intraplatelet Ca2+ levels both in the presence and in the absence of autologous polymorphonuclear leukocytes. (nih.gov)

[ 5 ] The factor XIII A chain gene is found on chromosome 6. (medscape.com)

Platelet-aggregating activity was found in the chloroform phase in 2 of 9, 1 of 8, 0 of 9, and 3 of 9 studies involving iris, retina, ciliary body, or cornea, respectively. (jamanetwork.com)
The PAF concentrations were estimated by assessing the aggregatory activity toward washed rabbit platelets (WRP). (sepoy.net)
Although nuclear factor kappa B (NF-κB) DNA-binding activity was increased significantly in MPTP-treated wild-type mice, this increase was not significant in PAF-R antagonist ginkgolide B (GB)-treated mice or PAF-R knockout (PAF-R -/- ) mice. (korea.ac.kr)

PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)
IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. (biolegend.com)

Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. (jci.org)

Circulation of plasma factor XIII occurs in association with its substrate, fibrinogen. (medscape.com)

Cells were exposed to one of three chemotactic stimuli: platelet-activating factor (PAF), N-formyl-methionyl-leucyl-phenylalanine (FMLP), or leukotriene B4 (LTB4). (nih.gov)
In platelets and other cells, factor XIII lacks the B domain, existing instead as an A 2 dimer. (medscape.com)
Platelets, red blood cells, and clotting factors circulate in your bloodstream. (msdmanuals.com)

Amplification of both platelet aggregation and intraplatelet Ca2+ movement was induced by PAF in the presence of leukocytes. (nih.gov)
Aggregation and intraplatelet Ca2+ mobilization were also observed in the presence of leukocytes activated by either FMLP or LTB4. (nih.gov)
Platelet thromboxane B2 production was also significantly increased in the presence of leukocytes. (nih.gov)
Screening for factor XIII is carried out when the enzyme's presence is suspected. (medscape.com)

Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. (nature.com)

The pellet resulting from centrifugation was further recentrifuged to acquire platelet-poor plasma (PPP). (sepoy.net)

This study aimed to validate Singinatha choornam as an effective drug against platelet activating factor-induced rhinosinusitis in rat model. (ijpsonline.com)

This complex regulates the amount of a molecule called platelet activating factor (PAF) in the brain. (medlineplus.gov)

Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. (cdc.gov)

Drugs that block your clotting factors are sometimes called "blood thinners. (msdmanuals.com)

Anatomy21

Organisms7

Diseases21

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes35

Disciplines and Occupations1

Information Science2

Health Care1

Acetylhydrolase3

Subunit2

Receptor9

Pulmonary6

Substances1

Inhibitors2

Thrombin12

Coagulation3

Procoagulant activity1

Mediator6

Intracellular2

Potent1

Lipids1

Antagonists2

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Inhibitory1

Microliter1

Recombinant3

Particles1

Leukocyte2

Synthesis1

Tumor2

Systemic1

Thrombocytopenia6

Encodes2

Protein7

Activation1

Cellular3

Fibrin3

Enzyme2

Thrombosis1

Anticoagulant1

Clot1

Calcium1

Chain1

Activity3

Cytokine2

Human1

Substrate1

Cells3

Presence4

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Plasma1

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